May 1, 2018 u vol. 115 u no. 18

From the Cover

4713 Genome duplication in insects E4179 Gene expression in castration-resistant prostate cancer 4565 Methane hydroxylation by iron zeolites 4601 Middle Pleistocene corpse burial 4672 Molecular regulation of vascular function

Contents

THIS WEEK IN PNAS 4519 In This Issue Cover image: Pictured is a club silverline butterfly (Spindasis syama)in Guangdong, China. Zheng Li et al. LETTERS (ONLINE ONLY) analyzed genomic data from more than E4144 How the manakin got its crown: A novel trait that is unlikely to cause speciation 150 hexapod species to investigate Gil G. Rosenthal, Molly Schumer, and Peter Andolfatto whether whole genome duplications occurred during hexapod evolution. The E4146 Reply to Rosenthal et al.: Both premating and postmating isolation likely authors found evidence of 18 ancient contributed to manakin hybrid speciation whole genome duplications and six Alfredo O. Barrera-Guzma´n, Alexandre Aleixo, Matthew D. Shawkey, and Jason T. Weir large-scale bursts of gene duplication, E4148 Iron status as a confounder in the gender gap in survival under suggesting that gene and genome extreme conditions duplications contributed to the Joris R. Delanghe, Marijn M. Speeckaert, and Marc L. De Buyzere evolution of hexapods. See the article by E4150 Reply to Delanghe et al.: Iron status is not likely to play a key role in the gender Li et al. on pages 4713–4718. Image survival gap under extreme conditions courtesy of Zheng Li. Virginia Zarulli, Kaare Christensen, and James W. Vaupel

SCIENCE AND CULTURE—How science intersects with culture 4522 Animal cognition research offers outreach opportunity John Carey

INNER WORKINGS—An over-the-shoulder look at scientists at work 4525 A new crop of landers and rovers seeks to answer key questions about Venus—and, by extension, Earth Sid Perkins

QNAS 4528 QnAs with Donald Geman Farooq Ahmed See Inaugural Article on page 4545

COMMENTARIES 4530 LSD1: A single target to combat lineage plasticity in lethal prostate cancer Leigh Ellis and Massimo Loda See companion article on page E4179

