DOCSLIB.ORG

Optimizing Reproductive Health in Women with Obesity and Infertility

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Optimizing Reproductive Health in Women with Obesity and Infertility REVIEW CPD Optimizing reproductive health in women with obesity and infertility Matea Belan MSc, Soren Harnois-Leblanc MSc, Blandine Laferrère MD, Jean-Patrice Baillargeon MD MSc n Cite as: CMAJ 2018 June 18;190:E742-5. doi: 10.1503/cmaj.171233 nfertility, defined as a failure to achieve a pregnancy after at least 12 months of regular and unprotected sexual inter- KEY POINTS course, affects 15% of all couples in Canada.1 Costs associ- • Obesity is a known risk factor for female infertility and can affect Iated with assisted reproductive technologies are growing, such maternal and newborn health. that equitable access to high-quality reproductive care is a chal- • Expert guidance recommends that women with obesity and lenge for health care systems. Obesity is a known modifiable risk infertility adopt a healthy lifestyle aimed at losing weight before factor for female infertility and can affect maternal health; it also natural or medically assisted conception. puts the offspring’s health at risk both as a newborn and later in • Lifestyle interventions promoting weight loss have, in most life (cardiometabolic health).2 As such, addressing obesity in studies, shown improvement of fertility in women with obesity, women seeking to become pregnant would be prudent, espe- mainly increasing the chance of spontaneous pregnancy. cially given that 25% of Canadian women of reproductive age are • Lifestyle modification is the preferred approach to preconception overweight (body mass index [BMI] 25–30) and 19% are obese weight loss, over bariatric surgery or pharmacologic agents. (BMI > 30).3 We review evidence on the effects of obesity on women’s fertility, recommendations regarding obesity manage- ment in women with infertility, and evidence of the benefits of women, there was a linear decline of 4% in the chances of a weight loss and lifestyle changes for fertility and pregnancy out- spontaneous pregnancy for each increase of one point in the BMI comes (Box 1 outlines our search strategy). score in obese women.9 Yet there are few existing cohort studies including obese women without PCOS, since the condition is What is the relation between obesity and fairly common, clinically exacerbated by obesity and the most women’s fertility? common cause of infertility in women.10,11 In women seeking fertility treatments, obesity was associated The risk of infertility is increased by 78% and 27% in women of with a decrease in pregnancy12,13 and live-birth rates.13 Further- childbearing age with obesity and overweight, respectively, as more, to achieve a pregnancy, women with obesity undergoing compared with women of normal weight (BMI 18.5–25).4 Obesity fertility treatments (intrauterine insemination or in vitro fertiliza- can negatively affect women’s fertility via menstrual and ovula- tion) are more likely to need higher doses of gonadotropin and tory disorders. Such disorders include polycystic ovary syndrome have more cancelled cycles12,14 and lower embryo quality.15 A (PCOS), the most common cause of female infertility, affecting meta-analysis found no associations between being overweight 6% to 10% of women of child-bearing age. Insulin resistance is and risks of ovarian hyperstimulation syndrome and multiple considered to play an important role in the association between pregnancies compared with normal-weight women, but reported PCOS and obesity, because elevated circulating levels of insulin a slight decline in the live-birth rate following assisted reproduc- stimulate androgen production by the ovaries.5 Moreover, higher tive technologies in obese women (odds ratio [OR] 0.90, 95% levels of circulating triglycerides and fatty acids, which are asso- confidence interval [CI] 0.82–1.00).11 ciated with obesity and insulin resistance, may directly induce androgen production in predisposed women.6 Obesity, especially What is the effect of maternal obesity at central obesity, exacerbates clinical features of PCOS:7,8 obesity conception on offspring? has a negative impact on the effectiveness of fertility treatments and confers a higher risk of pregnancy complications7 and Although fertility treatments are becoming more efficient in cardio metabolic diseases.5 However, the negative effects of obe- overcoming the effects of obesity on women’s fertility, prepreg- sity on women’s reproductive