The Friedman Brain Institute is proud to present the 10th issue of the FBI Informant. The Informant is a triennial newsletter highlighting announcements and events for basic and clinical neuroscience at Mount Sinai. The purpose of riedman rain nstitute the Informant is to keep everyone abreast of all that is going on in and out of the F B I labs and clinics that comprise the Friedman Brain Institute, as well as acknowledge those individuals responsible for its success. In addition to sharing the information, our hope is that the Informant can be used as a tool to inspire, informant congratulate, and support one another.

Announcements

5th Annual Neuroscience Retreat

While exciting science and the exchange of information form the centerpiece of the Friedman Brain Institute’s Annual Neuroscience Retreat, it is the participation and social interactions of the various departments that make these retreats so effective and enjoyable.

This year’s retreat took place on Friday, April 26th, 2013 at the New York Academy of Medicine. The morning session included a April 26, 2013 New York Academy of Medicine 1216 Fifth Avenue Dr. Daniela Schiller Geoffrey W. Smith Lauren Friedman stirring talk from Eric Nestler, director of the Friedman Brain Keynote Speaker Guest Speaker Guest Speaker Assistant!Professor of Director, President, and Center for Technology, Sinai Neuroscience Neuroscience Innovation and Outreach Program “SNOP” Institute and chair of Neuroscience Department. Dr. Nestler Entrepreneurship highlighted the successes of the Friedman Brain Institute and the 5th Annual Neuroscience Retreat presented ideas for the path forward. Friedman Brain Institute and the Neuroscience Training Area Keynote speaker Daniela Schiller gave a thought-provoking lecture about her group’s work aimed at understanding how the brain handles social interaction tasks.

A series of presentations selected from submitted abstracts illuminated work going on in a variety of participating departments. Retreat attendees enjoyed a wide range of interesting talks and posters, which were contributed by scientists from all participating departments including Genetics & Genomic Sciences, Neurology, Neuroscience, Ophthalmology, Pathology, Pharmacology & System Therapeutics, Preventive Medicine, Psychiatry and Radiology. A lively afternoon poster session was made all the more enjoyable with cocktails and hors d’oeuvres. This was followed by an awards ceremony, which included prizes for best poster and best oral presentation. Awards were chosen by the faculty, and went to Georgia Hodes for her talk entitled “Individual to register, please visit: differences in peripheral inflammatory signaling functionally http://neuroscience.mssm.edu/retreat/ contribute to social defeat stress” and to Michael Demars for his poster entitled “Differential Expression of the Lynx Family in Visual Mike Michaelides for information contact: Marie Kopp at

Cortex: Implications for Critical Period Plasticity”. [email protected] or 212-659-5913 photo by

The organizing committee was comprised of faculty members Matthew Shapiro and Andrew Chess along with the administrative staff: Marie Kopp, Celeste Reyes, Jenny Rivera, and Veronica Szarejko.

The 5th Annual Neuroscience Retreat exceeded our expectations. With the success of this year’s retreat, plans are already underway for the 6th Annual Retreat. We look forward to seeing you all there, as well as, to seeing others who could not attend this year.

To view the retreat pamphlet, please visit: http://icahn.mssm.edu/research/institutes/brain-institute/events/annual-retreat

To view images from the event, please visit: http://verje6.wix.com/fbi-gallery

1 Psychiatry Match Results

We’re excited to share with you our great news from the match.

Having received a record 1450 applications this year, we selected the top 11% for interviews and successfully matched with an extraordinarily accomplished group of 14 future psychiatrists. Our entering class of 6 women and 8 men is particularly diverse and brings with them demonstrated successes in academia, clinical and basic science research, and clinical care, as well as fluency in languages, music, the arts, and philanthropic, political, and financial organizations.

We’re additionally thrilled that 3 Mount Sinai students are staying with us for their Psychiatry training (2 for general adult and 1 in the Triple Board Program); this represents half of all Mount Sinai students matching in psychiatry. For our Physician-Scientist Research Track, we’re pleased to have matched with our top-ranked MD/PhD candidate. Our other incoming residents are from Wash U, Baylor, Duke, Georgetown, GW, MUSC, Downstate, UConn, Upstate, and Wright State.

We hope you will join us in enthusiastically welcoming this new group into our Department of Psychiatry.

And, special thanks to the faculty who spent time interviewing applicants, our essential team (especially Ron Asher, Michelle Melendez, and Hiwot Woldu), the child/adolescent and triple board faculty (John O’Brien, Alex Kolevzon, and Jen Liu), and our other current residents and faculty who participated in this year’s highly successful selection and recruitment. Finally, thank you to Eric Nestler, Pamela Sklar, Schahram Akbarian, Barbara Coffey, Dan Iosifescu, James Murrough, and the other faculty who spent additional time interviewing research applicants.

