Origins: Zhang Yuan-su, The Origins of Medicine Sheng Mai Formula Sheng Mai San (Yi Xue Qi Yuan) 1186.

Sheng Mai Formula (Sheng Mai San) was made famous during the Yuan Dynasty (1271-1368 C.E.) and has often been thought to originate from that period. Zhu Dan-xi and Li Dong-yuan (Li Gao), both Yuan Dynasty physicians, mention Sheng Mai San in their writings, but the formula can be traced back at least to Zhang Yuan-su’s book The Origins of Medicine (Yi Xue Qi Yuan) from 1186. General Signs/Symptoms As is implied in the formula’s name, Sheng Mai, or “Generate the Pulse,” a damaged pulse quality is a common feature in every presentation for which this formula has classical application. In every instance of classical use, the pulse will reflect some stage of depletion from damage to qi and body fluids. The damage results from heat in the lungs leading to scorched lungs, excessive sweating, or both. Common signs and symptoms include spontaneous sweating, dry mouth and thirst, chronic, weak cough, and possibly blocked urination. In the modern era, the formula has shown to be especially useful for treating a wide range of cardiovascular conditions. It can thereby be thought of as treating a variety of deficiency issues of the upper warmer, where qi and yin or fluids are both compromised.

Classical Applications 1. Qi and yin 2. Summerheat 3. Yang qi exhaustion/ 4. Strengthens the deficiency of the (use after high fever collapse (severe qi “upper source of lung w/ latent heat has subsided) and fluid damage water” • Chronic, weak cough • Dry mouth and thirst from warm disease) • Scant or blocked • Spontaneous • Scanty urination • Large, scattered pulse urination sweating • Irritability • No thirst, or desire for • Spontaneous sweating warm fluids • Shortness of breath • Lethargy • Dry mouth w/ thirst • Mild fever • Possible shortness of • Thin, weak pulse • Dry mouth with thirst breath • Empty, fine, or thready • Large, forceless pulse pulse or fine, empty and rapid Ingredients Pinyin Latin English Percent of Formula Ren Shen (Chief) Ginseng (radix) Asian Ginseng Root 37.5% Mai Men Dong (Deputy) Ophiopogonis (radix) Ophiopogon Tuber 37.5% Wu Wei Zi (Assistant) Schisandrae (fructus) Schisandra Fruit 25.0% General Indications / Modern Applications Altitude sickness Cough, chronic weak Myocardial infarction (recovery Alzheimer’s disease Diabetes mellitus from) Angina pectoris Dizziness due to low blood Myocarditis, viral Anxiety pressure Palpitations Arrhythmia Dyspnea Post-bypass (recovery phase) Asthma, chronic Forgetfulness Pulmonary tuberculosis (adjunct therapy) Breath, shortness of Hemorrhagic and/or cardiogenic shock SARS (recovery phase) Bronchitis, chronic Hyperthermic shock Shock, acute Cerebral infarction Hypotension Rheumatic heart disease Chemotherapy support Infertility Urination dark and scanty Congestive heart failure Insomnia caused by excessive sweating Coronary artery disease Leukopenia Vertigo from low blood pressure Sheng Mai Formula Monograph © September 2011, Herbal Medicine Press Sheng Mai Formula 2 tablets, 3times daily. The standard adult dosageis 2 D excess. for those with hypertension from shen), this formula contraindicated is toDue the presence (ren ginseng of M and/or kidney deficiency. severe spleenterm of cases in use no damage to fluids. body Avoid long phlegm-heat or when there been has coughof due to damp-phlegm or attack. Use with caution cases in or anydisease external pathogenic during the febrile acute phaseof This formulais contraindicated C C qi and fluids). body exhaustion with severe damage to andLarge scattered (yang qi summerheat). andLarge forceless (in acute Empty, fine or thready,possibly rapid. P coating. Dry, thin tongue, with little or no T F ongue ormula ulse ontraindications lassical • Constrains lungqi • Astringes yinandbodyfluids • Engendersfluids • Nourishesyin zong qi • Boosts • Tonifies qi osage odern A

