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Drug-Resistant Candida Species Threat Level Serious

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Drug-Resistant Candida Species Threat Level Serious DRUG-RESISTANT CANDIDA SPECIES THREAT LEVEL SERIOUS 34,800 1,700 Estimated cases Estimated in hospitalized deaths in patients in 2017 2017 Dozens of Candida species—a group of fungi—cause infections, ranging from mild oral and vaginal yeast infections to severe invasive infections. Many are resistant to the antifungals used to treat them. WHAT YOU NEED TO KNOW CASES OVER TIME ■ Only three classes of antifungal drugs are available to Resistant Candida are commonly detected in hospitalized treat severe Candida infections: azoles, echinocandins, patients. About 7% of bloodstream infections are resistant to and amphotericin B. antifungals. ■ Candida species commonly cause bloodstream 50,000 infections in hospitalized patients. About one in four of 44,800 44,900 these patients die. 42,000 40,200 40,000 38,700 ■ Candida species also cause common yeast infections, 34,800 which can affect the mouth, skin, and vagina, resulting in more than 3.6 million U.S. healthcare visits each year, 30,000 and $3 billion estimated direct medical costs. ■ Antibiotics used to treat bacterial infections increase in Hospitalized Patients in Hospitalized 20,000 the risk of Candida infections. All data represented excludes C. auris. Candida Estimated Cases of Drug-Resistant Estimated 10,000 0 2012 2013 2014 2015 2016 2017 40% 37% 35% 30% 27% 25% 20% Bloodstream Infections by Species by Infections Bloodstream 15% 14% 10% Candida 8% 5% 5% 3% 2% 2% 1% Percent of Percent 0% C. krusei C. albicans C. glabrata species C. tropicalis C. lusitaniae C. parapsilosis C. dubliniensis C. guilliermondiiOther or multiple 50,000 44,800 44,900 42,000 40,200 40,000 38,700 34,800 30,000 DRUG-RESISTANT Patients in Hospitalized 20,000 CANDIDA SPECIES Candida DIFFICULT TO DETECT THREAT Cases of Drug-Resistant Estimated BLOODSTREAM10,000 INFECTIONS Candida species are well known for causing infections Candida species are a common cause of bloodstream 0 in our mouth, skin, and vagina, but these germs are infections 2012and can 2013be drug-resistant 2014 2015 and difficult 2016 to 2017treat. also a common cause of life-threatening bloodstream infections in hospitals. Most Candida infections in 40% people are caused by Candida albicans, which has very 37% low levels of drug resistance. However, other types of 35% Candida, including Candida glabrata, are frequently 30% resistant and more deadly. 27% 25% Many clinical laboratories do not have the capacity to test Candida for drug resistance, limiting the ability 20% to guide treatment and track resistance. Additionally, new, highly resistant species, such as Candida auris, are Species by Infections Bloodstream 15% 14% emerging and can also be difficult to identify. CDC’s 10% Antibiotic Resistance Laboratory Network helps clinical Candida 8% 5% 5% labs across the United States identify emerging Candida 3% 2% 2% 1% species and test for antifungal resistance. This helps of Percent lab professionals and healthcare providers rapidly and 0% correctly identify the threat and stop its spread. C. krusei C. albicans C. glabrata species C. tropicalis C. lusitaniae C. parapsilosis C. dubliniensis C. guilliermondiiOther or multiple ONLINE RESOURCES About Candida infections www.cdc.gov/fungal/diseases/candidiasis/index.html About antifungal resistance www.cdc.gov/fungal/antifungal-resistance.html This fact sheet is part of CDC’s 2019 Antibiotic Resistance Threats Report. The full report, including data sources, is available at www.cdc.gov/DrugResistance/Biggest-Threats.html. CS298822-A.
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