PARK7 Monoclonal Antibody, Clone 1B11

PARK7 monoclonal antibody, clone Gene Alias: DJ-1, DJ1, FLJ27376, FLJ34360, 1B11 FLJ92274

Gene Summary: The product of this gene belongs to Catalog Number: MAB1076 the peptidase C56 family of proteins. It acts as a positive Regulatory Status: For research use only (RUO) regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as Product Description: Mouse monoclonal antibody a sensor for oxidative stress, and it apparently protects raised against full length recombinant PARK7. neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive Clone Name: 1B11 early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this Immunogen: Recombinant protein corresponding to gene. [provided by RefSeq] amino acids 1-189 of human PARK7. References: Host: Mouse 1. Improved detection of prostate cancer using a magneto-nanosensor assay for serum circulating Reactivity: Human autoantibodies. Xu L, Lee JR, Hao S, Ling XB, Brooks JD, Wang SX, Gambhir SS. PLoS One. 2019 Aug Applications: ELISA, WB-Ce 12;14(8):e0221051. doi: 10.1371/journal.pone.0221051. (See our web site product page for detailed applications eCollection 2019. information) 2. DJ-1 up-regulates glutathione synthesis during Protocols: See our web site at oxidative stress and inhibits A53T alpha-synuclein http://www.abnova.com/support/protocols.asp or product toxicity. Zhou W, Freed CR. J Biol Chem. 2005 Dec page for detailed protocols 30;280(52):43150-8. Epub 2005 Oct 14. 3. Interaction of DJ-1 with Daxx inhibits apoptosis Form: Liquid signal-regulating kinase 1 activity and cell death. Junn E, Taniguchi H, Jeong BS, Zhao X, Ichijo H, Mouradian Purification: Protein G purification MM. Proc Natl Acad Sci U S A. 2005 Jul 5;102(27):9691-6. Epub 2005 Jun 27. Isotype: IgG1, kappa

Recommend Usage: ELISA Western Blot (1:1000) The optimal working dilution should be determined by the end user.

Storage Buffer: In PBS, pH 7.4 (10% glycerol, 0.02% sodium azide).

Storage Instruction: Store at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C. Aliquot to avoid repeated freezing and thawing.

Entrez GeneID: 11315

Gene Symbol: PARK7

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