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The Reasons for Evisceration After Penetrating Keratoplasty Between 1995 and 2015 As Causas De Evisceração Após Ceratoplastia Penetrante Entre 1995 E 2015

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The Reasons for Evisceration After Penetrating Keratoplasty Between 1995 and 2015 As Causas De Evisceração Após Ceratoplastia Penetrante Entre 1995 E 2015 ORIGINAL ARTICLE The reasons for evisceration after penetrating keratoplasty between 1995 and 2015 As causas de evisceração após ceratoplastia penetrante entre 1995 e 2015 EVIN SINGAR OZDEMIR1, AYSE BURCU1, ZULEYHA YALNIZ AKKAYA1, FIRDEVS ORNEK1 ABSTRACT RESUMO Purpose: The purpose of this study was to determine the indications and frequency Objetivo: O objetivo deste estudo foi determinar as indicações e a frequência de of evisceration after penetrating keratoplasty (PK). evisceração ocular após cirurgia de ceratoplastia penetrante ou transplante de Methods: The medical records of all patients who underwent evisceration after PK córnea (PK). between January 1, 1995 and December 31, 2015 at Ankara Training and Research Métodos: Foram analisados os registros médicos de todos os pacientes submetidos à Hospital were reviewed. Patient demographics and the surgical indications for evisceração após PK entre 1o de janeiro de 1995 e 31 de dezembro de 2015 no Hospital PK, diagnosis for evisceration, frequency of evisceration, and the length of time de Treinamento e Pesquisa de Ankara. Foram registradas a demografia do paciente e between PK and evisceration were recorded. as indicações cirúrgicas de PK, diagnóstico de evisceração, frequência de evisceração, Results: The frequency of evisceration was 0.95% (16 of 1684), and the mean age tempo entre PK e evisceração. of the patients who underwent evisceration was 56.31 ± 14.82 years. The most Resultados: A frequência de evisceração foi de 0,95% (16 de 1684) e a média de idade common indication for PK that resulted in evisceration was keratoconus (37.5%), and foi de 56,31 ± 14,82 anos. A indicação mais comum para PK que terminou na evis­ the most common underlying cause leading to evisceration was endophthalmitis ceração foi o ceratocone (37,5%) e a causa subjacente à evisceração foi a endoftalmite (56.25%). The interval between PK and evisceration ranged from 9 to 78 months. (56,25%). O intervalo entre PK e evisceração variou de 9 a 78 meses. Conclusions: Although keratoplasty is one of the most successful types of sur- Conclusão: Embora a ceratoplastia seja uma das cirurgias mais bem sucedidas entre gery among tissue transplantations, our findings show that it is associated with os transplantes de tecidos, pode­se deduzir do estudo que não é tão inócua, pois pode a possible risk of evisceration. evoluir para a evisceração ocular. Keywords: Eye evisceration/etiology; Keratoplasty, penetrating/adverse effects; Descritores: Evisceração do olho/etiologia; Ceratoplastia penetrante/efeitos adversos; Endophthalmitis; Keratoconus Endoftalmite; Ceratocone INTRODUCTION METHODS Keratoplasty has become more common as a result of the deve- The procedures in this study were approved by the Human lopment of microsurgical techniques, improvement in eye banking Research Ethics Committee at Ankara Training and Research Hospital­­ procedures, and increased awareness regarding tissue and body (Ankara, Turkey), and they conform to the principles of the Decla- transplantation. Postoperative care and patient awareness have been ration of Helsinki (2008). The medical records of all patients who found to be at least as important as surgical performance. Despite underwent PK between January 1, 1995 and December 31, 2015 were these developments, complications are still common. Because of reviewed retrospectively. Our hospital is a tertiary referral hospital new topical and systemic medications used for infections, glaucoma, that specializes in the field of corneal surgery. The initial examination dry eye, and graft failure as well as novel surgical techniques deve- of the patients transferred from other cities was performed at our loped for glaucoma, these complications can be treated in a timely clinic each month in the first 3 months after PK, and subsequent manner. However, painful blindness can develop in cases that do examinations between 3 and 6 months after PK were performed not respond to treatment. For these cases, evisceration (i.e.; surgical at the referring clinics on a regular basis. Examinations 6 months removal of the content of the eye) is a recommended option. post-surgery were performed at our clinic every 3 months. The 73 pa- Evisceration after penetrating keratoplasty (PK) performed for tients who were examined at other centers between 3 and 6 months panophthalmitis that developed secondary to trauma(1-3) and endo- post-surgery were excluded from our study. Patients who underwent phthalmitis(4) have been previously reported, but our study is the first evisceration after PK were identified. study