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Outcomes of in Vitro Fertilization Cycles Following Fertility-Sparing Treatment in Stage IA Endometrial Cancer
Archives of Gynecology and Obstetrics (2019) 300:975–980 https://doi.org/10.1007/s00404-019-05237-2 GYNECOLOGIC ONCOLOGY Outcomes of in vitro fertilization cycles following fertility‑sparing treatment in stage IA endometrial cancer Myung Joo Kim1 · Seung‑Ah Choe1 · Mi Kyoung Kim2 · Bo Seong Yun2 · Seok Ju Seong2 · You Shin Kim1 Received: 19 April 2019 / Accepted: 28 June 2019 / Published online: 22 August 2019 © Springer-Verlag GmbH Germany, part of Springer Nature 2019 Abstract Purpose This study aimed to present cases involving in vitro fertilization (IVF) cycles in patients with stage IA endometrial adenocarcinoma (EC) who underwent fertility-sparing conservative treatment. Methods Twenty-two patients who underwent IVF cycles in a single fertility center between May 2005 and February 2017 after progestin treatment for stage IA EC were chosen for this study. Outcomes of IVF cycles were analyzed retrospectively. Results Women of a median age of 34 years (range 26–41 years) underwent a total of 49 embryo transfers within an aver- age of 2 months after their last progestin treatment. The clinical pregnancy rate per transfer was 26.5%, implantation rate was 16.7%, and live birth rate was 14.3%. The cumulative clinical pregnancy rate was 50% (11/22), resulting in 6 live births (27.3%) within 3 cycles of embryo transfer. The median endometrial thickness on the day of human chorionic gonadotro- pin injection in 34 fresh cycles was 9.0 mm (range 4–10 mm) in live births, 7.5 mm (range 6–9 mm) in miscarriages, and 6.0 mm (range 4–15 mm) in no pregnancy cases. -
Prevalence of Malignant Uterine Pathology in Utero-Vaginal Prolapse After Vaginal Hysterectomy
Pelviperineology Pelviperineology Pelviperineology Pelviperineology Pelviperineology Pelviperineology Pelviperineology Pelviperineology Pelviperineology Pelviperineology Pelviperineology Pelviperineology Pelviperineology Pelviperineology Pelviperineology Pelviperineology Pelviperineology Pelviperineology Pelviperineology Pelviperineology Pelviperineology Pelviperineology Pelviperineology Pelviperineology Pelviperineology Pelviperineology Pelviperineology Pelviperineology Pelviperineology Pelviperineology Pelviperineology Pelviperineology Pelviperineology Pelviperineology Pelviperineology Pelviperineology PelviperineologyORIGINAL Pelviperineology ARTICLE Pelviperineology Pelviperineology Pelviperineology Pelviperineology Pelviperineology Pelviperineology Pelviperineology Pelviperineology Pelviperineology Pelviperineology DOI: 10.34057/PPj.2020.39.04.006 Pelviperineology 2020;39(4):137-141 Prevalence of malignant uterine pathology in utero-vaginal prolapse after vaginal hysterectomy EDGARDO CASTILLO-PINO1, VALENTINA ACEVEDO1, NATALIA BENAVIDES1, VALERIA ALONSO1, WASHIGNTON LAURÍA2 1Department of Obstetrics and Gynaecology, Urogynaecology and Pelvic Floor Unit, School of Medicine, University of the Republic, Hospital de Clínicas “Dr. Manuel Quintela”, Montevideo, Uruguay 2Department of Obstetrics and Gynaecology, School of Medicine, University of the Republic, Hospital de Clínicas “Dr. Manuel Quintela”, Montevideo, Uruguay ABSTRACT Objective: The aim of this study was to establish the prevalence of malignant uterine pathology after vaginal -
Symptomatology of Endometriosis : with a Survey of 788 Cases Compiled from the Literature
University of Nebraska Medical Center DigitalCommons@UNMC MD Theses Special Collections 5-1-1938 Symptomatology of endometriosis : with a survey of 788 cases compiled from the literature Paul Milton Pedersen University of Nebraska Medical Center This manuscript is historical in nature and may not reflect current medical research and practice. Search PubMed for current research. Follow this and additional works at: https://digitalcommons.unmc.edu/mdtheses Part of the Medical Education Commons Recommended Citation Pedersen, Paul Milton, "Symptomatology of endometriosis : with a survey of 788 cases compiled from the literature" (1938). MD Theses. 