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Dry Eye Disease Management for IMPROVING PATIENT OUTCOMES

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Dry Eye Disease Management for IMPROVING PATIENT OUTCOMES CME MONOGRAPH Visit https://tinyurl.com/DEDOutcomesCME for online testing and instant CME certificate. CURRENT PERSPECTIVES Dry Eye Disease Management FOR IMPROVING PATIENT OUTCOMES FACULTY TERRY KIM, MD (CHAIR) • ROSA BRAGA-MELE, MD, MEd, FRCSC JESSICA CIRALSKY, MD • CHRISTOPHER J. RAPUANO, MD Original Release: May 1, 2019 • Expiration: May 31, 2020 This continuing medical education activity is jointly provided by New York Eye and Ear Infirmary of Mount Sinai and MedEdicus LLC. This continuing medical education activity is supported through an unrestricted educational grant from Shire. Distributed with LEARNING METHOD AND MEDIUM Jessica Ciralsky, MD, had a financial agreement or affiliation during the This educational activity consists of a supplement and ten (10) study past year with the following commercial interests in the form of Consultant/ questions. The participant should, in order, read the learning objectives Advisory Board: Allergan; and Shire. contained at the beginning of this supplement, read the supplement, Terry Kim, MD, had a financial agreement or affiliation during the past answer all questions in the post test, and complete the Activity year with the following commercial interests in the form of Consultant/ Evaluation/Credit Request form. To receive credit for this activity, Advisory Board: Actavis; Aerie Pharmaceuticals, Inc; Alcon; Allergan; please follow the instructions provided on the post test and Activity Avedro, Inc; Avellino Labs; Bausch & Lomb Incorporated; BlephEx; Evaluation/Credit Request form. This educational activity should take a CoDa Therapeutics, Inc; CorneaGen; Kala Pharmaceuticals; NovaBay maximum of 1.5 hours to complete. Pharmaceuticals, Inc; Novartis Pharmaceuticals Corporation; Ocular ACTIVITY DESCRIPTION Therapeutix, Inc; Ocunexus Therapeutics, Inc; Omeros Corporation; Dry eye disease (DED) is increasing in prevalence because of an aging PowerVision, Inc; Presbyopia Therapies; Shire; Silk Technologies Ltd; population and necessities of modern living (eg, office work and staring at Simple Contacts Inc; TearLab Corporation; TearScience; and Valeant; computer screens and other digital devices). Nonetheless, DED remains Ownership Interest (Stock options, or other holdings, excluding diversified underdiagnosed and undertreated. It is important to diagnose and treat mutual funds): CorneaGen; Kala Pharmaceuticals; NovaBay DED because it can affect daily function, quality of life, and outcomes of Pharmaceuticals, Inc; Ocular Therapeutix, Inc; Omeros Corporation; cataract and refractive surgery. The desired results of this activity are for Simple Contacts Inc; and TearScience. ophthalmologists to have a better understanding of the epidemiology and Christopher J. Rapuano, MD, had a financial agreement or affiliation consequences of DED and to use appropriate screening, diagnostic testing, during the past year with the following commercial interests in the form of and management approaches. Consultant/Advisory Board: Allergan; Avedro, Inc; Bio-Tissue; GlaxoSmithKline; Kala Pharmaceuticals; Novartis Pharmaceuticals TARGET AUDIENCE Corporation; Shire; Sun Ophthalmics; and TearLab Corporation; This educational activity is intended for ophthalmologists. Honoraria from promotional, advertising or non-CME services received LEARNING OBJECTIVES directly from commercial interests or their Agents (eg, Speakers Bureaus): Upon completion of this activity, participants will be better able to: Avedro, Inc; Bio-Tissue; and Shire. • Review the prevalence, economic burden, and quality of life burden NEW YORK EYE AND EAR INFIRMARY OF MOUNT SINAI of DED PEER REVIEW DISCLOSURE • Apply appropriate diagnostic testing for evaluating DED Angie E. Wen, MD, has no relevant commercial relationships to disclose. • Articulate the implications of inflammation in DED on treatment • Apply evidence of DED treatments for individualizing management EDITORIAL SUPPORT DISCLOSURES of DED in a variety of patient profiles Cheryl Guttman Krader; Melissa Carter-Ozhan; Cynthia Tornallyay, RD, MBA, CHCP; Kimberly Corbin, CHCP; Barbara Aubel; and ACCREDITATION STATEMENT Michelle Ong have no relevant commercial relationships to disclose. This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for DISCLOSURE ATTESTATION Continuing Medical Education (ACCME) through the joint providership of The contributing physicians listed above have attested to the following: New York Eye and Ear Infirmary of Mount Sinai and MedEdicus LLC. 1) that the relationships/affiliations noted will not bias or otherwise The New York Eye and Ear Infirmary of Mount Sinai is accredited by influence their involvement in this activity; the ACCME to provide continuing medical education for physicians. 