Thank you all, and congratulations once again,

Wayne

Brain Awareness Week: March 11-17, 2013 Sinai Neuroscience Outreach Program (SNOP) Brain Awareness Week is a global campaign created to promote public awareness of brain research. The Sinai Neuroscience Outreach Program (SNOP) hosted its first annual Brain Awareness Fair, as part of a city-wide week of events, for elementary, middle, and high school students and their parents. Attendees participated in a wide array of educational activities run by FBI students, postdocs and research associates, including an animal brains booth, “Build a Brain” where participants constructed pipe cleaner neurons and made their own brain hats, and “Decoding your brain” which included optical illusions and a skin conductance test. Mount Sinai faculty members, Yasmin Hurd, Miguel Gama Sosa, Mark Baxter, and Ting Wang, and representatives from the Alzheimer’s Association and Brain Injury Association of NY were on hand to answer questions and dispel myths about disease, addiction, and memory and cognition.

Visit Shekhar Patil’s blog to learn more about the Brain Awareness Fair: http://blog.mountsinai.org/blog/brain-awareness-fair/

Visit SNOP's website to learn more about SNOP: http://sinaineurooutreach.wordpress.com

Icahn School of Medicine’s blog: In conjunction with the Brain Awareness Fair, Drs. Hurd, Buxbaum, Russo and Han posted blogs on the Icahn School of Medicine’s blog page. See below for the links to their post.

Dr. Hurd: Is Marijuana Harmless? http://blog.mountsinai.org/blog/marijuana/

2 Brain Awareness Week continued...

Dr. Buxbaum: Breaking Through Autism http://blog.mountsinai.org/blog/seaver-autism-center/

Dr. Russo Treating Depression More Rapidly & Effectively http://blog.mountsinai.org/blog/treating-depression/

Dr. Han Rapid Treatment for the Depressed Brain http://blog.mountsinai.org/blog/rapid-treatment-for-the-depressed-brain/

Paisán-Ruiz Lab (Neurology)

Congratulations Dr. Paisán-Ruiz on her Dr. Harold and Golden Lamport Research Award. This award is designed to support Jr. faculty (first five years of tenure track assistant professor appointment) in either basic science or clinical research.

Mercedes Perez-Rodriguez (MIRECC Fellow in the Mood and Personality Disorders Research Program, Psychiatry)

Awards/Honors: • Military Suicide Research Consortium Pre-Conference Training Day and American Association of Suicidology meeting fellowship (April 24-27, 2013).

• 20Travel Award to attend the Society of Biological Psychiatry Annual Meeting (May 15-18, 2013).

• Selected to participate in the 2013 “Career Development Institute for Psychiatry” (CDI)

Recent Publications: • Perez-Rodriguez MM, Hazlett EA, Rich EL, Ripoll LH, Weiner DM, Spence N, Goodman M, Koenigsberg HW, Siever LJ, New AS. Striatal activity in borderline personality disorder with comorbid intermittent explosive disorder: Sex differences. J Psychiatr Res. 2012 Jun;46(6):797-804

Upcoming publications: • Antonia S. New, David M. Carpenter, M. Mercedes Perez-Rodriguez, Luis H. Ripoll, Jennifer Avedon, Uday Patil, Erin A. Hazlett, Marianne Goodman. Developmental Differences in Diffusion-Tensor Imaging Parameters in Borderline Personality Disorder. Journal of Psychiatric Research, in press

Pam Kennedy (Postdoctroral Fellow, Neuroscience)

Beginning this fall Pam Kennedy will be joining the Behavioral Neuroscience area of the UCLA Department of Psychology as a tenure-track Assistant Professor. Congratulations Dr. Kennedy!

Recent Publications: • Kennedy PJ, Feng J, Robison AJ, Maze I, Badimon A, Mouzon E, Chaudhury D, Damez-Werno DM, Haggarty SJ, Han MH, Bassel-Duby R, Olson EN, Nestler EJ. (2013) Class I HDAC inhibition blocks cocaine-induced plasticity by targeted changes in histone methylation. Nat Neurosci. Apr; 16(4):434-40

3

11 Filizola Lab (Structural and Chemical Biology)

Dr. Yi Shang (PhD in Molecular and Cellular Biology; Stony Brook University, Stony Brook, USA) joins the Filizola Lab as a new Postdoctoral Associate. Honors/Awards: • Congratulations to Dr. Filizola on her awarded Tenure. • The Filizola Lab's work on opioid receptors and GPCRs appears as a ‘Feature Story’ at the Texas Advanced Computing Center’: http://www.tacc.utexas.edu/news/feature-stories/2012/ disease-fighting-power and on insideHPC: http://insidehpc.com/2013/01/14/tacc-powers-research- towards-opioids-without-side-effects/ • Dr. Filizola has been invited as Distinguished Speaker at the Torrey Pines Institute for Molecular Studies, Port St. Lucie, Florida. • Dr. Filizola serves as a Guest Editor for PLOS Computational Biology. • Dr. Filizola becomes a member of Faculty of 1000. Recent Patents: • Patent application entitled “Organic Compounds (Anti-platelet agents)” based on a collaborative research between the Filizola Lab, The Rockefeller University (Barry Coller Lab) and the NIH Center for Advancing Translational Sciences (Craig Thomas Lab). • Provisional patent application entitled “Novel Kappa Opioid Receptor Ligands” based on a collaborative research between the Filizola Lab, Columbia University (Jonathan Javitch Lab) and Kansas University (Thomas Prisinzano Lab). Recent Publications: • Coudray, N, Valvo, S, Hu, M, Lasala, R, Kim, C, Vink, M, Zhou, M, Provasi, D, Filizola, M, Tao, J, Fang, J, Penczek, PA, Ubarretxena-Belandia, I, Stokes, DL “Inward-Facing Conformation of the Zinc Transporter YiiP revealed by Cryo-electron Microscopy” Proceedings of the National Academy of Science USA (2013) 110(6): 2140-2145 [PMID: 23341604] • Negri, A, Rives, ML, Caspers, M, Prisinzano, TE, Javitch, JA, Filizola, M “Discovery of a Novel Selective Kappa- Opioid Receptor Agonist Using Crystal Structure-Based Virtual Screening” Journal of Chemical Information and Modeling (2013) 53: 521-526 [PMID: 23461591] • Scarabelli, G, Provasi, D, Negri, A, and Filizola, M “Bioactive Conformations of Two Seminal Delta Opioid Receptor Penta-peptides Inferred from Free-Energy Profiles” Biopolymers (2013) Apr 6. doi: 10.1002/bip.22251. [Epub ahead of print] [PMID: 23564013]