health are observed even in nancy and gestational obesity are serious risk factors for preg- women with no apparent ovulatory or menstrual dysfunctions. In nancy and neonatal complications. According to an extensive a large prospective cohort, with more than 3000 eumenorrheic systematic review of published reviews, pregnant women with E742 CMAJ | JUNE 18, 2018 | VOLUME 190 | ISSUE 24 © 2018 Joule Inc. or its licensors scribing any fertility treatments, according to guidance from Box 1: Evidence used in this review expert bodies.20–22 In 2010, the ESHRE pointed out that the goal of We searched PubMed to find relevant reviews on the subject 5% weight loss should not be mandatory to access fertility treat- published within the past 10 years. We used a small number of ments. However, lifestyle modifications before fertility treat- REVIEW keywords to broaden our research, mainly to reach all types of ments can improve success of the treatments, prevent preg- studies and interventions in obesity and fertility: [“weight loss” OR nancy and neonatal complications, and limit associated costs.20 “weight management”] AND [“lifestyle” OR “multidisciplinary intervention/program”] AND [“fertil*” OR “infertil*” OR “pregnan*”]. The search for these keywords was limited to titles Do lifestyle modifications and weight loss and abstracts. Corresponding to our criteria, a total of 78 reviews improve fertility outcomes in women with were proposed, of which we included the 6 most recent and obesity and infertility? relevant to the subject. We added 14 original research articles because they were considered milestone studies in their field. Ten articles representing guidelines from health organizations relevant Weight loss recommendations during the preconception period to the subject were also included in this review. in women with obesity and infertility are primarily based on studies conducted in women with PCOS, among whom studies have shown that lifestyle modification can improve metabolic obesity have significantly higher odds of gestational diabetes (OR and reproductive outcomes.24 Women with PCOS could benefit 3.01 to 5.55), preeclampsia (OR 2.93 to 4.14), antenatal (OR 1.43) more from weight loss than women without PCOS because, for and postpartum depression (OR 1.30), and cesarean delivery (OR the same degree of obesity, they tend to have higher central obe- 2.01 to 2.26), compared with normal-weight women.2 Newborns sity and insulin resistance,25 which are linked to adverse meta- born to mothers with obesity are at a higher risk of preterm birth bolic and reproductive outcomes.5 However, obesity and insulin (< 32 weeks’ gestation; adjusted OR 1.33, 95% CI 1.12–1.57), mac- resistance are important factors in the disturbance of the repro- rosomia (> 4500 g; OR 3.23, 95% CI 2.39–4.37), perinatal death ductive axis in women without PCOS as well.26 (relative risk 1.34, 95% CI 1.22–1.47) and congenital anomalies — A systematic review of 11 observational studies and random- including neural tube defects (OR 2.24, 95% CI 1.86–2.29) and ized controlled trials (RCTs), most of which included women cardiovascular anomalies (OR 1.30, 95% CI 1.12–1.51) — com- undergoing in vitro fertilization treatments, found that the inci- pared with newborns born to mothers with normal prepregnancy dence of spontaneous pregnancy and live birth was increased in weight.2,16 In addition, maternal prepregnancy BMI and excessive women allocated to a lifestyle intervention compared with con- gestational weight gain are consistently associated with early trols.27 Two three-arm RCTs involving women with obesity and development of obesity and diabetes in the offspring.17 This risk PCOS who were previously resistant28 or not29 to clomiphene may be carried through epigenetic mechanisms and perpetuates citrate reported that the combination of clomiphene citrate with the transgenerational vicious cycle of obesity and cardiometa- lifestyle intervention increased the women’s ovulation rates as bolic diseases.18 compared with clomiphene citrate alone. There are few studies that have assessed the benefits of life- How should physicians advise overweight and style interventions as first-line therapy in the general population of obese women who seek infertility treatment? women with obesity and infertility. An Australian research group reported in 1998 the fertility effects of a program that consisted of As outlined above, extensive data support strong associations weekly group sessions with supervised physical activity practices between obesity and infertility in women, as well as notable and workshops covering different nutritional topics.30 After pregnancy and neonatal complications for obese women. 