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Real World Efficacy and Tolerability of Acotiamide, in Relieving Meal
testinal & in D o i tr g s e Journal of Gastrointestinal & a s t G i v f e o Narayanan et al., J Gastrointest Dig Syst 2018, 8:1 S l y a s n r ISSN: 2161-069Xt Digestive System DOI: 10.4172/2161-069X.1000553 e u m o J Research Article Open Access Real World Efficacy and Tolerability of Acotiamide, in Relieving Meal- related Symptoms of Functional Dyspepsia Varsha Narayanan*, Amit Bhargava and Shailesh Pallewar 1Department of Medical Services and Research, Lupin Ltd., India *Corresponding author: Narayanan V, Department of Medical Services and Research, Lupin Ltd., Mumbai, India, Tel: +912266402222; E-mail: [email protected] Received date: February 09, 2018; Accepted date: February 21, 2018; Published date: February 27, 2018 Copyright: © 2018 Narayanan V, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Abstract Background: Functional Dyspepsia (FD) is a highly prevalent clinical condition that imposes negative economic burden on health-care system as well as greatly impairs quality of life. Treatment of non-specific and bothersome meal-related FD symptoms like post-prandial fullness, upper abdominal bloating and early satiety, is a therapeutic challenge for the clinicians as poorly-defined and ill-understood pathogenesis has hampered efforts to develop effective treatments. Acotiamide is first-in-class drug that exerts its gastro-kinetic effect by enhancing acetylcholine release. Though evidence of its efficacy and tolerance are available through randomized clinical trials, real world data from its regular in-clinic use is lacking. -
PN0496-Acotiamide.Pdf
Acotiamide hydrochloride hydrate (Acofide®) 盐酸阿考替胺 Z-338 in Zeria; YM-443 in Astellas Tablet, oral, EQ 100 mg acotiamide Acotiamide is a peripheral acetylcholinesterase inhibitor, indicated for the treatment of functional dyspepsia (FD), which was first-in-class drug to treat FD in the world and approved in 2013 by Japan PMDA. It was originally discovered by Zeria, and co-developed with Astellas. The drug is co-marketing in Japan with a single brand name. The human recommended starting dose is 100 mg at a time, and 3 times a day before meals. Worldwide Key Approvals Global Sales ($Million) Key Substance Patent Expiration 2016-May (US5981557A) 2016-May (EP0870765B1) 2013-Mar (JP) Not available 2021-May (JP3181919B2) 2016-May (CN1063442C) Mechanism of Action Acotiamide hydrochloride hydrate is an acetylcholinesterase (AChE) inhibitor and enhanced the acetylcholine (ACh)-induced contraction and motility of the gastric antrum and the gastric body. Target Binding Selectivity In vitro Efficacy In vivo Efficacy Mixed pattern: Ki1= 0.61 µM Effect dose of contraction in gastric sample: Significantly improved the gastrointestinal motility: Ki2= 2.7 µM ACh-induced: at 1 µM In normal and gastric hypomotility dogs: at 10 mg/kg. Inhibition: IC50= 3 µM Electrical-induced: at 0.3 µM In gastric hypomotility rats: at 100 mg/kg. Pharmacokinetics Parameters Rats Dogs Healthy Humans 3 10 3 10 50 mg 100 mg 200 mg 400 mg 800 mg Dose (mg/kg) (i.v.) (p.o.) (i.v.) (p.o.) (p.o.) (p.o.) (p.o.) (p.o.) (p.o.) Tmax (hr) - 0.08 - 0.5 2.75 2.42 2.08 2.25 2.13 Cmax -
TELEMARK BOTANISKE FORENING LISTÉRA - Tidsskrift for Telemark Botaniske Forening (NBF, Telemarksavdelingen) 20
