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United States Patent (10) Patent No.: US 8,273,274 B2 Davalian (45) Date of Patent: *Sep

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United States Patent (10) Patent No.: US 8,273,274 B2 Davalian (45) Date of Patent: *Sep US008273274B2 (12) United States Patent (10) Patent No.: US 8,273,274 B2 DaValian (45) Date of Patent: *Sep. 25, 2012 (54) METHOD FOR THE MANUFACTURE OF 5,302.401 A 4/1994 Liversidge et al. STABLE, NANO-SIZED PARTICLES 5,336,507 A 8/1994 Na et al. 5,340,564 A 8/1994 Illig et al. 5,346,702 A 9, 1994 Na et al. (75) Inventor: Dariush Davalian, San Jose, CA (US) 5,352.459 A 10/1994 Hollister et al. 5,354,560 A 10, 1994 Lovrecich (73) Assignee: Abbott Cardiovascular Systems Inc., 5,384,124 A 1/1995 Courteille et al. Santa Clara, CA (US) 5,429,824 A 7, 1995 June 5,503,723 A 4/1996 Ruddy et al. c - r 5,510, 118 A 4/1996 Bosch et al. (*) Notice: Subject to any distic the t 5,518, 187 A 5/1996 Bruno et al. patent is extended or adjusted under 35 5,518,738 A 5/1996 Eickhoff et al. U.S.C. 154(b) by 288 days. 5,534.270 A 7/1996 De Castro 5,536,508 A 7/1996 Canal et al. This patent is Subject to a terminal dis- 5,552,160 A 9/1996 Liversidge et al. claimer. 5,560,931 A 10, 1996 Eickhoff et al. 5,560,932 A 10/1996 Bagchi et al. (21) Appl. No.: 12/727,129 5,565,188 A 10/1996 Wong et al. 5,569,448 A 10/1996 Wong et al. 1-1. 5,571,536 A 11/1996 Eickhoff et al. (22) Filed: Mar 18, 2010 5,573,783 A 1 1/1996 Desieno et al. (65) Prior Publication Data (Continued) US 2010/O244293 A1 Sep. 30, 2010 FOREIGN PATENT DOCUMENTS Related U.S. Application Data WO 93.25190 12/1993 (Continued) (63) Continuation of application No. 12/413.478, filed on Mar. 27, 2009, now Pat. No. 7,828,996. OTHER PUBLICATIONS (51) Int. Cl. U.S. Appl. No. 12/165,173, filed Jun. 30, 2008, Ngo et al. B6B I/O (2006.01) (Continued) (52) U.S. Cl. ................................. 264/9: 264/405; 425/6 (58) Field of Classification Search .............. 264/9, 405: Primary Examiner — Christina Johnson 425/6 Assistant Examiner — Saeed Huda See application file for complete search history. (74) Attorney, Agent, or Firm — Squire Sanders (US) LLP (56) References Cited (57) ABSTRACT U.S. PATENT DOCUMENTS The current invention relates to methods of making nano particles of a material with a narrow polydispersity. The par 3,737,337 A 6/1973 Schnoring et al. 4,162.282 A 7/1979 Fulwyler et al. ticle materials are active agents, organic compounds, poly 4,826,689 A 5, 1989 Volanto mers, and combinations thereof. 5,145,684 A 9/1992 Liversidge et al. 5,298,262 A 3, 1994 Na et al. 20 Claims, 2 Drawing Sheets US 8,273,274 B2 Page 2 U.S. PATENT DOCUMENTS Bin Choy et al., “Uniform Biodegradable Hydrogel Microspheres 5,580,579 A 12/1996 Ruddy et al. Fabricated by a Surfactant-Free Electric-Field-Assisted Method”. 5,585,108 A 12/1996 Ruddy et al. Macromol. Biosci. vol. 7, pp. 423-428 (2007). 5,587,143 A 12/1996 Wong Costa et al., “Effect of uniform sized polymeric microspheres pre 5,591,456 A 1/1997 Franson et al. pared by membrane emulsification technique On controlled release of 5,662,883. A 9/1997 Bagchi et al. anthracycline anti-cancer drugs'. Desalination vol. 200, issues 1-3, 5,662.938 A 9, 1997 Vert et al. pp. 498-500 (2006). 