Aristaless-Like Homeobox Protein 1 (ALX1) Variant Associated with Craniofacial Structure and Frontonasal Dysplasia in Burmese Cats
Developmental Biology 409 (2016) 451–458 Contents lists available at ScienceDirect Developmental Biology journal homepage: www.elsevier.com/locate/developmentalbiology Aristaless-Like Homeobox protein 1 (ALX1) variant associated with craniofacial structure and frontonasal dysplasia in Burmese cats Leslie A. Lyons a,f,n, Carolyn A. Erdman b,f, Robert A. Grahn c,f, Michael J. Hamilton d,f, Michael J. Carter e,f, Christopher R. Helps g, Hasan Alhaddad h, Barbara Gandolfi a,f a Department of Veterinary Medicine & Surgery, College of Veterinary Medicine, University of Missouri-Columbia, Columbia, MO 65211, USA b Department of Psychiatry, University of California-San Francisco, San Francisco, CA 94143, USA c Veterinary Genetics Laboratory, School of Veterinary Medicine, University of California-Davis, Davis, CA 96516, USA d Department of Cell Biology and Neuroscience, Institute for Integrative Genome Biology, Center for Disease Vector Research, University of California-Riv- erside, Riverside, CA 92521, USA e MDxHealth Inc, 15279 Alton Parkway, Suite #100, Irvine, CA 92618, USA f Department of Population Health and Reproduction, School of Veterinary Medicine, University of California-Davis, Davis, CA 95776, USA g Langford Veterinary Services, University of Bristol, Bristol BS40 5DU, UK h College of Science, Kuwait University, Safat, Kuwait article info abstract Article history: Frontonasal dysplasia (FND) can have severe presentations that are medically and socially debilitating. Received 2 October 2015 Several genes are implicated in FND conditions, including Aristaless-Like Homeobox 1 (ALX1), which is Received in revised form associated with FND3. Breeds of cats are selected and bred for extremes in craniofacial morphologies. In 3 November 2015 particular, a lineage of Burmese cats with severe brachycephyla is extremely popular and is termed Accepted 20 November 2015 Contemporary Burmese.
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