s ction /C autions The deputy herb, ophiopogon (mai dong) men , the one is of wheninsomnia caused by deficiency. can therefore address issues such irritability, as anxiety, and qi from collapse. It the has ability (spirit), to calm shen and spleen, engenders fluids, and has the ability to rescue the yang shen) strongly supplements the source qi, tonifies lung and Formula (renginseng fulfilled by is shen). Alone, (ren ginseng Thereis question no that in Sheng the Maichief role of Synergy of Ingredients for restoring depleted fluids. shen) and ophiopogon (mai dong) the men is strongest known the heart, lungs, and stomach. The (rencombinationginseng of bitter and slightly cold, the it has ability to mildly clear heat in both theof upper and middle warmers. Because slightly it is Ophiopogon (mai dong) men nourishes the all in yin organs digest and the than utilize other some of substances its in class. deficiency, sinceis it onlymildly cloying, and therefore easier to and generating fluids. body qi is especiallyin It of cases useful primary substances the in Materia Medica for nourishing yin descend rebellious lung qiand control cough. and helps it to the grasp the lung. qiof This action helps to fluids. In addition,schisandra (wu zi) wei nourishes the kidney other two substances (spirit) to calm shen and generate body sweat, and contain the lung qi. It shares also the the actions of its ability toby virtue of check fluid thebody lossthrough of essence. In Sheng Mai Formula, schisandra(wu zi) wei assists best known for its ability to astringe qi, leakage of sweat, and Schisandra (wu zi) wei the is assistant this in formula. It is of fluids throughof sweatfurther damages the qi, which relies the lungof and some residual heat remained. Continued loss infectious condition wherein heat had damaged the qiand yin pulse pulse “threatens to off.” cut be 1186.in The formulaused to was treat a condition where the by Zhang Yuan-su, and published ofMedicine the in Origins Sheng Mai Formula Mai (Sheng San) originally was developed andQi Yin Deficiencythe Lung, of Latent with Heat Analysis of Indications Classical tongue will usuallytongue present will with little dry as or no coating. may shortness be also breath of mouth or dry with thirst. The cough with spontaneous sweating and adeficient pulse. There off.” symptoms Thechief forthis condition arechronic, weak (fine).yin is It shrinking, and therefore “threateningcut be to therefore empty and fine, reflectingof qi (empty) the loss and anchoringof causes the yang to float upward. is Thepulse upon the to yin anchor it. The theweakness qi and of the lack i The specific pattern post-was a Sheng Mai Formula 3 - (“Fei wei (“Fei of water,” upper source the is lung “The his of Blood Discussion In yuan.”) zhi shang shui Zong-hai Tang 1884), Zheng, Lun (Xue Patterns (Sheng Mai Formula use Mai of Sheng encourages qi of in yin and lung the the supplement to San) of source upper “the as role its facilitate to order one body, in the sources water Of three the water.” lung’s the , (sanjiao) warmers of three in each the of qi”. “governor as role its to is related function in lung the by qi commanded the follows Moisture aspect One a river. mist follows that way same the dis is- to role of water” source “upper of lung’s the aspect (an the of yin qi)through “mist” this tribute aspect of the Another all tissues. nourish body to used water conducts it is that source as a water lung water warmer triple via the warmer, lower the to Yang QiExhaustion/Collapse Yang Sheng using recommends school Bing Wen The - col yang treat to San) (Sheng Mai Formula Mai disease a warm has considerable when caused lapse This 1798). Ju-tang, qi (Wu source the to damage application, original Yuan-su’s Zhang is similar to yang True severe. is more damage indicated the but the but condition, is a life-threatening qi collapse for of in brink order the be death on needn’t patient be useful. to San) (Sheng Mai Formula Mai Sheng exhaustion qi yang when can be used formula The - “defi (also called qi exhaustion Yang is apparent. - grad is the “vacuity desertion”) or ciency desertion” prolonged of qi from depletion yang critical, yet ual, empty, and thin pulse The become will first illness. forceless and floating, larger, become willbut later begins separate. to yang as the ofWater” “Upper Source the Strengthen comes water the warmer, lower in the Once ways. - “Strengthen of kidney. command the the under for is a treatment of water” source upper the ing an is There dryness. clumped and weakness chronic