12 months of follow-up, 90% of women who completed the inter- Accordingly, targeting women with obesity before conception vention resumed spontaneous ovulation, 78% conceived, of which may be essential to reduce the burden of infertility and costs of 33% conceived spontaneously, and 67% delivered a live newborn, fertility treatment, as well as obesity and cardiometabolic dis- as compared with none of the women in the control group. eases. As such, physicians should warn women with obesity A recent multicentre RCT
Load more

Recommended publications
  • European Academic Research
    EUROPEAN ACADEMIC RESEARCH Vol. IV, Issue 5/ August 2016 Impact Factor: 3.4546 (UIF) ISSN 2286-4822 DRJI Value: 5.9 (B+) www.euacademic.org Impact of Obesity on Serum Testosterone, Luteinizing Hormone and Follicular Stimulating Hormone levels in Sudanese Obese Male MOSYAB AWAD MOHAMED Clinical Chemistry Department Faculty of Medical Laboratory Sciences AL- Neelain University, Khartoum, Sudan MARIAM ABBAS IBRAHIM Clinical Chemistry Department College of Medical Laboratory Science Sudan University of Science and Technology Khartoum, Sudan Abstract: Obesity contributes to infertility by reducing semen quality, changing sperm proteomes, contributing to erectile dysfunction and inducing other physical problems related to obesity. The aim of this study was to provide current scenario linking obesity and male fertility. Obesity has been linked to male fertility because of lifestyle changes, internal hormonal environment alterations. The present study included 40 obese males as test group and the control group consists of 40 healthy males with normal weight, age was matched in two groups (30 ± 10 years). Estimation of testosterone, LH, and FSH levels was done by Enzyme Linked Immune Sorbent assay using an Instrument MAPLAP plus (ITALY). Statistical analysis was done by SPSS computer program and results showed a negative correlation of increasing BMI on testosterone level with a mean concentration of (1.0550 + 0.62755 ng/ml) in obese male and (2.9575 + 0.64127 ng/ml) in control subjects with (P. value =0. 00). However the results revealed a positive correlation of increasing BMI on FSH level with mean concentration of (4.0875 + 3.808 mlU/ml) in 4636 Mosyab Awad Mohamed, Mariam Abbas Ibrahim- Impact of Obesity on Serum Testosterone, Luteinizing Hormone and Follicular Stimulating Hormone levels in Sudanese Obese Male obese male and (2.9875 + 1.81266 mlU/ml) in control subjects with (P.
    [Show full text]
  • Prohibitin-Induced Obesity Leads to Anovulation and Polycystic Ovary in Mice Sudharsana Rao Ande1,*, Khanh Hoa Nguyen1,*, Yang Xin Zi Xu1 and Suresh Mishra1,2,‡
    © 2017. Published by The Company of Biologists Ltd | Biology Open (2017) 6, 825-831 doi:10.1242/bio.023416 RESEARCH ARTICLE Prohibitin-induced obesity leads to anovulation and polycystic ovary in mice Sudharsana Rao Ande1,*, Khanh Hoa Nguyen1,*, Yang Xin Zi Xu1 and Suresh Mishra1,2,‡ ABSTRACT and Dunphy, 2014). Along with the increase in the prevalence of Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder overweight and obesity in women, there has been an increase in and the most common cause of female infertility. However, its etiology anovulatory infertility (Giviziez et al., 2016). Androulakis et al. and underlying mechanisms remain unclear. Here we report that a (2014) reported that visceral adiposity index is related to the severity transgenic obese mouse (Mito-Ob) developed by overexpressing of anovulation and other clinical features in women with polycystic prohibitin in adipocytes develops polycystic ovaries. Initially, the ovaries. An increase in subcutaneous abdominal fat has also been female Mito-Ob mice were equally fertile to their wild-type littermates. associated with anovulation in women with obesity (Kuchenbecker The Mito-Ob mice began to gain weight after puberty, became et al., 2010). It is believed that anovulatory infertility accounts for significantly obese between 3-6 months of age, and ∼25% of them 25-50% of causes of female infertility (Weiss and Clapauch, 2014). had become infertile by 9 months of age. Despite obesity, female One of the main causes of anovulatory infertility is polycystic Mito-Ob mice maintained glucose homeostasis and insulin sensitivity ovaries (Ben-Shlomo et al., 2008; Messinis et al., 2015).
