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From January 2018 Drug & Therapeutics Committee NICE Drug Technology Appraisals ratified by D&TC since 2018 These medicines have a positive NICE Technology Appraisal and are listed in the Trust Medicines Formulary when used in line with NICE recommendations and/or Local Trust Guidelines D&TC date NICE TA date Drug name Indication January 2018 November 2017 Aflibercept For treating choroidal neovascularisation (TA486) (recombinant fusion protein) January 2018 November 2017 Venetoclax For treating chronic (TA487) (selective inhibitor of B-cell lymphocytic leukaemia lymphoma-2 (BCL-2)) January 2018 November 2017 Regorafenib For previously treated (TA488) (inhibitor of several protein kinases) unresectable or metastatic gastrointestinal stromal tumours January 2018 November 2017 Vismodegib For treating of adult patients with: symptomatic metastatic basal (TA489) (hedgehog pathway inhibitor) cell carcinoma; locally advanced basal cell carcinoma inappropriate for surgery or radiotherapy. January 2018 November 2017 Nivolumab For treating squamous cell carcinoma of the head and neck after (TA490) (human immunoglobulin G4 platinum-based chemotherapy monoclonal antibody) January 2018 November 2017 Ibrutinib For treating Waldenstrom’s macroglobulinaemia (TA491) (tyrosine kinase inhibitor) January 2018 December 2017 Atezolizumab For untreated locally (TA492) (monoclonal antibody, which binds advanced or metastatic urothelial cancer to the programmed death-1 (PD-1) when cisplatin is unsuitable receptor) January 2018 December 2017 Cladribine For treating (TA493) (antimetabolite) relapsing–remitting multiple sclerosis March 2018 December 2017 Naltrexone – bupropion Adjunct to a reduced-calorie diet and increased physical activity, for (TA 494) (Centrally acting appetite the management of weight in adult patients (aged 18 and over) suppressants) with an initial BMI of: 30 kg/m2 or more (obese) or from 27 kg/m2 to 30 kg/m2 (overweight) in the presence of one or more weight-related co-morbidities (such as type 2 diabetes, dyslipidaemia, or controlled hypertension). Treatment should be stopped after 16 weeks if the patient has not lost at least 5% of their initial body weight. March 2018 December 2017 Palbociclib with an aromatase For previously untreated, hormone (TA 495) inhibitor (selective, small-molecule receptor-positive, HER2-negative, locally inhibitor of cyclindependent advanced or metastatic breast cancer kinases 4 and 6) March 2018 December 2017 Ribociclib with an aromatase For previously untreated, hormone receptor-positive, HER2- (TA 496) inhibitor negative, locally advanced or metastatic breast cancer March 2018 January 2018 Golimumab For treating non-radiographic axial spondyloarthritis (TA 497) (Cytokine modulator) March 2018 January 2018 Lenvatinib with everolimus For previously (TA 498) treated advanced renal cell carcinoma March 2018 January 2018 Glecaprevir–pibrentasvir (Maviret) For treating chronic hepatitis C (genotypes 1-6) (TA 499) March 2018 January 2018 Ceritinib For untreated ALK-positive non-small-cell lung cancer (TA 500) (tyrosine kinase inhibitor) March 2018 January 2018 Intrabeam radiotherapy system For adjuvant treatment of early breast cancer (TA 501) (mobile irradiation System) March 2018 January 2018 For treating relapsed or (TA 502) Ibrutinib refractory mantle cell lymphoma (tyrosine kinase inhibitor) March 2018 January 2018 Fulvestrant For untreated locally (TA 503) advanced or metastatic oestrogenreceptor (estrogen receptor antagonists) positive breast cancer March 2018 February 2018 Pirfenidone For treating idiopathic (TA 504) pulmonary fibrosis (Pyridones) March 2018 February 2018 Ixazomib (proteasome inhibitor) For treating relapsed or (TA 505) with lenalidomide and refractory multiple myeloma dexamethasone March 2018 February 2018 Lesinurad For treating chronic hyperuricaemia in people with gout (together (TA 506) with a xanthine oxidase inhibitor) (oral selective inhibitor of the URAT1 and OAT4 uric acid (UA)) May 2018 February 2018 Sofosbuvir–velpatasvir–voxilaprevir For treating chronic hepatitis C (TA 507) May 2018 March 2018 Autologous chondrocyte For treating symptomatic articular cartilage defects of the knee implantation using chondrosphere (TA 508) May 2018 March 2018 Pertuzumab with trastuzumab and For treating HER2-positive docetaxel breast cancer (TA 509) May 2018 March 2018 Daratumumab monotherapy For treating relapsed and refractory multiple myeloma (TA 510) (humanised monoclonal antibody that targets the CD38 protein) May 2018 March 2018 Brodalumab For treating moderate to severe plaque psoriasis (TA 511) (recombinant human monoclonal antibody) May 2018 March 2018 Tivozanib For treating advanced renal cell carcinoma (TA 512) (tyrosine kinase inhibitor) May 2018 March 2018 Obinutuzumab