May 1, 2018 u vol. 115 u no. 18 From the Cover 4713 Genome duplication in insects E4179 Gene expression in castration-resistant prostate cancer 4565 Methane hydroxylation by iron zeolites 4601 Middle Pleistocene corpse burial 4672 Molecular regulation of vascular function Contents THIS WEEK IN PNAS 4519 In This Issue Cover image: Pictured is a club silverline butterfly (Spindasis syama)in Guangdong, China. Zheng Li et al. LETTERS (ONLINE ONLY) analyzed genomic data from more than E4144 How the manakin got its crown: A novel trait that is unlikely to cause speciation 150 hexapod species to investigate Gil G. Rosenthal, Molly Schumer, and Peter Andolfatto whether whole genome duplications occurred during hexapod evolution. The E4146 Reply to Rosenthal et al.: Both premating and postmating isolation likely authors found evidence of 18 ancient contributed to manakin hybrid speciation whole genome duplications and six Alfredo O. Barrera-Guzma´n, Alexandre Aleixo, Matthew D. Shawkey, and Jason T. Weir large-scale bursts of gene duplication, E4148 Iron status as a confounder in the gender gap in survival under suggesting that gene and genome extreme conditions duplications contributed to the Joris R. Delanghe, Marijn M. Speeckaert, and Marc L. De Buyzere evolution of hexapods. See the article by E4150 Reply to Delanghe et al.: Iron status is not likely to play a key role in the gender Li et al. on pages 4713–4718. Image survival gap under extreme conditions courtesy of Zheng Li. Virginia Zarulli, Kaare Christensen, and James W. Vaupel SCIENCE AND CULTURE—How science intersects with culture 4522 Animal cognition research offers outreach opportunity John Carey INNER WORKINGS—An over-the-shoulder look at scientists at work 4525 A new crop of landers and rovers seeks to answer key questions about Venus—and, by extension, Earth Sid Perkins QNAS 4528 QnAs with Donald Geman Farooq Ahmed See Inaugural Article on page 4545 COMMENTARIES 4530 LSD1: A single target to combat lineage plasticity in lethal prostate cancer Leigh Ellis and Massimo Loda See companion article on page E4179 Free online through the PNAS open access option. PNAS u May 1, 2018 u vol. 115 u no. 18 u iii–vii Downloaded by guest on October 4, 2021 4532 Sizing up a supercharged ferryl COMPUTER SCIENCES Kyle M. Lancaster 4613 An explainable deep machine vision framework for See companion article on page 4565 plant stress phenotyping 4535 PDCD5 says no to NO Sambuddha Ghosal, David Blystone, Asheesh K. Singh, Baskar Ganapathysubramanian, Arti Singh, and Soumik Sarkar Dario F. Riascos-Bernal, Nicholas E. S. Sibinga, and Richard N. Kitsis See companion article on page 4672 EARTH, ATMOSPHERIC, AND PLANETARY SCIENCES 4577 GoAmazon2014/5 campaign points to deep-inflow approach to deep convection across scales PNAS PLUS Kathleen A. Schiro, Fiaz Ahmed, Scott E. Giangrande, 4538 Significance Statements and J. David Neelin Brief statements written by the authors about the significance of their ENGINEERING papers. 