    [Show full text]
  • Obesity Occurring in Apolipoprotein E-Knockout Mice Has Mild Effects on Fertility
    REPRODUCTIONRESEARCH Obesity occurring in apolipoprotein E-knockout mice has mild effects on fertility Ting Zhang*, Pengyuan Dai1,*, Dong Cheng2, Liang Zhang1, Zijiang Chen, Xiaoqian Meng1, Fumiao Zhang1, Xiaoying Han1, Jianwei Liu1, Jie Pan1, Guiwen Yang1 and Cong Zhang Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Renji hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200135, China, 1Key Laboratory of Animal Resistance Research, College of Life Science, Shandong Normal University, 88 East Wenhua Road, Ji’nan, Shandong 250014, China and 2Shandong Center for Disease Control and Prevention, 16992 Jingshi Road, Ji’nan, Shandong 250014, China Correspondence should be addressed to C Zhang; Email: [email protected] *(T Zhang and P Dai contributed equally to this work) Abstract The Apolipoprotein (Apo) family is implicated in lipid metabolism. There are five types of Apo: Apoa, Apob, Apoc, Apod, and Apoe. Apoe has been demonstrated to play a central role in lipoprotein metabolism and to be essential for efficient receptor-mediated plasma K K clearance of chylomicron remnants and VLDL remnant particles by the liver. Apoe-deficient (Apoe / ) mice develop atherosclerotic plaques spontaneously, followed by obesity. In this study, we investigated whether lipid deposition caused by Apoe knockout affects K K reproduction in female mice. The results demonstrated that Apoe / mice were severely hypercholesterolemic, with their cholesterol metabolism disordered, and lipid accumulating in the ovaries causing the ovaries to be heavier compared with the WT counterparts. In addition, estrogen and progesterone decreased significantly at D 100. Quantitative PCR analysis demonstrated that at D 100 the expression of cytochromeP450 aromatase (Cyp19a1), 3b-hydroxysteroid dehydrogenase (Hsd3b), mechanistic target of rapamycin (Mtor), and nuclear factor-kB(Nfkb) decreased significantly, while that of BCL2-associated agonist of cell death (Bad) and tuberous K K sclerosis complex 2 (Tsc2) increased significantly in the Apoe / mice.
    [Show full text]
  • Obesity and Reproduction: a Committee Opinion
    Obesity and reproduction: a committee opinion Practice Committee of the American Society for Reproductive Medicine American Society for Reproductive Medicine, Birmingham, Alabama The purpose of this ASRM Practice Committee report is to provide clinicians with principles and strategies for the evaluation and treatment of couples with infertility associated with obesity. This revised document replaces the Practice Committee document titled, ‘‘Obesity and reproduction: an educational bulletin,’’ last published in 2008 (Fertil Steril 2008;90:S21–9). (Fertil SterilÒ 2015;104:1116–26. Ó2015 Use your smartphone by American Society for Reproductive Medicine.) to scan this QR code Earn online CME credit related to this document at www.asrm.org/elearn and connect to the discussion forum for Discuss: You can discuss this article with its authors and with other ASRM members at http:// this article now.* fertstertforum.com/asrmpraccom-obesity-reproduction/ * Download a free QR code scanner by searching for “QR scanner” in your smartphone’s app store or app marketplace. he prevalence of obesity as a exceed $200 billion (7). This populations have a genetically higher worldwide epidemic has underestimates the economic burden percent body fat than Caucasians, T increased dramatically over the of obesity, since maternal morbidity resulting in greater risks of developing past two decades. In the United States and adverse perinatal outcomes add diabetes and CVD at a lower BMI of alone, almost two thirds of women additional costs. The problem of obesity 23–25 kg/m2 (12). and three fourths of men are overweight is also exacerbated by only one third of Known associations with metabolic or obese, as are nearly 50% of women of obese patients receiving advice from disease and death from CVD include reproductive age and 17% of their health-care providers regarding weight BMI (J-shaped association), increased children ages 2–19 years (1–3).
