0 Illustration inspired by the work of Dorothy Hodgkin Springer Experiments The research solution for the life sciences

Dr. Robin Padilla Director of Product Management, Springer Nature Experiments

May. 19th 2021 1 Contents

1. Springer Protocols: General Overview

2. The Information Overload Problem

3. Springer Nature Experiments: General Overview

4. Springer Nature Experiments Demo & Upcoming Developments 2 Springer Protocols: General Overview

1 3 What are (Lab) Protocols?

Protocol: step-by-step instructions to execute lab techniques

● Standardized scientific procedure

● Any scientist anywhere must be able to follow and replicate

● Includes detailed list of materials, equipment, caution steps, troubleshooting, calculations

● Reliably deliver pre-defined results

● Protocols can be adapted/modified as needed 4 Protocols vs. “Other” Scientific Content

Research Article Method Protocol Reports new discoveries; Describes experiments & Step-by-step procedures to advancements, applications, etc. procedures to address scientific delivery specific outcomes question Includes section on methods & Nearly always includes multiple Can be applied/modified for materials, results, discussion protocols various methods and studies

Example: CRISPR is a fast, easy Example: Using CRISPR for gene Example: How to grow cells, way to edit DNA therapy in the eye amplify genes, analyze outcome 5 What do Protocols Look Like? Part 1 6 What do Protocols Look Like? Part 2 7 Why are Protocols so Important?

● Report how to get a desired lab result ● Are a critical pillar of experimental work: ● Necessary in both research and instructional settings; lab protocols are vital to current and future lab researchers 8

• Started in 1980; originally based on the classic book series “Methods in ”

• The single largest life science protocols collection

• ~180 book volumes & ~3,000 protocols published annually

• Content hosted on SpringerLink and searchable on Springer Nature Experiments

• No protocols removed, updated/alternate versions added

• Currently 58,000+ protocols

• 2019 Usage: 19 million+ downloads globally 9 10

Content Growth Volume distribution

70000 Methods in 24 Biotechnology 38 21

60000 47 Springer Protocols 147 Handbooks

141 50000 Non Series

40000 Neuromethods Number of ArticlesofNumber 30000 Methods in and

20000 Methods in Molecular Medicine 2015 2016 2017 2018 2019 2045

Publication Year Methods in Molecular Biology

• Approx. 10% content growth per year 11 The Information Overload Problem

2 12 Life Science Research Marches On

Scientific output grows 8-9% per year

Scientific output expected to double every 9 years

1) All documents indexed by Incites & Web of Science for all life science areas, 1988–2018. 2) “Global scientific output doubles every nine years”. Nature News Blog. May 7, 2014 13 The Ocean of Scientific Content • The Global Scientific Research 1-3 Landscape in 2018:

8,000,000 active researchers 3,700,000 patent applications 15,000 books released

2,200,000 journal articles published • And many other data sources: • Research data repositories3: ≥ 2,000 • Dark data4: ???

1) Research publications indexed by Clarivate Incites & Web of Science. Feb. 25 2019. 2) “The STM Report, 5th Edition”. International Association of STM Publishers, Oct. 2018. 3) World Intellectual Property Office. Dec. 3 2018. 4) Registry of Research Data Repositories, re3data.org. 5) “Dark analytics: Illuminating opportunities hidden within unstructured data”, Deloitte Insights Feb. 7, 2017 14 How Much Time Does it Take to Find...

• If 1 life science researcher searches for 20 minutes per day...

푚𝑖푛 푤표푟푘𝑖푛𝑔 푑푎푦푠 1 ℎ표푢푟 ℎ표푢푟푠 20 푑푎푦 x 250 푦푒푎푟 x 60 푚𝑖푛 = 83 푦푒푎푟

• If 2 million researchers1 search for 20 minutes per day...

