Review on Biophysical Modelling and Simulation Studies for Transcranial Magnetic Stimulation Jose Gomez-Tames1, Ilkka Laakso2, and Akimasa Hirata1 1. Nagoya Institute of Technology, Department of Electrical and Mechanical Engineering, Nagoya, Aichi 466-8555, Japan 2. Department of Electrical Engineering and Automation, Aalto University, FI-00076, Finland. Corresponding author: Jose Gomez-Tames Nagoya Institute of Technology Tel & Fax: +81-52-735-7916 E-mail:
[email protected] 1 Abstract Transcranial magnetic stimulation (TMS) is a technique for noninvasively stimulating a brain area for therapeutic, rehabilitation treatments and neuroscience research. Despite our understanding of the physical principles and experimental developments pertaining to TMS, it is difficult to identify the exact brain target as the generated dosage exhibits a non-uniform distribution owing to the complicated and subject-dependent brain anatomy and the lack of biomarkers that can quantify the effects of TMS in most cortical areas. Computational dosimetry has progressed significantly and enables TMS assessment by computation of the induced electric field (the primary physical agent known to activate the brain neurons) in a digital representation of the human head. In this review, TMS dosimetry studies are summarised, clarifying the importance of the anatomical and human biophysical parameters and computational methods. This review shows that there is a high consensus on the importance of a detailed cortical folding representation and an accurate modelling of the surrounding cerebrospinal fluid. Recent studies have also enabled the prediction of individually optimised stimulation based on magnetic resonance imaging of the patient/subject and have attempted to understand the temporal effects of TMS at the cellular level by incorporating neural modelling.