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DATA SHEET Goat anti-Flotillin 2 / FLOT2 (C Term) Antibody Item Number dAP-0498 Target Molecule Principle Name: Flotillin 2 / FLOT2 (C Term); Official Symbol: FLOT2; All Names and Symbols: FLOT2; flotillin 2; reggie-1; ESA; ESA1; M17S1; Flotillin 2 (epidermal surface antigen 1); ECS-1; ECS1; membrane component; chromosome 17; surface marker 1 (35kD protein identified by monoclonal antibody ECS-1); Accession Number (s): NP_004466.2; Human Gene ID(s): 2319; Non-Human GeneID(s): Immunogen SKIPLIKKATGVQV, is from C Terminus Applications Pep ELISA, WB, IHC Species Tested: Human Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied As lyophilized powder of 50ug or 100ug IgG; Reconsititute IgG with 100ul or 200ul sterile DI Water and final product will be formulated as 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing. Peptide ELISA Peptide ELISA: antibody detection limit dilution 1 to 32000. Western Blot Western Blot: Approx 48kDa band observed in Human Brain (Cerebellum), Lung and Testis lysates (calculated MW of 47.1kDa according to NP_004466.2). Recommended concentration: 0.1-0.3µg/ml. IHC Immunohistochemistry: Paraffin embedded Human Tonsil and Kidney. Recommended concentration: 3.75µg/ml. Reference Reference(s): Rajendran L, Masilamani M, Solomon S, Tikkanen R, Stuermer CA, Plattner H, Illges H. Asymmetric localization of flotillins/reggies in preassembled platforms confers inherent polarity to hematopoietic cells. Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8241-6. Epub 2003 Optimal dilutions should be determined by each laboratory for each application. The listed dilutions are for recommendation only and the final condi- tions should be optimized by the ender users! This product is sold for Research Use Only Angio-Proteomie | 11 Park Drive, Suite 12 Boston, MA 02215, USA | Tel: 001‐617‐549‐2665 | Fax: 001‐480‐247‐4337 | Email： [email protected] .

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Environmental Influences on Endothelial Gene Expression
ENDOTHELIAL CELL GENE EXPRESSION John Matthew Jeff Herbert Supervisors: Prof. Roy Bicknell and Dr. Victoria Heath PhD thesis University of Birmingham August 2012 University of Birmingham Research Archive e-theses repository This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder. ABSTRACT Tumour angiogenesis is a vital process in the pathology of tumour development and metastasis. Targeting markers of tumour endothelium provide a means of targeted destruction of a tumours oxygen and nutrient supply via destruction of tumour vasculature, which in turn ultimately leads to beneficial consequences to patients. Although current anti -angiogenic and vascular targeting strategies help patients, more potently in combination with chemo therapy, there is still a need for more tumour endothelial marker discoveries as current treatments have cardiovascular and other side effects. For the first time, the analyses of in-vivo biotinylation of an embryonic system is performed to obtain putative vascular targets. Also for the first time, deep sequencing is applied to freshly isolated tumour and normal endothelial cells from lung, colon and bladder tissues for the identification of pan-vascular-targets. Integration of the proteomic, deep sequencing, public cDNA libraries and microarrays, delivers 5,892 putative vascular targets to the science community.