For untreated advanced follicular lymphoma (TA 513) (anti-lymphocyte monoclonal antibody) May 2018 March 2018 Regorafenib For previously treated advanced hepatocellular carcinoma (TA 514) (inhibitor of several protein kinases) May 2018 March 2018 Eribulin For treating locally advanced or metastatic breast cancer after 1 chemotherapy regimen (TA 515) (non-taxane microtubule dynamics inhibitor) May 2018 March 2018 Cabozantinib For treating medullary thyroid cancer (TA 516) (inhibitor of several protein kinases) May 2018 April 2018 Avelumab For treating metastatic Merkel cell carcinoma (TA 517) (monoclonal antibody) May 2018 April 2018 Tocilizumab For treating giant cell arteritis (TA 518) (recombinant, humanized, anti- human interleukin 6 (IL-6) receptor monoclonal antibody) July 2018 April 2018 Pembrolizumab (Keytruda) For the treatment of locally advanced or metastatic urothelial (TA 519) carcinoma in adults who have received prior platinum-containing chemotherapy July 2018 May 2018 Atezolizumab For treating locally advanced or metastatic non-small-cell lung (TA 520) (Tecentriq) cancer (NSCLC) in adults who have had chemotherapy (and targeted treatment if they have an EGFR- or ALK-positive tumour) July 2018 June 2018 Guselkumab For treating plaque psoriasis in adults (TA 521) July 2018 June 2018 Pembrolizumab For untreated locally advanced or metastatic urothelial carcinoma (TA 522) in adults when cisplatin-containing chemotherapy is unsuitable July 2018 June 2018 Midostaurin For treating newly diagnosed acute FLT3-mutation-positive myeloid (TA 523) leukaemia with standard daunorubicin and cytarabine as induction therapy, with high-dose cytarabine as consolidation therapy, and alone after complete response as maintenance therapy July 2018 June 2018 Brentuximab vedotin For treating CD30‑positive Hodgkin lymphoma in adults with (TA 524) relapsed or refractory disease July 2018 June 2018 Atezolizumab For treating locally advanced or metastatic urothelial carcinoma in (TA 525) adults who have had platinum-containing chemotherapy July 2018 June 2018 Arsenic trioxide For inducing remission and consolidation in acute promyelocytic (TA 526) leukaemia (characterised by the presence of the t[15;17] translocation or the PML/RAR-alpha gene) in adults September 2018 June 2018 Beta-interferons and glatiramer Evidence-based recommendations for treating multiple sclerosis in (TA527) acetate adults. September 2018 July 2018 Niraparib For treating relapsed, platinum-sensitive high-grade serous (TA528) epithelial ovarian, fallopian tube or primary peritoneal cancer that has responded to the most recent course of platinum-based chemotherapy in adults September 2018 July 2018 Crizotinib For treating ROS1-positive advanced non-small-cell lung cancer (TA529) September 2018 July 2018 Nivolumab For treating locally advanced unresectable or metastatic urothelial (TA 530) cancer after platinum-containing chemotherapy September 2018 July 2018 Pembrolizumab For untreated PD-L1-positive metastatic non-small-cell lung cancer (TA 531) September 2018 July 2018 Cenegermin For the treatment of moderate (persistent epithelial defect) or (TA 532) severe (corneal ulcer) neurotrophic keratitis in adults September 2018 July 2018 Ocrelizumab For the treatment of adult patients with relapsing forms of multiple (TA 533) sclerosis (RMS) with active disease defined by clinical or imaging features September 2018 August 2018 Dupilumab For the treatment of moderate to severe atopic dermatitis in adults (TA534) who are candidates for systemic therapy September 2018 August 2018 Lenvatinib and sorafenib For treating progressive, locally advanced or metastatic (TA 535) differentiated thyroid cancer September 2018 August 2018 Alectinib For untreated anaplastic lymphoma kinase (ALK)-positive advanced (TA 536) non-small-cell lung cancer (NSCLC) in adults September 2018 August 2018 Ixekizumab For treating active psoriatic arthritis in adults (TA 537) September 2018 August 2018 Dinutuximab beta For treating high-risk neuroblastoma (TA 538) August 2018 Lutetium (177Lu) oxodotreotide For 'unresectable or metastatic, progressive, well-differentiated (TA 539) (G1 and G2), somatostatin receptor-positive gastroenteropancreatic neuroendocrine tumours (GEP NETs) in adults November 2018 September 2018 Pembrolizumab For treating relapsed or refractory classical Hodgkin lymphoma (TA 540) November 2018 September 2018 Inotuzumab ozogamicin For treating relapsed or refractory B-cell acute lymphoblastic (TA 541) leukaemia November 2018 October 2018 Cabozantinib For untreated advanced renal cell carcinoma (TA 542) November 2018 October 2018 Tofacitinib For treating active psoriatic arthritis after inadequate response to (TA 543) DMARDs November 2018 October 2018 Dabrafenib with trametinib
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