4583 Mechanisms of sampling interstitial fluid from skin using a microneedle patch PERSPECTIVE Pradnya P. Samant and Mark R. Prausnitz 4541 A call for more science in forensic science 4589 Thermally stable, highly efficient, ultraflexible Suzanne Bell, Sunita Sah, Thomas D. Albright, S. James Gates Jr., organic photovoltaics M. Bonner Denton, and Arturo Casadevall Xiaomin Xu, Kenjiro Fukuda, Akchheta Karki, Sungjun Park, Hiroki Kimura, Hiroaki Jinno, Nobuhiro Watanabe, Shuhei Yamamoto, Satoru Shimomura, Daisuke Kitazawa, Tomoyuki Yokota, Shinjiro INAUGURAL ARTICLE Umezu, Thuc-Quyen Nguyen, and Takao Someya 4545 Digitizing omics profiles by divergence from a baseline PHYSICS Wikum Dinalankara, Qian Ke, Yiran Xu, Lanlan Ji, Nicole 4595 Interaction instability of localization in Pagane, Anching Lien, Tejasvi Matam, Elana J. Fertig, quasiperiodic systems Nathan D. Price, Laurent Younes, Luigi Marchionni, Marko Zˇnidaric and Marko Ljubotina and Donald Geman See QnAs on page 4528 STATISTICS 4545 Digitizing omics profiles by divergence from PHYSICAL SCIENCES a baseline Wikum Dinalankara, Qian Ke, Yiran Xu, Lanlan Ji, Nicole BIOPHYSICS AND COMPUTATIONAL BIOLOGY Pagane, Anching Lien, Tejasvi Matam, Elana J. Fertig, E4294 DRUG-NEM: Optimizing drug combinations using Nathan D. Price, Laurent Younes, Luigi Marchionni, and Donald Geman single-cell perturbation response to account for intratumoral heterogeneity See QnAs on page 4528 Benedict Anchang, Kara L. Davis, Harris G. Fienberg, Brian D. Williamson, Sean C. Bendall, Loukia G. Karacosta, Robert SOCIAL SCIENCES Tibshirani, Garry P. Nolan, and Sylvia K. Plevritis 4553 MinE conformational switching confers robustness on ANTHROPOLOGY self-organized Min protein patterns 4601 Hominin skeletal part abundances and claims Jonas Denk, Simon Kretschmer, Jacob Halatek, Caroline Hartl, of deliberate disposal of corpses in the Petra Schwille, and Erwin Frey Middle Pleistocene Charles P. Egeland, Manuel Domı´nguez-Rodrigo, Travis Rayne Pickering, Colin G. Menter, and Jason L. Heaton CHEMISTRY E4255 Discovery of recombinases enables genome mining PSYCHOLOGICAL AND COGNITIVE SCIENCES of cryptic biosynthetic gene clusters in Burkholderiales species 4607 Individuals, institutions, and innovation in the Xue Wang, Haibo Zhou, Hanna Chen, Xiaoshu Jing, Wentao debates of the French Revolution Zheng, Ruijuan Li, Tao Sun, Jiaqi Liu, Jun Fu, Liujie Huo, Alexander T. J. Barron, Jenny Huang, Rebecca L. Spang, Yue-zhong Li, Yuemao Shen, Xiaoming Ding, Rolf Mu¨ller, and Simon DeDeo Xiaoying Bian, and Youming Zhang 4559 Shewanella oneidensis as a living electrode for BIOLOGICAL SCIENCES controlled radical polymerization Gang Fan, Christopher M. Dundas, Austin J. Graham, AGRICULTURAL SCIENCES Nathaniel A. Lynd, and Benjamin K. Keitz E4151 Draft genome sequence of Camellia sinensis var. 4565 Structural characterization of a non-heme iron active sinensis provides insights into the evolution of site in zeolites that hydroxylates methane the tea genome and tea quality Benjamin E. R. Snyder, Lars H. Bo¨ttger, Max L. Bols, James J. Chaoling Wei, Hua Yang, Songbo Wang, Jian Zhao, Chun Liu, Yan, Hannah M. Rhoda, Ariel B. Jacobs, Michael Y. Hu, Jiyong Liping Gao, Enhua Xia, Ying Lu, Yuling Tai, Guangbiao She, Jun Zhao, E. Ercan Alp, Britt Hedman, Keith O. Hodgson, Sun, Haisheng Cao, Wei Tong, Qiang Gao, Yeyun Li, Weiwei Robert