There lungs. deficient the from moistening uneven a weak urination, scanty of dry skin, be patches may dry mouth, sweating, spontaneous cough, chronic pulse The weak. willthinand be thirst. and - - - Summerheat Summerheat of was a disciple Zhang (Li Gao) Li Dong-yuan of- his teach application the extended He Yuan-su. summerheat. from damage treat to formula er’s en- to of result over-exposure is the Summerheat scanty thirst, fever, high causing heat, vironmental and (“Sunstroke” vexation. heart and urination, that conditions for names modern are “heatstroke” pulse The “summerheat”.) of category the fall under or stage) (early forceless as and large present may Sheng stages). later the (in rapid and empty fine, to tonifying is too San) (Sheng Mai Formula Mai febrile the For is high. still fever the while apply (KPC 1090 Bai Decoction Tiger White use stage, Sheng control, is under fever the Once . Tang) Hu be used to should San) (Sheng Mai Formula Mai - recti yin and qi and restoring by recovery facilitate pulse. fying the ous sweating and further loss of yin. This formula formula This of loss yin. further and ous sweating the boosts in turn qi that yuan the boost acts to The astringent wei and qi. of (qi chest) zong the qi, lung the contain to helps quality of formula the fluids retain and damage, further from it protect the yin from to damage and loss further prevent to formula in the herbs All sweating. spontaneous jinye the nourish and moisten to ability the have re and fluids lost the replenish They (body fluids). tion of yin and the leakage of lung qi. As the lung lung the As of of leakage qi. tion lung the yin and qi) is weithe qi (defensive progresses, qi deficiency exterior the protect to is unable and also damaged the regulate qi to ying the with coordinate to and spontane causing of pores, closing the and opening leakage. further from them strain This application of the formula places it in the the it in places offormula the application This to continue can condition The ofrealm tonic. rescue symptoms the because if corrected, not degenerate, the to say: is That it. also advance of condition the a persistent stimulate to continues yin deficiency consump the to contributes in turn which cough, The deficient pulse is usually empty/forceless and and empty/forceless pulseusually is deficient The is aggravating heat if latent also be rapid the may still pathogen if or external initial the condition the has- been suf there Once lung. in the has presence and empty the pulse as present will loss, fluid ficient thready. or fine Sheng Mai Formula 4 pathogen. a cell mediated immune response to the initial stages, and, depending on the individual, can have ously unknown disease. SARS several has distinct for herbal new protocols for treating this previ- drome 2003created in (SARS) China in the need The outbreakSevere of Acute Respiratory Syn- building the lung qiand yin. and frequency or eliminate the acute attacks by vasion at the time. The goalis to lessen theseverity the lung qi, there pathogenic if are noof - in signs between the acute attacks to tonify and astringe Mai Formula Mai (Sheng San) would in used be presents with lung qiand deficiency. yin Sheng Mai Formula Mai (Sheng San) the patient if Chronic asthma may treated be with Sheng continue when use an external pathogen present. is to resist further depletion. The patient should- dis orderin to strengthen the lung qiand order in yin tonic when the patient no bronchial has infection other exposures. This formula givenshouldbe asa but may have also developed from smoking or pattern may arise from or aging weak constitution, Mai San) .underlying The lung qi and deficientyin cessfully treated with Sheng Mai Formula (Sheng chronic formsSome of bronchitis may suc be - the disease.stage of should during used not be the initial inflammatory known to an immune be stimulant. This formula muscles.second The a stage infectionTB of is to further weakening the lung of and diaphragm severe cough and shortness breath of that leads This stage is TB of characterized by a chronic, treated by Sheng Mai Formula Mai (Sheng San). second stage pulmonary can tuberculosis be (TB) The resulting lung qi and deficiencyyin caused by Yin Deficiency Pulmonary Diseasesto Lung Due and Qi system diseases. categories: pulmonary, cardiac, and circulatory by research. These applicationsin fall three main Mai Formula Mai (Sheng San) have verified been modernA applications variety wide of of Sheng Modern Applications ii ii Ginseng (ren shen), herb, the chief is iii