Free online through the PNAS open access option. PNAS u May 1, 2018 u vol. 115 u no. 18 u iii–vii Downloaded by guest on October 4, 2021 4532 Sizing up a supercharged ferryl COMPUTER SCIENCES Kyle M. Lancaster 4613 An explainable deep machine vision framework for See companion article on page 4565 plant stress phenotyping 4535 PDCD5 says no to NO Sambuddha Ghosal, David Blystone, Asheesh K. Singh, Baskar Ganapathysubramanian, Arti Singh, and Soumik Sarkar Dario F. Riascos-Bernal, Nicholas E. S. Sibinga, and Richard N. Kitsis See companion article on page 4672 EARTH, ATMOSPHERIC, AND PLANETARY SCIENCES 4577 GoAmazon2014/5 campaign points to deep-inflow approach to deep convection across scales PNAS PLUS Kathleen A. Schiro, Fiaz Ahmed, Scott E. Giangrande, 4538 Significance Statements and J. David Neelin Brief statements written by the authors about the significance of their ENGINEERING papers. 4583 Mechanisms of sampling interstitial fluid from skin using a microneedle patch PERSPECTIVE Pradnya P. Samant and Mark R. Prausnitz 4541 A call for more science in forensic science 4589 Thermally stable, highly efficient, ultraflexible Suzanne Bell, Sunita Sah, Thomas D. Albright, S. James Gates Jr., organic photovoltaics M. Bonner Denton, and Arturo Casadevall Xiaomin Xu, Kenjiro Fukuda, Akchheta Karki, Sungjun Park, Hiroki Kimura, Hiroaki Jinno, Nobuhiro Watanabe, Shuhei Yamamoto, Satoru Shimomura, Daisuke Kitazawa, Tomoyuki Yokota, Shinjiro INAUGURAL ARTICLE Umezu, Thuc-Quyen Nguyen, and Takao Someya 4545 Digitizing omics profiles by divergence from a baseline PHYSICS Wikum Dinalankara, Qian Ke, Yiran Xu, Lanlan Ji, Nicole 4595 Interaction instability of localization in Pagane, Anching Lien, Tejasvi Matam, Elana J. Fertig, quasiperiodic systems Nathan D. Price, Laurent Younes, Luigi Marchionni, Marko Zˇnidaric and Marko Ljubotina and Donald Geman See QnAs on page 4528 STATISTICS 4545 Digitizing omics profiles by divergence from PHYSICAL SCIENCES a baseline Wikum Dinalankara, Qian Ke, Yiran Xu, Lanlan Ji, Nicole BIOPHYSICS AND COMPUTATIONAL BIOLOGY Pagane, Anching Lien, Tejasvi Matam, Elana J. Fertig, E4294 DRUG-NEM: Optimizing drug combinations using Nathan D. Price, Laurent Younes, Luigi Marchionni, and Donald Geman single-cell perturbation response to account for intratumoral heterogeneity See QnAs on page 4528 Benedict Anchang, Kara L. Davis, Harris G. Fienberg, Brian D. Williamson, Sean C. Bendall, Loukia G. Karacosta, Robert SOCIAL SCIENCES Tibshirani, Garry P. Nolan, and Sylvia K. Plevritis 4553 MinE conformational switching confers robustness on ANTHROPOLOGY self-organized Min protein patterns 4601 Hominin skeletal part abundances and claims Jonas Denk, Simon Kretschmer, Jacob Halatek, Caroline Hartl, of deliberate disposal of corpses in the Petra Schwille, and Erwin Frey Middle Pleistocene Charles P. Egeland, Manuel Domı´nguez-Rodrigo, Travis Rayne Pickering, Colin G. Menter, and Jason L. Heaton CHEMISTRY E4255 Discovery of recombinases enables genome mining PSYCHOLOGICAL AND COGNITIVE SCIENCES of cryptic biosynthetic gene clusters in Burkholderiales species 4607 Individuals, institutions, and innovation in the Xue Wang, Haibo Zhou, Hanna Chen, Xiaoshu Jing, Wentao debates of the French Revolution Zheng, Ruijuan Li, Tao Sun, Jiaqi Liu, Jun Fu, Liujie Huo, Alexander T. J. Barron, Jenny Huang, Rebecca L. Spang, Yue-zhong Li, Yuemao Shen, Xiaoming Ding, Rolf Mu¨ller, and Simon DeDeo Xiaoying Bian, and Youming Zhang 4559 Shewanella oneidensis as a living electrode for BIOLOGICAL SCIENCES controlled radical polymerization Gang Fan, Christopher M. Dundas, Austin J. Graham, AGRICULTURAL SCIENCES Nathaniel A. Lynd, and Benjamin K. Keitz E4151 Draft genome sequence of Camellia sinensis var. 4565 Structural characterization of a non-heme iron active sinensis provides insights into the evolution of site in zeolites that hydroxylates methane the tea genome and tea quality Benjamin E. R. Snyder, Lars H. Bo¨ttger, Max L. Bols, James J. Chaoling Wei, Hua Yang, Songbo Wang, Jian Zhao, Chun Liu, Yan, Hannah M. Rhoda, Ariel B. Jacobs, Michael Y. Hu, Jiyong Liping Gao, Enhua Xia, Ying Lu, Yuling Tai, Guangbiao She, Jun Zhao, E. Ercan Alp, Britt Hedman, Keith O. Hodgson, Sun, Haisheng Cao, Wei Tong, Qiang Gao, Yeyun Li, Weiwei Robert A. Schoonheydt, Bert F. Sels, and Edward I. Solomon Deng, Xiaolan Jiang, Wenzhao Wang, Qi Chen, Shihua Zhang, Haijing Li, Junlan Wu, Ping Wang, Penghui Li, Chengying Shi, See Commentary on page 4532 Fengya Zheng, Jianbo Jian, Bei Huang, Dai Shan, Mingming Shi, 4571 Vibrations of a molecule in an external force field Congbing Fang, Yi Yue, Fangdong Li, Daxiang Li, Shu Wei, Bin Norio Okabayashi, Angelo Peronio, Magnus Paulsson, Toyoko Han, Changjun Jiang, Ye Yin, Tao Xia, Zhengzhu Zhang, Jeffrey L. Arai, and Franz J. Giessibl Bennetzen, Shancen Zhao, and Xiaochun Wan

