DOCSLIB.ORG

Restless Nocturnal Eating: a Common Feature of Willis-Ekbom Syndrome (RLS) Michael J

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Restless Nocturnal Eating: a Common Feature of Willis-Ekbom Syndrome (RLS) Michael J http://dx.doi.org/10.5664/jcsm.2036 Restless Nocturnal Eating: A Common Feature of Willis-Ekbom Syndrome (RLS) Michael J. Howell, M.D.1; Carlos H. Schenck, M.D.2 1Department of Neurology, University of Minnesota, Minneapolis, MN; 2Department of Psychiatry, University of Minnesota, Minneapolis, MN Study Objectives: To determine the frequency of nocturnal than INS (8%; p < 0.0001). Further, NE and SRED in RLS eating (NE) and sleep related eating disorder (SRED) in rest- were not secondary to dopaminergic therapy, as RLS patients less legs syndrome (RLS) versus psychophysiological insom- demonstrated a substantial drop (68% to 34%; p = 0.0026) in nia (INS), and the relationship of these conditions with dopami- the frequency of NE after dopamine agents were initiated, and nergic and sedative-hypnotic medications. there were no cases of dopaminergic agents inducing novel Design: Prospective case series. NE or SRED. Setting: Sleep disorders center. Conclusion: NE is common in RLS and not due to frequent Patients: Newly diagnosed RLS or INS. nocturnal awakenings or dopaminergic agents. Amnestic Intervention: RLS or INS pharmacotherapy with systematic SRED occurs predominantly in the setting of RLS mistreat- follow up interview for NE/SRED. ment with sedating agents. In light of previous reports, these Measurements and Results: Patients presenting with RLS fi ndings suggest that nocturnal eating is a non-motor manifes- (n = 88) or INS (n = 42) were queried for the presence of NE tation of RLS with several clinical implications discussed here. and SRED. RLS patients described nocturnal eating (61%) Keywords: Nocturnal eating, sleep related eating disorder, and SRED (36%) more frequently than INS patients (12% and restless legs syndrome, Willis-Ekbom Syndrome, psychophys- 0%; both p < 0.0001). These fi ndings were not due to arousal iological insomnia, dopaminergic therapy, sedative-hypnotics, frequency, as INS patients were more likely to have prolonged benzodiazepines/benzodiazepine receptor agonists nightly awakenings (93%) than RLS patients (64%; p = 0.003). Citation: Howell MJ; Schenck CH. Restless nocturnal eating: Among patients on sedative-hypnotics, amnestic SRED and a common feature of Willis-Ekbom Syndrome (RLS). J Clin sleepwalking were more common in the setting of RLS (80%) Sleep Med 2012;8(4):413-419. SCIENTIFIC INVESTIGATIONS estless legs syndrome, or Willis-Ekbom Syndrome (la- beled RLS), is characterized by an underlying discomfort, BRIEF SUMMARY R Current Knowledge/Study Rationale: This study compared the prev- primarily in the lower extremities that compels the affl icted to alence of NE and SRED in RLS to INS, a disorder with similar sleep move. These symptoms are relieved, although only momen- disruption to determine whether nocturnal feeding behavior in RLS is tarily, with movement and may interfere with sleep initiation merely “killing time.” We then prospectively determined therapeutic re- or maintenance.1 sponse with dopaminergic and sedative medications. RLS has been associated with non-motor phenomena. In par- Study Impact: TThis study expands the clinical manifestation of RLS to include restless eating and proves that NE and SRED can be relieved by ticular, patients with RLS often describe other comorbidities dopaminergic therapy. Further this study suggests that other parasom- 2 such as mood and anxiety disorders, as well as other noctur- nias (such as sleepwalking) may frequently be due to the mistreatment nal compulsions such as nocturnal smoking that interfere with of RLS with sedative agents. sleep.3 Further, patients with these non-motor manifestations of RLS have more severe motor restlessness as measured by the International RLS Rating Scale.3 upon SRED. However, we have noticed subtler non-dysfunc- Recently, an investigation demonstrated a high frequency of tional forms of NE, commonly in the