Decoction would combined be withthe Clear Nutritive Level happened, Sheng Mai Formula Mai (Sheng San) ying (nutritive) and xue levels. (blood) When this the infection,of the heat pathogen would enter the patients,small number of during the phase peak the obstruction and disseminate the lung qi. In a pathogen and transforming dampness to move ment on focused clearing the toxic, damp-heat as diagnosed “atypical pneumonia.” The treat- term SARS being coined, the pattern being was heat toxin obstructing lung function. Prior to the usuallywas marked by the presence damp- of slightly different presentations.initial The stage damage. recovery and prevent life-long effectsfrom the San) during the recovery SARS to stage speed of often prescribe Sheng Mai Formula Mai (Sheng in the heart muscles, xi cardiac contractility, Sheng Mai Formula Maimula (Sheng San) for cardiovascular disease. support the following Sheng benefits Maiof For are cardiovascular. There are numerous studies to well known modern applications for this formula application pulmonary in conditions, the most In the spite formula’s of and origins its frequent Deficiency and YangQi Collapse Cardiovascular System­ and increases arterial blood flow in the heart. tects against shock, expands the coronary arteries, the classic formula appropriate. is Cardiac, septic, Sheng Mai Formula heart failure. hyperthermic shock, septic shock, or congestive situations such as cardiogenic, hemorrhagic shock, ly used in hospitals in China to treat emergency sometimes excluding schisandrae seng Shengmai Zhusheye ed with Sheng Mai Formula Mai (Sheng San). and/or zong qideficiency be can successfully treat- Arrhythmia and heart palpitations due to heart most commonly used for these shock.types of For chronic hypotension, astandard dosage of (ren shen) v