iv u www.pnas.org Contents Downloaded by guest on October 4, 2021 4613 An explainable deep machine vision framework for 4655 Dynamic activation and regulation of the plant stress phenotyping mitogen-activated protein kinase p38 Sambuddha Ghosal, David Blystone, Asheesh K. Singh, Baskar Ganesan Senthil Kumar, Michael W. Clarkson, Micha B. A. Ganapathysubramanian, Arti Singh, and Soumik Sarkar Kunze, Daniele Granata, A. Joshua Wand, Kresten Lindorff-Larsen, Rebecca Page, and Wolfgang Peti APPLIED BIOLOGICAL SCIENCES 4661 Large SOD1 aggregates, unlike trimeric SOD1, 4619 Rapid selection of a pyrethroid metabolic enzyme do not impact cell viability in a model of CYP9K1 by operational malaria control activities amyotrophic lateral sclerosis John Vontas, Linda Grigoraki, John Morgan, Dimitra Tsakireli, Cheng Zhu, Matthew V. Beck, Jack D. Griffith, Mohanish Godwin Fuseini, Luis Segura, Julie Niemczura de Carvalho, Deshmukh, and Nikolay V. Dokholyan Raul Nguema, David Weetman, Michel A. Slotman, 4666 A folding nucleus and minimal ATP binding domain and Janet Hemingway of Hsp70 identified by single-molecule 4625 Developmentally inspired programming of adult force spectroscopy human mesenchymal stromal cells toward Daniela Bauer, Sarah Meinhold, Roman P. Jakob, Johannes stable chondrogenesis Stigler, Ulrich Merkel, Timm Maier, Matthias Rief, Paola Occhetta, Sebastien Pigeot, Marco Rasponi, Boris and Gabriel Zˇolda´k Dasen, Arne Mehrkens, Thomas Ullrich, Ina Kramer, Sabine Guth-Gundel, Andrea Barbero, and Ivan Martin CELL BIOLOGY 4631 Biomaterial surface energy-driven ligand assembly E4179 LSD1 activates a lethal prostate cancer gene network strongly regulates stem cell mechanosensitivity independently of its demethylase function and fate on very soft substrates Archana Sehrawat, Lina Gao, Yuliang Wang, Armand Bankhead III, Tojo Razafiarison, Claude N. Holenstein, Tino Stauber, Shannon K. McWeeney, Carly J. King, Jacob Schwartzman, Milan Jovic, Edward Vertudes, Marko Loparic, Joshua Urrutia, William H. Bisson, Daniel J. Coleman, Sunil K. Maciej Kawecki, Laetitia Bernard, Unai Silvan, Joshi, Dae-Hwan Kim, David A. Sampson, Sheila Weinmann, and Jess G. Snedeker Bhaskar V. S. Kallakury, Deborah L. Berry, Reina Haque, Stephen K. Van Den Eeden, Sunil Sharma, Jared Bearss, BIOCHEMISTRY Tomasz M. Beer, George V. Thomas, Laura M. Heiser, and Joshi J. Alumkal E4159 eIF1 Loop 2 interactions with Met-tRNA control the i See Commentary on page 4530 accuracy of start codon selection by the scanning preinitiation complex E4189 DNA methylation and transcriptome aberrations α Anil Thakur and Alan G. Hinnebusch mediated by ER in mouse seminal vesicles following developmental DES exposure 4637 Human N-acetylglucosaminyltransferase II substrate Yin Li, Katherine J. Hamilton, Tianyuan Wang, Laurel A. Coons, recognition uses a modular architecture that Wendy