Erectile Dysfunction in Family Practice: The

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Erectile Dysfunction in Family Practice: The ERECTILE DYSFUNCTION IN FAMILY PRACTICE: THE PREVALENCE AND CLINICAL CORRELATES AMONG ADULT MALE PATIENTS PRESENTING AT THE GENERAL OUTPATIENTS DEPARTMENT, UNIVERSITY COLLEGE HOSPITAL, IBADAN. A DISSERTATION SUBMITTED TO THE FACULTY OF FAMILY MEDICINE OF THE NATIONAL POSTGRADUATE MEDICAL COLLEGE OF NIGERIA IN PARTIAL FULFILMENT OF THE REQUIREMENTS FOR THE FELLOWSHIP IN FAMILY MEDICINE BY ADEBUSOYE, LAWRENCE ADEKUNLE MB;BS(Ibadan) MAY 2008 ETHICAL APPROVAL 2 DEDICATION This dissertation is dedicated to Almighty God, my darling and supportive wife Adekemi and my children: Oluwadamilola, Oluwafemi and Oluwatobi. 3 CERTIFICATION We certify that this study has been carried out by Dr. LAWRENCE ADEKUNLE ADEBUSOYE in the General Outpatients’ Department, University College Hospital, Ibadan, Nigeria. Supervisors: ___________________________________ Dr M.M.A. Ladipo MB;BS (Ib), FMCGP (Nig), FWACP (FM). Consultant Family Physician Head, General Outpatients’ Department University College Hospital, Ibadan, Nigeria. _______________________________ Mr E.O. Olapade-olaopa FWACS, FRCS Consultant urologist Department of Surgery University College Hospital, Ibadan, Nigeria. 4 DECLARATION I do hereby declare that this work has not been presented to any other College or a body for examination purposes or elsewhere for publication. _________________________________ ADEBUSOYE, LAWRENCE ADEKUNLE MB,BS (Ibadan) 5 ACKNOWLEDGEMENT My gratitude goes to the Almighty God who sustained me through the Postgraduate programme in Family Medicine. I wish to express my sincere gratitude to my supervisors Dr M.M.A. Ladipo, trainer, mentor, and the Head of General Outpatients’ department of the University College Hospital, Ibadan and Mr E.O. Olapade-Olaopa for their support, guidance and encouragement. I acknowledge with gratitude Drs E. Ibeneme, I. Ajayi and A. Irabor for their support, training, guidance and assistance. My sincere appreciation goes to the resident doctors and the nursing staff of the General Outpatients’ department of University College Hospital, Ibadan for their support. Finally, I express my utmost appreciation for the encouragement, understanding and support of my wife and children throughout the period of this study. 6 TABLE OF CONTENTS PAGES TITLE PAGE ………………. ……………………i ETHICAL APPROVAL…………….. ……………ii DEDICATION……………………… ……………iii CERTIFICATION………………….. ……………………..iv DECLARATION…………………… ………….…...v ACKNOWLEDGEMENT……….. ..……….………….vi TABLE OF CONTENTS………… ..…………………..vii LIST OF TABLES……………….. …….……………...ix LIST OF FIGURES……………… …….………………...x LIST OF ABBREVIATIONS………. …………….xi ABSTRACT……………………. …………………..….xiii CHAPTER ONE - INTRODUCTION ……... 1 CHAPTER TWO - LITERATURE REVIEW …….7 CHAPTER THREE - SUBJECTS AND METHODS ……33 CHAPTER FOUR - RESULTS ……43 CHAPTER FIVE - DISCUSSION …….65 7 CONCLUSION - ………77 RECOMMENDATIONS - ………79 LIMITATIONS OF THE STUDY - ……… 80 REFERENCES - ………81 APPENDICES - ………....94 8 LIST OF TABLES PAGES Table 1 Sociodemographic characteristics of respondents 45 Table 2 Sociodemographic characteristics of respondents by severity of erectile dysfunction. 53 Table 3 Severity of erectile dysfunction by BMI 54 Table 4 Severity of erectile dysfunction by physical activities 55 Table 5 Severity of erectile dysfunction by chronic medical illnesses 57 Table 6 Severity of erectile dysfunction by medications use 59 Table 7 Severity of erectile dysfunction by lifestyle habits 61 Table 8 Severity of erectile dysfunction by sexual life and partner(s) satisfaction 62 Table 9 Severity of erectile dysfunction by frequency of sexual activities 63 9 LIST OF FIGURES PAGES FIGURE 1 Age distribution of respondents 46 FIGURE 2 Social class of respondents 47 FIGURE 3 BMI of respondents 48 FIGURE 4 Prevalence of erectile dysfunction 49 FIGURE 5 Prevalence of erectile dysfunction by Age group 50 10 LIST OF ABBREVIATIONS ADL - Activities of Daily Living AMD - Age- related Macular Degeneration BMI - Body Mass Index BPH - Benign Prostatic Hyperplasia. CDC - Center for Disease Control CED - Chronic Energy Deficiency COPD - Chronic Obstructive Pulmonary Disease DASH - Dietary Advice to Stop Hypertension DNA - Deoxyribonucleic Acid ED - Erectile dysfunction FBG - Fasting Blood Glucose GOPD - General Outpatients’ Department HIV/AIDS - Human Immunodeficiency Virus / Acquired Immune Deficiency Syndrome IIEF - International Index of Erectile Function JNC - Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure 11 NIDDM - Non Insulin Dependent Diabetes Mellitus NPTR - Nocturnal penile tumescence and rigidity testing RNA - Ribo-Nucleic Acid UCH - University College Hospital USA - United States of America WHO - World Health Organization Wonca - World Organization of Family Doctors (Formerly