Zachariou Lab (Neuroscience)

Recent Publications: • Stratinaki M, Varidaki A, Mitsi V, Ghose S, Magida J, Dias C, Russo SJ, Vialou V, Caldarone BJ, Tamminga CA, Nestler EJ, Zachariou V. (2013) Regulator of G protein signaling is a crucial modulator of antidepressant drug action in depression and neuropathic pain models. Proc. Natl. Acad. Sci. USA Apr 29. [Epub ahead of print]

Dara Dickstein, Ph.D. (Neuroscience)

Dr. Dickstein was interviewed by The Source, Forum of Diversity for an article entitled “Cultural roadblocks may impede early diagnosis of Alzheimer’s”.

To view the article: http://thelasource.com/en/2013/04/22/cultural-roadblocks-may-impede-early- diagnosis-of-alzheimers/

4 Casaccia Lab (Neuroscience) Dr. Casaccia gave the plenary lecture at the ISN Meeting in Cancun April 19, 2013.

Dr. Casaccia was a speaker at a Symposium on Global Health in honor of the signing of the bilateral agreement between the University of Brescia (Italy ) and Mount Sinai School of medicine on April 2.

Dr. Casaccia and Drs. Oscar Gomez-Vidaurre and Jeffrey Haines shared the latest discoveries in axonal damage and repair with MS patients during the "after hour" seminar on March 28, 2013.

Congratulations to Marylens Hernandez, a graduate student in the Casaccia lab. She was awarded a F31 pre-doctoral fellowship from NIH NINDS.

Recent Publications: • Huynh JL, Casaccia P (2013). Epigenetic mechanisms in multiple sclerosis: implications for pathogenesis and treatment. Lancet Neurol 12(2): 195-206.

Hof Lab (Neuroscience)

Dr Hof was part of an international effort to redefine the classification and nomenclature of cortical GABAergic interneurons according to structure-function relationships, topographical distribution, and connectivity with pyramidal cells, using web-based tools and supervised classification models. The study was recently published in Nature Neuroscience Reviews.

The Hof lab welcomes Dr. Timothy Rumbell. Dr. Rumbell is a computational neuroscientist who graduated from the Plymouth University in the UK and will work on modeling cellular determinants of cognitive decline during brain aging in non-human primates.

Dr. Hof was awarded a Phase II SBIR grant (R44 MH093011) to develop automated 3D quantitative analysis of dendritic spines imaged with light microscopy, in partnership with MBF Bioscience.

Recent Publications: • DeFelipe J, López-Cruz PL, Benavides-Piccione R, Bielza C, Larrañaga P, Anderson S, Burkhalter A, Cauli B, Fairén A, Feldmeyer D, Fishell G, Fitzpatrick D, Freund TF, González-Burgos G, Hestrin S, Hill S, Hof PR, Huang J, Jones EG, Kawaguchi Y, Kisvarday Z, Kubota Y, Lewis DA, Marín O, Markram H, McBain CJ, Meyer HS, Monyer H, Nelson SB, Rockland K, Rossier J, Rubinstein JLR, Rudy B, Scanziani M, Shepherd GM, Sherwood CC, Staiger JF, Tamás G, Thomson A, Wang Y, Yuste R, Ascoli GA (2013) New insights into the classification and nomenclature of cortical GABAergic interneurons. Nat. Rev. Neurosci. 14, 202-216. • Van Dam NT, Sano M, Mitsis EM, Grossman HT, Gu X, Park Y, Hof PR, Fan J. (2013) Functional neural correlates of attentional deficits in amnestic mild cognitive impairment. PLoS One 8(1), e54035. • Bauernfeind AL, de Sousa AA, Avasthi T, Dobson SD, Raghanti MA, Lewandowski AH, Zilles K, Semendeferi K, Allman JM, Craig AD, Hof PR, Sherwood CC (2013) A volumetric comparison of the insular cortex and its subregions in primates. J. Hum. Evol. 64, 263-279. • Baizer JS, Weinstock N, Witelson SF, Sherwood CC, Hof PR (2013) The nucleus pararaphales in the human, macaque monkey, and chimpanzee. Brain Struct. Funct. 218, 389-403.