setting of RLS. Also, we dysfunctional nocturnal eating (SRED) in patients with RLS. have noted that many cases of zolpidem-induced SRED had This community-based case-control study found that 33 of 100 been originally misdiagnosed as having psychophysiological RLS patients met criteria for SRED compared to only 1% of nor- insomnia (INS), a condition for which a benzodiazepine recep- mal population controls.4 The authors pondered whether SRED tor agonist was prescribed, but later noted to have underlying was related to underlying RLS brain pathology or whether it motor restlessness as the cause of their sleep diffi culties. was merely “killing time” during prolonged nocturnal awaken- To establish whether NE is common in RLS and whether ings, as previously suggested.5 Conversely it has been suggested NE is a product of frequent nocturnal awakenings, we com- SRED in RLS may be due to anti-RLS dopaminergic agents.6,7 pared the frequency of NE as well as SRED among patients Most investigations of nocturnal eating (NE; eating after an presenting with RLS and INS, a distinct condition of cognitive arousal from sleep, prior to terminal awakening) have focused hypervigilance that manifests with frequent nocturnal awaken- 413 Journal of Clinical Sleep Medicine, Vol. 8, No. 4, 2012 MJ Howell and CH Schenck One investigator (MJH) performed all clinical evaluations, us- Table 1—RLS versus psychophysiological insomnia ing a structured interview and examination. ICSD-2 criteria 1 RLS INS p value were used to diagnose both RLS and INS. Patients were ex- Total patients 88 42 cluded if they met criteria for both syndromes or if they had Gender (F/M) 63/25 23/19 0.0751 other causes of sleep initiation or maintenance failure. The most common disorder of exclusion was Circadian Rhythm Sleep Age (mean) 56.1 (CI = 2.67) 52.9 (CI = 4.35) 0.102 Disorder, Delayed Sleep Phase Type. BMI (mean) 32.4 (CI = 1.67) 28.2 (CI = 1.82) 0.0032 Once diagnosed with either RLS or INS, using a structured # NE3 54 (61%) 5 (12%) < 0.00011 1-page nocturnal eating questionnaire, patients were queried # SRED 32 (36%) 0 (0%) < 0.00011 1 about the frequency and characterization of both nocturnal # Pts who average at 56 (64%) 39 (93%) 0.0003 arousals and nocturnal eating. A prolonged nocturnal arousal least one prolonged (> 5 min) nightly was defined as lasting > 5 minutes. Previous exposure to do- awakening paminergic or sedative-hypnotic medication was specifically asked and documented. 1Fisher exact test (2-sided). 2Type 2 T-Test with 2 tails. 3NE: both non- A patient was considered to have NE if they admitted to noc- dysfunctional nocturnal eating and SRED. turnal eating at least once a month; inquiries were subsequently made into whether the feeding behavior was dysfunctional. SRED Table 2—Prior sedative exposure was diagnosed if recurrent nocturnal eating was present with one or more of the following criteria: (1) ingestion of unusual or ined- RLS INS ible substances, (2) difficulty falling back asleep or nonrestorative # Pts with exposure to 15 25 sleep, (3) sleep related injury or potentially injurious behaviors, benzodiazepine or BRA1 (4) morning anorexia, (5) or adverse health consequences.1 # Pts with amnestic 12/15 (80%) 2/25 (8%) p < 0.00012 SRED or Sleepwalking on If NE was present, the food types and subjective nature of the benzodiazepine or BRA feeding episodes were documented. In particular, the patient’s hunger, memory, and control of NE were all quantified. Bed 1Benzodiazepine receptor agonist. 