World Organization of Colleges and Academia of Family Medicine) 12 ABSTRACT BACKGROUND: The prevalence of erectile dysfunction (ED) is high globally, and it is increasing. Erectile dysfunction causes immense psychological distress in the sufferer which could lead to strained relationships, which lead to separation in the family and tense interpersonal relations with family and friends. ED causes mental stress, which leads to fearfulness, anxiety, depression, loss of self image and suicide in the sufferer. Erectile dysfunction is therefore an important public health problem which needs to be studied. This study among male patients presenting in a frontline hospital, will help the Family Physicians appreciate the magnitude of the problem among their male patients and ascertain the clinical correlates that exist in this environment. OBJECTIVES: The objectives of this study was to determine the prevalence of erectile dysfunction in this catchment area, and described its relationship to the physical characteristics, medical and psychosocial factors of the individuals, as well as its effect on the family relationship. MATERIALS AND METHODS: This was a descriptive cross-sectional study of four hundred and fifty adult male patients aged 18 to 70 years who presented at the General Outpatients’ Department of the University College Hospital, Ibadan between February 2005 and April 2005. They were interviewed with the International Index of Erectile Function (IIEF) questionnaire. 13 RESULTS: The overall prevalence of ED was 55.1%. The prevalence of the mild ED was 32.6%, moderate ED was 17.8%, whilst severe ED was 4.7%. The prevalence of ED increased significantly with age (p = 0.008) and its severity also worsened with increasing age. The prevalence of ED was found to be significantly associated with an increase in the social class of respondents (p = 0.011). The low level of physical activities was significantly associated with an increase in the prevalence of erectile dysfunction (p = 0.025). There was a significant association between the prevalence of erectile dysfunction and increase in BMI of the respondents (p = 0.012). Among the diabetic respondents, the prevalence of ED was 72.7%, while among the hypertensive, peptic ulcer disease and depressed respondents; it was 70.6%, 70.4% and 59.2% respectively. Additionally, the prevalence of ED in men taking medications for the treatment of chronic medical illnesses such as oral hypoglycemic agents, antidepressants, antihypertensive and peptic ulcer drugs was 87.5%, 83.3%, 57.1% and 50.0% respectively. As expected, the respondents’ dissatisfaction with sexual life was found to increase significantly with the severity of erectile dysfunction (p = 0.000). Partner(s) dissatisfaction with the respondents also increased significantly with the severity of erectile dysfunction (p = 0.000). The frequency of sexual activities was found to have a significant inverse association with the severity of erectile dysfunction in the respondents (p = 0.000). 14 CONCLUSION: The prevalence of erectile dysfunction was high among males in this setting. It was easily diagnosed in the primary care setting with the use of the IIEF questionnaire and clinical assessment. Efforts should be made by the Family physicians to detect this condition, find the possible aetiology or clinical correlates and institute management promptly to alleviate the social and psychological problems that result. 15 CHAPTER ONE 1.0 INTRODUCTION Traditionally, the term impotence had been used to describe the inability of the male to attain and maintain erection of the penis sufficient to permit satisfactory sexual intercourse1. The United States of America (U.S.A) National Institute of Health Consensus Development Panel on Impotence in 1992 identified the confusion in the definition and suggested a more precise term “erectile dysfunction”2. This is defined as the inability of the male to achieve an erect penis as part of an overall multifaceted process of male sexual function. This definition takes a variety of physical aspects with important psychological and behavioural overtones into consideration. The term erectile dysfunction is useful for practical diagnosis, and in the design of clinical trials with a high degree of objectivity2, 3. The aetiology of erectile dysfunction could be psychological, organic, or of mixed aetiology with both factors present2. The psychological causes are more common in young men less than 35 years of age and elderly men starting a new relationship2. These psychological aetiological factors include; problems in a relationship, anxiety about sexual performance, depression, bereavement, tiredness and stress, guilt about sex, unresolved homosexual feelings and an unattractive partner2, 3. Though, psychological factors
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