Steven Ravett Brown, Ph.D. (Neuroscience)

Recent Publications: Brown, SR (2012). Emergence in the central nervous system. Cognitive Neurodynamics, 1-23.

5 Buxbaum Lab (Psychiatry)

The Buxbaum lab welcomes new member: Silvia De Rubeis, PhD.

Recent Publications: • Cross-Disorder Group of the Psychiatric Genomics Consortium, Smoller JW, Craddock N, Kendler K, Lee PH, Neale BM, Nurnberger JI, Ripke S, Santangelo S, Sullivan PF. Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Lancet. 2013 Apr 20;381(9875):1371-9. Epub 2013 Feb 28. Erratum in: Lancet. 2013 Apr 20;381(9875):1360.

• Reitz C, Jun G, Naj A, Rajbhandary R, Vardarajan BN, Wang LS, Valladares O, Lin CF, Larson EB, Graff-Radford NR, Evans D, De Jager PL, Crane PK, Buxbaum JD, Murrell JR, Raj T, Ertekin-Taner N, Logue M, Baldwin CT, Green RC, Barnes LL, Cantwell LB, Fallin MD, Go RC, Griffith P, Obisesan TO, Manly JJ, Lunetta KL, Kamboh MI, Lopez OL, Bennett DA, Hendrie H, Hall KS, Goate AM, Byrd GS, Kukull WA, Foroud TM, Haines JL, Farrer LA, Pericak-Vance MA, Schellenberg GD, Mayeux R; Alzheimer Disease Genetics Consortium. Variants in the ATP- binding cassette transporter (ABCA7), apolipoprotein E ϵ4,and the risk of late-onset Alzheimer disease in African Americans. JAMA. 2013 Apr 10;309(14):1483-92.

• Smith JJ, Kuraku S, Holt C, Sauka-Spengler T, Jiang N, Campbell MS, Yandell MD, Manousaki T, Meyer A, Bloom OE, Morgan JR, Buxbaum JD, Sachidanandam R, Sims C, Garruss AS, Cook M, Krumlauf R, Wiedemann LM, Sower SA, Decatur WA, Hall JA, Amemiya CT, Saha NR, Buckley KM, Rast JP, Das S, Hirano M, McCurley N, Guo P, Rohner N, Tabin CJ, Piccinelli P, Elgar G, Ruffier M, Aken BL, Searle SM, Muffato M, Pignatelli M, Herrero J, Jones M, Brown CT, Chung-Davidson YW, Nanlohy KG, Libants SV, Yeh CY, McCauley DW, Langeland JA, Pancer Z, Fritzsch B, de Jong PJ, Zhu B, Fulton LL, Theising B, Flicek P, Bronner ME, Warren WC, Clifton SW, Wilson RK, Li W. Sequencing of the sea lamprey (Petromyzon marinus) genome provides insights into vertebrate evolution. Nat Genet. 2013 Apr;45(4):415-21.

• Liu L, Sabo A, Neale BM, Nagaswamy U, Stevens C, Lim E, Bodea CA, Muzny D, Reid JG, Banks E, Coon H, Depristo M, Dinh H, Fennel T, Flannick J, Gabriel S, Garimella K, Gross S, Hawes A, Lewis L, Makarov V, Maguire J, Newsham I, Poplin R, Ripke S, Shakir K, Samocha KE, Wu Y, Boerwinkle E, Buxbaum JD, Cook EH Jr, Devlin B, Schellenberg GD, Sutcliffe JS, Daly MJ, Gibbs RA, Roeder K. Analysis of Rare, Exonic Variation amongst Subjects with Autism Spectrum Disorders and Population Controls. PLoS Genet. 2013 Apr;9(4):e1003443.

• Ionita-Laza I, Lee S, Makarov V, Buxbaum JD, Lin X. Eur J, Family-based association tests for sequence data, and comparisons with population-based association tests. Hum Genet. 2013 Feb 6.

• Lim ET, Raychaudhuri S, Sanders SJ, Stevens C, Sabo A, MacArthur DG, Neale BM, Kirby A, Ruderfer DM, Fromer M, Lek M, Liu L, Flannick J, Ripke S, Nagaswamy U, Muzny D, Reid JG, Hawes A, Newsham I, Wu Y, Lewis L, Dinh H, Gross S, Wang LS, Lin CF, Valladares O, Gabriel SB, dePristo M, Altshuler DM, Purcell SM; NHLBI Exome Sequencing Project, State MW, Boerwinkle E, Buxbaum JD, Cook EH, Gibbs RA, Schellenberg GD, Sutcliffe JS, Devlin B, Roeder K, Daly MJ. Rare complete knockouts in humans: population distribution and significant role in autism spectrum disorders. Neuron. 2013 Jan 23;77(2):235-42.

• Glessner JT, Smith AV, Panossian S, Kim CE, Takahashi N, Thomas KA, Wang F, Seidler K, Harris TB, Launer LJ, Keating B, Connolly J, Sleiman PM, Buxbaum JD, Grant SF, Gudnason V, Hakonarson H. Copy number variations in alternative splicing gene networks impact lifespan. PLoS One. 2013;8(1):e53846.