iv (QingYing Tang). Doctors would also ix An intravenous form the of formula, and ophiopogon , which is a combination gin of vi (Sheng Mai San)

reduces oxygen consumption vii (Sheng Mai San) adjusts blood pressure, pro —Heart and Lung Qi (mai men dong) (wu wei zi) is common strengthens —is viii

­— - - - - Sheng Mai Formula 5 - - (Sheng (Sheng Mai (Sheng Mai

xvii and Eight Immortals Immortals Eight and Increasing proper elimination elimination proper Increasing xix xviii pattern has marked lung qi deficiency, qi deficiency, lung has marked pattern Sheng Mai Formula Formula Mai This a Sheng is because . has also San) (Sheng Mai Formula Mai Sheng immuno-supportive many have to been shown functions. cellular immune enhance to effects killer cells natural and cells blood white Building function. is one Formula Mai San) Mai Formula Comparisons Formula Formula Mai Sheng qi and treat of both formulas these though Even - to differenti it is important yin deficiency, lung focus The formula. correct the apply to further ate Chang (Ba Xian Formula of Immortals Eight yin of and lung the the nourish is to Wan) Shou so much qi, lung the tonify does not It kidneys. of yin with loss qi and lung further as prevents it pulse The . wei of zi) (wu inclusion schisandra the Chang (Ba Xian Formula Immortals Eight in the but rapid, possibly and is thin pattern Wan) Shou - pat be in the as would it empty, necessarily is not Formula Mai Sheng by treated tern Circulatory System Circulatory (Sheng Mai Formula ofMai ability The Sheng expand and contractility cardiac increase to San) blood and oxygen as as well the arteries coronary reason primary the is arteries coronary the to flow effect extraordinary an has such formula this that circula also the but itself, heart the on only not system. tory also qi hasyang a ofheart action the The boosting of - infertil pattern One fertility. on effect positive spark qi to of yang failure heart the involves ity and initiate to channels chong and ren kidney, the in- cycle, of menstrual regularity the the maintain A of ovulation. egg release during the the cluding Mai Sheng that showed in 1996, published study treating in was effective San) (Sheng Mai Formula anovulation. to due infertility San) of “blood wastes” through phagocytosis is another is another phagocytosis through “blood wastes” of Formula of Mai effect boosting Sheng immune . San) (Sheng Mai Eight Immor of Eight the component a necessary not pattern. Chang Wan) Shou (Ba Xian Formula tals -

xiv for five five for - ef side Other xiii San) (ShengMai A test was conducted was conducted test A Recovery from coronary coronary from Recovery xvi xv

