nutrients Article The Metabolic Syndrome: Emerging Novel Insights Regarding the Relationship between the Homeostasis Model Assessment of Insulin Resistance and other Key Predictive Markers in Young Adults of Western Algeria Mohammed Ilyes Belhayara 1, Zoheir Mellouk 1 , Mohammed Seddik Hamdaoui 2, Malika Bachaoui 2, Omar Kheroua 1 and Willy J. Malaisse 3,* 1 Laboratory of Physiology of Nutrition and Food Safety, Department of Biology, Faculty of Natural and Life Sciences, Université Oran1, 31000 Oran, Algeria;
[email protected] (M.I.B.);
[email protected] (Z.M.);
[email protected] (O.K.) 2 Department of Internal Medicine, University Hospital Institution of Oran, 31000 Oran, Algeria;
[email protected] (M.S.H.);
[email protected] (M.B.) 3 Department of Biochemistry, Université Libre de Bruxelles, B-1070 Brussels, Belgium * Correspondence:
[email protected]; Tel.: +32-2-555-6237 Received: 31 January 2020; Accepted: 8 March 2020; Published: 10 March 2020 Abstract: Several biological markers have been identified as risk factors for cardiovascular disease and are associated with increased risk of metabolic syndrome (MetS). This study provides a factual information on promising biomarkers that are associated with MetS and can aid in early detection and management of MetS in young adults of Western Algeria. We studied a total of one hundred subjects aged between thirty and forty years with MetS, in which anthropometric measurements, insulin resistance, C peptide and HbA1c, lipid profile, circulating adipokines and glucagon-like peptide-1 were measured by suitable methods, in comparison to two groups of control. MetS is closely linked to altered glucose homeostasis, the plasma insulin/glucose ratio; i.e., the insulinogenic index helps to estimate the level of insulin secretion and also for assessing β-cell function.