• Liu L, Sabo A, Neale BM, Nagaswamy U, Stevens C, Lim E, Bodea CA, Muzny D, Reid JG, Banks E, Coon H, Depristo M, Dinh H, Fennel T, Flannick J, Gabriel S, Garimella K, Gross S, Hawes A, Lewis L, Makarov V, Maguire J, Newsham I, Poplin R, Ripke S, Shakir K, Samocha KE, Wu Y, Boerwinkle E, Buxbaum JD, Cook EH Jr, Devlin B, Schellenberg GD, Sutcliffe JS, Daly MJ, Gibbs RA, Roeder K. Analysis of Rare, Exonic Variation amongst Subjects with Autism Spectrum Disorders and Population Controls. PLoS Genet. 2013 Apr;9(4):e1003443. Epub 2013 Apr 11.

6 Maeso Lab (Psychiatry) Recent Publications: • Moreno JL, Holloway T, Rayannavar V, Sealfon SC, González-Maeso J. Chronic treatment with LY341495 decreases 5-HT2A binding and hallucinogenic effects of LSD in mice. Neuroscience Letters 536: 69-73 (2013). • Kurita M, Moreno JL, Holloway T, Kozlenkov A, Mocci G, Garcia-Bea A, Neve R, Nestler EJ, Russo SJ, González-Maeso J. Repressive epigenetic changes at the mGlu2 promoter in frontal cortex of 5-HT2A knockout mice. Molecular Pharmacology (2013) Epub ahead of print. • Moreno JL, Holloway T, González-Maeso J. Structure and function of GPCR heterocomplexes. In: Oligomerization in Health and Disease, Volume 117 (Progress in Molecular Biology and Translational Science). Academic Press (2013). ISBN: 978-0123869319

Morishita Lab (Psychiatry)

Dr. Morishita would like to welcome Mari Sajo (PhD, U. of Tokyo) as a postdoctoral fellow.

Dr. Morishita was awarded 2013 Basil O'Connor Starter Scholar Research Award from March of Dimes, and 2013 Competitive Renewal Grant from Knights Templar Eye Foundation.

Congratulations to Ayan Hussein (PREP scholar) who was awarded a travel award (Terry endowment for maternal and child health) for Emory University STEM Symposium.

Ehrlich-Gandy Labs (Neurology) • John W. Steele, Ph.D., is now a postdoctoral fellow with Paul Greengard at The Rockefeller University. • Rachel Lane, Ph.D. is now Program Officer for the Alzheimer's Drug Discovery Foundation. • Dr. Gandy is now MSSM Site PI and international program director for the Cure Alzheimer's Fund (CAF) Stem Cell Consortium. Other sites are at The Rockefeller University, Harvard Medical School, Massachusetts General Hospital, Hadassah University, and the New York Stem Cell Foundation. CAF has awarded $600,000 for the first year of a two year program. Recent Publications: • Fuchs T, Saunders-Pullman R, Masuho I, Luciano MS, Raymond D, Factor S, Lang AE, Liang TW, Trosch RM, White S, Ainehsazan E, Hervé D, Sharma N, Ehrlich ME, Martemyanov KA, Bressman SB, Ozelius LJ. Mutations in GNAL cause primary torsion dystonia. Nat Genet. 2013 Jan;45(1):88-92. doi: 10.1038/ng.2496. Epub 2012 Dec 9. PubMed PMID: 23222958; PubMed Central PMCID: PMC3530620. • Lane RF, Steele JW, Cai D, Ehrlich ME, Attie AD, Gandy S. Protein Sorting Motifs in the Cytoplasmic Tail of SorCS1 Control Generation of Alzheimer's Amyloid-β Peptide. J Neurosci. 2013 Apr 17;33(16):7099-7107. PubMed PMID: 23595767. • Dekosky ST, Blennow K, Ikonomovic MD, Gandy S. Acute and chronic traumatic encephalopathies: pathogenesis and biomarkers. Nat Rev Neurol. 2013 Apr;9(4):192-200. doi: 10.1038/nrneurol.2013.36. PubMed PMID: 23558985. • Gandy S, Haroutunian V, DeKosky ST, Sano M, Schadt EE. CR1 and the "vanishing amyloid" hypothesis of Alzheimer's disease. Biol Psychiatry. 2013 Mar1;73(5):393-5. doi: 10.1016/j.biopsych.2013.01.013. PubMed PMID: 23399469; PubMed Central PMCID: PMC3600375. • Steele JW, Gandy S. Latrepirdine (Dimebon (®) ), a potential Alzheimer therapeutic, regulates autophagy and neuropathology in an Alzheimer mouse model. Autophagy. 2013 Apr 1;9(4):617-8. doi: 10.4161/auto.23487. Epub 2013 Feb 4. PubMed PMID: 23380933. • Gandy S, DeKosky ST. Toward the treatment and prevention of Alzheimer's disease: rational strategies and recent progress. Annu Rev Med. 2013;64:367-83. doi: 10.1146/annurev-med-092611-084441. PubMed PMID: 23327526; PubMed Central PMCID: PMC3625402. • Gandy S, DeKosky ST. 2012: the year in dementia. Lancet Neurol. 2013 Jan;12(1):4-6. doi: 10.1016/S1474-4422 (12)70284-3. Review. PubMed PMID: 23237888.