N. Jefferson, Ruifang Li, Yu Wang, Sara A. Grimm, includes a convergent exosite J. Tyler Ramsey, Liwen Liu, Kevin E. Gerrish, Carmen J. Renuka Kadirvelraj, Jeong-Yeh Yang, Justin H. Sanders, Lin Liu, Williams, Paul A. Wade, and Kenneth S. Korach Annapoorani Ramiah, Pradeep Kumar Prabhakar, Geert-Jan Boons, Zachary A. Wood, and Kelley W. Moremen E4199 Nuclear export of ubiquitinated proteins via the UBIN-POST system 4643 Disparate binding kinetics by an intrinsically Shoshiro Hirayama, Munechika Sugihara, Daisuke Morito, disordered domain enables temporal regulation Shun-ichiro Iemura, Tohru Natsume, Shigeo Murata, of transcriptional complex formation and Kazuhiro Nagata Neil O. Robertson, Ngaio C. Smith, Athina Manakas, Mahiar Mahjoub, Gordon McDonald, Ann H. Kwan, 4672 Programmed cell death 5 suppresses AKT-mediated and Jacqueline M. Matthews cytoprotection of endothelium Seung-Hyun Lee, Jaesung Seo, Soo-Yeon Park, Mi-Hyeon 4649 Complementary charge-based interaction between Jeong, Hyo-Kyoung Choi, Chan Joo Lee, Mi Jeong Kim, Garam the ribosomal-stalk protein L7/12 and IF2 is the Guk, SooYeon Lee, Hyewon Park, Jae-Wook Jeong, Chang key to rapid subunit association Hoon Ha, Sungha Park, and Ho-Geun Yoon Xueliang Ge, Chandra Sekhar Mandava, Christoffer Lind, Johan See Commentary on page 4535 A˚qvist, and Suparna Sanyal 4678 Deubiquitylation and stabilization of p21 by USP11 is critical for cell-cycle progression and DNA BIOPHYSICS AND COMPUTATIONAL BIOLOGY damage responses E4169 Study of protein folding under native conditions by Tanggang Deng, Guobei Yan, Xin Song, Lin Xie, Yu Zhou, rapidly switching the hydrostatic pressure inside Jianglin Li, Xiaoxiao Hu, Zhen Li, Jun Hu, Yibin Zhang, Hui an NMR sample cell Zhang, Yang Sun, Peifu Feng, Dong Wei, Bin Hu, Jing Liu, Cyril Charlier, T. Reid Alderson, Joseph M. Courtney, Jinfa Weihong Tan, and Mao Ye Ying, Philip Anfinrud, and Adriaan Bax 4684 Control of vacuole membrane homeostasis by 4545 Digitizing omics profiles by divergence from a resident PI-3,5-kinase inhibitor a baseline PC Malia, Johannes Numrich, Taki Nishimura, Ayele´n Gonza´lez Wikum Dinalankara, Qian Ke, Yiran Xu, Lanlan Ji, Nicole Montoro, Christopher J. Stefan, and Christian Ungermann Pagane, Anching Lien, Tejasvi Matam, Elana J. Fertig, Nathan D. Price, Laurent Younes, Luigi Marchionni, DEVELOPMENTAL BIOLOGY and Donald Geman 4690 Formate rescues neural tube defects caused by See QnAs on page 4528 mutations in Slc25a32 4553 MinE conformational switching confers robustness on Jimi Kim, Yunping Lei, Jin Guo, Sung-Eun Kim, Bogdan J. self-organized Min protein patterns Wlodarczyk, Robert M. Cabrera, Ying Linda Lin, Torbjorn K. Jonas Denk, Simon Kretschmer, Jacob Halatek, Caroline Hartl, Nilsson, Ting Zhang, Aiguo Ren, Linlin Wang, Zhengwei Yuan, Petra Schwille, and Erwin Frey Yu-Fang Zheng, Hong-Yan Wang, and Richard H. Finnell