2) that practice recommendations given relevant to the companies with whom they have relationships/affiliations will be supported by the best In July 2013, the Accreditation Council for Continuing Medical available evidence or, absent evidence, will be consistent with generally Education (ACCME) awarded New York Eye and Ear Infirmary of accepted medical practice; and Mount Sinai “Accreditation with Commendation,” for six years as 3) that all reasonable clinical alternatives will be discussed when making a provider of continuing medical education for physicians, the practice recommendations. highest accreditation status awarded by the ACCME. OFF-LABEL DISCUSSION AMA CREDIT DESIGNATION STATEMENT This CME activity includes discussion of unlabeled and/or investigative uses The New York Eye and Ear Infirmary of Mount Sinai designates this of drugs. Please refer to the official prescribing information for each drug enduring material for a maximum of 1.5 AMA PRA Category 1 Credits™. discussed in this activity for FDA-approved dosing, indications, and warnings. Physicians should claim only the credit commensurate with the extent of their participation in the activity. NEW YORK EYE AND EAR INFIRMARY OF MOUNT SINAI PRIVACY & CONFIDENTIALITY POLICIES GRANTOR STATEMENT http://www.nyee.edu/health-professionals/cme/enduring-activities This continuing medical education activity is supported through an unrestricted educational grant from Shire. CME PROVIDER CONTACT INFORMATION For questions about this activity, call 212-870-8127. DISCLOSURE POLICY STATEMENT It is the policy of New York Eye and Ear Infirmary of Mount Sinai that TO OBTAIN AMA PRA CATEGORY 1 CREDIT™ the faculty and anyone in a position to control activity content disclose any To obtain AMA PRA Category 1 Credit™ for this activity, read the real or apparent conflicts of interest relating to the topics of this educational material in its entirety and consult referenced sources as necessary. activity, and also disclose discussions of unlabeled/unapproved uses of Please take this post test and evaluation online by going to drugs or devices during their presentation(s). New York Eye and Ear https://tinyurl.com/DEDOutcomesCME. Upon passing, you will receive Infirmary of Mount Sinai has established policies in place that will your certificate immediately. You must score 70% or higher to receive identify and resolve all conflicts of interest prior to this educational activity. credit for this activity, and may take the test up to 2 times. Upon registering Full disclosure of faculty/planners and their commercial relationships, and successfully completing the post test, your certificate will be made if any, follows. available online and you can print it or file it. DISCLOSURES DISCLAIMER Rosa Braga-Mele, MD, MEd, FRCSC, had a financial agreement or The views and opinions expressed in this educational activity are those of affiliation during the past year with the following commercial interests in the the faculty and do not necessarily represent the views of New York Eye form of Consultant/Advisory Board: Alcon; and Johnson & Johnson Vision and Ear Infirmary of Mount Sinai, MedEdicus LLC, Shire, EyeNet, or Care, Inc. the American Academy of Ophthalmology. 2 For instant processing, complete the CME Post Test online: https://tinyurl.com/DEDOutcomesCME FACULTY TERRY KIM, MD (CHAIR) Professor of Ophthalmology Duke University School of Medicine CURRENT PERSPECTIVES Chief, Cornea and External Disease Division Director, Refractive Surgery Service Dry Eye Disease Management Duke University Eye Center FOR IMPROVING PATIENT OUTCOMES Durham, North Carolina ROSA BRAGA-MELE, MD, MEd, FRCSC EPIDEMIOLOGY AND CHALLENGES OF Professor of Ophthalmology DRY EYE DISEASE University of Toronto TERRY KIM, MD Director of Cataract Surgery Dry eye disease (DED) is a common condition that often brings patients Kensington Eye Institute to the ophthalmologist’s office because it can result in significant Toronto, Canada discomfort and affect visual function. The estimated prevalence of DED reported in a number of studies varies from 3.4% to 48.0%; this wide JESSICA CIRALSKY, MD range can be explained by differences in study populations and the Associate Professor of Ophthalmology criteria used to define DED (Table 1).1-4 Weill Cornell Medicine Table 1. Estimates of Dry Eye Prevalence New York, New York Study Population Age, years Prevalence, % CHRISTOPHER J. RAPUANO, MD Salisbury Eye Study1 ≥ 65 14.6 Professor of Ophthalmology 1 ≥ Sidney Kimmel Medical College Beaver Dam 48 14.4 Thomas Jefferson University Women’s Health Study1 ≥ 49 7.8 Chief, Cornea Service 1 ≥ Wills Eye Hospital Blue Mountains 50 16.6 Philadelphia, Pennsylvania Sumatra (Asian)1 ≥ 21 27.5 Allergan phone survey2
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