A. Schoonheydt, Bert F. Sels, and Edward I. Solomon Deng, Xiaolan Jiang, Wenzhao Wang, Qi Chen, Shihua Zhang, Haijing Li, Junlan Wu, Ping Wang, Penghui Li, Chengying Shi, See Commentary on page 4532 Fengya Zheng, Jianbo Jian, Bei Huang, Dai Shan, Mingming Shi, 4571 Vibrations of a molecule in an external force field Congbing Fang, Yi Yue, Fangdong Li, Daxiang Li, Shu Wei, Bin Norio Okabayashi, Angelo Peronio, Magnus Paulsson, Toyoko Han, Changjun Jiang, Ye Yin, Tao Xia, Zhengzhu Zhang, Jeffrey L. Arai, and Franz J. Giessibl Bennetzen, Shancen Zhao, and Xiaochun Wan iv u www.pnas.org Contents Downloaded by guest on October 4, 2021 4613 An explainable deep machine vision framework for 4655 Dynamic activation and regulation of the plant stress phenotyping mitogen-activated protein kinase p38 Sambuddha Ghosal, David Blystone, Asheesh K. Singh, Baskar Ganesan Senthil Kumar, Michael W. Clarkson, Micha B. A. Ganapathysubramanian, Arti Singh, and Soumik Sarkar Kunze, Daniele Granata, A. Joshua Wand, Kresten Lindorff-Larsen, Rebecca Page, and Wolfgang Peti APPLIED BIOLOGICAL SCIENCES 4661 Large SOD1 aggregates, unlike trimeric SOD1, 4619 Rapid selection of a pyrethroid metabolic enzyme do not impact cell viability in a model of CYP9K1 by operational malaria control activities amyotrophic lateral sclerosis John Vontas, Linda Grigoraki, John Morgan, Dimitra Tsakireli, Cheng Zhu, Matthew V. Beck, Jack D. Griffith, Mohanish Godwin Fuseini, Luis Segura, Julie Niemczura de Carvalho, Deshmukh, and Nikolay V. Dokholyan Raul Nguema, David Weetman, Michel A. Slotman, 4666 A folding nucleus and minimal ATP binding domain and Janet Hemingway of Hsp70 identified by single-molecule 4625 Developmentally inspired programming of adult force spectroscopy human mesenchymal stromal cells toward Daniela Bauer, Sarah Meinhold, Roman P. Jakob, Johannes stable chondrogenesis Stigler, Ulrich Merkel, Timm Maier, Matthias Rief, Paola Occhetta, Sebastien Pigeot, Marco Rasponi, Boris and Gabriel Zˇolda´k Dasen, Arne Mehrkens, Thomas Ullrich, Ina Kramer, Sabine Guth-Gundel, Andrea Barbero, and Ivan Martin CELL BIOLOGY 4631 Biomaterial surface energy-driven ligand assembly E4179 LSD1 activates a lethal prostate cancer gene network strongly regulates stem cell mechanosensitivity independently of its demethylase function and fate on very soft substrates Archana Sehrawat, Lina Gao, Yuliang Wang, Armand Bankhead III, Tojo Razafiarison, Claude N. Holenstein, Tino Stauber, Shannon K. McWeeney, Carly J. King, Jacob Schwartzman, Milan Jovic, Edward Vertudes, Marko Loparic, Joshua Urrutia, William H. Bisson, Daniel J. Coleman, Sunil K. Maciej Kawecki, Laetitia Bernard, Unai Silvan, Joshi, Dae-Hwan Kim, David A. Sampson, Sheila Weinmann, and Jess G. Snedeker Bhaskar V. S. Kallakury, Deborah L. Berry, Reina Haque, Stephen K. Van Den Eeden, Sunil Sharma, Jared Bearss, BIOCHEMISTRY Tomasz M. Beer, George V. Thomas, Laura M. Heiser, and Joshi J. Alumkal E4159 eIF1 Loop 2 interactions with Met-tRNA control the i See Commentary on page 4530 accuracy of start codon selection by the scanning preinitiation complex E4189 DNA methylation and transcriptome aberrations α Anil Thakur and Alan G. Hinnebusch mediated