7 Welcome New Faculty to the Psychiatry Department:

Dr. Rita Goldstein

Dr. Goldstein has been recruited to serve as Professor of Psychiatry and will hold a secondary appointment in the Department of Neuroscience.

Nationally and internationally known for her and neuropsychological studies in drug addiction, Dr. Goldstein formulated a theoretical model known as Impaired Response Inhibition and Salience Attribution (iRISA). The model uses multiple neuroimaging modalities—including MRI, EEG/ERP, PET and neuropsychological tests—to explore the neurobiological underpinnings of iRISA in drug addiction and related conditions. Her work has contributed to the development of relevant machine-learning algorithms for innovative analyses applied to this multidimensional data set.

Dr. Goldstein’s interests also include pharmacological fMRI, including administering oral methylphenidate to cocaine addicted individuals to improve self-control, neurofeedback such as Brain Computer Interface, and brain stimulation with Transcranial Magnetic Stimulation. She has also been exploring the contribution of individual differences, including polymorphisms in monoaminergic genes, to addiction and aggression, with a focus on the neural mechanisms underlying reinforcement learning and extinction, choice and decision-making, and self-awareness and insight into severity of illness.

In her new role, Dr. Goldstein will serve as chief of Neuropsychoimaging of Addiction and Related Conditions (NARC) Research Program. She will be responsible for directing the lab in its continued use of multimodality functional neuroimaging methods to explore the neurobiological bases of impaired cognitive and emotional functioning in human drug addiction and other disorders of self-control. An important application of this research is to facilitate the development of intervention modalities that would improve treatment outcome in drug addiction and other chronically relapsing disorders of self-regulation.

Dr. Goldstein will contribute to Mount Sinai’s research efforts in the area of psychiatric neuroimaging, neuropsychology, and cognitive neuroscience, and play an important role in enhancing translational research in drug addiction, Intermittent Explosive Disorder and related disorders, bridging the gap between basic research in the Department of Neuroscience and clinical interventions and treatment in numerous facilities including Bronx VA, Phoenix House, and Samaritan Village.

Prior to joining Mount Sinai, Dr. Goldstein was a tenured Scientist at the Medical Department at Brookhaven National Laboratory in Upton, NY. She earned her bachelor’s degree in Psychology from Tel Aviv University in Israel and her doctorate in Health Clinical Psychology from the University of Miami in Florida.

News: The NARC (Neuropsychoimaging of Addiction and Related Conditions) moved from Brookhaven National Laboratory (BNL) to MSSM in January 2013. Our new home is in the CSM 10th floor and Atran 2nd floor; our subjects’ testing will be conducted in the KCC (neuropsychology including CANTAB tests, EEG/ERPs and Brain Computer Interface experiments, rTMS, clinical/diagnostic interviews) and CSM (fMRI, PET-MRI).

Group members who moved here from BNL are Rita Z. Goldstein (Chief), Nelly Alia-Klein (co-Chief), Scott J. Moeller (an F32 funded post-doc fellow), Muhammad A. Parvaz (an F32 funded post-doc fellow), Anna B. Konova (a graduate student in the department of Psychology, Stony Brook University), Michail Misyrlis (a graduate student in the department of Computer Science, Stony Brook University), and our undergraduate student volunteers (Pias Malaker, Vishvas Parwani, and Farnum Kazi). We are happy to welcome Benazir Ali, Kristin Schneider, and Fred Uquillas to our group. We also welcome Monja Frobose from the Donders Institute in the Netherlands for a 6-month internship with us and we say goodbye to Julia Lushing who, after a brief training with us, will join the lab of Kent Kiehl and Vince Calhoun at the Mind Research Network in New Mexico to pursue her PhD.

Our NIDA and NIMH grants support neuroimaging studies in individuals with inhibitory control deficits, encompassing drug addiction and/or intermittent explosive disorders with a focus on developing brain-gene-behavior markers of and interventions to characterize and reduce craving, anger, and relapse in these psychopathologies. Active cross- disciplinary collaborations with computer science allow the development of targeted and specialized machine-learning algorithms to facilitate data analyses and enrich interpretations.8

6 Welcome New Faculty to the Psychiatry Department continued...

Rita Goldstein

2012 Publications • Parvaz MA, Konova AB, Tomasi D, Volkow ND, Goldstein RZ. (2012). Structural integrity of the prefrontal cortex modulates electrocortical sensitivity to reward. Journal of Cognitive Neuroscience 24(7), 1560-70. • Konova AB, Moeller SJ, Tomasi D, Volkow ND, Goldstein RZ. (2013). Effects of methylphenidate on resting-state functional connectivity of the mesocorticolimbic dopamine pathways in cocaine addiction. JAMA Psychiatry, in press. • Moeller SJ, Parvaz MA, Shumay E, Beebe-Wang N, Konova AB, Alia-Klein N, Volkow ND, Goldstein RZ. (2013). Gene × abstinence effects on drug cue reactivity in addiction: Multimodal evidence. Journal of Neuroscience, in press.