Contents PNAS u May 1, 2018 u vol. 115 u no. 18 u v Downloaded by guest on October 4, 2021 4696 Muscularis macrophage development in the absence IMMUNOLOGY AND INFLAMMATION of an enteric nervous system E4236 MK2 contributes to tumor progression by Marina Avetisyan, Julia E. Rood, Silvia Huerta Lopez, Rajarshi promoting M2 macrophage polarization Sengupta, Elizabeth Wright-Jin, Joseph D. Dougherty, and tumor angiogenesis Edward M. Behrens, and Robert O. Heuckeroth Lucia Suarez-Lopez, Ganapathy Sriram, Yi Wen Kong, Sandra Morandell, Karl A. Merrick, Yuliana Hernandez, Kevin M. ECOLOGY Haigis, and Michael B. Yaffe E4209 Plasmodium-associated changes in human odor 4743 Anti–HIV-1 B cell responses are dependent on B cell attract mosquitoes precursor frequency and antigen-binding affinity Ailie Robinson, Annette O. Busula, Mirjam A. Voets, Khalid B. Pia Dosenovic, Ervin E. Kara, Anna-Klara Pettersson, Beshir, John C. Caulfield, Stephen J. Powers, Niels O. Verhulst, Andrew T. McGuire, Matthew Gray, Harald Hartweger, Peter Winskill, Julian Muwanguzi, Michael A. Birkett, Renate C. Eddy S. Thientosapol, Leonidas Stamatatos, Smallegange, Daniel K. Masiga, W. Richard Mukabana, and Michel C. Nussenzweig Robert W. Sauerwein, Colin J. Sutherland, Teun Bousema, John A. Pickett, Willem Takken, James G. Logan, 4749 Role of PD-1 during effector CD8 T cell differentiation and Jetske G. de Boer Eunseon Ahn, Koichi Araki, Masao Hashimoto, Weiyan Li, James L. Riley, Jeanne Cheung, Arlene H. Sharpe, Gordon J. 4702 Temperature accelerates the rate fields Freeman, Bryan A. Irving, and Rafi Ahmed become forests 4755 Shared epitope–aryl hydrocarbon receptor crosstalk Jason D. Fridley and Justin P. Wright underlies the mechanism of gene–environment interaction in autoimmune arthritis ENVIRONMENTAL SCIENCES Jiaqi Fu, Sarah V. Nogueira, Vincent van Drongelen, Patrick E4219 Integrating effects of species composition and soil Coit, Song Ling, Edward F. Rosloniec, Amr H. Sawalha, properties to predict shifts in montane forest and Joseph Holoshitz carbon–water relations Toby M. Maxwell, Lucas C. R. Silva, and William R. Horwath MEDICAL SCIENCES 4707 Urbanization prolongs hantavirus epidemics in cities E4245 Endoplasmic reticulum stress activates SRC, Huaiyu Tian, Shixiong Hu, Bernard Cazelles, Gerardo Chowell, relocating chaperones to the cell surface where Lidong Gao, Marko Laine, Yapin Li, Huisuo Yang, Yidan Li, Qiqi GRP78/CD109 blocks TGF-β signaling Yang, Xin Tong, Ru Huang, Ottar N. Bjornstad, Hong Xiao, Yuan-Li Tsai, Dat P. Ha, He Zhao, Anthony J. Carlos, Shan Wei, and Nils Chr. Stenseth Tsam Kiu Pun, Kaijin Wu, Ebrahim Zandi, Kevin Kelly, and Amy S. Lee EVOLUTION 4583 Mechanisms of sampling interstitial fluid from skin E4227 Horizontal transfer of retrotransposons between using a microneedle patch bivalves and other aquatic species of multiple phyla Pradnya P. Samant