1302 Plazomicin Sulfate ASHP INJECTABLE DRUG INFORMATION

Plazomicin Sulfate AHFS 8:12.02

Products Stability Plazomicin sulfate is available in a concentration equivalent Intact vials of plazomicin sulfate should be stored under refrig- to plazomicin base 50 mg/mL in 10-mL single-dose (preserva- eration at 2 to 8°C.3431 Plazomicin sulfate injection is a clear, tive-free) vials.3431 Each vial also contains sodium hydroxide colorless to yellow solution.3431 The manufacturer states that for pH adjustment and water for injection.3431 The appropriate the solution may become yellow, but that this change does not dose of plazomicin solution should be diluted in sodium chloride indicate a decrease in potency.3431 0.9% or Ringer’s injection, lactated to achieve a final volume of The manufacturer states that a solution of plazomicin diluted 3431 50 mL. for infusion in sodium chloride 0.9% or Ringer’s injection, pH lactated to concentrations of 2.5 to 45 mg/mL is stable for up to 24 hours at room temperature.3431 Adjusted to 6.5.3431 Trade Name(s) Zemdri Administration Plazomicin sulfate is administered by intravenous infusion over 30 minutes after dilution in sodium chloride 0.9% or Ringer’s injection, lactated.3431

Compatibility Information Solution Compatibility

Plazomicin sulfate

Test Soln Name Mfr Mfr Conc/L or % Remarks Ref C/I

Ringer’s injection, lactated ACH 2.5 to 45 g Stable for 24 hr at room temperature 3431 C

Sodium chloride 0.9% ACH 2.5 to 45 g Stable for 24 hr at room temperature 3431 C

Y-Site Injection Compatibility (1:1 Mixture)

Plazomicin sulfate

Test Drug Mfr Conc Mfr Conc Remarks Ref C/I

Albumin human BXT 250 mg/mL ACH 24 mg/mLc Measured turbidity increases immediately 3432 I

Amiodarone HCl MYL 2 mg/mLc ACH 24 mg/mLc Measured turbidity increases immediately; 3432 I pH increased by >1 unit within 30 min

Amphotericin B XGN 0.1 mg/mLa ACH 24 mg/mLa Measured turbidity increases immediately 3432 I

Ampicillin sodium– AUR 20 mg/mLc d ACH 24 mg/mLc Physically compatible for 1 hr at 20 to 25°C 3432 C sulbactam sodium

Anidulafungin PF 0.77 mg/mLc ACH 24 mg/mLc Measured turbidity increases within 15 min; 3432 I pH increased by >1 unit within 30 min

Azithromycin PF 2 mg/mLc ACH 24 mg/mLc Physically compatible for 1 hr at 20 to 25°C 3432 C

Aztreonam FRK 20 mg/mLc ACH 24 mg/mLc Physically compatible for 1 hr at 20 to 25°C 3432 C

Bumetanide HOS 0.25 mg/mL ACH 24 mg/mLc Physically compatible for 1 hr at 20 to 25°C 3432 C

DOI: 10.37573/9781585286850.318 ASHP INJECTABLE DRUG INFORMATION Plazomicin Sulfate 1303

Y-Site Injection Compatibility (1:1 Mixture) (Cont.)

Test Drug Mfr Conc Mfr Conc Remarks Ref C/I

Calcium chloride HOS 20 mg/mLc ACH 24 mg/mLc White particulates form within 1 hr; pH 3432 I increased by >1 unit within 30 min

Calcium gluconate FRK 20 mg/mLc ACH 24 mg/mLc Physically compatible for 1 hr at 20 to 25°C 3432 C

Caspofungin acetate ME 0.5 mg/mLb ACH 24 mg/mLb Physically compatible for 1 hr at 20 to 25°C 3432 C

Cefazolin sodium SGT 20 mg/mLc ACH 24 mg/mLc Physically compatible for 1 hr at 20 to 25°C 3432 C

Cefepime HCl WG 40 mg/mLc ACH 24 mg/mLc Physically compatible for 1 hr at 20 to 25°C 3432 C

Cefoxitin sodium FRK 20 mg/mLc ACH 24 mg/mLc Physically compatible for 1 hr at 20 to 25°C 3432 C