5,665,331 A 9/1997 Bagchi et al. Dubey et al., “Factorial Effect of Process Parameters on Pharmaceu 5,718,919 A 2/1998 Ruddy et al. tical Characteristics & Stability Study of PLGA Microspheres Con 5,747,001 A 5, 1998 Wiedmann et al. taining Water-Soluble Drug', downloaded from www. 5,916,596 A 6, 1999 Desai et al. drugdeliverytech.com/cgi-bin/articles.cgi?idArticle=229, Apr. 9. 6,440,493 B1 8, 2002 Gibson et al. 6,506,411 B2 1/2003 Hunter et al. 2008, 13 pgs. 6,623,761 B2 9, 2003 Hassan Finsy et al., “Particle Sizing by Photon Correlation Spectroscopy: 6,998,051 B2 2/2006 Chattopadhyay et al. Part II: Average values”. Particle and particle Systems Characteriza 2004/0170654 A1 9, 2004 Pinkerton tion vol. 8, issue 1-4, pp. 187-193, Abstract 1 pg. (2004). Han et al., "Stability and size dependence of protein microspheres FOREIGN PATENT DOCUMENTS prepared by ultrasonication”. J. Mat. Chem. 18; pp. 5162-5166 WO 96.24336 8, 1996 (2008) Abstract. WO 97.14407 4f1997 Hanus et al., “Conversion of intensity-averaged photon correlation WO 98.35666 8, 1998 spectroscopy measurements to number-averaged particle size distri WO 99.65469 12/1999 butions. I. Theoretical development, Langmuir vol. 15, No. 9. WO OOf 18374 4/2000 Abstract 1 pg. (1999). WO OOf 27369 5, 2000 Hua Ai et al., "Biomedical applications of electrostatic layer-by WO OO.30615 6, 2000 layer nano-assembly of polymers, enzymes, and nanoparticles”. Cell WO O3.002094 1, 2003 Biochem. and Biophysics, vol.39, No. 1, Abstract 1 pg. (2003). WO 03/002103 1, 2003 Jaros et al., “The Measuring of Ultrasound Probes”. FRVS project WO 2008/054523 5, 2008 No. 1657, downloaded from www.feec.vutbr.cz/EEICT/2004/ OTHER PUBLICATIONS sbornik/03-Doktorskeprojekty/01-Elektronics 13Jaros, 5 pgs. Kim et al., “Drug Delivery, Contolled-release' Office of Technology “90Plus Particle Size Analyzer' Brookhaven Instruments Corp. Management Univ. of Ill., 2 pgs. (2005-2006). downloaded from www.bic.com/90Plus.html. Mar. 4, 2008, 6 pgs. Kippax, "Measuring particle size using modern laser diffraction "Available Particle Characterization Technologies”, downloaded techniques', downloaded from www.analytica-world.com/articles/ from www.malvern.com/LabEng/support/technologies.htm., Mar. 5, ef, Mar. 5, 2008, 4pgs. 2008, 3 pgs. Kosvintsev et al., "Liquid-Liquid Membrane Dispersion in a Stirred “Laser Light Scattering', downloaded from www.ap-lab.com/light Cell with and without Controlled Shear”, Ind. Eng. Chem. Res. 44. scattering.htm, Mar. 5, 2008, 8 pgs. pp. 9323-9330 Abstract only, 1 pg. (2005). Liversidge et al., “Particle size reduction for improvement of oral “Microemulsion characterization using dynamic light scattering”. bioavailability of hydrophobic drugs. I. Absolute oral bioavailability Zetasizer Nano application note, downloaded from www.malvern. of nanocrystalline danazol in beagle dogs.” Int. J. of Pharm. 