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1 Supporting Information for a Microrna Network Regulates
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Evolutionarily Conserved Intercalated Disc Protein Tmem65 Regulates Cardiac Conduction and Connexin 43 Function
ARTICLE Received 11 Aug 2014 | Accepted 18 Aug 2015 | Published 25 Sep 2015 DOI: 10.1038/ncomms9391 Evolutionarily conserved intercalated disc protein Tmem65 regulates cardiac conduction and connexin 43 function Parveen Sharma1,*, Cynthia Abbasi1,*, Savo Lazic2, Allen C.T. Teng1, Dingyan Wang1, Nicole Dubois3, Vladimir Ignatchenko4, Victoria Wong5, Jun Liu6, Toshiyuki Araki4, Malte Tiburcy7, Cameron Ackerley8, Wolfram H. Zimmermann7, Robert Hamilton8,11, Yu Sun6, Peter P. Liu9, Gordon Keller3, Igor Stagljar5, Ian C. Scott2,8,11, Thomas Kislinger4,10 & Anthony O. Gramolini1,11 Membrane proteins are crucial to heart function and development. Here we combine cationic silica-bead coating with shotgun proteomics to enrich for and identify plasma membrane-associated proteins from primary mouse neonatal and human fetal ventricular cardiomyocytes. We identify Tmem65 as a cardiac-enriched, intercalated disc protein that increases during development in both mouse and human hearts. Functional analysis of Tmem65 both in vitro using lentiviral shRNA-mediated knockdown in mouse cardiomyocytes and in vivo using morpholino-based knockdown in zebraﬁsh show marked alterations in gap junction function and cardiac morphology. Molecular analyses suggest that Tmem65 interaction with connexin 43 (Cx43) is required for correct localization of Cx43 to the intercalated disc, since Tmem65 deletion results in marked internalization of Cx43, a shorter half-life through increased degradation, and loss of Cx43 function. Our data demonstrate that the membrane protein Tmem65 is an intercalated disc protein that interacts with and functionally regulates ventricular Cx43. 1 Department of Physiology, University of Toronto, Toronto General Hospital Research Institute, Toronto, Ontario, Canada M5G 1L7. 2 Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada M5S 1A8.
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Anti-Flotillin 2 (C-Terminal) Polyclonal Antibody (CABT-B1717) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use
Anti-Flotillin 2 (C-terminal) polyclonal antibody (CABT-B1717) This product is for research use only and is not intended for diagnostic use. PRODUCT INFORMATION Immunogen Synthetic peptide corresponding to the C-terminus of human Flotillin 2. Isotype IgG Source/Host Rabbit Species Reactivity Human, Rat, Mouse Purification Antigen Affinity Purified Conjugate Unconjugated Applications WB, ICC, IHC Epitope C-terminus Molecular Weight ~45 kDa observed. Uncharacterized bands may be observed in some lysate(s). Format Liquid Concentration Please refer to lot specific datasheet. Size 100 µL Buffer 1XPBS, 20% Glycerol (pH7), and 0.025% proclin. Preservative None Storage Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. BACKGROUND Introduction Flotillin-2 (also known as Epidermal surface antigen, ESA, or Membrane component chromosome 17 surface marker 1) is encoded by the FLOT2 gene (Entrez Gene ID 2319; also 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 1 © Creative Diagnostics All Rights Reserved known as ECS1, ECS-1, ESA1, M17S1) in human. Flotillin 2 is a caveolae-associated, integral membrane protein that is involved in Caveolae-mediated vesicular trafficking and signal transduction. GENE INFORMATION UniProt ID Q14254 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 2 © Creative Diagnostics All Rights Reserved.
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BASIC RESEARCH www.jasn.org Phosphoproteomic Analysis Reveals Regulatory Mechanisms at the Kidney Filtration Barrier †‡ †| Markus M. Rinschen,* Xiongwu Wu,§ Tim König, Trairak Pisitkun,¶ Henning Hagmann,* † † † Caroline Pahmeyer,* Tobias Lamkemeyer, Priyanka Kohli,* Nicole Schnell, †‡ †† ‡‡ Bernhard Schermer,* Stuart Dryer,** Bernard R. Brooks,§ Pedro Beltrao, †‡ Marcus Krueger,§§ Paul T. Brinkkoetter,* and Thomas Benzing* *Department of Internal Medicine II, Center for Molecular Medicine, †Cologne Excellence Cluster on Cellular Stress | Responses in Aging-Associated Diseases, ‡Systems Biology of Ageing Cologne, Institute for Genetics, University of Cologne, Cologne, Germany; §Laboratory of Computational Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland; ¶Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; **Department of Biology and Biochemistry, University of Houston, Houston, Texas; ††Division of Nephrology, Baylor College of Medicine, Houston, Texas; ‡‡European Molecular Biology Laboratory–European Bioinformatics Institute, Hinxton, Cambridge, United Kingdom; and §§Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany ABSTRACT Diseases of the kidney ﬁltration barrier are a leading cause of ESRD. Most disorders affect the podocytes, polarized cells with a limited capacity for self-renewal that require tightly controlled signaling to maintain their integrity, viability, and function. Here, we provide an atlas of in vivo phosphorylated, glomerulus- expressed
