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Purina Reveals a Revolutionary Approach to Managing a Major Cat Allergen

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Purina Reveals a Revolutionary Approach to Managing a Major Cat Allergen PURINA REVEALS A REVOLUTIONARY APPROACH TO MANAGING A MAJOR CAT ALLERGEN THE SCIENCE BEHIND REDUCING ACTIVE FEL D 1 AT ITS SOURCE IN CATS’ SALIVA As many as 1 in 5 adults, worldwide, suffer from sensitivities to cat Allergies to cats affect 1,2 allergens. The main recommendation for people with these sensitivities is approximately 1 in 5 to avoid cats.3 Now, after more than 10 years of research, Purina scientists 1 discovered a new approach that can give people and cats a chance to stay adults worldwide. closer together. This safe and proven approach uses cat food coated with an egg product ingredient that neutralizes the major cat allergen, Fel d 1, at its source in cats’ saliva before the allergen gets into the environment.4,5 This offers people sensitized to cat allergens a way to reduce their exposure to the allergen, not the cat. A common problem for people and cats Cat allergens can impair quality of life for allergy sufferers by interfering with daily activities.6,7 They also limit interactions between the allergic person and cats. Allergy to cats is a common reason for relinquishment to shelters,8-13 as well as a barrier to cat ownership.9,14 Fel d 1 is the major cat allergen Fel d 1 is produced primarily in cats’ salivary and sebaceous glands, spread throughout the hair coat during grooming, and shed into the environment with hair and dander.15,17 All cats produce Fel d 1 regardless of breed, sex, age, hair length, hair color, or body weight.3,7,15,17-21 The function of Fel d 1 is not yet known, but studies suggest a pheromone or chemical signaling role.2,15,22 A new approach to allergen management Most methods of allergen management are effort-intensive, costly, and focus on managing exposure to the allergen in the environment.7,23 With Purina’s approach, the cat simply eats a nutritious food coated with an egg product ingredient containing anti-Fel d 1 antibodies.4,5 As the cat chews the kibble, the antibodies bind to active Fel d 1 in the cat’s saliva. Once bound, Fel d 1 is neutralized, and no longer recognized as an allergen. The neutralized Fel d 1 is transferred to the cat’s hair and dander during grooming, ultimately reducing active Fel d 1 levels in the environment. Neutralized Fel d 1 This approach does not stop a cat’s natural production of Fel d 1. A comprehensive safety study confirmed the ingredient is safe for cats.24 Purina’s breakthrough Proven science maintains normal allergen production by the cat 4,5 In peer-reviewed, published studies cats showed significant reductions of without affecting the cat’s active Fel d 1 in their saliva, and on their hair and dander, when fed a diet coated with an egg product ingredient containing anti-Fel d 1 antibodies. overall physiology. n 97% of cats showed reduced active Fel d 1 on their hair and dander.5 n 47% reduction, on average, of active Fel d 1 on cats’ hair beginning with the third week of feeding the diet.5 For more information on this 5 n 86% of cats had a reduction of at least 30% from baseline levels. breakthrough, visit Reducing active allergen levels can have real and positive impacts.25,26 www.PurinaInstitute.com Cat-allergic people exposed to dander from cats fed this diet showed significant reductions in nasal allergy symptoms and some ocular symptoms.25 This revolutionary new approach reduces exposure to the allergen, not to the cat—bringing cats and people closer together. References 1. Bousquet, P.-J., Chinn, S., Janson, C., Kogevinas, M., Burney, P. 10. Coe, J. B., Young, I., Lambert, K., Dysart, L., Borden, Journal of Feline Medicine and Surgery, 21(10), 867-874. doi: & Jarvis, D. (2007). Geographical variation in the prevalence L. N. & Rajic, A. (2014). A scoping review of published 10.1177/1098612X19850973 of positive skin tests to environmental aeroallergens in the research on the relinquishment of companion animals. 18. Butt, A., Rashid, D., & Lockey, R. F. (2012). Do hypoallergenic European Community Respiratory Health Survey I. Allergy, Journal of Applied Animal Welfare Science, 17, 253-273.doi: dogs and cats exist? Annals of Allergy, Asthma & Immunology, 62, 301-309. 