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Clinical and Experimental Contents Health Sciences RESEARCH ARTICLES Naringenin Reduces Hepatic Inflammation and Apoptosis Induced by Vancomycin in Rats ...............................................191 Zuhal Uckun Sahinogullari, Sevda Guzel, Necmiye Canacankatan, Cem Yalaza, Deniz Kibar, Gulsen Bayrak Nicotine Dependence Levels of Individuals Applying to a Family Health Center and Their Status of Being Affected by Warnings on Cigarette Packs ............................................................................................................................................................199 Erdal Akdeniz, Selma Oncel Urine Influences Growth and Virulence Gene Expressions in Uropathogenic E. coli: A Comparison with Nutrient Limited Medium ...........................................................................................................................................................................209 Fatma Kalayci Yuksek, Defne Gumus, Gulsen Uz, Ozlem Sefer, Emre Yoruk, Mine Ang Kucuker Turkish Adaptation of Attention Function Index: A Validity and Reliability Study ..............................................................215 Nese Uysal, Gulcan Bagcivan, Filiz Unal Toprak, Yeter Soylu, Bektas Kaya Effect of Web-Based Training on Complication Control and Quality of Life of Spinal Cord Damaged Individuals: Randomized Controlled Trial .................................................................................................................................................................220 Elif Ates, Naile Bilgili Relationship Between Psychiatric Nurses’ Resilience and Empathic Tendencies ................................................................228 Nareg Doğan, Nur Elçin Boyacıoğlu Knowledge Level About Insects and Mites of Health School Students ...............................................................................235 Nil Bagriacik, Cigdem Samanci Tekin The Effect of Mobile Application Support for Postpartum Women on Postpartum Quality of Life .....................................242 Pinar Malli, Ayla Ergin The Effects of Continuous Labor Support by Midwife: A Randomized Controlled Trial .......................................................251 Gulsemin Bostanoglu, Meltem Demirgoz Bal The Effect of Various Canal Contents on the Accuracy of Two Electronic Apex Locators in Detecting Different Size of Root Perforations .....................................................................................................................................................................258 Tulin Dogan Cankaya, Zeliha Ugur Aydin, Demet Altunbas Association of Physical Fitness Indicators with Health Profile and Lifestyle of Children .....................................................263 Eren Timurtas, Eda Cinar, Neslihan Karabacak, Ilksan Demirbuken, Mine Gulden Polat The Impact of Body Mass Index Values on the Quality of Cardiopulmonary Resuscitation: A Manikin Study .....................269 Kadir Kucukceran, Mustafa Kursat Ayranci, Muhammet Rasit Ozer The Potent Cytotoxic and Oxidative Effects of β-2 Selective ICI-118,551 on Breast Adenocarcinoma Cell Lines with Different Aggressiveness .................................................................................................................................................................273 Berna Kavakcioglu Yardimci Contents Assessment of Awareness and Knowledge of Oral Cancer Among Tobacco-Using Dental Patients .....................................279 Gaye Keser, Merve Ozturk, Filiz Namdar Pekiner Exercise Program for Covid-19 Survivors: A Telerehabilitation Framework ........................................................................285 Eren Timurtas, Aysel Yildiz Ozer, Ender Ersin Avci, Ilksan Demirbuken, Mine Gulden Polat The Relationship Between Fat Tissue & Lean Body Mass and Sit to Stand Task in Obese Individuals .................................291 Eren Timurtas, Ender Ersin Avci, Ilksan Demirbuken, Irem Akgun, Yasar Sertbas, Mine Gulden Polat Evaluation of Foveal Thickness and Macular Choroidal Thickness with Optical Coherence Tomography in Behcet’s Disease .. 