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Update on Streptococcus Suis Research and Prevention In pathogens Conference Report Conference Report Update on StreptococcusUpdate on suisStreptococcus Research and suis Research and Prevention Prevention in thein Era the of Era Antimicrobial of Antimicrobial Restriction: Restriction: 4th y † 4th InternationalInternational Workshop on Workshop S. suis on S. suis 1, 2,‡ 1, 3,‡ 2, 4,‡ 3, 4, Mariela Segura *, Virginia AragonMariela Segura, Susan L.*, Brockmeier Virginia Aragon , Conniez , Gebhart Susan L. Brockmeier, Astrid de z, Connie Gebhart z , 5,‡ 6,‡ 7,‡5, 8,‡6, 9,‡ 7, 8, Greeff , Anusak Kerdsin , AstridMark A de O’Dea Greeff , zMasatoshi, Anusak Kerdsin Okura ,z Mariette, Mark Saléry A O’Dea , z , Masatoshi Okura z, 10,‡ 9, 11,‡ 12,‡10, 13,14,‡ 11, 12, Constance Schultsz , Peter Valentin-WeigandMariette Saléry z, Constance, Lucy A. SchultszWeinert ,z ,Jerry Peter M. Valentin-Weigand Wells and z, Lucy A. Weinert z, 1, 13,14, 1, Marcelo Gottschalk * Jerry M. Wells z and Marcelo Gottschalk * 1 Research Group on Infectious Diseases1 Research in Producti Groupon on Animals Infectious and Diseases Swine and in Production Poultry Infectious Animals Diseases and Swine and Poultry Infectious Diseases Research Centre, Faculty of VeterinaryResearch Medicine, Centre, University Faculty of of Veterinary Montreal, Medicine, St-Hyacinthe, University QC J2S of 2M2, Montreal, St-Hyacinthe, QC J2S 2M2, Canada Canada 2 IRTA, Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la Universitat Autònoma de 2 IRTA, Centre de Recerca en SanitatBarcelona, Animal (CReSA, 08193 Bellaterra, IRTA-UAB), Spain; Campus [email protected] de la Universitat Autònoma de Barcelona, Bellaterra 08193, Spain;3 USDA,[email protected] ARS, National Animal Disease Center, Ames, IA 50010, USA; [email protected] 3 USDA, ARS, National Animal Disease4 College Center, of Veterinary Ames, IA Medicine,50010, USA; University [email protected] of Minnesota, St. Paul, MN 55108, USA; [email protected] 4 College of Veterinary Medicine,5 UniversityWageningen of Minnesota, Bioveterinary St. Paul, Research, MN 5510 82218, RA USA; Lelystad, [email protected] The Netherlands; astrid.degreeff@wur.nl 5 Wageningen Bioveterinary Rese6 arch,Faculty Lelystad of Public 8221 RA, Health, The KasetsartNetherlands; University [email protected] Chalermphrakiat Sakon Nakhon Province Campus, 6 Faculty of Public Health, Kasetsart SakonUniversity Nakhon Chalermphrakiat 47000, Thailand; Sako [email protected] Nakhon Province Campus, Sakon Nakhon 47000, Thailand; [email protected] Antimicrobial Resistance and Infectious Disease Laboratory, School of Veterinary and Life Sciences, 7 Antimicrobial Resistance and InfectiousMurdoch Disease University, Laboratory, Perth, School Western of Veteri Australianary 6150, and Life Australia; Sciences, [email protected] Murdoch University, Perth, Western8 Division Australia of Bacterial6150, Austra andlia; Parasitic [email protected] Diseases, National Institute of Animal Health, National Agriculture and 8 Division of Bacterial and Parasitic Diseases,Food Research National Organization, Institute ofTsukuba, Animal Health Ibaraki, National 305-0856, Agriculture Japan; mokura@a and ffrc.go.jp Food Research Organization, Tsukuba,9 French Ibaraki Agency 305-0856, for Veterinary Japan; [email protected] Medicinal Products-French Agency for Food, Environmental and 9 French agency for veterinary medicinalOccupational productsHealth - French Safety agency (Anses-ANMV), for food, environmental 35302 Foug andères, France; [email protected] occupational health safety (Anses-ANMV),10 Department Fougères of Global 35302, Health-Amsterdam France; [email protected] Institute for Global Health and Development and Department of 10 Department of Global Health-AmsterdamMedical Institute Microbiology, for Global Amsterdam Health and University Development Medical and Centers, Department University of of Amsterdam, Medical Microbiology, Amsterdam1105 University BP Amsterdam, Medical Centers, The Netherlands; University [email protected] of Amsterdam, 1105 BP Amsterdam, The Netherlands; [email protected] for Microbiology, University of Veterinary Medicine, 30173 Hannover, Germany; 11 Institute for Microbiology, [email protected] of Veterinary Medicine, Hannover, 30173, Germany; [email protected] Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, UK; [email protected] 12 Department of Veterinary Medicine,13 Host-Microbe University of Interactomics Cambridge, Cambridge, Group, Department CB3 0ES, Animal UK; [email protected] Sciences, Wageningen University and Research, 13 Host-Microbe Interactomics Group,6709 Department PG Wageningen, Animal Sciences, The Netherlands; Wageningen [email protected] University and Research, Wageningen, 6709 PG, The Nether14 lands;Department [email protected] of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, UK 14 Department of Veterinary Medicine,* Correspondence: University of Cambridge, [email protected] Cambridge CB3 0ES, (M.S.); UK [email protected] (M.G.); ‡ Co-authors are listed in alphabeticalTel.: order.