Oxidative Stress and Space Biology: an Organ-Based Approach
Total Page：16
File Type：pdf, Size：1020Kb
International Journal of Molecular Sciences Books Oxidative Stress and Space Biology: An Organ-Based Approach Edited by Melpo Christofidou-Solomidou and Thomas J. Goodwin Printed Edition of the Special Issue Published in IJMS www.mdpi.com/journal/ijms MDPI Oxidative Stress and Space Biology: An Organ-Based Approach Special Issue Editors Melpo Christofidou-Solomidou Books Thomas J. Goodwin MDPI • Basel • Beijing • Wuhan • Barcelona • Belgrade MDPI Special Issue Editors Melpo Christofidou-Solomidou University of Pennsylvania Perelman School of Medicine USA Thomas J. Goodwin Infectious Disease Research Center Colorado State University USA Editorial Office MDPI St. Alban-Anlage 66 Basel, Switzerland This edition is a reprint of the Special Issue published online in the open access journal International Journal of Molecular Sciences (ISSN ISSN 2072-6651) in 2017–2018 (available at: http://www.mdpi.com/ Books journal/ijms/special issues/space biology 2016). For citation purposes, cite each article independently as indicated on the article page online and as indicated below: Lastname, F.M.; Lastname, F.M. Article title. Journal Name Year, Article number, page range. First Editon 2018 Cover photo courtesy of Melpo Christofidou-Solomidou. ISBN 978-3-03842-903-6 (Pbk) ISBN 978-3-03842-904-3 (PDF) Articles in this volume are Open Access and distributed under the Creative Commons Attribution (CC BY) license, which allows users to download, copy and build upon published articles even for commercial purposes, as long as the author and publisher are properly credited, which ensures maximum dissemination and a wider impact of our publications. The book taken as a whole is c 2018 MDPI, Basel, Switzerland, distributed under the terms and conditions of the Creative Commons license CC BY-NC-ND (http://creativecommons.org/licenses/by-nc-nd/4.0/). MDPI Table of Contents About the Special Issue Editors ..................................... v Preface to ”Oxidative Stress and Space Biology: An Organ-Based Approach” .......... vii Thomas J. Goodwin and Melpo Christofidou-Solomidou Oxidative Stress and Space Biology: An Organ-Based Approach doi: 10.3390/ijms19040959 ....................................... 1 Joshua S. Alwood, Luan H. Tran, Ann-Sofie Schreurs, Yasaman Shirazi-Fard, Akhilesh Kumar, Diane Hilton, Candice G. T. Tahimic and Ruth K. Globus Dose- and Ion-Dependent Effects in the Oxidative Stress Response to Space-Like Radiation Exposure in the Skeletal System doi: 10.3390/ijms18102117 ....................................... 11 Srinivasan Shanmugarajan, Ye Zhang, Maria Moreno-Villanueva, Ryan Clanton, Larry H. Rohde, Govindarajan T. Ramesh, Jean D. Sibonga and Honglu Wu Combined Effects of Simulated Microgravity and Radiation Exposure on Osteoclast Cell Fusion doi: 10.3390/ijms18112443 ....................................... 28 Ye Tian, Xiaoli Ma, Chaofei Yang, Peihong Su, Chong Yin and Ai-Rong Qian The Impact of Oxidative Stress on the Bone System in Response to the Space Special Environment Books doi: 10.3390/ijms18102132 ....................................... 40 Candice G. T. Tahimic and Ruth K. Globus Redox Signaling and Its Impact on Skeletal and Vascular Responses to Spaceflight doi: 10.3390/ijms18102153 ....................................... 49 Ken Takahashi, Hiroki Okumura, Rui Guo and Keiji Naruse Effect of Oxidative Stress on Cardiovascular System in Response to Gravity doi: 10.3390/ijms18071426 ....................................... 67 Elizabeth A. Blaber, Michael J. Pecaut and Karen R. Jonscher Spaceflight Activates Autophagy Programs and the Proteasome in Mouse Liver doi: 10.3390/ijms18102062 ....................................... 76 Viktoria Anselm, Svetlana Novikova and Victor Zgoda Re-Adaption on Earth after Spaceflights Affects the Mouse Liver Proteome doi: 10.3390/ijms18081763 ....................................... 99 Jorge S. Burns and Gina Manda Metabolic Pathways of the Warburg Effect in Health and Disease: Perspectives of Choice, Chain or Chance doi: 10.3390/ijms18122755 .......................................111 Stefanie Endesfelder, Ulrike Weichelt, Evelyn Strauß, Anja Schl¨or, Marco Sifringer, Till Scheuer, Christoph B ¨uhrerand Thomas Schmitz Neuroprotection by Caffeine in Hyperoxia-Induced Neonatal Brain Injury doi: 10.3390/ijms18010187 .......................................139 iii MDPI Anastasia Velalopoulou, Shampa Chatterjee, Ralph A. Pietrofesa, Cynthia Koziol-White, Reynold A. Panettieri, Liyong Lin, Stephen Tuttle, Abigail Berman, Constantinos Koumenis and Melpo Christofidou-Solomidou Synthetic Secoisolariciresinol Diglucoside (LGM2605) Protects Human Lung in an Ex Vivo Model of Proton Radiation Damage doi: 10.3390/ijms18122525 .......................................163 