296 Erman Bozali, Haydar Erdogan, Ayhan Dursun, Ayse Vural Ozec, Mustafa Ilker Toker, Mustafa Kemal Arici The Comparison of the Effectiveness of Local Ice and Manual Pressure Applications in Decreasing Pain Related to Intramuscular Injection ...........................................................................................................................................................................302 Sebnem Bilgic The Relation Between Emphatic Tendency and Level of Compassion among Midwifery Students .....................................308 Bihter Akin, Sema Dereli Yilmaz, Elif Alakas Effect of Different Crown Removing Procedures on the Implant Stability Quotient and Removal Torque Values of Dental Implants ...........................................................................................................................................................................314 Hakan Akin, Yasemen Unal, Kaan Yilmazer Investigation of Fracture Resistance of Zirconia Restorations After Different Surface Treatments .....................................320 Turker Akar, Hakan Akin Oxidative Stress in Controlled Hypotension: Assessment with a Novel Oxidative Stress Marker ........................................324 Cihan Doger, Ayca Tuba Dumanli Ozcan, Ezgi Erkilic, Suleyman Ellik, Semsi Mustafa Aksoy, Murat Alisik, Ozcan Erel Upper Extremity Functioning in Individuals with Type 2 Diabetes Mellitus: A Comparative Study .....................................330 Tuba Yerlikaya, Bilge Basakci Calik, Ugur Cavlak, Ozgur Sirkeci The Impact of Human Values on Ethical Climate: A Private Hospital Practice .....................................................................334 Ali Arslanoglu, Hasan Giray Ankara Assessment of The Frequency and Correlation of Carotid Artery Calcifications and Pulp Stones with Idiopathic Osteosclerosis Using Digital Panoramic Radiographs ................................................................................................................................340 Sema Sonmez Kaplan, Tuna Kaplan, Guzide Pelin Sezgin The Effect of Dental Paste with Herbal Content on Remineralization and the Imaging with Fluorescent Technique in Teeth with White Spot Lesion.....................................................................................................................................................346 Zeynep Beyza Kiristioglu, Funda Yanikoglu, Elif Alkan, Dilek Tagtekin, Gulcin Bilgin Gocmen, Can Ilgin Retrospective Evaluation of Different Shade Selection Methods in the Context of the Vital Bleaching Technique ..............352 Ezgi Tuter Bayraktar, Zuhre Hale Cimilli, Nevin Kartal, Cafer Turkmen The Relationship Between the Learning Styles and Academic Performance of Medical Faculty Students...........................356 Sema Arici, Ozlem Sarikaya, Aysegul Yabaci REVIEW Treatment Approach for Oral Candidiasis: Two Case Reports .............................................................................................. 360 Gaye Keser, Filiz Namdar Pekiner CASE REPORT The Effect of Probiotic and Omega-3 Supplements on Total Oxidant and Total Antioxidant Levels in Experimental Colitis ....... 364 Havvanur Yoldas Ilktac, Gul Kiziltan, Mehmet Ozansoy, Ulkan Kilic, Sine Ozmen Togay, Ilknur Keskin, Ekrem Musa Ozdemir, Mehmet Yalcin Gunal Clinical and Experimental Health Sciences Naringenin Reduces Hepatic Inflammation and Apoptosis Induced by Vancomycin in Rats Zuhal Uckun Sahinogullari 1 , Sevda Guzel 2 , Necmiye Canacankatan 3 , Cem Yalaza 4 , Deniz Kibar 5 , Gulsen Bayrak 5 1 Mersin University, Faculty of Pharmacy, Department of Pharmaceutical Toxicology, Yenisehir, Mersin, Turkey. 2 Mersin University, Faculty of Pharmacy, Department of Pharmacognosy, Yenisehir, Mersin, Turkey. 3 Mersin University, Faculty of Pharmacy, Department of Biochemistry, Yenisehir, Mersin, Turkey. 4 Toros University, Vocational School, Department of Medical Services and Techniques, Yenisehir, Mersin, Turkey. 5 Mersin University, Faculty of Medicine, Department of Histology and Embryology, Yenisehir, Mersin, Turkey. Correspondence Author: Zuhal Uckun Sahinogullari E-mail: [email protected] Received: 31.05.2020 Accepted: 26.10.2020 ABSTRACT Objective: This investigation aimed to detect the possible protective impacts of naringenin (NAR) on vancomycin (VCM)-induced liver toxicity through measuring caspase-3, – 8 and – 9 activities as markers of apoptosis and the levels of tumor necrosis factor-alpha, cyclooxygenase-2 and vascular endothelial growth factor as inflammation markers and assessing the histopathological alterations in rats. Methods: The rats were allocated into seven groups as, the control group (saline, intraperitoneally (i.p.)), VCM group (400 mg/kg/day, i.p.), carboxymethyl cellulose (CMC) group (0.5%, orally), NAR100 group (100 mg/kg/day, orally), VCM+NAR25 group (25 mg/kg/day, orally), VCM+NAR50 group (50 mg/kg/day, orally), VCM+NAR100 group (100 mg/kg/day, orally). The caspase enzyme activities and inflammation markers were measured using colorimetric methods and ELISA, respectively. Histopathological examinations were performed. Results: The caspase activities and levels of inflammation markers were significantly higher in the VCM group as opposed to the other groups. The caspase activities were significantly ameliorated in the VCM+NAR25 group compared to the VCM+NAR50 and VCM+NAR100 groups, but the levels of inflammation
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