performed to establish the indications of evisceration after PK. All donor tissues were obtained from the International Eye Bank The aim of this study was to investigate the diagnosis, influential of Ankara. A standard microsurgical technique was used for perfor- factors, and incidence of evisceration surgery after PK. ming PK in all cases. The host cut ranged from 7.0 to 8.5 mm in dia- Submitted for publication: July 26, 2016 Funding: No specific financial support was available for this study. Accepted for publication: January 16, 2017 Disclosure of potential conflicts of interest: None of the authors have any potential conflict of 1 Department of Ophthalmology, Ankara Training and Research Hospital, Ankara, Turkey. interest to disclose. Corresponding author: Evin Singar Ozdemir. Department of Ophthalmology. Ankara Training and Research Hospital. Sukriye Mahallesi, Ulucanlar Caddesi, No: 89 Altındag - Ankara, 06340, Turkey. E-mail: [email protected] Approved by the following research ethics committee: Ankara Training and Research Hospital (# 0637). 168 Arq Bras Oftalmol. 2017;80(3):168-71 http://dx.doi.org/10.5935/0004-2749.20170041 OZDEMIR ES, ET AL . meter and a donor graft that was 0.25/0.5 mm larger (7.25-9.0 mm in for glaucoma after PK; extracapsular cataract surgery for cataract and diameter) was used. The graft was sutured with a 10-0 monofilament Ahmed glaucoma valve implantation for glaucoma after PK surgery nylon by continuous, interrupted, or combined suturing techniques were performed on the other patient. after placing four cardinal sutures. Anterior vitrectomy and syne- Trauma was the cause for evisceration in three eyes. Because of chiotomy were performed when indicated. Subconjunctival injec- advanced prolapse and loss of intraocular tissues during trauma, tions of corticosteroid (1 ml dexamethasone) and antibiotic (0.5 ml evisceration was performed on the patients with no light perception gentamicin 80 mg/ml) were administered at the end of the surgery. as the primary treatment after trauma. Postoperative medications included prednisolone sodium Surgical therapies applied before evisceration included 21 am- phosphate 1% eye drops hourly and 0.3% ciprofloxacin drops six niotic membrane transplantations in 10 eyes (one time in two eyes, ti mes a day. Systemic immunosuppressive medications, antimicrobial two times in five eyes, three times in three eyes) to treat epithelial treatment, antiglaucoma medications, and artificial tears were used defects and corneal melting; keratoplasty in three eyes (one eye when necessary. The antibiotic drops were stopped 4-6 weeks after limbal failure, two eye graft failures); reparation for trauma in two surgery, and the corticosteroid eye drops were tapered over a pe- eyes; and resuturing because of suture loosening in one eye (Table 1). riod of 1 year according to each patient’s clinical course. Because of both prolonged treatment and unwillingness to be treated Endophthalmitis was defined by the presence of severe pain with immunosuppressants, especially the patients with corneal and intraocular inflammation with hypopyon or fibrin in the anterior melting requested to undergo evisceration. chamber. Cultures from the anterior chamber and/or vitreous were also required for diagnosing these cases. DISCUSSION Before evisceration, visual acuity was determined and slit-lamp biomicroscopy was performed. Ultrasound examination of the pos- Despite the favorable outcomes of PK, it is not free of compli- terior segment was performed when fundus examination was not cations, which include wound leaks and wound displacement, per- possible because of opaque media. sistent epithelial defects, suture-related complications, elevated Data reviewed from the medical records included: age, sex, latera- intraocular pressure, severe intraocular inflammation, anterior syne- lity, indication for PK, reasons for evisceration, length of time between chiae formation, pupillary block, infectious keratitis, endophthalmitis, (5) PK and evisceration, duration of follow-up, total number of PKs, the and primary donor failure . Nowadays, our biggest challenges are incidence of graft infection, and the trauma incidence after PK. the cases that do not respond to treatment, resulting in painful blindness. Surgical removal of the eye is a recommended therapeutic modality, with enucleation and evisceration being the two available RESULTS alternatives(6). Our study revealed that 16 of the 1684 (0.95%) PK cases perfor- Surgical removal of the eye is a very difficult decision to make for med between 1995 and 2015 resulted in evisceration being perfor- both the ophthalmologist and the patient because it is an irreversi- med. The mean age of the patients that underwent to evisceration ble procedure that has physical, socioeconomic, and psychological was 56.31 ± 14.82 years (range 12-76 years); 10 subjects were male effects on the individual(7). Surgeons usually perform evisceration and
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