xii Sheng Mai Formula Formula Mai Sheng has been San) (Sheng Mai Formula Mai Sheng altitude/ for protection be effective an to shown oxygen blood increasing by sickness mountain signifi- to is relocated subject the when transport altitudes. higher cantly nation of the heart muscle after surgery. surgery. after muscle of heart nation the days prior to their relocation to a higher altitude. a higher to relocation their to prior days on humans and animals using declining levels of levels declining animals using and humans on - declin for as sodium-peptide indicator an atrial animals and Both transport. oxygen blood ing they when markers these with improved humans took bypass surgery is yet another application of this application another is yet bypass surgery strengthen to ability The formula. extraordinary arteries coronary the expand contractility, cardiac blood arterial and flow oxygen increasing (thus rejuve and process healing the in is essential flow) fects of chemotherapy, such as a decrease in white in as white a decrease such offects chemotherapy, be improved may (leukopenia) count cell blood Also, . San) (Sheng Mai Formula Mai Sheng with stomatitis, of severity and ulcerative incidence the treatments, of effect chemotherapy side a common use of the with formula. this be reduced may One of the undesirable risks connected with with connected risks ofOne undesirable the and colon, breast, for treatments chemotherapy cardiac is adriamycin-induced cancer pancreatic San) (Sheng Mai Formula Mai Sheng damage. risk. this mediate be used to may hemorrhagic, hyperthermic or hypothermic shock, shock, hypothermic or hyperthermic hemorrhagic, qi collapse of danger yang immediate an with of Shengmai formula IV an with be treated would Zhusheye. has been San) (Sheng Mai Formula Mai Sheng to in Chinese medicine generations many used for Formula Mai Sheng disease. artery coronary treat in- decrease to has been shown San) (Sheng Mai output cardiac increase failure, ofcidence cardiac Sheng that has shown Research contractility. and against protect can San) (Sheng Mai Formula Mai of formula the Use of attack. heart incidence the severity size and the reduce can infarct an during activation the through infarction of a myocardial - kinase of opening of mitochon C and the protein channels. KATP drial 6 Accompanying signs and symptoms of the Eight Sheng Mai Formula and Restore the Lung Immortals Formula (Ba Xian Chang Shou Wan) Formula

or m ula pattern may include constipation, hemoptysis, and These two formulas both help restore the lung qi af- F night sweats, to name a few. Sheng Mai Formula ter an illness has depleted it. Restore the Lung For- ai (Sheng Mai San) is more appropriate in cases where mula (Bu Fei Tang), some think, is actually a modi- M qi deficiency, either in the form of lung qi and/or fication ofSheng Mai Formula (Sheng Mai San),

heng yuan qi deficiency is the primary symptom. There but the focus of Restore the Lung Formula (Bu Fei S may also be deficiency heat signs from lung yin de- Tang) is more concentrated on stopping the cough. It ficiency, primarily dryness in the form of thirst; dry contains prepared rehmannia (shu di huang) to help tongue; thicker, difficult to expectorate sputum and the kidneys grasp the qi of the lung, and two herbs qi deficiency symptoms including: weakness, fatigue, that help to descend the lung qi and stop cough: shortness of breath, palpitations, and spontaneous aster root (zi wan) and white mulberry bark (sang sweating. bai pi). The cough may be more pronounced in the Sheng Mai Formula and Lily Preserve Metal Restore the Lung Formula (Bu Fei Tang) pattern, but the condition of the pulse is more serious in the Formula Sheng Mai Formula (Sheng Mai San) pattern. Lily Preserve Metal Formula (Bai He Gu Jin Tang) includes American ginseng (xi yang shen) instead of Sheng Mai Formula, Blood Palace Formula, Asian ginseng (ren shen). American ginseng cools and San Qi Tablets while it tonifies, and is therefore more appropriate All three of these formulas can be used to treat coro- while heat still lingers in the lungs. Lily bulb (bai nary artery disease and angina pectoris. A key differ- he) itself is efficient at clearing heat out of the lungs. ence is that Sheng Mai Formula (Sheng Mai San) Symptoms that may be treated by Lily Preserve treats the vessels through the qi while the other two Metal Formula (Bai He Gu Jin Tang) include; cough formulas focus on the blood itself. The mechanism with blood and sputum, dry mouth, lips, cough, or of Sheng Mai Formula to expand the arterial nose; sore throat from dryness, night sweats and five walls, oxygenate the cardiac muscle, and improve palm heat. Sheng Mai Formula (Sheng Mai San) is cardiac contractility is all accomplished through more appropriate in cases where lung qi deficiency supporting the yuan qi, lung and fluids.Blood is as prominent or more prominent than the yin Palace Formula (Xue Fu Zhu Yu Tang) and San deficiency. LikeEight Immortals Formula (Ba Xian Qi Tablets relieve chest pain by Chang Shou Wan), Lily Preserve Metal Formula (San Qi Wan) (Bai He Gu Jin Tang) also treats lung and kidney yin moving blood and dispelling stasis, which will deficiency with dryness. ButLily Preserve Metal free the qi. Blood Palace Formula (Xue Fu Zhu Formula (Bai He Gu Jin Tang) is stronger to clear Yu Tang) and San Qi Tablets (San Qi Wan) heat and resolve lingering phlegm in the lungs. Lily treat an excess of stagnation/stasis, while Sheng Preserve Metal Formula (Bai He Gu Jin Tang) Mai Formula (Sheng Mai San) as a tonic, treats is designed for the lingering, sub-acute phase of a deficiency. warm upper respiratory disease. In fact, for treating post-illness, one might consider using Lily Preserve Metal Formula (Bai He Gu Jin Tang) just prior to Sheng Mai Formula (Sheng Mai San) in order to insure that the residual heat is cleared out before one begins to tonify. Useful Combinations