2 - 2 0 0 5 TELEMARK BOTANISKE FORENING LISTÉRA - Tidsskrift for Telemark Botaniske Forening (NBF, Telemarksavdelingen) 20. årgang, 2005, nummer 2 **************************************************************** ADRESSER OG TELEFONER: TELEMARK BOTANISKE FORENING, Postboks 25 Stridsklev, 3904 Porsgrunn Postgirokonto: 0530 3890647. Foreningens e-mail-kontakt: [email protected] Foreningens hjemmeside: www.miclis.no/tbf Kasserer: Åse Halvorsen, Langerødvegen 4, 3719 Skien Tlf.: 35 50 01 35 Styremedlem: Esther Broch, Oscars gate 53, 3725 Skien Tlf.: 35 53 05 86 Styremedlem: Målfrid Ergon, Steinringen 47, 3931 Porsgrunn Tlf.: 35 51 25 16 Styremedlem: Bjørn Erik Halvorsen, Utsikten 4, 3911 Porsgrunn Tlf.: 35 55 42 57 Styremedlem: Trond Risdal, Orionvegen 88, 3942 Porsgrunn Tlf.: 35 51 29 69 1. Varamedlem: Grete Stendalen, Wettergreensveg 5, 3738 Skien Tlf.: 35 59 43 73 2. Varamedlem: Anne Vinorum, Raskenlundvegen 29, 3928 Porsgrunn Tlf: 35 51 25 16 Floraatlas: Bjørn Erik Halvorsen, Utsikten 4, 3911 Porsgrunn Tlf.: 35 55 42 57 Roger Halvorsen, Hanevoldvn. 15, 3090 Hof Mobiltelefon: 41 50 54 12 Trond Risdal, Orionvegen 88, 3942 Porsgrunn Tlf.: 35 51 29 69 **************************************************************** I redaksjonen: Norman Hagen (e-post: [email protected]), Priscilla Hansen (e-post: peahans@online. no), Grete Stendalen (e-post: [email protected]) Forsidebildet: Bukkeblad (”Saltgras”). Akvarell av Sigrid Nordskog. Se art. på side 105. ISSN: 0801 - 9460 Listéra 2005, nr. 2 3 FRA REDAKSJONEN Tidlig i april 1980 kunne Sønder-Jylland, Skåne (to ganger), telemarkinger lese i lokalavisene Väster-Götland, Møn, Valdres, innbydelsen til et møte for botanisk Langeland i Danmark, Røros og interesserte. Det skulle holdes på Karmøy. Opplevelser sto i kø – er det Skomvær kafé i Porsgrunn 17. -
Ringvirkninger Av Reiseliv I Buskerud, Telemark Og Vestfold
Ringvirkninger av reiseliv i Buskerud, Telemark og Vestfold Petter Dybedal TØI rapport 780/2005 TØI rapport 780/2005 Ringvirkninger av reiseliv i Buskerud, Telemark og Vestfold Petter Dybedal Transportøkonomisk institutt (TØI) har opphavsrett til hele rapporten og dens enkelte deler. Innholdet kan brukes som underlagsmateriale. Når rapporten siteres eller omtales, skal TØI oppgis som kilde med navn og rapport- nummer. Rapporten kan ikke endres. Ved eventuell annen bruk må forhåndssamtykke fra TØI innhentes. For øvrig gjelder åndsverklovens bestemmelser. ISSN 0802-0175 ISBN 82-480-0520-8 Papirversjon ISBN 82-480-052-6 Elektronisk versjon Oslo, juni 2005 Tittel: Ringvirkninger av reiseliv i Buskerud, Title: Economic impact of tourism in the Buskerud, Telemark og Vestfold Telemark and Vestfold counties of Norway Forfatter(e): Petter Dybedal Author(s): Petter Dybedal TØI rapport 780/2005 TØI report 780/2005 Oslo, 2005-06 Oslo: 2005-06 48 sider 48 pages ISBN 82-480-0520-8 Papirversjon ISBN 82-480-0520-8 Paper version ISBN 82-480-0521-6 Elektronisk versjon ISBN 82-480-0521-6 Electronic version ISSN 0802-0175 ISSN 0802-0175 Finansieringskilde: Financed by: Buskerud, Vestfold og Telemark fylkeskommuner - The county administrations of Buskerud, Telemark and BTV, Innovasjon Norge Buskerud og Vestfold og Vestfold, Innovasjon Norge Buskerud and Vestfold, and Innovasjon Norge Telemark Innovasjon Norge Telemark Prosjekt: 3074 Fylkesvis ringvirkningsanalyse for Project: 3074 County level impact of tourism in the reiseliv i BTV-regionen BTV-region Prosjektleder: -
Bremnes Seashore Joins Salmon Group
