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Malakoplakia Associated with Adrenal and Islet Cell Hyperplasia and Glucagonoma

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Malakoplakia Associated with Adrenal and Islet Cell Hyperplasia and Glucagonoma Postgrad Med J: first published as 10.1136/pgmj.63.740.497 on 1 June 1987. Downloaded from Postgraduate Medical Journal (1987) 63, 497-500 Malakoplakia associated with adrenal and islet cell hyperplasia and glucagonoma John McClure, D.S. Fairweather,1 A.R. Mene and S.S. Banerjee Departments ofPathology, and 'Geriatric Medicine, University ofManchester, Manchester, UK. Summary: Extensive involvement of the urinary tract and related structures by malakoplakia presented difficult diagnostic problems in two elderly individuals. At post-mortem examination there was bilateral adrenal cortical hyperplasia in both patients and, in one, there was also a pancreatic glucagonoma and diffuse hyperplasia of the pancreatic islet tissues. There is now an increasing body of evidence that malakoplakia is associated with hypercorticosteroidism possibly due to an effect on macrophage exocytotic mechanisms. The coexistence of malakoplakia and glucagonoma has not been previously described. Introduction Malakoplakia is an uncommon granulomatous condi- it also has a high incidence in older age groups. It tion characterized by the aggregation of large, gran- occurs much less frequently in males.6 Clinically ular, eosinophilic cells (von Hansemann cells) which malakoplakia may present complex, challenging diag- contain typical intracytoplasmic inclusions called nostic and therapeutic problems. This may be due to copyright. Michaelis-Gutmann (MG) bodies.' These are between the absolute rarity of the condition, relative lack of 5 and 1Ogm in diameter and exhibit concentric awareness of it and its association with other disease laminations so that they are variously described as processes. Recently we have had experience ofmalak- being 'targetoid' or 'owl's eye' in appearance. MG oplakia in two elderly patients in whom the diagnosis bodies always contain calcium and phosphate in the was not clarified until post-mortem examination and form of hydroxyapatitite crystals and, not infrequen- in whom there was morphological evidence of tly, quantities of iron.2 The most common site of endocrine abnormalities. malakoplakia is the mucosa of the urinary tract http://pmj.bmj.com/ especially its lower part3 ' 5 and there is a strong association with urinary tract infections by coliform Case reports organisms.6 Before 1958 malakoplakia had only been described Patient I within the confines of the urinary tract and renal parenchyma. Since then the condition has been A 73 year old man was admitted with an ill-defined described not only in structures relatively close to history of weight loss over 8 weeks and intermittent on September 29, 2021 by guest. Protected these, including testis,7 prostate8 and retroperitoneum9 diarrhoea. He was thin (59 kg) and there was non- but also in more remote sites such as brain,'0 lung," palpable purpura on both legs which rapidly progres- bone' and gastrointestinal tract.'3 These cases of sed to form haemorrhagic sheets. Skin biopsy showed malakoplakia outside the urinary tract often show sub-epithelial bullae and a minimal inflammatory extensive involvement of more than one organ and infiltrate with no evidence of vasculitis. The bleeding frequently exhibit a systemic disorder in which the time was prolonged to 9.5 minutes, but coagulation background is often one of immunosuppression or tests were normal as was the white cell ascorbate level. hypercortico-steroidism.' 14, 15 The purpura resolved over several weeks. Although malakoplakia of the urinary tract is Urinalysis persistently showed significant bac- predominantly a disease ofwomen in their fifth decade teriuria, pyuria and desquamated epithelial cells. Despite several courses of appropriate antibiotics, his Correspondence: J. McClure, B.Sc., M.D., M.R.C.Path., urine remained infected with E. coli, proteus and Department of Histopathology, UHSM, Nell Lane, West enterococci species, and he had two episodes of Didsbury, Manchester M20 8LR, UK. septicaemia. He later developed an abscess in the left Accepted: 23 December 1986. groin which was drained surgically. Despite intensive A) The Fellowship of Postgraduate Medicine, 1987 Postgrad Med J: first published as 10.1136/pgmj.63.740.497 on 1 June 1987. Downloaded from 498 CLINICAL REPORTS treatment with antibiotics and intravenous fluids, he species and enterococci were frequently cultured from gradually deteriorated and died 5 months after his the urine. Appropriate antibiotics were administered initial presentation. but with no lasting effects. She had intermittent At post-mortem examination the body weighed pyrexia and leucocytosis. Her catheter became 54 kg (182 cm in length). A sinus was present in the left