For coronary artery disease resulting from a combination of qi and blood deficiency (specifically lung or yuan or zong qi plus Use with Tang Kuei & Salvia Formula. heart and/or liver blood deficiency)

For adjuvant cancer therapy, for relieving side effects of chemotherapy or to repair damage to the blood caused by Use with Five Mushroom Formula. chemotherapy and radiation

For blood stasis, qi and yin deficiency found in aging, as well as to preserve yin, strengthen zong qi and regulating the heart Use with Blood Palace Formula. and vessels

Endnotes iSchied, V., Bensky, D., Ellis, A. & Barolett, R.. Chinese Herbal Medicine: Formulas & Strategies, 2nd ed. Seattle, WA: Eastland Press, 2009. ii Dharmananda, S., “Sheng Mai San: An ancient formula now used in Chinese hospitals”, Institute for Traditional Medicine, Portland, OR, November 2001. iii Chunxiang, T., “How to Tonify Asthma patients with Chinese Herbs”, Journal of Chinese Medicine, Beijing, December 2006 iv Lin, L, et al., “Treating Severe Acute Respiratory Syndrome with Integrated Chinese and Western Medicine”, Journal of Chinese Medicine, Vol. 72, June 2003. v Ibid, Lin, L, et al. vi Jiang Jian, Fang Jing, and Luo Decheng, “Effects of Shengmai yin on left ventricular performance and exercise tolerance in patients with dilated cardiomyopathy,” Chinese Journal of Cardiology, 1988; 16(1): 65-67, 125. vii Xu X. (chief editor), The English-Chinese Encyclopedia of Practical Traditional Chinese Medicine, Volume 5, Higher Education Press, Beijing, 1990. viii Ibid, Xu X.. ix Zhang, G., et al., “Long-Term Treatment with a Chinese herbal formula, Sheng-Mai-San, improves cardiac contractile function in aged rats: The role of Ca2+ homeostasis.”Rejuvenation Research, Vol. 11(6), pp. 991-1000, 2008. x Lee, I., et al., “Sheng Mai San, a Chinese herbal medicine, protects against renal ischemic injury during heat stroke in the rat”, Clinical Experimental Pharmacology and Physiology, Vol. 32, Issue 9, pp 742-748, 2005. xi Ibid, Xu Xiangcai xii Dharmananda, S., “Shengmai San: An ancient formula now used in Chinese hospitals”, Institute for Traditional Medicine, Portland, OR, November 2001. xiii You, .J, et al., “Sheng Mai San Reduces Adriamycin-Induced Cardiomyopathy in Rats”, The American Journal of Chinese Medicine, Vol. 34, Issue 2, pp. 295-305, 2006. xiv Liu H., et al., “Journal of Research in Tumor Prevention and Treatment”, Vol. 25, Issue 5, pp. 404-405, 1998. xv Wang, N., et al., “Treatment with Sheng Mai Formula reduces myocardial infarct size through activation of protein Kinase C and opening S heng of mitochondrial KATP channel”, American Journal of Chinese Medicine, Circulatory Journal, Vol. 66, pp. 763-768, 2002. xvi Zhang Z. and Song L., High altitude conditions and qi deficiency (III)—A trial of Sheng Mai Yin applied to prevent high altitude reactions, 1990 (6): 42–44. M xvii Ren, Z., et al., Journal of Applied Internal Medicine in TCM, Vol. 10, Issue 1, p. 24, 1996. ai xviii Rong, W., et al., Journal of Hunan College of TCM, Vol. 17, Issue 4, pp. 48-50, 1997 F xix Ibid, Rong. or m ula 7 Sheng Mai Formula Monograph ©September 2011, Herbal Medicine Press Sheng Mai Formula 8 Bensky, D., Clavey, S., Stoger, E., &Gamble, A. Chinese Herbal Medicine: Materia Medica R Zhou G., Zhao N., Zhang H., Jia H., Zhang W., Zhao L.,Lu C., He Y., and Lu A., “ formula, Sheng-Mai-San, improves cardiac contractile function aged in rats: The Ca2+ homeostasis.”role of Zhang, G. Zhang, H., Liu, W., Dong, H., Fong, W., Tang, L.,Xiong, Y., Yu, Z., and Ko, K. “Long-Term Treatment herbal with aChinese Wang, N., Minatoguchi, S., Uno, Y., Arai, M., Hashimoto, K., Hashimoto, Y., Yamaguchi, K., Fukuda, K., Akao, S., Fujiwara, H., “Treatment Tanaka, T. “ Shaoying, X., translated by, Al-Khafaji, M. Running piglet. qi Journal ofChinese Medicine, Vol. 30, pp. 10-13, 1989. Scott, J., Monda, L.,and Heuertz, J. Clinical Guide toCommonly Used Chinese Herbal Formulas, 5 Schied, V., Bensky, D., Ellis, A., and Barolett, Chinese Herbal R. Medicine: Formulas &Strategies, 2nd ed.Seattle, WA: Eastland Press, 2009. L.,HeLin D., Han Y., Xu, J., Z., Lin “Treating severe Acute Respiratory (SARS) Syndrome with integrated and Chinese Western Li, P., Poon, K., and Ko, K., myocardial chinensis-dependent “Schisandra protective Sheng action Mai of Formula rats”, in American Journal Flaws, B. Treatment ofModern Western with Chinese Diseases Medicine, Boulder, CO: Blue Poppy Press, 1994. Ellis, A. Notes from South Mountain: AGuide toConcentrated Herb Granules . Berkeley, CA:Thin Moon, 2003. Deng, T. Practical Diagnosisin Traditional Chinese Medicine. Edinburgh, UK: Churchill Livingstone, 2000. Dharmananda, S., “Shengmai San - An ancient formula hospitals”, now Chinese in used Institute for Traditional Medicine, Portland, OR, Chunxiang, T., to“How tonify asthma patients herbs”, with Chinese Journal of Traditional Medicine Chinese December 2006. Chen, J. &Chen, T. Chinese Medical. and Industry, Herbology Pharmacology City of CA, MedicineArt of Press, 2004. Chen, J. &Chen, T. Chinese Herbal Formulas and Applications. Industry, City of CA, MedicineArt of Press, 2009. ef erences in micein with collagen-induced arthritis Rejuvenation Research, Vol. 11(6), pp. 991-1000, 2008. channel”, Circulation Journal, Vol. 66, pp. 763-768, 2002. with Sheng Mai Formula reduces myocardial infarct sizethrough activation protein of Cand Kinase opening Clinical Exp. and Obstetrics Gynecology, Vol. 28(1), pp. 20-3. 2001. Journal ofChinese Medicine, Vol. 72: June 2003. Medicine–A report on 103hospitalised at cases the Second Affiliatedof Guangzhou Hospital University Chinese of Medicine, China”, of Chinese Medicine, Vol. 24, pp. 255-62, 1996. November 2001. Effects of herbalEffects medicineof on menopausal symptomsinduced by gonadotropin-releasing hormoneagonist therapy

,” World Journal Vol. ofGastroenterology 11(34), pp. 5373-5376, 2005. Effect of Zhi Gui EffectDecoction on entericof mucosalimmune , 3 rd ed.Seattle, WA: Eastland Press, 2004. th ed., Herbal Medicine Press, 2009. of mitochondrialof KATP .” Abstract.