2Fisher exact test (two-sided). partner report, if available, was also gathered. Further, RLS NE patients were asked whether they had restlessness symptoms at Table 3—Amnestic NE and sedative1 exposure the time of the NE. Both RLS and INS patients were then treated in a standard- RLS NE+ INS NE+ ized fashion and followed prospectively. The patients sleep ini- # Of NE patients with recall data 41 4 tiation and maintenance symptoms, restlessness, as well as NE # Of pts with complete or partial amnesia 23 (56%) 0 (0%) and SRED were serially evaluated with a structured follow-up Partial amnesia 7 0 interview. # On sedative (%) 2/7 (29%) N/A Complete amnesia 16 0 RESULTS # On sedative (%) 13/16 (81%) N/A # Without any amnesia 18 (44%) 4 (100%) RLS patients were overwhelmingly more likely to demon- # On sedative (%) 1/18 (6%) 2/4 (50%) strate NE and SRED than patients with INS, despite being less likely to have prolonged nocturnal awakenings (Table 1). Fur- 1Benzodiazepine or BRA (only one RLS patient was exposed to a ther, patients with RLS were far more likely to have amnestic benzodiazepine alone without a BRA). SRED or sleepwalking when exposed to sedative-hypnotics than patients with INS (Tables 2, 3). Examples of other para- ings. Moreover, we reviewed prior sedative-hypnotic exposure, somnia behaviors among RLS but not INS patients on sedating either benzodiazepines or benzodiazepine receptor agonists, to agents included amnestic sexual behavior and smoking. determine whether RLS patients were more likely to manifest Of the 12 RLS patients with sedative-induced SRED or sleep- amnestic SRED or other sleepwalking behaviors than patients walking, all had previously been misdiagnosed and treated as with INS. Finally, we followed RLS patients prospectively to having insomnia. Eleven of the 12 discontinued BRA once the evaluate the effect of dopaminergic agents on NE and SRED. diagnosis of RLS was made. All 11 patients described a cessa- tion of amnestic nocturnal events after stopping the BRA, with METHODS complete elimination of NE in 3 patients, while the remaining 8 patients had persisting wakeful NE that was subsequently Consecutive adult patients who presented to the University responsive to dopaminergic therapy (see dopaminergic treat- of Minnesota Medical Center, Sleep Disorders Center or the ment below). Conversely, in most patients with INS, treatment Minnesota Regional Sleep Disorders Center with a complaint (either CBT-I or sedative-hypnotic) was well tolerated. Only 2 of difficulty sleeping were screened for either RLS or INS. All INS patients had a report of BRA induced amnestic behavior, patients completed a 9-page comprehensive sleep questionnaire both isolated to one event, and are still on sedative-hypnotics.
Load more

Recommended publications
  • Obesity Without Sleep Apnea Is Associated with Daytime Sleepiness
    ORIGINAL INVESTIGATION Obesity Without Sleep Apnea Is Associated With Daytime Sleepiness Alexandros N. Vgontzas, MD; Edward O. Bixler, PhD; Tjiauw-Ling Tan, MD; Deborah Kantner, BS; Louis F. Martin, MD; Anthony Kales, MD Background: Daytime sleepiness and fatigue is a fre- onset of sleep, and total wake time were significantly quent complaint of obese patients even among those who lower, whereas the percentage of sleep time was signifi- do not demonstrate sleep apnea. cantly higher in obese patients compared with controls. In contrast, during the nighttime testing, obese patients Objective: To assess in the sleep laboratory whether obese compared with controls demonstrated significantly higher patients without sleep apnea are sleepier during the day wake time after onset of sleep, total wake time, and lower compared with healthy controls with normal weight. percentage of sleep time. An analysis of the relation be- tween nighttime and daytime sleep suggested that day- Methods: Our sample consisted of 73 obese patients time sleepiness in obese patients is a result of a circa- without sleep apnea, upper airway resistance syn- dian abnormality rather than just being secondary to drome, or hypoventilation syndrome who were consecu- nighttime sleep disturbance. tively referred for treatment of their obesity and 45 con- trols matched for age. All patients and healthy controls Conclusions: Daytime sleepiness is a morbid charac- were monitored in the sleep laboratory for 8 hours at night teristic of obese patients with a potentially significant im- and at 2 daytime naps, each for 1 hour the following day. pact on their lives and public safety. Daytime sleepiness in individuals with obesity appears to be related to a meta- Results: Obese patients compared with controls were bolic and/or circadian abnormality of the disorder.