Press release 2020-10-26 Bremnes Seashore joins Salmon Group SALMA producer Bremnes Seashore today enters as shareholder in Salmon Group, a network of 41 fish farmers who emphasize local ownership and interaction with the local communities. Through the ownership, Bremnes Seashore also takes part in Salmon Group's innovative feed collaboration. - Salmon Group is very pleased to welcome a company who has such a good eye for the important drivers. Through a long period of conversations and discussion on important matters for us both, we are now well acquainted to each other. We are very confident that Bremnes Seashore is an aquaculture farmer who will fit well in our network, says Jan Olav Langeland, CEO of Salmon Group. - We have a common set of values with the other owners in Salmon Group, a group of salmon and trout farmers who are at the forefront of the development of sustainable farming. All companies will contribute to activity and jobs in the local communities along the coast. This makes us a good fit with the network, says Einar Eide, CEO of Bremnes Seashore. Common sustainability philosophy In recent years, Salmon Group has distinguished itself with its systematic and concrete work on sustainability. Based on their feasibility study "Sustainable farming of salmon and trout - What is that?", the network has been able to make specific adjustments of its own feed recipe. The changes are specific and have so far resulted in a 36% reduction in the carbon footprint from the production of salmon and trout that are fed with SG feed. - Salmon Group has taken major steps to reduce the footprint from feed production and transport and set the standard for sustainable feed for the aquaculture industry. -
Pharmacological Agents Currently in Clinical Trials for Disorders in Neurogastroenterology
Pharmacological agents currently in clinical trials for disorders in neurogastroenterology Michael Camilleri J Clin Invest. 2013;123(10):4111-4120. https://doi.org/10.1172/JCI70837. Clinical Review Esophageal, gastrointestinal, and colonic diseases resulting from disorders of the motor and sensory functions represent almost half the patients presenting to gastroenterologists. There have been significant advances in understanding the mechanisms of these disorders, through basic and translational research, and in targeting the receptors or mediators involved, through clinical trials involving biomarkers and patient responses. These advances have led to relief of patients’ symptoms and improved quality of life, although there are still significant unmet needs. This article reviews the pipeline of medications in development for esophageal sensorimotor disorders, gastroparesis, chronic diarrhea, chronic constipation (including opioid-induced constipation), and visceral pain. Find the latest version: https://jci.me/70837/pdf Review Pharmacological agents currently in clinical trials for disorders in neurogastroenterology Michael Camilleri Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER), Mayo Clinic, Rochester, Minnesota, USA. Esophageal, gastrointestinal, and colonic diseases resulting from disorders of the motor and sensory functions represent almost half the patients presenting to gastroenterologists. There have been significant advances in under- standing the mechanisms of these disorders, through basic and translational research, and in targeting the recep- tors or mediators involved, through clinical trials involving biomarkers and patient responses. These advances have led to relief of patients’ symptoms and improved quality of life, although there are still significant unmet needs. This article reviews the pipeline of medications in development for esophageal sensorimotor disorders, gastropa- resis, chronic diarrhea, chronic constipation (including opioid-induced constipation), and visceral pain. -