blocked because of further bleeding and she required groin communicating with an ill-defined mass arising blood transfusion. Two months after admission she in the prostate and extending onto the left pelvic wall. developed acute renal failure and died. The urinary bladder contained purulent urine. Both At post-mortem examination the body weighed kidneys were scarred and finely granular. There was 41 kg (156cm in length). There was an extensive colonic diverticular disease and the rectum was bilateral bronchopneumonia. Both kidneys were adherent to the prostatic lesion. The adrenal glands swollen but the capsules stripped easily. There was were enlarged with a combined weight of 70 g. severe gangrenous pyelitis with marked destruction of Microscopically the inguinal sinus, and the related the calyces. The tips ofthe renal papillae were necrotic. prostatic mass, was a malakoplakic lesion containing The pelves and ureters were lined by a thick fibrino- numerous large histiocytes (von Hansemann cells) purulent membrane. The urinary bladder was dilated with intracytoplasmic inclusions (Michaelis-Gutmann and there was a transmural necrosis with the forma- bodies). These were of a typical targetoid appearance, tion of a pseudomembrane on the mucosal aspect of contained calcium salts (Figure 1) and iron and the bladder. Loops of small intestine were adherent to exhibited PAS positivity (diastase resistance). There the outer surface of the bladder. Both adrenals were was bilateral adrenal cortical nodular hyperplasia. enlarged, the combined weight being 80g. The cut The pituitary was microscopically normal. Death was surfaces showed nodularity and were slightly due to generalized microscopic pulmonary embolism haemorrhagic. from thrombosis of the periprostatic venous plexus. Microscopically there was a severe mixed inflam- matory process involving the bladder mucosa contain- Patient 2 ing large numbers of von Hansemann cells with MG bodies. These showed typical staining reactions and An 81 year old female was admitted with malaise and contained calcium and iron salts. Malakoplakic infil-copyright. confusion. Her physical deterioration had begun one trates were present in the mucosa ofthe ureters and the year previously. She had no relevant past medical urinary pelves. There was bilateral renal papillary history. Examination and investigation showed severe necrosis and acute pyelonephritis. There was no megaloblastic anaemia (haemoglobin 4.0 g/dl) due to evidence of renal malakoplakia. There was bilateral vitamin B12 deficiency. nodular adrenal cortical hyperplasia. In the pancreas Four days after admission she developed there was prominence of islet tissue and a single islet haematuria and acute urinary retention. An intraven- cell tumour (Figure 2). This was 1 cm in diametet and ous urogram showed bilateral hydronephrosis. At composed of trabeculae of uniform cells related to an http://pmj.bmj.com/ cystoscopy the bladder epithelium was almost entirely appreciable vasculature. Immunocytochemical stain- covered by a white membrane. Coliforms, Proteus ing of formalin-fixed paraffin-embedded sections using a peroxidase-antiperoxidase (PAP) method demonstrated the presence ofglucagon only. Staining reactions for insulin, gastrin, somatostatin and ACTH were negative. The pituitary was microscopically normal. on September 29, 2021 by guest. Protected Discussion These two cases eluded accurate diagnosis until post- mortem examination was performed. In both instan- ces the observed malakoplakic process was more extensive than the usual case in which the condition is limited to the mucosa of the urinary bladder. Wide- spread malakoplakia has been described in several cases in which there was clear evidence of hypercor- ticosteroidism. A case associated with Cushing's syn- drome due to ectopic production of ACTH by a Figure 1 Typical Michaelis-Gutmann (MG) bodies are bronchial carcinoid is on record.'5 There have also arrowed (von Kossa/light green). been reports ofcases in which immunosuppression has Postgrad Med J: first published as 10.1136/pgmj.63.740.497 on 1 June 1987. Downloaded from CLINICAL REPORTS 499 of Cushing's disease was not made in life. The co-existence of malakoplakia and a glucagon- oma has not been previously documented. It is not 74~~~~~~6 possible to decide ifthis is fortuitous but both are rare, making a chance association very unlikely. It is interesting that there was also a diffuse hyperplasia of pancreatic islet tissue and this might be part of a hyperplastic process involving pancreatic and adrenal endocrine tissue and that the common factor in both cases was the adrenal hyperplasia. If the malakoplakia is associated with hypercor- ticosteroidisn then it is necessary to consider the mechanisms of this association. It would appear that malakoplakic macrophages are functionally disor- dered in that their exocytotic
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