    [Show full text]
  • Sleep-Related Movement Disorders and Disturbances of Motor Control
    REVIEW CORE Metadata, citation and similar papers at core.ac.uk Provided by Bern Open Repository and Information System (BORIS) CURRENT OPINION Sleep-related movement disorders and disturbances of motor control Panagiotis Bargiotas and Claudio L. Bassetti Purpose of review Review of the literature pertaining to clinical presentation, classification, epidemiology, pathophysiology, diagnosis, and treatment of sleep-related movement disorders and disturbances of motor control. Recent findings Sleep-related movement disorders and disturbances of motor control are typically characterized by positive motor symptoms and are often associated with sleep disturbances and consequent daytime symptoms (e.g. fatigue, sleepiness). They often represent the first or main manifestation of underlying disorders of the central nervous system, which require specific work-up and treatment. Diverse and often combined cause factors have been identified. Although recent data provide some evidence regarding abnormal activation and/or disinhibition of motor circuits during sleep, for the majority of these disorders the pathogenetic mechanisms remain speculative. The differential diagnosis is sometimes difficult and misdiagnoses are not infrequent. The diagnosis is based on clinical and video-polysomnographic findings. Treatment of sleep- related motor disturbances with few exceptions (e.g. restless legs/limbs syndrome) are based mainly on anecdotal reports or small series. Summary More state-of-the-art studies on the cause, pathophysiology, and treatment of sleep-related
    [Show full text]
  • Prevalence and Associated Factors of Nocturnal Eating Behavior And
    Journal of Clinical Medicine Article Prevalence and Associated Factors of Nocturnal Eating Behavior and Sleep-Related Eating Disorder-Like Behavior in Japanese Young Adults: Results of an Internet Survey Using Munich Parasomnia Screening Kentaro Matsui 1,2,3,4 , Yoko Komada 5 , Katsuji Nishimura 2, Kenichi Kuriyama 4 and Yuichi Inoue 1,6,* 1 Japan Somnology Center, Neuropsychiatric Research Institute, Tokyo 1510053, Japan; [email protected] 2 Department of Psychiatry, Tokyo Women’s Medical University, Tokyo 1628666, Japan; [email protected] 3 Clinical Laboratory, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo 1878551, Japan 4 Department of Sleep-Wake Disorders, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo 1878551, Japan; [email protected] 5 Liberal Arts, Meiji Pharmaceutical University, Tokyo 2048588, Japan; [email protected] 6 Department of Somnology, Tokyo Medical University, Tokyo 1608402, Japan * Correspondence: [email protected]; Tel.: +81-3-6300-5401 Received: 25 March 2020; Accepted: 21 April 2020; Published: 24 April 2020 Abstract: Nocturnal (night) eating syndrome and sleep-related eating disorder have common characteristics, but are considered to differ in their level of consciousness during eating behavior and recallability. To date, there have been no large population-based studies determining their similarities and differences. We conducted a cross-sectional web-based survey for Japanese young adults aged 19–25 years to identify factors associated with nocturnal eating behavior and sleep-related eating disorder-like behavior using Munich Parasomnia Screening and logistic regression. Of the 3347 participants, 160 (4.8%) reported experiencing nocturnal eating behavior and 73 (2.2%) reported experiencing sleep-related eating disorder-like behavior.
