31St International Epilepsy Congress Istanbul, Turkey 5Th – 9Th September 2015
ABSTRACTS 31st International Epilepsy Congress Istanbul, Turkey 5th – 9th September 2015 Epilepsia, 56(Suppl. 1):3–263, 2015 doi: 10.1111/epi.13241 Platform Session: Basic Science 0002 Sunday, 6th September 2015 MORPHOLOGICAL CHANGES IN EEG, AQUAPORIN- 4, C-FOS AND THE HIPPOCAMPUS OF ANIMAL 0001 MODELS WITH TEMPORAL LOBE EPILEPSY SODIUM SELENATE RETARDS EPILEPTOGENESIS INDUCED BY KAINIC ACID ı † † † ‡ VIA ACTIVATING PROTEIN PHOSPHATASE 2A E. Taskiran*,C.Ylmaz , N. Orhan , M. Bahceci , M. Kaya , B. Ahishali‡, M. Kucuk†, N. Arican‡, C. Gurses§ P. Zheng*, S. Liu*, N. Jones*, S. Shultz*, G. Dezsi*, D. Wright†, *Neurology Department, Istanbul Medipol University, Istanbul, C. Hovens‡, T.J. O’Brien*,§ † *The Royal Melbourne Hospital, Medicine, Melbourne, Turkey, Istanbul University, Research Institute of Experimental Medicine, Istanbul, Turkey, ‡Istanbul University Istanbul Australia, †The Florey Institutes of Neuroscience and Mental Faculty of Medicine, Istanbul, Turkey, §Department of Health, Melbourne, Australia, ‡The Royal Melbourne Hospital, Surgery, Melbourne, Australia, §Melbourne Brain Centre, Neurology and Clinical Neurophysiology, Istanbul University, Neurology, Melbourne, Australia Istanbul Faculty of Medicine, Istanbul, Turkey Purpose: Temporal lobe epilepsy (TLE) is the most frequent type of Purpose: Epileptogenesis describes the neurobiological processes that localization-related focal epilepsy seen in humans. It has a frequency rate convert a healthy brain into an epileptic brain. There are no treatments of 30–35% among all epilepsies, and comprises 70% of intractable available to mitigate epileptogenesis in clinical practice. Down-regula- epilepsies. With hippocampal sclerosis as the most often observed tion of protein phosphatase 2A (PP2A) activity increases phosphorylated histopathological finding, its epileptogenesis is still researched. tau (p-tau), which is implicated in acquired epilepsy.
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