+1-450-773-8521 (ext. 0080) (M.S.); +1-450-773-8521 (ext. 8374) (M.G.) * Correspondence: [email protected] 4th International (M.S.); [email protected] Workshop on Streptococcus suis was (M.G.); sponsored Tel.: +1- by the Organisation for Economic y 450-773-8521 x 0080 (M.S.); and; Tel.:Co-operation +1-450-773-8521 and Developmentx 8374 (M.G.) (OECD), Co-operative Research Programme on Biological Resource Management for Sustainable Agricultural Systems, whose financial support made it possible for most of the † The 4th International Workshop on Streptococcus suis was sponsored by the Organisation for Economic Co-operation and Development (OECD), Co- operative Research Programmeinvited on Biological speakers toResource participate Management in the workshop. for Sustainable Agricultural Systems,The whose opinions financial expressed support and arguments made it employedpossible for in thismost publication of the invited are the sole responsibility of the authors speakers to participate in the workshop.and do not necessarily reflect those of the OECD or of the governments of its Member countries. Co-authors are listed in alphabetical order. z The opinions expressed and arguments employed in this publication are the sole responsibility of Received: 19 April 2020; Accepted: 8 May 2020; Published: 13 May 2020 the authors and do not necessarily reflect those of the OECD or of the governments of its Member countries. Abstract: Streptococcus suis is a swine pathogen and a zoonotic agent afflicting people in close Received: 19 April 2020; Accepted:contact 8 May 2020; with Published: infected pigsdate or pork meat. Sporadic cases of human infections have been reported worldwide. In addition, S. suis outbreaks emerged in Asia, making this bacterium a primary health Abstract: Streptococcus suis is a concernswine pathogen in this partand a of zoonotic the globe. agent In afflicting pigs, S. people suis disease in close results contact in decreased performance and with infected pigs or pork meat. Sporadic cases of human infections have been reported worldwide. Pathogens 2020, 9, x; doi: FOR PEER REVIEWPathogens 2020, 9, 374; doi:10.3390/pathogens9050374www.mdpi.com/journ al/pathogens www.mdpi.com/journal/pathogens PathogensPathogens2020, 9 2020, 374, 9, x FOR PEER REVIEW 2 of 392 of 38 In addition, S. suis outbreaks emerged in Asia, making this bacterium a primary health concern in increasedthis part mortality, of the whichglobe. haveIn pigs, a significant S. suis disease economic results impact in decreased on swine productionperformance worldwide. and increased Facingmortality, the new which regulations have a in significant preventive economic use of antimicrobials impact on swine in livestockproduction and worldwide. lack of eff ectiveFacing the vaccines,new controlregulations of S. in suis preventiveinfections use is worrisome. of antimicrobials Increasing in livestock and sharing and oflack knowledge of effective on vaccines, this pathogencontrol is of utmostS. suis infections importance. is worrisome. As such,the Increasing pathogenesis and sharing and epidemiology of knowledge of on the this infection, pathogen is antimicrobialof utmost resistance, importance. progress As such, on the diagnosis, pathogenesis prevention, and epidemiology and control of were the infection, among the antimicrobial topics discussedresistance, during progress the 4th on International diagnosis, prevention, Workshop onandStreptococcus control were suis among(held the in topics Montreal, discussed Canada, during Junethe 2019). 4th ThisInternational review gathers Workshop together on Streptococcus recent findings suis on (held this importantin Montreal, pathogen Canada, from June lectures 2019). This performedreview by gathers lead researchers together recent from findings several countries on this important including pathogen Australia, from Canada, lectures France, performed Germany, by lead Japan,researchers Spain, Thailand, from several The Netherlands, countries UK,including and USA. Australia, Finally, policiesCanada, and France, recommendations Germany, Japan, for the Spain, manufacture,Thailand, quality The Netherlands, control, and use UK, of inactivatedand USA. autogenousFinally, policies vaccines and are recommendations addressed to advance for the this importantmanufacture, field quality in veterinary control,
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