    [Show full text]
  • Personality Traits and Night Eating Syndrome in Women with Bulimia Nervosa and Binge Eating Disorder
    Personality Traits and Night Eating Syndrome in Women With Bulimia Nervosa and Binge Eating Disorder Natasha D Melunsky University College London https://orcid.org/0000-0003-0954-2132 Francesca Solmi UCL: University College London Zoë Haime UCL: University College London Sarah Rowe ( [email protected] ) UCL: University College London Virginia VW McIntosh University of Canterbury Janet D Carter University of Canterbury Jennifer Jordan University of Otago Research Article Keywords: binge eating disorder, bulimia nervosa, eating disorders, night eating syndrome, personality, trait Posted Date: February 18th, 2021 DOI: https://doi.org/10.21203/rs.3.rs-198585/v1 License: This work is licensed under a Creative Commons Attribution 4.0 International License. Read Full License Page 1/12 Abstract Purpose Evidence suggests that the harm avoidance personality type is more common among individuals with night eating syndrome (NES) than in the general population. Evidence of associations with other personality traits is limited. The current study investigated the association between a range of personality traits and NES. Methods Cross-sectional data were used from women with bulimia nervosa or binge eating disorder referred for treatment in an outpatient psychotherapy trial. Regression analyses were used to test associations between personality traits (measured with the Temperament and Character Inventory-Revised) and NES symptoms (measured with the Night Eating Questionnaire), adjusting for potential confounding variables. Results The sample included 111 women. Low cooperativeness scores were associated with greater NES symptoms in the multivariable model (mean difference: -.10, 95% condence intervals: -.20 to -.01, p = 0.033). There was weak evidence of associations between both high harm avoidance and low self-directedness personality traits and greater NES symptoms.
    [Show full text]
  • Active Reward Processing During Human Sleep: Insights from Sleep-Related Eating Disorder Lampros Perogamvros University of Geneva
    Washington University School of Medicine Digital Commons@Becker Open Access Publications 2012 Active reward processing during human sleep: Insights from sleep-related eating disorder Lampros Perogamvros University of Geneva Patrick Baud University Hospitals of Geneva Roland Hasler University Hospitals of Geneva Claude Robert Cloninger Washington University School of Medicine in St. Louis Sophie Schwartz University of Geneva See next page for additional authors Follow this and additional works at: https://digitalcommons.wustl.edu/open_access_pubs Recommended Citation Perogamvros, Lampros; Baud, Patrick; Hasler, Roland; Cloninger, Claude Robert; Schwartz, Sophie; and Perrig, Stephen, ,"Active reward processing during human sleep: Insights from sleep-related eating disorder." Frontiers in Neurology.3,. 168. (2012). https://digitalcommons.wustl.edu/open_access_pubs/2232 This Open Access Publication is brought to you for free and open access by Digital Commons@Becker. It has been accepted for inclusion in Open Access Publications by an authorized administrator of Digital Commons@Becker. For more information, please contact [email protected]. Authors Lampros Perogamvros, Patrick Baud, Roland Hasler, Claude Robert Cloninger, Sophie Schwartz, and Stephen Perrig This open access publication is available at Digital Commons@Becker: https://digitalcommons.wustl.edu/open_access_pubs/2232 CLINICAL CASE STUDY published: 27 November 2012 doi: 10.3389/fneur.2012.00168 Active reward processing during human sleep: insights from sleep-related eating disorder
    [Show full text]
  • Download PDF File
    guidelines Treatment of overweight and obesity during and after a pandemic. Let’s not wait for the development of complications — new guidelines for doctors Guidelines developed by Experts endorsed by the Polish Association for the Study of Obesity, Polish Psychiatric Association, Polish Society of Hypertension, Scientific Section of Telepsychiatry of the Polish Psychiatric Association, Polish Association of Cardiodiabetology, Polish Association of Endocrinology, and The College of Family Physicians in Poland Social patronage of the Foundation for People with Obesity OD-WAGA Magdalena Olszanecka-Glinianowicz1, Dominika Dudek2, Krzysztof J. Filipiak3, Marek Krzystanek4, Leszek