Anti-SYT11 Antibody (ARG59976)

Product datasheet [email protected]

ARG59976 Package: 100 μl anti-SYT11 antibody Store at: -20°C

Summary

Product Description Rabbit Polyclonal antibody recognizes SYT11

Tested Reactivity Hu, Ms, Rat

Tested Application ICC/IF, IHC-P, WB

Host Rabbit

Clonality Polyclonal

Isotype IgG

Target Name SYT11

Antigen Species Human

Immunogen Recombinant fusion protein corresponding to aa. 37-200 of Human SYT11 (NP_689493.3).

Conjugation Un-conjugated

Alternate Names SYT12; sytXI; SytXI; Synaptotagmin XI; Synaptotagmin-11

Application Instructions

Application table Application Dilution

ICC/IF 1:50 - 1:100

IHC-P 1:50 - 1:100

WB 1:500 - 1:2000

Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Positive Control Rat brain, Mouse brain and U251

Calculated Mw 48 kDa

Observed Size 48 kDa

Properties

Form Liquid

Purification Affinity purified.

Buffer PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.

Preservative 0.02% Sodium azide

Stabilizer 50% Glycerol

Storage instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. www.arigobio.com 1/3 Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Gene Symbol SYT11

Gene Full Name synaptotagmin XI

Background This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that are known calcium sensors and mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. The encoded protein is also a substrate for ubiquitin-E3-ligase parkin. The gene has previously been referred to as synaptotagmin XII but has been renamed synaptotagmin XI to be consistent with mouse and rat official nomenclature. [provided by RefSeq, Apr 2010]

Function May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. [UniProt]

Cellular Localization Membrane; Single-pass membrane protein. Cell junction, synapse. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein. Note=In substantia nigra, observed in neuronal cell bodies and neurites. Found in the core of the Lewy bodies in the brain of sporadic Parkinson disease patients. [UniProt]

Images

ARG59976 anti-SYT11 antibody ICC/IF image

Immunofluorescence: U2OS cells stained with ARG59976 anti-SYT11 antibody at 1:100 dilution.

ARG59976 anti-SYT11 antibody IHC-P image

Immunohistochemistry: Paraffin-embedded Human stomach stained with ARG59976 anti-SYT11 antibody at 1:100 dilution.

www.arigobio.com 2/3 ARG59976 anti-SYT11 antibody WB image

Western blot: 25 µg of Rat brain, Mouse brain and U251 cell lysates stained with ARG59976 anti-SYT11 antibody at 1:1000 dilution.

ARG59976 anti-SYT11 antibody IHC-P image

Immunohistochemistry: Paraffin-embedded Human liver injury stained with ARG59976 anti-SYT11 antibody at 1:100 dilution.