Awards / Recognition Rita Z. Goldstein, PhD: • Received the Joel Elkes Research Award, American College of Neuropsychopharmacology http://www.bnl.gov/ newsroom/news.php?a=11475 (ACNP) • Named member of the Program and Scientific Communications Committee, ACNP • Chaired a symposium on “Non-invasive brain modulation to enhance inhibitory control and drive in psychiatric disorders: a translational approach with a focus on dopaminergic modulation of fronto-striatal pathways”, ACNP, Hollywood FL, December 2012

Scott J Moeller, PhD: • Received the NIDA Director’s Travel Award to CPDD, 2013 • Mentored two high school students: one was named an Intel-Semifinalist in January 2013 (Nicasia Beebe-Wang), the other was named a Neuroscience Research Finalist of the American Academy of Neurology 2013 (Salina Wu).

Anna B Konova, MA: • Received the 2012 Basic Psychological Science Research Grant, APAGS • Poster accepted in the late-breaking session at the Society of Biological Psychiatry’s 68th annual meeting, May 16-18, 2013, San Francisco, CA and considered for the meeting’s 2013 Top Poster Award: Konova AB, Moeller SJ, Tomasi D, Goldstein RZ. “Effects of chronic and acute stimulant exposure on brain connectivity hubs.”

Dr. Alia-Klein

Dr. Alia-Klein has been recruited to serve as Professor of Psychiatry, working closely with the Bronx VA, and will hold a secondary appointment in the Department of Neuroscience.

Known for her gene-brain behavior studies in anger and aggression phenotypes, Dr. Alia-Klein uses multiple neuroimaging techniques and neuropsychological tests to explore the neurobiological underpinnings of reactive aggression, that characterize Intermittent Explosive Disorder. Her interests emphasize the integration into prediction of individual differences, including polymorphisms and epigenetic patterns, personality traits, and responses to provocation.

In her new role, Dr. Alia-Klein will serve as co-director of the Neuropsychoimaging of Addiction and Related Conditions (NARC) research program. With her team at NARC, she will also be studying the efficacy of select interventions including neurofeedback, using Brain Computer Interface and targeted brain stimulation with Transcranial Magnetic Stimulation to reduce reactivity to provocation. Dr. Alia-Klein will help expand research at Mount Sinai in the area of psychiatric disorders of self-regulation as evident in drug addiction and Intermittent Explosive Disorder with well- characterized phenotypes.

As part of her research in gene-brain-behavior modeling, Dr. Alia-Klein will collaborate with the institutes for Genomic and Multiscale Biology, Genetics and Genomics Sciences, Translational and Molecular Imaging Institute at Mount Sinai, as well as institutions and consortia throughout the U.S. and the world. Dr. Alia-Klein is particularly committed to educational outreach and impact on the general public of the neurobiological study of anger and aggression. She is also

9 Welcome New Faculty to the Psychiatry Department continued...

Dr. Alia-Klein deeply committed to the application of research for interventions that enhance self-regulation and quality of life for people suffering from psychiatric disorders.

Prior to joining Mount Sinai, Dr. Alia-Klein was a Scientist at the Medical Department at Brookhaven National Laboratory in Upton, NY. She earned her bachelor’s degree in Psychology and English Literature from Adelphi University in New York and her doctorate in Psychology from the Graduate School of Arts and Sciences at Columbia University.

Awards / Recognition • Invited speaker at the 22nd Annual Joel G. Hardman Pharmacology Forum on the Neurobiology of Criminals, Vanderbilt University, April 11, 2013, Nashville Tennessee • Reviewer for the European Commission’s 7th Framework Programme for Research: Paediatric conduct disorders characterised by aggressive traits and/or social impairment: from preclinical research to treatment • Performance Reviewer for the Pennsylvania Department of Health • TV appearances: Nova Science Now, PBS series on the neurobiology of violent behavior, title: Can Science Stop Crime? (Aired 10/17/2012) http://www.pbs.org/wgbh/nova/tech/can-science-stop-crime.html and PBS special After Newtown http://video.pbs.org/video/2320006234/

Dr. Sophia Frangou, MD, PhD.

Dr. Sophia Frangou, MD, PhD will serve as Professor of Psychiatry and Chief of Psychosis Research in the Division of Psychiatric Genomics.

A leading authority on neuroimaging in and , Dr. Frangou was recruited to Mount Sinai to establish a Clinical and Translational Psychosis Program. By building on Mount Sinai’s strength in clinical investigation, the program will rapidly transfer research in genetics, neuroimaging, and neurobiology into clinical trials and clinical care. The new program will also include early assessment and support, as well as relapse prevention and recovery components.

Dr. Frangou has published innovative research on the use of neuroimaging as a tool to diagnose and evaluate psychosis. Her work has marked out the neural pathways associated with disease expression, vulnerability, and resilience and their association with known genetic risk factors. This body of work represents important paradigm shifts in refining conceptual models for psychosis and has the potential to reduce public skepticism of psychiatry and the stigmatization of patients.

Prior to joining Mount Sinai, Dr. Frangou was Professor of Psychiatry and Head of the Section of Neurobiology of Psychosis at King’s College London. She received her medical degree from the University of and a master’s degree in neuroscience, as well as a doctorate degree, from the University of London.