Markuszewski5, Marek Ruchała6, Elżbieta Tomiak7 1Health Promotion and Obesity Management Unit, Department of Pathophysiology, Medical Faculty in Katowice, Medical University of Silesia, Polish Association for the Study of Obesity 2Department of Psychiatry, Collegium Medicum, Jagiellonian University in Cracow, Polish Psychiatric Association 31st Department and Clinic of Cardiology, Medical University of Warsaw, Polish Association of Hypertension 4Department of Psychiatric Rehabilitation, Medical Faculty in Katowice, Medical University of Silesia, Scientific Section of Telepsychiatry of the Polish Psychiatric Association 5Centre for Heart and Vascular Diseases, Internal and Metabolic Diseases, Faculty of Medical Sciences and Health Sciences, University of Humanities and Technology in Radom, Polish Association of Cardiodiabetology 6Department and Clinic of Endocrinology,
    [Show full text]
  • Sleep Disturbance As a Contributor to Pediatric Obesity: Implications and Screening Gitanjali Srivastava1*, Valerie O’Hara2 and Nancy Browne2
    ISSN: 2572-4053 Srivastava et al. J Sleep Disord Manag 2018, 4:019 DOI: 10.23937/2572-4053.1510019 Volume 4 | Issue 1 Journal of Open Access Sleep Disorders and Management REVIEW ARTICLE Sleep Disturbance as a Contributor to Pediatric Obesity: Implications and Screening Gitanjali Srivastava1*, Valerie O’Hara2 and Nancy Browne2 1Department of Medicine, Section of Endocrinology, Diabetes, Nutrition & Weight Management, Nutrition Check for and Weight Management Center, Boston University School of Medicine, Boston, USA updates 2Department of Pediatrics, Eastern Maine Medical Center, WOW Pediatric & Adolescent Weight & Cardiometabolic Clinic, Orono, Maine, USA *Corresponding author: Gitanjali Srivastava, MD, Department of Medicine, Section of Endocrinology, Diabetes, Nutrition & Weight Management, Nutrition and Weight Management Center, Boston University School of Medicine, 720 Harrison Avenue, Doctors Office Building, Suite 801D, Boston, MA 02118, USA, E-mail:[email protected] Abstract lescents is approximately 27% of school-aged children and 45% of adolescents; lower levels of parental edu- Obesity causes more than 200 medical disorders includ- ing cardiovascular disease, diabetes, hypertension, sleep cation, increased caffeine consumption, and presence apnea. In particular, the prevalence and rate of obesity in of electronics in the child’s bedroom overnight may be children and adolescents have increased with over 1/3 of predictive of insufficient sleep duration [2]. the US pediatric population afflicted with overweight and obesity. Though
    [Show full text]
  • Curbing Nocturnal Binges in Sleep-Related Eating Disorder
    pSYCHIATRY Curbing nocturnal binges in sleep-related eating disorder Sleepwalking-like behavior is a frequently undiagnosed cause of patients’ obesity s. G, age 39, has a body mass index® Dowden(BMI) >35 Health Media kg/m2 and is pursuing bariatric surgery to treat Mobesity. She is frustrated with dieting and describes a decade of Copyrightunconscious Fornocturnal personal eating, use only including peanut butter and uncooked spaghetti. This behavior began after her divorce 10 years ago. Initially she had partial recall of the nocturnal binges, but now describes full amnesia. Treatment for a depressive episode did not control her nocturnal eating. Sleep-related eating disorder (SRED) can be associated with disrupted sleep, weight gain, and major chronic morbidity. In SRED—involuntary eating while asleep, BENNETT with partial or complete amnesia—the normal suppres- PETER sion of eating during the sleep period is disinhibited. 2007 © The disorder can be idiopathic, associated with medi- cation use, or linked to other sleep disorders such as Michael J. Howell, MD Minnesota Regional Sleep Disorders Center somnambulism (sleepwalking), restless legs syndrome Hennepin County Medical Center (RLS), periodic limb movement disorder (PLMD), or Assistant professor, department of neurology obstructive sleep apnea (OSA). Carlos Schenck, MD SRED is more common in women than men; it Minnesota Regional Sleep Disorders Center usually begins in the third decade of life but can be- Hennepin County Medical Center Associate professor, department of psychiatry gin in childhood or middle age. About one-half of Scott J. Crow, MD SRED patients also have a psychiatric illness, usu- Director, Clinical Populations/Assessment Core ally a mood disorder.