10.1080/10888705.2014.899910 108, 74-76. doi: 10.1016/j.anai.2011.12.005 2. Zahradnik, E. & Raulf, M. (2017). Respiratory allergens from 11. Weiss, E., Gramann, S., Drain, N., Dolan, E., & Slater, M. 19. Salo, P. M., Cohn, R. D., & Zeldin, D. C. (2018). Bedroom furred mammals: environmental and occupational exposure. (2015). Modification of the Feline-AlityTM Assessment and the allergen exposure beyond house dust mites. Current Allergy Veterinary Sciences 4, 38. doi: 10.3390/vetsci4030038 ability to predict adopted cats’ behaviors in their new homes. and Asthma Reports, 18, 52. doi: 10.1007/s11882-018-0805-7 3. Dávila, I., Dominguez-Ortega, J., Navarro-Pulido, A., Alonso, Animals, 5, 71-88. doi: 10.3390/ani5010071 20. Nicholas, C., Wegienka, G., Havstad, S., Ownby, D., & A., Antolin-Amerigo, D., Gonzalez-Mancebo, E.,…Torrecillas, 12. Zito, S., Morton, J., Vankan, D., Paterson, M., Bennett, P. C., Johnson, C. C. (2008). Influence of cat characteristics on M. (2018). Consensus document on dog and cat allergy. Rand, J., Phillips, C. J. C. (2016). Reasons people surrender Fel d1 levels in the home. Annals of Allergy, Asthma & Allergy, 73(6), 1206-1222. doi: 10.1111/all.13391 unowned and owned cats to Australian animal shelters Immunology, 101, 47-50. 4. Satyaraj, E., Li, Q., Sun, P. & Sherrill, S. (2019). Anti-Fel d and barriers to assuming ownership of unowned cats. 21. Durairaj, R., Pageat, P., & Bienboire-Frosini, C. (2018). Another 1 immunoglobulin Y antibody-containing egg ingredient Journal of Applied Animal Welfare Science, 19, 303-319. doi: cat and mouse game: deciphering the evolution of the SCGB lowers allergen levels in cat saliva. Journal of Feline Medicine 10.1080/10888705.206.1141682 superfamily and exploring the molecular singularity of major and Surgery, 21(10), 875-881. doi: 10.1177/1098612X19861218 13. Svanes, C., Zock, J.-P., Anto, J., Dharmage, S., Norback, D., cat allergen Fel d1 and mouse ABP using computational 5. Satyaraj, E., Gardner, C., Filipi, I., Cramer, K. & Sherrill, S. Wjst, M., & the Early Life Working Group of the European approaches. PLoS ONE, 13(5), e0197618; doi: 10.1371/journal. (2019). Reduction of active Fel d 1 from cats using an antiFel Community Respiratory Health Survey. (2006). Do asthma pone.0197618 d 1 egg IgY antibody. Immunity, Inflammation & Disease, 7, and allergy influence subsequent pet keeping? An analysis 22. Björnsdottir, U. S., Jakobinudottir, S., Runarsdottir, V. & 68-73. doi: 10.1002/iid3.244 of childhood and adulthood. Journal of Allergy and Clinical Juliusson S. (2003). The effect of reducing levels of cat allergen 6. Leynaert, B., Neukirch, C., Liard, R., Bousquet, J. & Neukirch, Immunology, 118(3), 691-698. doi: 10.1016/j.jaci.2006.06.017 (Fel d1) on clinical symptoms in patients with cat allergy. F. (2000). Quality of life in allergic rhinitis and asthma: A 14. Bonnet, B., Messaoudi, K., Jacomet, F., Michaud, E. Fauquert, Annals of Allergy, Asthma and Immunology, 91, 189-194. population-based study of young adults. American Journal of J. L., Caillaud, D., & Evrard, B. (2018). An update on molecular 23. Matulka, R. A., Thompson, L. & Corley, D. (2019). Evaluation Respiratory and Critical Care Medicine, 162, 1391-1396. cat allergens: Fel d1 and what else? Chapter 1: Fel d1, the of a multi-level safety study of anti-Fel d1 IgY. 7. Cosme-Blanco, W., Arce-Ayala, Y., Malinow, I. & Nazario, major cat allergen. Allergy, Asthma and Clinical Immunology, 14, 14. doi: 10.1186/s13223-018-0239-8 24. Wedner, J., Satyaraj, E., Gardner, C., Al-Hammadi, N., Sherrill, S. (2018). Primary and Secondary Environmental Control S. & Mantia, T. (2019, June) Pilot study to determine effect of Measures for Allergic Diseases. In Mahmoudi, M. (Ed.), 15. Tsolakis, N., Malinovschi, A., Nordvall, L., Mattsson, L., feeding cat food made with egg product containing anti-Fel Allergy and Asthma (pp. 1-36). Switzerland: Springer Nature. Lidholm, J., Pedroletti, C.,...Alving, K. (2017). Sensitization d1 antibodies to cats on human allergy symptoms. Presented doi: 10.1007/978-3-319-58726-4_36-1 to minor cat allergen components is associated with type-2 at the annual meeting of the European Academy of Allergy 8. Eriksson, P., Loberg, J., & Andersson, M. (2009). A survey of biomarkers in young asthmatics. Clinical and Experimental and Clinical Immunology, Lisbon, Portugal. Allergy, 48(9), 1186-1194. doi: 10.1111/cea.13135 cat shelters in Sweden. Animal Welfare, 18, 283-288. 25. Wickman, M., Egmar, A.-C., Emenius, G., Almqvist, C., 9. American Humane Association. (2012). Keeping pets (dogs 16. Kelly, S. M., Karsh, J., Marcelo, J., Boeckh, D., Stepner, N., Berglind, N., Larsson, P. & Van Hage-Hamsten, M. (1999). Fel and cats) in homes: A three-phase retention study. Phase Litt, D.,...Yang, W. H. (2018). Fel d1 and Fel d4 levels in cat fur, d 1 and Can f1 in settled dust and airborne Fel d 1 in allergen I: Reasons for not owning a dog or cat. Retrieved from saliva and urine. Journal of Allergy and Clinical Immunology, avoidance day-care centres for atopic children in relation American Humane Association website: https://www. 142, 1990-1992.e3. doi: 10.1016/j.jaci.2018.07.033 to number of pet-owners, ventilation and general cleaning. americanhumane.org/app/uploads/2016/08/aha-petsmart- 17. Bastien, B., Gardner, C. & Satyaraj, E. (2019).
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