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And Post-Translationally N-Myristoylated Proteomes in Human Cells
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Table S1. 103 Ferroptosis-Related Genes Retrieved from the Genecards
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Supplementary Methods
1 SUPPLEMENTARY METHODS 2 3 Antibodies 4 Monoclonal antibodies used were against transglutaminase 2 (TG2) (IA12, 5 University of Sheffield, UK; CUB 7402, MA5-12739 Invitrogen, UK), α-smooth 6 muscle actin (α-SMA) [1A4] (ab7817, Abcam, UK) and flotillin-2 (FLOT2) (610383, 7 BD Transduction Laboratories, UK). Polyclonal antibodies used were against 8 syndecan-4 (SDC4) (ab24511, Abcam, UK), TG2 (ab421, Abcam, UK), cyclophilin- 9 A (ab41684, Abcam, UK), β-Tubulin (ab6046, Abcam, UK), hemagglutinin (HA) 10 (C29F4, Cell Signaling Technology, UK) and GFP (ab290, Abcam, UK). 11 12 Unilateral ureteric obstruction 13 Experimental unilateral ureteric obstruction (UUO) was performed in TG2-KO and 14 control (Wild Type, WT) C57BL/6J mice as described by Vielhauer et al. (2001).1 15 To perform UUO, mice were anaesthetized with 5% isoflurane and anesthesia 16 maintained with 2% isoflurane during the surgical process. The left ureter of the 17 mice was obstructed using a legating clip (Hemoclip Plus, Weck Closure Systems). 18 ADEPT® [4% (w/v) icodextrin solution] was dispensed in the peritoneum to 19 prevent post-surgical adhesions prior to closing. The muscle wall was sealed with 20 continuous stitching and skin wound closed with interrupted stitching using 21 absorbable sutures. After the procedure, buprenorphine (0.1 mg/kg) was 22 administered to the mice for pain-relieving. Animal were allowed free access to 23 standard rodent chow and tap water. Mice were sacrificed and the left kidneys 24 harvested 21 days post-operation. All experimental procedures were carried out 25 under license in accordance with regulations laid down by Her Majesty’s 26 Government, UK (Animals Scientific Procedures Act ASPA, 1986), and were 1 27 approved by the University of Sheffield Animal Ethical Review Committee (ASPA 28 Ethical Review Process) and Nottingham Trent University Ethical Review 29 Committee (ASPA Ethical Review Process).
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FLOT2 293 Cell Lysate Storage: Store at -80°C
From Biology to Discovery™ FLOT2 293 Cell Lysate Storage: Store at -80°C. Minimize freeze-thaw cycles. After addition of 2X SDS Loading Buffer, the lysates can be stored Subcategory: Cell Lysate at -20°C. Product is guaranteed 6 months from the date of Cat. No.: 401297 shipment. Unit: 0.1 mg For research use only, not for diagnostic or therapeutic Description: procedures. Antigen standard for flotillin 2 (FLOT2) is a lysate prepared from HEK293T cells transiently transfected with a TrueORF gene-carrying pCMV plasmid (OriGene Technologies, Inc.) and then lysed in RIPA Buffer. Protein concentration was determined using a colorimetric assay. The antigen control carries a C-terminal Myc/DDK tag for detection. Applications: ELISA, WB, IP Format: This product includes 3 vials: 1 vial of gene-specific cell lysate, 1 vial of control vector cell lysate, and 1 vial of loading buffer. Each lysate vial contains 0.1 mg lysate in 0.1 ml (1 mg/ml) of RIPA Buffer (50 mM Tris-HCl pH7.5, 250 mM NaCl, 5 mM EDTA, 50 mM NaF, 1% NP40). The loading buffer vial contains 0.5 ml 2X SDS Loading Buffer (125 mM Tris-Cl, pH6.8, 10% glycerol, 4% SDS, 0.002% Bromophenol blue, 5% beta-mercaptoethanol). Alternate Names: Flotillin 2 (epidermal surface antigen 1); membrane component chromosome 17 surface marker 1; membrane component, chromosome 17, surface marker 1 (35kD protein identified by monoclonal antibody ECS-1); FLOT2; ECS-1; ECS1; ESA; ESA1; M17S1 Accession No.: NP_004466 Application Notes: WB: Mix equal volume of lysates with 2X SDS Loading Buffer.
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