    [Show full text]
  • The Implications of Hypersomnia in the Context of Major Depression: Results from a Large, International, Observational Study
    European Neuropsychopharmacology (2019) 29, 471–481 www.elsevier.com/locate/euroneuro The implications of hypersomnia in the context of major depression: Results from a large, international, observational study a a, b c a A. Murru , G. Guiso , M. Barbuti , G. Anmella , a, d ,e a ,f , g g h N. Verdolini , L. Samalin , J.M. Azorin , J. Jules Angst , i j k a, l C.L. Bowden , S. Mosolov , A.H. Young , D. Popovic , m c a, ∗ a M. Valdes , G. Perugi , E. Vieta , I. Pacchiarotti , For the BRIDGE-II-Mix Study Group a Barcelona Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain b Clinica Psichiatrica, Dipartimento di Igiene e Sanità, Università di Cagliari, Italy c Division of Psychiatry, Clinical Psychology and Rehabilitation, Department of Medicine, University of Perugia, Santa Maria della Misericordia Hospital, Edificio Ellisse, 8 Piano, Sant’Andrea delle Fratte, 06132, Perugia, Italy d FIDMAG Germanes Hospitalàries Research Foundation, Sant Boi de Llobregat, Barcelona, Catalonia, Spain e Division of Psychiatry, Clinical Psychology and Rehabilitation, Department of Medicine, Santa Maria della Misericordia Hospital, University of Perugia, Perugia, Italy f CHU Clermont-Ferrand, Department of Psychiatry, University of Auvergne, Clermont-Ferrand, France g Fondation FondaMental, Hôpital Albert Chenevier, Pôle de Psychiatrie, Créteil, France h Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Zurich,
    [Show full text]
  • Sleep-Related Eating Disorder in a Patient with Parkinson's Disease
    Open Access Case Report DOI: 10.7759/cureus.3345 Sleep-related Eating Disorder in a Patient with Parkinson's Disease Harleen Kaur 1 , Muhammad Umair Jahngir 2 , Junaid H. Siddiqui 2 1. Neurology, Univeristy of Missouri, Columbia, USA 2. Neurology, University of Missouri, Columbia, USA Corresponding author: Harleen Kaur, [email protected] Abstract Sleep disorders constitute a major aspect of the non-motor symptoms of Parkinson’s disease (PD). Rapid eye movement (REM) behavior disorders are the most frequently experienced parasomnias in patients with PD. Non-REM sleep disorders like confusional arousals, sleep terrors, sleepwalking, and sleep-related eating disorder (SRED) are also associated with PD. Parasomnias can affect the quality of life of the patients as well as the night time sleep of their bed partners. Hence, it is important for physicians to recognize the occurrence of parasomnias in PD. We report an unusual case of PD with SRED along with obstructive sleep apnea (OSA) and REM behavior disorder. To our knowledge, only two cases have been reported in the literature highlighting the association of SRED with PD. We also explain the different night-time eating disorders like nocturnal eating syndrome and binge eating syndrome, which can be seen in PD, and differentiate them from SRED. Categories: Neurology Keywords: parkinson\'s disease, parasomnias, sleep related eating disorder, sred, parkinson's disease Introduction Parkinson’s disease (PD) is a neurodegenerative disease with a spectrum of motor and non-motor symptoms. The non-motor symptoms of PD manifest as dysautonomia, cognitive changes, mood disorders, and sleep-related disorder. Parasomnias are frequently experienced in patients with PD as non-motor symptoms.