688. https://digitalcommons.unmc.edu/mdtheses/688 This Thesis is brought to you for free and open access by the Special Collections at DigitalCommons@UNMC. It has been accepted for inclusion in MD Theses by an authorized administrator of DigitalCommons@UNMC. For more information, please contact [email protected]. THE SYMPTOMATOLOGY OF ENDOMETRIOSIS WITH A SURVEY OF 788 CASES COMPILED FROM LITERATURE SENIOR THESIS PAUL MILTON PEDERSEN *** j I !,' i PRESENTED TO THE THE UNIVERSITY OF NEBRASKA OJIAHA., 1938 .. 480965 THE SYMPTOMATOLOGY OF ENDOMETRIOSIS WITH A SURVEY OF 788 CASES COMPILED FROM LITERATURE Introduction. The history of this disease is very similar to that of many others in that it has been developed as a clinical entity within the past twenty years. The present day knowledge of the subject is not as general as it might· be considering the relatively numerous articles which have appeared upon this subject within the past five years. Endometriosis is a very intriguing subject; the unique features in the symptoms that it provokes are indeed class ical, and the interest with which this is regarded has caused us to consider that phase in detail. -
Chronic Unopposed Vaginal Estrogen Therapy
October, 1999. The Rx Files: Q&A Summary S. Downey BSP, L.D. Regier BSP, BA Chronic Unopposed Vaginal Estrogen Therapy The question of whether progestagen opposition is required in a patient on chronic vaginal estrogen is controversial. The literature is not clear on this matter and the SOGC conference on Menopause did not reach a consensus. Endometrial hyperplasia is directly related to the dose and duration of estrogen therapy. The PEPI study showed that 10 per cent of women taking unopposed estrogen (equivalent to 0.625 mg CEE) will develop complex or atypical endometrial hyperplasia within 1 year. With long-term HRT, it is now considered standard practice to add progestagen opposition to oral estrogen therapy in women with an intact uterus. The case is less clear for vaginal estrogen therapy. The makers of Premarinâ vaginal cream indicate their product is for short term management of urogenital symptoms and the monograph clearly states "precautions recommended with oral estrogen administration should also be observed with this route". In one recent study looking at "Serum and tissue hormone levels of vaginally and orally administered estradiol" (Am J Obstet Gynecol 1999;180:1480-3), serum levels were 10 times higher after vaginal vs. oral administration for exactly the same dose while endometrial concentrations were 70 times higher. This suggests that in some cases very little estrogen is required vaginally to produce significant serum levels and there may be preferential absorption into the endometrium. Hence equivalent vaginal doses may sometimes be much lower on a mg per mg basis compared to oral, largely because of bypassing the "first pass" effect. -
Amenorrhea in Teenagers in Concepts of Homoeopathy
Amenorrhea in Teenagers in concepts of Homoeopathy © Dr. Rajneesh Kumar Sharma MD (Homoeopathy) Homoeo Cure Research Institute NH 74- Moradabad Road Kashipur (UTTARANCHAL) - INDIA Ph- 09897618594 E. mail- [email protected] www.homeopathictreatment.org.in www.treatmenthomeopathy.com www.homeopathyworldcommunity.com Introduction Menstrual irregularities are common within first 2–3 years after menarche. If amenorrhea is prolonged, it is abnormal and can be associated with some major disease, depending on the adolescent whether she is oestrogen-deficient or oestrogen-replete. Oestrogen-deficient amenorrhea (Psora) is concomitant with reduced bone mineral density (Syphilis) and increased fracture risk, while oestrogen-replete amenorrhea (Syphilis) can lead to dysfunctional uterine bleeding in the short term (Pseudopsora/ Sycosis) and predispose to endometrial carcinoma (Cancerous) in the long term. Hypothalamic amenorrhea (Psora) is predominant cause of amenorrhea in the adolescents and often leads to polycystic ovary syndrome (Pseudopsora/ Sycosis). In anorexia nervosa (Psora), exercise- induced amenorrhea (Causa occasionalis) and chronic illness amenorrhea, energy shortage results in suppression of GnRH secretion (Psora) by hypothalamus. Normal Menstrual Cycle Menarche Menarche is the time when a girl has her first menstrual period. It usually occurs between the ages of 10 and 14 years. Physiology Stimulation of Pituitary Neurosecretory neurons of the preoptic area of the hypothalamus secrete a decapeptide, called Gonadotropin-releasing hormone (GnRH). This hormone is poured into the capillaries of the hypophysial portal system which transport it to the anterior pituitary, where it stimulates (Psora) the synthesis and secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Control of GnRH The GnRH is released in rhythms in response to serum levels of gonadal steroids. -