Ceftaroline fosamil FAC 12 mg/mLc ACH 24 mg/mLc Physically compatible for 1 hr at 20 to 25°C 3432 C

Ceftazidime SGT 40 mg/mLc ACH 24 mg/mLc Physically compatible for 1 hr at 20 to 25°C 3432 C

Ceftazidime– GSK 40 mg/mLc e ACH 24 mg/mLc Physically compatible for 1 hr at 20 to 25°C 3432 C avibactam sodium

Ceftolozane sulfate– ME 20 mg/mLc f ACH 24 mg/mLc Physically compatible for 1 hr at 20 to 25°C 3432 C tazobactam sodium

Ceftriaxone sodium HOS 20 mg/mLc ACH 24 mg/mLc Physically compatible for 1 hr at 20 to 25°C 3432 C

Cefuroxime sodium HIK 30 mg/mLc ACH 24 mg/mLc Physically compatible for 1 hr at 20 to 25°C 3432 C

Ciprofloxacin CLA 2 mg/mLc ACH 24 mg/mLc Physically compatible for 1 hr at 20 to 25°C 3432 C

Cisatracurium besylate ABV 0.4 mg/mLc ACH 24 mg/mLc Physically compatible for 1 hr at 20 to 25°C 3432 C

Colistimethate sodium PAR 4.5 mg/mLc ACH 24 mg/mLc Physically compatible for 1 hr at 20 to 25°C 3432 C

Daptomycin TE 20 mg/mLb ACH 24 mg/mLb Measured turbidity increases immediately 3432 I

Dexamethasone FRK 1 mg/mLc ACH 24 mg/mLc Physically compatible for 1 hr at 20 to 25°C 3432 C sodium phosphate

Dexmedetomidine HCl HOS 4 mcg/mL ACH 24 mg/mLc Physically compatible for 1 hr at 20 to 25°C 3432 C

Digoxin WW 0.25 mg/mL ACH 24 mg/mLc Physically compatible for 1 hr at 20 to 25°C 3432 C

Diltiazem HCl AKN 5 mg/mL ACH 24 mg/mLc Physically compatible for 1 hr at 20 to 25°C 3432 C

Diphenhydramine HCl FRK 50 mg/mL ACH 24 mg/mLc Physically compatible for 1 hr at 20 to 25°C 3432 C

Dobutamine HCl HOS 4.1 mg/mLc ACH 24 mg/mLc Physically compatible for 1 hr at 20 to 25°C 3432 C

Dopamine HCl HOS 0.8 mg/mLc ACH 24 mg/mLc Physically compatible for 1 hr at 20 to 25°C 3432 C

Doripenem SHI 10 mg/mLc ACH 24 mg/mLc Physically compatible for 1 hr at 20 to 25°C 3432 C

Doxycycline hyclate FRK 1 mg/mLc ACH 24 mg/mLc Physically compatible for 1 hr at 20 to 25°C 3432 C

Epinephrinel HOS 16 mcg/mLc ACH 24 mg/mLc Physically compatible for 1 hr at 20 to 25°C 3432 C

Eptifibatide ME 2 mg/mL ACH 24 mg/mLb Physically compatible for 1 hr at 20 to 25°C 3432 C

Ertapenem sodium ME 20 mg/mLb ACH 24 mg/mLb Physically compatible for 1 hr at 20 to 25°C 3432 C

Esmolol HCl MYL 10 mg/mL ACH 24 mg/mLc Physically compatible for 1 hr at 20 to 25°C 3432 C

Esomeprazole sodium ASZ 0.8 mg/mLc ACH 24 mg/mLc Measured turbidity increases within 1 hr; pH 3432 I decreased by nearly 3 units within 30 min

Famotidine FRK 4 mg/mLc ACH 24 mg/mLc Physically compatible for 1 hr at 20 to 25°C 3432 C

Fentanyl citrate WW 50 mcg/mL ACH 24 mg/mLc Physically compatible for 1 hr at 20 to 25°C 3432 C

Fluconazole SGT 2 mg/mLc ACH 24 mg/mLc Physically compatible for 1 hr at 20 to 25°C 3432 C

Fosphenytoin sodium AMB 25 mg/mLc g ACH 24 mg/mLc Physically compatible for 1 hr at 20 to 25°C 3432 C