    [Show full text]
  • Sleep-Related Eating Disorder in a 29 Year-Old Man: a Case Report with Diagnostic Polysomnographic Findings
    106 Sleep-Related Eating Disorder in a 29 Year-Old Man: A Case Report with Diagnostic Polysomnographic Findings Shih-Bin Yeh1 and Carlos H. Schenck2 Abstract- This is a case of a 29-year-old man with a 6 year history of sleep-related eating disorder (SRED) that occurred with partial consciousness on a nightly basis. His family or wife witnessed up to 5 episodes every night, with each eating episode lasting 8-16 minutes. Polysomnography documented 4 episodes of sleep-related eating arising from stage 2 Non-REM sleep, when he consumed cookies that he had brought to the sleep lab that night. While eating, his EEG remained in stage 2 sleep or else was a wakeful EEG, and the eating episodes lasted for a mean 13.3 minutes. There was no epileptiform EEG activity during the polysomnogrphic study with a seizure montage and fast paper speed. Therapy with clonazepam, 0.5 mg bedtime, did not control the nocturnal eating. The patient tried to limit access to food in his home before bedtime, and this had modest benefit. This case of SRED has both typical and atypical features, which are discussed. Key Words: Sleep-related eating, Parasomnia, Eating disorder, Nocturnal eating, Sleepwalking, Clonazepam, Polysomnography Acta Neurol Taiwan 2007;16:106-110 INTRODUCTION four cases(2-3), until the formal identification of “sleep related eating disorder” (SRED) by Schenck et al. in Abnormal nocturnal eating was first reported by 1991(4). The initial reported series of 19 consecutive Stunkard et al. in 1955 as the “night-eating syndrome” patients was expanded to a larger series of 38 patients (NES) affecting 20 adults with refractory obesity who that was reported in 1993(5).
    [Show full text]
  • Relationship Between Night Eating Syndrome and Self-Esteem: a Cross-Sectional Population-Based Study in Karachi, Pakistan
    Open Access Original Article DOI: 10.7759/cureus.5540 Relationship between Night Eating Syndrome and Self-esteem: A Cross-sectional Population-based Study in Karachi, Pakistan Simran Batra 1 , Rohan Kumar Ochani 2 , Zahid Ali Memon 3 , Asim Shaikh 2 , Nazuk E. Qureshi 2 , Sameer Bhimani 4 , Muhammad Khalid Abbasi 5 , Arsala Farhan 2 , Suha S. Qureshi 6 , Kheenpal Das 7 1. Internal Medicine, Dow Medical College, Dow University of Health Sciences, Karachi, PAK 2. Internal Medicine, Dow University of Health Sciences, Karachi, PAK 3. Surgery, Civil Hospital Karachi, Dow University of Health Sciences, Karachi, PAK 4. Internal Medicine, Jinnah Sindh Medical University, Karachi, PAK 5. Internal Medicine, Ziauddin Medical College, Ziauddin University, Karachi, PAK 6. Internal Medicine, Ziauddin University, Karachi, PAK 7. Psychiatry, Civil Hospital Karachi, Dow University of Health Sciences, Karachi, PAK Corresponding author: Rohan Kumar Ochani, [email protected] Abstract Background The amount of literature shedding light upon eating disorders in developing countries, such as Pakistan, is scarce. This is partially because talking about such matters is considered taboo in the general population. Night Eating Syndrome’s (NES) link with depression and obesity has been established; however, presently, no study has been conducted which solely focuses on NES’s correlation with self-esteem. Therefore, to bridge this knowledge gap, we conducted this study to assess the prevalence of NES in Karachi and its association with self-esteem. Methods We conducted a cross-sectional study in August 2018 using convenience sampling in 395 individuals, out of which 197 belonged to the age group 18-24 and 198 to 25-30.
    [Show full text]