The Differential Diagnosis of Acute Pelvic Pain in Various Stages of The
Osteopathic Family Physician (2011) 3, 112-119 The differential diagnosis of acute pelvic pain in various stages of the life cycle of women and adolescents: gynecological challenges for the family physician in an outpatient setting Maria F. Daly, DO, FACOFP From Jackson Memorial Hospital, Miami, FL. KEYWORDS: Acute pain is of sudden onset, intense, sharp or severe cramping. It may be described as local or diffuse, Acute pain; and if corrected takes a short course. It is often associated with nausea, emesis, diaphoresis, and anxiety. Acute pelvic pain; It may vary in intensity of expression by a woman’s cultural worldview of communicating as well as Nonpelvic pain; her history of physical, mental, and psychosocial painful experiences. The primary care physician must Differential diagnosis dissect in an orderly, precise, and rapid manner the true history from the patient experiencing pain, and proceed to diagnose and treat the acute symptoms of a possible life-threatening problem. © 2011 Elsevier Inc. All rights reserved. Introduction female’s presentation of acute pelvic pain with an enlarged bulky uterus may often be diagnosed as a leiomyoma in- Women at various ages and stages of their life cycle may stead of a neoplastic mass. A pregnant female, whose preg- present with different causes of acute pelvic pain. Estab- nancy is either known to her or unknown, presenting with lishing an accurate diagnosis from the multiple pathologies acute pelvic pain must be rapidly evaluated and treated to in the differential diagnosis of their specific pelvic pain may prevent a rapid downward cascading progression to mater- well be a challenge for the primary care physician. -
Changes Before the Change1.06 MB
Changes before the Change Perimenopausal bleeding Although some women may abruptly stop having periods leading up to the menopause, many will notice changes in patterns and irregular bleeding. Whilst this can be a natural phase in your life, it may be important to see your healthcare professional to rule out other health conditions if other worrying symptoms occur. For further information visit www.imsociety.org International Menopause Society, PO Box 751, Cornwall TR2 4WD Tel: +44 01726 884 221 Email: [email protected] Changes before the Change Perimenopausal bleeding What is menopause? Strictly defined, menopause is the last menstrual period. It defines the end of a woman’s reproductive years as her ovaries run out of eggs. Now the cells in the ovary are producing less and less hormones and menstruation eventually stops. What is perimenopause? On average, the perimenopause can last one to four years. It is the period of time preceding and just after the menopause itself. In industrialized countries, the median age of onset of the perimenopause is 47.5 years. However, this is highly variable. It is important to note that menopause itself occurs on average at age 51 and can occur between ages 45 to 55. Actually the time to one’s last menstrual period is defined as the perimenopausal transition. Often the transition can even last longer, five to seven years. What hormonal changes occur during the perimenopause? When a woman cycles, she produces two major hormones, Estrogen and Progesterone. Both of these hormones come from the cells surrounding the eggs. Estrogen is needed for the uterine lining to grow and Progesterone is produced when the egg is released at ovulation. -
Endometrial Hyperplasia