Årsskrift for Modum Historielag 2006 21
ÅRSSKRIFT FOR MODUM HISTORIELAG 2006 21. ÅRGANG ÅRSSKRIFT FOR MODUM HISTORIELAG 2006 21. ÅRGANG I redaksjonen: Jon Mamen Erling Diesen Aase Hanna Fure Asbjørn Lind Andreas Øvergaard Historielagets styre: Wermund Skyllingstad, leder/sekretær Per A. Knudsen, nestleder Aase Hanna Fure, kasserer Ingar Hellerud Ragnhild Flannum Liv Enger Sigmund Heier Bjørg Randi Hovde Erling Løken Historielagets adresse: Postboks 236, 3371 Vikersund Gamle Modums adresse: Jon Mamen Fjerdingstadveien, 3330 Skotselv e-post: [email protected] Tlf. 32 75 30 65 Layout og trykk: Caspersens Trykkeri AS, Vikersund Innholdsfortegnelse: JON MAMEN: RUNE MARTINSEN: Mathias Amlund ............................................... 3 40 år siden det første Ørpen-stevnet .............. 42 ARNE SØRENSEN: AASE HANNA FURE: Presten og klokkeren ........................................ 10 Overgang til ny skole høsten 1951 ................ 45 INGAR HELLERUD: HANS P. FURE: Sundsted og oversett i Tale for dagen 17. mai 1945 ............................ 47 Vestre Sponefjerdingen m. m. ........................ 11 THORBJØRN FORMO: TORE BRØNNER: Risper fra Modum II ........................................ 49 Kalkovnene rundt Mælum-Damtjern ........... 16 INGER-LISE MOEN: ARNT BERGET: Hilmar Moens erindringer ............................. 50 Skjebnesvangert griseslakt............................... 22 BJØRG RANDI HOVDE: OLAV SØRENSEN: Et dykk i gamle papirer .................................. 57 Vikersund meieri 1935 ..................................... 26 ØYVIND HAUGEN: ANDREAS ØVERGAARD: Ernst -
PHARMACEUTICAL APPENDIX to the TARIFF SCHEDULE 2 Table 1
Harmonized Tariff Schedule of the United States (2020) Revision 19 Annotated for Statistical Reporting Purposes PHARMACEUTICAL APPENDIX TO THE HARMONIZED TARIFF SCHEDULE Harmonized Tariff Schedule of the United States (2020) Revision 19 Annotated for Statistical Reporting Purposes PHARMACEUTICAL APPENDIX TO THE TARIFF SCHEDULE 2 Table 1. This table enumerates products described by International Non-proprietary Names INN which shall be entered free of duty under general note 13 to the tariff schedule. The Chemical Abstracts Service CAS registry numbers also set forth in this table are included to assist in the identification of the products concerned. For purposes of the tariff schedule, any references to a product enumerated in this table includes such product by whatever name known. -
International Response to Infectious Salmon Anemia: Prevention, Control, and Eradication: Proceedings of a Symposium; 3Ð4 September 2002; New Orleans, LA
