W&M ScholarWorks Undergraduate Honors Theses Theses, Dissertations, & Master Projects 5-2011 Hypothiocyanous Acid Oxidation of Tubulin Cysteines Inhibits Microtubule Polymerization Hillary Meghan Clark College of William and Mary Follow this and additional works at: https://scholarworks.wm.edu/honorstheses Part of the Chemistry Commons Recommended Citation Clark, Hillary Meghan, "Hypothiocyanous Acid Oxidation of Tubulin Cysteines Inhibits Microtubule Polymerization" (2011). Undergraduate Honors Theses. Paper 398. https://scholarworks.wm.edu/honorstheses/398 This Honors Thesis -- Open Access is brought to you for free and open access by the Theses, Dissertations, & Master Projects at W&M ScholarWorks. It has been accepted for inclusion in Undergraduate Honors Theses by an authorized administrator of W&M ScholarWorks. For more information, please contact
[email protected]. Hypothiocyanous acid oxidation of tubulin cysteines inhibits microtubule polymerization A thesis submitted in partial fulfillment of the requirement for the degree of Bachelor of Science in Chemistry from The College of William and Mary by Hillary Meghan Clark Accepted for _________________________ (Honors) ___________________________________ Dr. Lisa M. Landino, Director ___________________________________ Dr. Lizabeth A. Allison ___________________________________ Dr. Gary W. Rice Williamsburg, VA April 27, 2011 i Table of Contents List of Figures iii List of Tables iv List of Abbreviations v Chemical Index vi Introduction 1 Reactive Oxygen Species 1 Antioxidants