Endometrial Imaging Darcy J. Wolfman, MD Section Chief of Genitourinary Imaging American Institute for Radiologic Pathology Clinical Associate Johns Hopkins Community Radiology Division Washington, DC, USA Nothing to disclose Thickened Endometrium . Patients with abnormal uterine bleeding 2.1 cm Endovaginal ultrasound to exclude endometrial cancer and other endometrial abnormalities. Smith-Bindman R, Kerlikowske K, Feldstein VA, Subak L, Scheidler J, Segal M, Brand R, Grady D JAMA. 1998 Nov 4; 280(17):1510-7. Thickened Endometrium . Patients with abnormal uterine bleeding . Post menopausal . 5mm and over 2.1 cm Endovaginal ultrasound to exclude endometrial cancer and other endometrial abnormalities. Smith-Bindman R, Kerlikowske K, Feldstein VA, Subak L, Scheidler J, Segal M, Brand R, Grady D JAMA. 1998 Nov 4; 280(17):1510-7. Thickened Endometrium . Patients with abnormal uterine bleeding . Post menopausal . 5mm and over . Detects 96% of endometrial cancer 2.1 cm Endovaginal ultrasound to exclude endometrial cancer and other endometrial abnormalities. Smith-Bindman R, Kerlikowske K, Feldstein VA, Subak L, Scheidler J, Segal M, Brand R, Grady D JAMA. 1998 Nov 4; 280(17):1510-7. Thickened Endometrium . Patients with abnormal uterine bleeding . Post menopausal . 5mm and over . Detects 96% of endometrial cancer . Hormone replacement does not change cutoff value 2.1 cm Endovaginal ultrasound to exclude endometrial cancer and other endometrial abnormalities. Smith-Bindman R, Kerlikowske K, Feldstein VA, Subak L, Scheidler J, Segal M, Brand R, Grady D JAMA. 1998 Nov 4; 280(17):1510-7. Thickened Endometrium . Patients with abnormal uterine bleeding . Post menopausal . 5mm and over . Pre menopausal . 15mm and over 2.1 cm Endovaginal ultrasound to exclude endometrial cancer and other endometrial abnormalities. -
The Woman with Postmenopausal Bleeding
THEME Gynaecological malignancies The woman with postmenopausal bleeding Alison H Brand MD, FRCS(C), FRANZCOG, CGO, BACKGROUND is a certified gynaecological Postmenopausal bleeding is a common complaint from women seen in general practice. oncologist, Westmead Hospital, New South Wales. OBJECTIVE [email protected]. This article outlines a general approach to such patients and discusses the diagnostic possibilities and their edu.au management. DISCUSSION The most common cause of postmenopausal bleeding is atrophic vaginitis or endometritis. However, as 10% of women with postmenopausal bleeding will be found to have endometrial cancer, all patients must be properly assessed to rule out the diagnosis of malignancy. Most women with endometrial cancer will be diagnosed with early stage disease when the prognosis is excellent as postmenopausal bleeding is an early warning sign that leads women to seek medical advice. Postmenopausal bleeding (PMB) is defined as bleeding • cancer of the uterus, cervix, or vagina (Table 1). that occurs after 1 year of amenorrhea in a woman Endometrial or vaginal atrophy is the most common cause who is not receiving hormone therapy (HT). Women of PMB but more sinister causes of the bleeding such on continuous progesterone and oestrogen hormone as carcinoma must first be ruled out. Patients at risk for therapy can expect to have irregular vaginal bleeding, endometrial cancer are those who are obese, diabetic and/ especially for the first 6 months. This bleeding should or hypertensive, nulliparous, on exogenous oestrogens cease after 1 year. Women on oestrogen and cyclical (including tamoxifen) or those who experience late progesterone should have a regular withdrawal bleeding menopause1 (Table 2). -
Perimenopausal Bleeding and Bleeding After Menopause
AQ The American College of Obstetricians and Gynecologists FREQUENTLY ASKED QUESTIONS FAQ162 GYNECOLOGIC PROBLEMS Perimenopausal Bleeding and Bleeding After Menopause • What are menopause and perimenopause? • What are some of the common changes that occurf in the menstrual cycle during perimenopause? • How can I tell if bleeding is abnormal? • What are some of the common causes of abnormal bleeding? • How is abnormal bleeding diagnosed? • What treatment is available for abnormal bleeding? • Glossary What are menopause and perimenopause? Menopause is defined as the absence of menstrual periods for 1 year. The average age of menopause is 51 years, but the normal range is 45 years to 55 years. The years leading up to this point are called perimenopause. This term means “around menopause.” This phase can last for up to 10 years. During perimenopause, shifts in hormone levels can affect ovulation and cause changes in the menstrual cycle. What are some of the common changes that occur in the menstrual cycle during perimenopause? During a normal menstrual cycle, the levels of the hormones estrogen and progesterone increase and decrease in a regular pattern. Ovulation occurs in the middle of the cycle, and menstruation occurs about 2 weeks later. During perimenopause, hormone levels may not follow this regular pattern. As a result, you may have irregular bleeding or spotting. Some months, your period may be longer and heavier. Other months, it may be shorter and lighter. The number of days between periods may increase or decrease. You may begin to skip periods. How can I tell if bleeding is abnormal? Any bleeding after menopause is abnormal and should be reported to your health care provider. -