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6 New Grants: PI Agency Title/Description

Schahram Akbarian, PSY NIH Remodeling Neuronal Chromatin in Mouse Models for Depression Schahram Akbarian, PSY NIH Epigenome Mapping in Cortical Interneurons Schahram Akbarian, PSY BBRF Genome organization at the GAD67 (chr.2q31) locus in prefrontal cortex of subjects with schizophrenia

David Bechhofer, PST NIH/NIGMS Global Analysis of mRNA Decay in Bacillus Subtilis

Kristen Brennand, PSY BBRF Modeling Schizophrenia Using Human Induced Pluripotent Stem Cells: Assessing the Contribution of Glutamatergic and Dopaminergic Neurons to Disease

Arthur Cederbaum, PST NIH/NIAAA Role of Autophagy on the Modulation of CYP2E1 Alcohol Liver Toxicity

Barbara Coffey, PSY OAPI A Multicenter, Randomized, Double-blind, Placebo-controlled Study Evaluating the Safety and Efficacy of Fixed-dose Once-daily Oral Aripiprazole in Children and Adolescents with Tourette's Disorder 293

Bernard Cohen, NEUROL NIH Vestibular Control of the Vasovagal Response

Mandip Dhamoon, NEUROL NIH The trajectory of functional status and quality of life before and after stroke

Graham Ellis-Davies, NEU Cold Spring Harbor A light-regulated protein tagging method to study local translation in Laboratory neurons

Deveroux Ferguson, NEU NARSAD Novel Role for Sirtuin Signaling Mechanisms and Downstream Targets in Depression

Vilma Gabbay, PSY TSA Gamma-Aminobutyric Acid in Tourettes Disorder: An MR Spectroscopy Study

Sam Gandy, PSY Cure Alzheimer’s Foundation Grant for the Cure Alzheimer's Fund Stem Cell Foundation Consortium

Rita Goldstein, PSY NIA Machine learning discovery of patterns of self-regulation in drug addiction and intermittent explosive disorder

Wayne Goodman, PSY Simons Foundation A Clinical Pilot Study Examining Bilateral Inhibition of the Lateral Habenula as a Target for Deep Brain Stimulation in Intractable Depression

Georgia Hodes, NEU NARSAD A functional role for Interleukin 6 Susceptibility to Stress

Brian Iacoviello, PSY BBRF Cognitive Training in Depression

Gareth John, NEUROL Guthy-Jackson Anti-VEGF-A therapy for relapsing Neuromyelitis Optica Foundation

Pavel Katsel, PSY NIH Role of DISC1 and NRG1 in oligodendrocyte development in schizophrenia

Alexander Kolevzon, PSY SynapDx Corp. SynapDx Autism Spectrum Disorder Gene Expression Analysis (STORY) Alexander Kolevzon, PSY Hoffmann-La Roche A randomized, parallel-group, double-blind, placebo-controlled, Inc. safety and exploratory efficacy and pharmacokinetic study of RO491752311 in pediatric patients with Fragile X Syndrome

10 New Grants continued PI Agency Title/Description

Avi Maayan, PST NIH/NIGMS Expression2Kinases: mRNA Profiling Linked to Multiple Upstream Regulatory Avi Maayan, PST The Irma T. Hirchl Novel Gene-Set Libraries, Network2C Trust Charles Mobbs, NEU Diabetes Action Reversal of diabetic neuropathyby a ketogenic diet Charles Mobbs, NEU JDRF Prevention an epigenetic mechanisms of metabolic memory Hirofumi Morishita, PSY BBRF Developmental GABA-Myelin Interaction Across Critical Period: Relevance for Schizophrenia Hirofumi Morishita, PSY March of Dimes Strategies for Preventing Vision Loss Due to Eye Birth Defects Hirofumi Morishita, PSY Knights Templar Eye Molecular and Circuit Based Therapeutic Strategy for Amblyopia Foundation Coro Paisan-Ruiz, NEUROL NIH Dissecting the genetic underpinnings of essential tremor Coro Paisan-Ruiz, NEUROL NIH Elucidating and understanding the genetic basis of movement disorders Stephen Salton, NEU Diabetes Action Role of VGF in beta cell function, insulin secretion and glucose homeostasis Larry Siever, PSY NIH A D1 Agonist for Working Memory Enhancement in the Schizophrenia Spectrum Fellowships:

Elizabeth Heller, NEU NRSA - F32 In Vivo Gene-Specific Regulation using Engineered ZFPs in Drug Abuse Abuse

Marylens Hernandes, NEU NRSA - F31 Nuclear Structure Reorganization during oligogendrocyte

Mitra Heshmati, NEU NRSA - F30 Inhibitory synaptic control of social avoidance Muhammad A. Parvaz, PSY NIDA BCI-based feedback system to promote cognitive control of craving

Promotions:

Elizabeth Cropper, PhD Congratulations to Dr. Cropper on her promotion from Associate Professor to Professor in the Department of Neuroscience.

New additions to the Neuroscience Department (and future contributors to the Informant):

Silas Quinn LaPlant Sophia

Son of Dani and Quincy Daughter of Jia Liu and brother to from the Casaccia lab Alexa and Nikita

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10 Future issues of the Informant:

Please send updates of your laboratory, clinic, or department to Veronica Szarejko ([email protected]).

The next issue will be sent out September 2013 All submissions are due August 23rd

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