and Mark R. Prausnitz Michael J. Metzger, Ashley N. Paynter, Mark E. Siddall, and Stephen P. Goff 4761 Tunable cytotoxic aptamer–drug conjugates for the treatment of prostate cancer 4713 Multiple large-scale gene and genome duplications Bethany Powell Gray, Linsley Kelly, Douglas P. Ahrens, during the evolution of hexapods Ashley P. Barry, Christina Kratschmer, Matthew Levy, Zheng Li, George P. Tiley, Sally R. Galuska, Chris R. and Bruce A. Sullenger Reardon, Thomas I. Kidder, Rebecca J. Rundell, and Michael S. Barker 4767 Mutations in the pancreatic secretory enzymes CPA1 and CPB1 are associated with pancreatic cancer GENETICS Koji Tamura, Jun Yu, Tatsuo Hata, Masaya Suenaga, Koji Shindo, Toshiya Abe, Anne MacGregor-Das, Michael Borges, 4719 Next-generation CRISPR/Cas9 transcriptional Christopher L. Wolfgang, Matthew J. Weiss, Jin He, Marcia activation in Drosophila using flySAM Irene Canto, Gloria M. Petersen, Steven Gallinger, Sapna Yu Jia, Rong-Gang Xu, Xingjie Ren, Ben Ewen-Campen, Syngal, Randall E. Brand, Anil Rustgi, Sara H. Olson, Elena Rajendhran Rajakumar, Jonathan Zirin, Donghui Yang-Zhou, Stoffel, Michele L. Cote, George Zogopoulos, James B. Potash, Ruibao Zhu, Fang Wang, Decai Mao, Ping Peng, Huan-Huan Fernando S. Goes, Richard W. McCombie, Peter P. Zandi, Qiao, Xia Wang, Lu-Ping Liu, Bowen Xu, Jun-Yuan Ji, Qingfei Mehdi Pirooznia, Melissa Kramer, Jennifer Parla, James R. Liu, Jin Sun, Norbert Perrimon, and Jian-Quan Ni Eshleman, Nicholas J. Roberts, Ralph H. Hruban, Alison Patricia 4725 Synthetically engineered Medea gene drive system Klein, and Michael Goggins in the worldwide crop pest Drosophila suzukii Anna Buchman, John M. Marshall, Dennis Ostrovski, Ting MICROBIOLOGY Yang, and Omar S. Akbari E4255 Discovery of recombinases enables genome mining 4731 O6-methylguanine–induced transcriptional of cryptic biosynthetic gene clusters in mutagenesis reduces p53 tumor-suppressor function Burkholderiales species Monika Ezerskyte, Joa˜o A. Paredes, Stefano Malvezzi, John A. Xue Wang, Haibo Zhou, Hanna Chen, Xiaoshu Jing, Wentao Burns, Geoffrey P. Margison, Magnus Olsson, David A. Zheng, Ruijuan Li, Tao Sun, Jiaqi Liu, Jun Fu, Liujie Huo, Scicchitano, and Kristian Dreij Yue-zhong Li, Yuemao Shen, Xiaoming Ding, Rolf Mu¨ller, 4737 Ribosomal DNA copy loss and repeat instability in Xiaoying Bian, and Youming Zhang ATRX-mutated cancers E4264 Polysialic acid is a cellular receptor for human Maheshi Udugama, Elaine Sanij, Hsiao P. J. Voon, adenovirus 52 Jinbae Son, Linda Hii, Jeremy D. Henson, F. Lyn Chan, Annasara Lenman, A. Manuel Liaci, Yan Liu, Lars Fra¨ngsmyr, Fiona T. M. Chang, Yumei Liu, Richard B. Pearson, Paul Martin Frank, Ba¨rbel S. Blaum, Wengang Chai, Iva I. Kalitsis, Jeffrey R. Mann, Philippe Collas, Ross D. Hannan, Podgorski, Bala´zs Harrach, Ma´ria Benko,} Ten Feizi, Thilo and Lee H. Wong Stehle, and Niklas Arnberg

