PURINA REVEALS A REVOLUTIONARY APPROACH TO MANAGING A MAJOR

THE SCIENCE BEHIND REDUCING ACTIVE FEL D 1 AT ITS SOURCE IN ’ SALIVA

As many as 1 in 5 adults, worldwide, suffer from sensitivities to cat Allergies to cats affect 1,2 . The main recommendation for people with these sensitivities is approximately 1 in 5 to avoid cats.3 Now, after more than 10 years of research, Purina scientists 1 discovered a new approach that can give people and cats a chance to stay adults worldwide. closer together. This safe and proven approach uses coated with an egg product ingredient that neutralizes the major cat allergen, Fel d 1, at its source in cats’ saliva before the allergen gets into the environment.4,5 This offers people sensitized to cat allergens a way to reduce their exposure to the allergen, not the cat.

A common problem for people and cats

Cat allergens can impair quality of life for allergy sufferers by interfering with daily activities.6,7 They also limit interactions between the allergic person and cats. Allergy to cats is a common reason for relinquishment to shelters,8-13 as well as a barrier to cat ownership.9,14

Fel d 1 is the major cat allergen

Fel d 1 is produced primarily in cats’ salivary and sebaceous glands, spread throughout the hair coat during grooming, and shed into the environment with hair and dander.15,17 All cats produce Fel d 1 regardless of breed, sex, age, hair length, hair color, or body weight.3,7,15,17-21 The function of Fel d 1 is not yet known, but studies suggest a pheromone or chemical signaling role.2,15,22 A new approach to allergen management

Most methods of allergen management are effort-intensive, costly, and focus on managing exposure to the allergen in the environment.7,23 With Purina’s approach, the cat simply eats a nutritious food coated with an egg product ingredient containing anti-Fel d 1 antibodies.4,5 As the cat chews the kibble, the antibodies bind to active Fel d 1 in the cat’s saliva. Once bound, Fel d 1 is neutralized, and no longer recognized as an allergen. The neutralized Fel d 1 is transferred to the cat’s hair and dander during grooming, ultimately reducing active Fel d 1 levels in the environment. Neutralized Fel d 1 This approach does not stop a cat’s natural production of Fel d 1. A comprehensive safety study confirmed the ingredient is safe for cats.24

Purina’s breakthrough Proven science maintains normal allergen production by the cat 4,5 In peer-reviewed, published studies cats showed significant reductions of without affecting the cat’s active Fel d 1 in their saliva, and on their hair and dander, when fed a diet coated with an egg product ingredient containing anti-Fel d 1 antibodies. overall physiology. n 97% of cats showed reduced active Fel d 1 on their hair and dander.5 n 47% reduction, on average, of active Fel d 1 on cats’ hair beginning with the third week of feeding the diet.5 For more information on this 5 n 86% of cats had a reduction of at least 30% from baseline levels. breakthrough, visit Reducing active allergen levels can have real and positive impacts.25,26 www.PurinaInstitute.com Cat-allergic people exposed to dander from cats fed this diet showed significant reductions in nasal allergy symptoms and some ocular symptoms.25 This revolutionary new approach reduces exposure to the allergen, not to the cat—bringing cats and people closer together.

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