Bacterial Vaginosis – More Questions Than Answers
THEME SEXUAL HEALTH Marie Pirotta Kath A Fethers Catriona S Bradshaw MBBS, FRACGP, DipRANZOCG, MMed (WomHlth), MBBS, MM, FAChSHM, is MBBS(Hons), FAChSHM, PhD, is a sexual PhD, is a general practitioner and Senior Research a sexual health physician, health physician and NHMRC Research Fellow, Fellow, Primary Care Research Unit, Department Melbourne Sexual Health Department of Epidemiology and Preventive of General Practice, University of Melbourne, Centre, Victoria. Medicine, Monash University and Melbourne Victoria. [email protected] Sexual Health Centre, The Alfred Hospital, Victoria. Bacterial vaginosis More questions than answers Bacterial vaginosis (BV) is one of the commonest genital Background conditions ocurring in women of reproductive age. In public Bacterial vaginosis is the commonest cause of abnormal vaginal health terms, it plays a significant role as a risk factor for a discharge in women of reproductive age and is associated with wide range of health problems, including preterm birth, serious pregnancy related sequelae and increased transmission of sexually transmissible infections, including HIV. The aetiology, spontaneous abortion, and enhanced transmission of sexually pathology, microbiology and transmission of bacterial vaginosis transmissible infections (STIs), including human remain poorly understood. immunodeficiency virus (HIV). Objective Previous names for BV include: ‘leukorrhea’, ‘nonspecific vaginitis’, This article discusses the prevalence, clinical features and ‘haemophilus vaginalis vaginitis’, ‘gardnerella’ and ‘anaerobic possible complications of bacterial vaginosis. It summarises what is known about the aetiology, pathophysiology and vaginitis’. Its changing name belies the interesting fact that, despite treatment of the condition and highlights directions for further an increased understanding of its physiology and sequelae, the research. precise pathogenesis of BV remains controversial and it's aetiology, pathology, microbiology and transmission is still poorly understood. -
Heavy Menstrual Bleeding: Care for Adults and Adolescents of Reproductive
Heavy Menstrual Bleeding Care for Adults and Adolescents of Reproductive Age Summary This quality standard addresses care for people of reproductive age who have heavy menstrual bleeding, regardless of the underlying cause. The quality standard includes both acute and chronic heavy menstrual bleeding, and applies to all care settings. It does not apply to people with non-menstrual bleeding or with heavy menstrual bleeding occurring within 3 months of a pregnancy, miscarriage, or abortion. Table of Contents About Quality Standards 1 How to Use Quality Standards 1 About This Quality Standard 2 Scope of This Quality Standard 2 Why This Quality Standard Is Needed 2 Principles Underpinning This Quality Standard 3 How We Will Measure Our Success 3 Quality Statements in Brief 4 Quality Statement 1: Comprehensive Initial Assessment 6 Quality Statement 2: Shared Decision-Making 9 Quality Statement 3: Pharmacological Treatments 12 Quality Statement 4: Endometrial Biopsy 14 Quality Statement 5: Ultrasound Imaging 17 Quality Statement 6: Referral to a Gynecologist 19 Quality Statement 7: Endometrial Ablation 22 Quality Statement 8: Acute Heavy Menstrual Bleeding 25 Quality Statement 9: Dilation and Curettage 28 Quality Statement 10: Offering Hysterectomy 31 TABLE OF CONTENTS CONTINUED Quality Statement 11: Least Invasive Hysterectomy 33 Quality Statement 12: Treatment for Fibroids Causing Heavy Menstrual Bleeding 36 Quality Statement 13: Bleeding Disorders in Adolescents 39 Quality Statement 14: Treatment of Anemia and Iron Deficiency 41 Acknowledgements 44 References 45 About Health Quality Ontario 46 About Quality Standards Health Quality Ontario, in collaboration with clinical experts, patients, residents, and caregivers across the province, is developing quality standards for Ontario.