vi u www.pnas.org Contents Downloaded by guest on October 4, 2021 4559 Shewanella oneidensis as a living electrode for PSYCHOLOGICAL AND COGNITIVE SCIENCES controlled radical polymerization 4607 Individuals, institutions, and innovation in the Gang Fan, Christopher M. Dundas, Austin J. Graham, debates of the French Revolution Nathaniel A. Lynd, and Benjamin K. Keitz Alexander T. J. Barron, Jenny Huang, Rebecca L. Spang, 4773 Origin, antigenicity, and function of a secreted form and Simon DeDeo of ORF2 in hepatitis E virus infection Xin Yin, Dong Ying, Se´bastien Lhomme, Zimin Tang, Christopher M. SYSTEMS BIOLOGY Walker, Ningshao Xia, Zizheng Zheng, and Zongdi Feng E4294 DRUG-NEM: Optimizing drug combinations using 4779 Spatial determinants of quorum signaling in single-cell perturbation response to account for a Pseudomonas aeruginosa infection model intratumoral heterogeneity Sophie E. Darch, Olja Simoska, Mignon Fitzpatrick, Juan P. Benedict Anchang, Kara L. Davis, Harris G. Fienberg, Brian D. Barraza, Keith J. Stevenson, Roger T. Bonnecaze, Jason B. Williamson, Sean C. Bendall, Loukia G. Karacosta, Robert Shear, and Marvin Whiteley Tibshirani, Garry P. Nolan, and Sylvia K. Plevritis – NEUROSCIENCE E4304 Deep learning improves prediction of drug drug and drug–food interactions E4274 Desynchronization of slow oscillations in the basal Jae Yong Ryu, Hyun Uk Kim, and Sang Yup Lee ganglia during natural sleep Aviv D. Mizrahi-Kliger, Alexander Kaplan, Zvi Israel, and Hagai Bergman CORRECTIONS (ONLINE ONLY) 4785 Spatial and temporal heterogeneity of neural responses in human posteromedial cortex MEDICAL SCIENCES Amy L. Daitch and Josef Parvizi E4312 Diagnostic utility of telomere length testing in PLANT BIOLOGY a hospital-based setting Jonathan K. Alder, Vidya Sagar Hanumanthu, Margaret A. E4284 Drought delays development of the sorghum root Strong, Amy E. DeZern, Susan E. Stanley, Clifford M. microbiome and enriches for monoderm bacteria Takemoto, Ludmilla Danilova, Carolyn D. Applegate, Ling Xu, Dan Naylor, Zhaobin Dong, Tuesday Simmons, Grady Stephen G. Bolton, David W. Mohr, Robert A. Brodsky, Pierroz, Kim K. Hixson, Young-Mo Kim, Erika M. Zink, Kristin M. James F. Casella, Carol W. Greider, J. Brooks Jackson, Engbrecht, Yi Wang, Cheng Gao, Stephanie DeGraaf, Mary A. and Mary Armanios Madera, Julie A. Sievert, Joy Hollingsworth, Devon Birdseye, Henrik V. Scheller, Robert Hutmacher, Jeffery Dahlberg, Christer Jansson, John W. Taylor, Peggy G. Lemaux, NEUROSCIENCE and Devin Coleman-Derr E4313 Fatty-acid–binding protein 5 controls retrograde 4791 Reduced vacuolar β-1,3-glucan synthesis affects endocannabinoid signaling at central carbohydrate metabolism as well as plastid homeostasis glutamate synapses and structure in Phaeodactylum tricornutum Samir Haj-Dahmane, Roh-Yu Shen, Matthew W. Elmes, Keith Weichao Huang, Ilka Haferkamp, Bernard Lepetit, Mariia Studholme, Martha P. Kanjiya, Diane Bogdan, Panayotis K. Molchanova, Shengwei Hou, Wolfgang Jeblick, Carolina Rı´o Thanos, Jeremy T. Miyauchi, Stella E. Tsirka, Dale G. Deutsch, Ba´rtulos, and Peter G. Kroth and Martin Kaczocha

Contents PNAS u May 1, 2018 u vol. 115 u no. 18 u vii Downloaded by guest on October 4, 2021