Books iv MDPI About the Special Issue Editors Melpo Christofidou-Solomidou, PhD, Research Professor of Medicine, received her undergraduate degree in Biological Sciences from the State University of NY (S.U.N.Y.) at Stony Brook and her M.Sc. and Ph.D. in Cell Biology from the University of Bonn, in Germany. After completing post-doctoral training at Albany Medical College in NY, she joined the Pulmonary Division of the Department of Medicine at the University of Pennsylvania, in Philadelphia, where she serves currently. She is an NIH-funded investigator actively involved in preclinical and clinical studies at UPenn. Her research focus involves a) the investigation of novel antioxidant approaches to acute and chronic lung disease with a special interest in pulmonary inflammation and lung fibrosis related to radiation; b) chemoprevention of lung carcinogenesis and evaluation of anticarcinogenic effects of common botanicals and c) ischemia/reperfusion injury related to lung transplantation. Her research group at UPenn has been supported by research awards from the NIH (NCI, NIAID, NIEHS, NCCIH), NASA and other national agencies over the past 25 years and has published extensively in peer-reviewed journals. Thomas J. Goodwin, PhD— NASA cellular physiologist (Retired), pioneer and authority in 3D biology, tissue engineering, bioelectromagnetic field effects, and synthesized tissue growth. Dr. Goodwin was the Manager of the Disease Modeling and Tissue Analogues Laboratory at the NASA Johnson Books Space Center and Lead Scientist for the Oxidative Stress and Damage research discipline for more than 15 years. Dr. Goodwin is Honorary President and Chair of the Personalized Medicine panel of the European Society of Translational Medicine (EUSTM). He holds adjunct positions at the University of Texas Medical School, Galveston Texas, Dept. of Surgery, Division of Cardiothoracic Surgery, the University of Houston, Dept. of Health and Human Performance, and is an Adjunct Scientist at the Texas Biomedical Research Institute and the Southwest National Primate Research Center which is sponsored by the National Institutes of Health. He has authored or co-authored over 65 peer review articles, four book chapters on three-dimensional biology and personalized spaceflight medicine, has been awarded 23 U.S. patents, on 3D biology and human physiology, electromagnetic tissue effects, and is the recipient of more than 70 NASA Scientific and Technical awards. v MDPI Books MDPI Preface to ”Oxidative Stress and Space Biology: An Organ-Based Approach” Technological advances now allow the planning of deep space exploration missions with the aim to discover new habitats for humankind. The National Aeronautics and Space Administration (NASA) has spearheaded this effort and the research into the identification of risks to crew members associated with such lengthy missions. Exciting work from a multitude of investigators across the US, Europe and Japan have identified oxidative damage as a significant risk to major organs that could pose a threat to the health of the astronauts and the success of the mission. This Special Issue of IJMS is dedicated to providing a comprehensive overview of the identified risks and focus on how oxidative stress specifically could impact major organ systems when exposed to space-relevant conditions such as cosmic/galactic radiation, solar particle events, hypogravity, hyperoxia and hypoxia or a combination of stressors. Melpo Christofidou-Solomidou, Thomas J. Goodwin Special Issue Editors Books vii MDPI Books MDPI International Journal of Molecular Sciences Editorial Oxidative Stress and Space Biology: An Organ-Based Approach Thomas J. Goodwin 1,* and Melpo Christofidou-Solomidou 2,* 1 The National Aeronautics and Space Administration (NASA, retired) Johnson Space Center, Houston, TX 77058, USA 2 Division of Pulmonary, Allergy, and Critical Care Medicine and the Department of Medicine, University of Pennsylvania Perelman School of Medicine, 3450 Hamilton Walk, Edward J. Stemmler Hall, 2nd Floor, Office Suite 227, Philadelphia, PA 19104, USA * Correspondence: [email protected] (T.J.G.); [email protected] (M.C.-S.); Tel.: +1-832-524-9651 (T.J.G.); +1-215-573-9917 (M.C.-S.); Fax: +1-215-573-4469 (M.C.-S.) Received: 2 March 2018; Accepted: 21 March 2018; Published: 23 March 2018 1. Introduction The environment of space provides many challenges to the human physiology and therefore to extended habitation and exploration. Research to define and countermeasures to address these challenges have been explored for well over 40 years yet success in alleviating these challenges has been inadequate, due in part to the lack of investigative tools (subject number and technology) Books to monitor and diagnose conditions in real time and by the overall lack of a relevant