United States Department of Agriculture International Response Animal and Plant Health to Infectious Salmon Inspection Service Anemia: Prevention, United States Department of the Interior Control, and Eradication U.S. Geological Survey United States Department of Commerce National Marine Fisheries Service Technical Bulletin No. 1902 The U.S. Departments of Agriculture (USDA), the Interior (USDI), and Commerce prohibit discrimination in all their programs and activities on the basis of race, color, national origin, sex, religion, age, disability, political beliefs, sexual orientation, or marital or family status. (Not all prohibited bases apply to all programs.) Persons with disabilities who require alternative means for communication of program information (Braille, large print, audiotape, etc.) should contact USDA’s TARGET Center at (202) 720–2600 (voice and TDD). To file a complaint of discrimination, write USDA, Director, Office of Civil Rights, Room 326–W, Whitten Building, 1400 Independence Avenue, SW, Washington, DC 20250–9410 or call (202) 720–5964 (voice and TDD). USDA, USDI, and Commerce are equal opportunity providers and employers. The opinions expressed by individuals in this report do not necessarily represent the policies of USDA, USDI, or Commerce. Mention of companies or commercial products does not imply recommendation or endorsement by USDA, USDI, or Commerce over others not mentioned. The Federal Government neither guarantees nor warrants the standard of any product mentioned. Product names are mentioned solely to report factually on available data and to provide specific information. Photo credits: The background illustration on the front cover was supplied as a photo micrograph by Michael Opitz, of the University of Maine, and is reproduced by permission. -
Monitoring Anthropogenic Activity in the Hardangervidda Wild Reindeer Range Possible Applications of Crowdsourced Strava-Data in Remote Settings
Faculty of Biosciences, Fisheries and Economics. Department of Arctic and Marine Biology. Monitoring anthropogenic activity in the Hardangervidda wild reindeer range Possible applications of crowdsourced Strava-data in remote settings Vilde Grøthe Holtmoen Master’s thesis in Biology, BIO-3950, May 2021 Preface This master thesis (60ECTS) was written as the final thesis of the study-program Masters in Biology at University of Tromsø (UiT), faculty of Biosciences, Fisheries and Economics, department of Arctic and Marine Biology. My supervisors has been Audun Stien (UiT) and Vegard Gundersen (NINA, dep. Lillehammer). Maps showing habitat suitability for wild reindeer on Hardangervidda in summer used in this thesis, was created by Manuela Panzacchi and Bram Van Moorter for NINA’s project Renewable Reindeer (RenewableReindeer (nina.no)) and will be published in an upcoming report (Tema-rapport) for NINA in 2021 (Panzacchi et.al., 2021, in press). Methods, analyses and results are previously published in Panzacchi et.al., 2015a. NINA had the main idea for this thesis and has contributed with the material for my analyses such as raw data from automatic counters, Strava-data and GPS-data from GPS-collared wild reindeer. 2 Abstract Seen in light of the increasing interest of nature-based tourism and recreational outdoor activities in Norway the last decades (Reimers, Eftestøl & Colman, 2003; Haukeland, Grue & Veisten, 2010), spatiotemporal information on human activity in remote areas and knowledge about how this activity may affect wildlife and nature is a crucial part of a knowledge-based management (Gundersen et.al., 2011, p.14; Gundersen, Strand & Punsvik, 2016, p.166). Hardangervidda is the largest national park in mainland Norway and is also home to the largest population of wild mountain reindeer (Rangifer tarandus tarandus), a specie of international responsibility in management and conservation and recently added to the Norwegian red list (Kjørstad et.al., 2017, p.26; Artsdatabanken, 2021). -