ℎ표푢푟푠 푟푒푠푒푎푟푐ℎ푒푟푠 2,000,000 x 83 푦푒푎푟 =

ℎ표푢푟푠 · 푟푒푠푒푎푟푐ℎ푒푟 166,000,000 푦푒푎푟

1) This estimate is based on historical OECD data, InCites article output data, Springer Nature user survey demographics, and the National Science Foundation survey - Doctorate Recipients in the USA 15 Finding Appropriate Research Protocols is Very Inefficient

Library Other Website Publishers 16 Addressing the Challenges When Trying to Find and Implement Lab Protocols

• Quickly find relevant and reliable protocols

• Need multiple ways to evaluate the protocols

• Implement the procedure in one’s own distinctive environment

Develop a research solution specifically optimized for life THE IDEA science protocols and methods 17 The Search Platform

• Launched in October 2017

• Advanced platform to find and evaluate protocols and methods across the entire Springer Nature Protocols & Methods portfolio

• Platform optimized for the life sciences

• Free to search & accessible from any device: experiments.springernature.com 18 Springer Nature Experiments: General Overview

3 19 Springer Nature Experiments: An Advanced Discovery Layer

The largest and highest quality collection for protocols & methods is covered by Springer Nature Experiments! Springer Nature Protocols and Methods Portfolio 20 • The largest & most prestigious portfolio: critical resources for the training and support of life science researchers

• Faster in publishing • First to publish cutting • Publishes introductory • Based on “Methods in protocols for new edge methods, solving overviews of methods and Molecular Biology” series; techniques, with high impact important biological techniques pioneered the modern for future research. Based on questions protocol format with the newest innovative applications in all life science research areas

Unique & sophisticated search platform

• Launched in 2017, free-to-use from any device

• Unified search across the entire protocols and methods portfolio; advance search and sort options 21 A Wide Scope of Content – from Common to Niche Areas

• • Genetics/ • Molecular Medicine • • Imaging • • Biotechnology • Immunology • Pharmacology and Toxicology • Oncology • Infectious Diseases • Plant Science • • • Protein Science 22

Finding and Evaluating Procedures with Springer Nature Experiments

• Aggregated search across Springer Finding Nature Protocols and Methods content protocols - 70,000+ articles! and methods • Dedicated filters, optimized search, and AI-based indexing

• Extract relevant information for at-a- glance evaluation of the search results - Evaluating Search Page article relevance • Overview of the article’s key information - Evaluation Page 23 Springer Nature Experiments: Demo & Upcoming Developments

4 24 Springer Nature Experiments: Live Demo! 25 Springer Nature Experiments Purpose-built Search Logic

CONCEPT RECOGNITION SORTING OPTIONS Our powerful algorithm Order the results in the recognises techniques, most meaningful way, organisms and cell lines by relevance, in search queries publication time, citations, downloads

SEARCH FILTERS ARTICLES TECHNIQUES Narrow down results & MODELS by publication year, Each search result video, technique, snippet lists the article type or source techniques and models used in the article https://experiments.springernature.com/ 26 Springer Nature Experiments Unique Article Evaluation Pages

AUTHORS Complete list of authors with FIGURES & VIDEOS contact details Gain insight into the when provided techniques covered in the article and support RELATED ARTICLES complex manipulations Based on the use of similar research CITATIONS techniques To gauge successful and consistent application in other research projects

KEYWORDS Sorted by techniques and models https://experiments.springernature.com/ 27 Topic Pages: Browse – Explore – Discover

https://experiments.springernature.com/ 28 Springer Nature Experiments Key Benefits

Covering the largest and most Most established and prestigious comprehensive collection of books and journals in the protocols & methods protocols and methods field

Save valuable time assessing the Easily use powerful and relevance of each article with specialized searching features key information on the Article Evaluation pages 29 SN Experiments: Future Directions…

Reagents & Equipment Experimental Troubleshooting Research Workflow Integration 30 Thanks for your attention! Any questions? Feedback? Contact us!

Dr. Robin Padilla Product Director, Springer Nature Experiments [email protected] 31 Extras 32 Research Output at Helmholtz UFZ 33 Top Researchers by Publication & Area 34 Helmholtz UFZ Authors: Protocols & Methods 35

Knowledge Models

What is a Defined list of concepts falling under a certain category: for knowledge protocols and methods we start with techniques and model model? organisms

Why these These are the categories that users search - meaning we categories? optimize search and filtering options based on these

Why do we Our knowledge model helps recognize and automatically need a extract techniques and organisms mentioned in the articles to knowledge optimize search and add additional value beyond the content model? 36 Concept Extraction in Springer Nature Experiments

Existing knowledge House-built Springer Nature Springer models knowledge protocols & Nature Experiments model methods

Manual curation Automatic concept extraction (ML) Most relevant results