125, pp. co.uk, 3 pgs. no date. 91-97 (1995). "Pigment Milling and Monitoring Particle Size Using Dynamic Light Marko et al., “Nonlinear modeling of interactions between Scattering Techniques from Malvern Instruments', downloaded from ultrasound propagation and cavitation bubbles'. OSA/DAGA vol. www.azom.com/details.asp?ArticleID=2724. Apr. 10, 2008, 5 pgs. 92, No. 1, pp. 165-167 (2006) Abstract. “Sonication 101’, downloaded from www.opsdiagnostics.com/ Micropore Technologies emulsions-particles-filtration, Abstract, 1 notes/ranpri/rpsonication 101.htm, Dec. 12, 2008, 1 pg. pg. downloaded from www.micropore.co.UK, Mar. 19, 2008. "Taking the "suspense' out of Nanosuspension Specifications”. Nagasaki'Design of porous inorganic nanoparticles hybridized with downloaded from www.pharmtech.find pharma.com/pharmtech/ acetal-PEG-b-polyamine block copolymers for high performance content/printContentPopup.jsp., Apr. 9, 2008, 3 pgs. drug carrier'. Kobunshi Ronbunshu vol. 65, No. 6, pp. 405-415, “Toner size and shape characterization using FPLA-2 100. FPIA English Abstract (2008). 2100 application note, downloaded from www.malvern.co.uk, 5 pgs. Nakashima et al., “Particle control of emulsion by membrane emul no date. sification and its applications”. Advanced Drug Del. Rev. 45 pp. “Ultrasonics', from Wikipedia, the free encyclopedia, downloaded: 47-56 (2000). http://en.wikipedia.org/wiki/Ultrasonics, Dec. 22, 2008, 2 pgs. Nomura et al., “Analysis of an ultrasonic field attenuated by Oscil “When Particle Size is Important”. Brookhaven Instruments corp. lating cavitation bubbles'. Acoust. Sci. & Tech. 22, pp. 283-291 downloaded from www.bic.com/Particle sizers overview html, (2001). Mar. 5, 2008, 7 pgs. Servant et al., “Numerical simulation of cavitation bubble dynamics Baba et al., “A new Method for Delivering a Hydrophobic Drug for induced by ultrasound waves in a high frequency reactor'. Ultrason Photodynamic Therapy. Using Pure Nanocrystal Form of the Drug.” ics Sonochemistry vol. 7, issue 4, pp. 217-227 (2000) Abstract. Mol. Pharm. 4, (2), pp. 289-297. Sjöström et al., “The Formation of Submicron Organic Particles by Banert et al., “Operating parameters of a continuous sono-chemical Precipitation in an Emulsion”. Dispersion Science and Techn. 15, pp. precipitation reactor'. Fifth World congress on Particle Technology 89-117 (1994). 10 pgs. (2006). Son et al., “Analysis of the Ultrasonic Cavitation Energy in a Pilot Berkland et al., “Controlling surface namo-structure using flow Scale Sonoreactor”, Jpn. J. Appl. Phys. 47, pp. 4119-4122 (2008) limited field-injection electrostatic spraying (FFESS) of poly(D, Abstract. L-lactide-co-glycolide)”. Biomaterials 25, pp. 5649-5658 (2004). Takahashi et al., “Preparation of a novel PEG-clay hybrid as a DDS Berkland et al., “Fabrication of PLG microspheres with precisely material Dispersion stability and sustained release profiles,” J. of controlled and monodisperse size distributions”. J. of Controlled Controlled Release 107, pp. 408-416 (2005). Release 73, pp. 59-74 (2001). Tejinder et al., “Control of crystal size and distribution of zeolite A'. Berkland et al., “Precise control of PLG microsphere size provides Ind. and Engineering Chem. Research vol. 40, No. 4, pp. 1133-1139 enhanced control of drug release rate'. J. of Controlled Release 82. (2001) Abstract. pp. 137-147 (2002). The knowledge database about lactose, Particle Size Distribution Berkland et al., “Precission Polymer Microparticles for Controlled D10, D50 and D90, downloaded from www.lactose.com/particle Release Drug Delivery”, Am.
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