Country Site Town Company Number of Projectors Technology
Country Site Town Company Number of Technology Projector Projector's type Projector's Server Number of Supplier of 3D projectors resolution 3D screens technology N Tysvær kommunales kino Aksdal TYSVÆR KOMMUNALES 2 DLP Cinema Christie CP2220/ CP2230 2K Doremi 1 Dolby KINO N Aurora Kino Alta Alta AURORA KINO 1 DLP Cinema Christie CP2000ZX 2K Doremi 1 XpanD N Arendal Kino Arendal ARENDAL KINO 4 DLP Cinema Christie CP2210/ CP2220/ CP2230 2K Doremi 2 RealD N Asker Kino Asker NORSK KINO 5 DLP Cinema/ Barco/Sony DP2000/ DP3000/SRX-R320 2K/4K Dolby/Sony 5 RealD SXRD N Askim Kino Askim NORSK KINO 2 SXRD Sony SRX-R320 4K Sony 2 RealD N Trudvang Kino Aurland TRUDVANG KINO 1 DLP Cinema Christie CP2220 2K Doremi 1 Dolby N Friberg Kino Balestrand FRIBERG KINO 1 DLP Cinema Christie CP2210 2K Doremi - - N KonsertPaleet Bergen BERGEN KINO 13 DLP Cinema/ Christie/Sony CP2210/ CP2220/ CP2230/SRX- 2K/4K Doremi/Sony 3 RealD SXRD R220/SRX-R320 N Magnus Barfot Bergen BERGEN KINO 5 DLP Cinema Christie/ Barco CP2230/ DP2000/ DP3000 2K Doremi 3 RealD N Fram Kino Bodø FRAM KINO 3 DLP Cinema Christie CP2220/ CP2230 2K Doremi 1 Dolby N Bømlo kino Bremnes BØMLO KINO 3 DLP Cinema Christie CP2220/ CP2230 2K Doremi 1 Dolby N Storstova Bryne STORSTOVA PÅ JÆREN 1 DLP Cinema Christie CP2230 2K Doremi 1 Dolby N Fjaler Kino Dale I Sunnfjord FJALER KINO 1 DLP Cinema Christie CP2220 2K Doremi 1 Dolby N Sentrum Kino Dokka SENTRUM KINO 1 DLP Cinema Christie CP2230 2K Doremi - - N Kinocity Drammen KINOCITY 6 DLP Cinema Christie CP2220/ CP2230 2K Doremi 2 MasterImage N Egersund -
Gulen Kyrkjelydsblad Nr. 1, 2019.Pdf
Gulen kyrkjelydsblad Nr 1 April 2019 62. årgang Vikarprest Børge Ryland og flinke konfirmantar gjennomførte ei flott samtalegudsteneste i Gulen kyrkje 17.03.19. (Foto: Ivar Rutledal) REDAKSJON: Anne R. Tveit, tlf. Redaksjonen 48228353. Eivindvikvegen 1117, 5966 Eivindvik [email protected] Kyrkjelydsbladet kjem i år med fire nummer: Nr.1 (påske/konfirmasjon), KORREKTUR: Marit Sandal, 5966 nr.2 (juni), nr.3 (haust, i samband med Eivindvik Tlf. 57784129 / 95997182 soknerådsvalet), og 4 (desember/jul). BANKGIROKONTO: 3817 15 51282 GOD PÅSKE til lesarane våre! Kontingenten er fri. Innsendingsfrist neste nr: 20. mai. TRYKKERI: Norengros, 3701 Skien SOKNEPREST i GULEN, BREKKE OG MJØMNA SOKN: Jens Linde, 5966 Eivindvik. Tlf. 97509035 [email protected] KYRKJEVERJE: Trude Brosvik, 5966 Eivindvik, Tlf. 57782090/91314389 [email protected] Kontor:Ikkje onsd. KONTORPERSONALE: Margrethe Skåden, Tlf. 57782093 Kontortid torsdag kl.12.40-16.00 og fredag kl.08.00-12.00. ORGANIST: Peter Tiborc Jobbagy, 5966 Eivindvik. Tlf. kontor 57782092. SOKNERÅD/FELLESRÅD: Gulen sokn: Maike Norman Bøe. Tlf. 95349801. [email protected] Brekke sokn: Cathrine Waage Tveit. Tlf. 91759076. [email protected] Mjømna sokn: Bente Haugen. Tlf. 99264861. [email protected] Fellesråd: Målfrid Undertun. Tlf. Altarteppet på Dalsøyra 41610983. [email protected] Teppet er laga ca. år 1995-97, av ungdomstrinnet på Dalsøyra skule. KYRKJA SI HEIMESIDE: www.gulen.kyrkja.no Alle elevane laga kvar si rute. Nina Dyregrov laga midtruta. FACEBOOK: Er du på Facebook, kan Agnes Grahl Madsen sydde rutene du gå inn på gruppa «Kyrkja i Gulen» og saman. Teppet har sidan vore brukt på «like» sida vår.