    [Show full text]
  • Obesity and Female Fertility: a Primary Care Perspective Scott Wilkes, Alison Murdoch
    REVIEW J Fam Plann Reprod Health Care: first published as 10.1783/147118909788707995 on 1 July 2009. Downloaded from Obesity and female fertility: a primary care perspective Scott Wilkes, Alison Murdoch Abstract obese women. Body mass index (BMI) treatment limits for ART throughout the UK vary. The mainstay for treatment Infertility affects approximately one in six couples during is weight loss, which improves both natural fertility and their lifetime. Obesity affects approximately half of the conception rates with ART. The most cost-effective general population and is thus a common problem among treatment strategy for obese infertile women is weight the fertile population. Obese women have a higher reduction with a hypo-caloric diet. Assisted reproduction is prevalence of infertility compared with their lean preferable in women with a BMI of 30 kg/m2 or less and counterparts. The majority of women with an ovulatory weight loss strategies should be employed within primary disorder contributing to their infertility have polycystic care to achieve that goal prior to referral. ovary syndrome (PCOS) and a significant proportion of women with PCOS are obese. Ovulation disorders and Keywords family practice, infertility, obesity, polycystic obesity-associated infertility represent a group of infertile ovary syndrome, primary care couples that are relatively simple to treat. Maternal morbidity, mortality and fetal anomalies are increased with obesity and the success of assisted reproductive J Fam Plann Reprod Health Care 2009; 35(3): 181–185 technology (ART) treatments is significantly reduced for (Accepted 22 April 2009) Introduction Key message points Obesity is an increasing problem encountered by general practitioners (GPs) and its impact on fertility is significant.
    [Show full text]
  • Review on Effects of Obesity on Male Reproductive System and the Role of Natural Products
    Journal of Applied Pharmaceutical Science Vol. 9(01), pp 131-141, January, 2019 Available online at http://www.japsonline.com DOI: 10.7324/JAPS.2019.90118 ISSN 2231-3354 Review on effects of obesity on male reproductive system and the role of natural products Joseph Bagi Suleiman1, Ainul Bahiyah Abu Bakar2, Mahaneem Mohamed3* 1Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Malaysia and Department of Science Laboratory Technology, Akanu Ibiam Federal Polytechnic, Unwana, Nigeria. 2Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Malaysia. 3Department of Physiology and Unit of Integrative Medicine, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Malaysia. ARTICLE INFO ABSTRACT Received on: 15/07/2018 Obesity is a major complex disease caused by the interaction of a myriad of genetic, dietary, lifestyle, and Accepted on: 28/08/2018 environmental factors that lead to increased body fat mass. Over the years, it has grown to pandemic proportions Available online: 31/01/2019 affecting many children, adolescents, and young adults exposed to this disorder for a longer period. Overactivity of aromatase cytochrome P450 enzyme which leads to increases of estrogen disrupting the hypothalamus–pituitary axis, leptin secretion in testicular tissues, scrotal temperature, adipocytes’ environmental toxins/other toxic species, and Key words: vascular endothelial dysfunction have been implicated in obesity. The use of natural products and their derivatives has Natural products, obesity, been historically valuable as sources of therapeutic agents in the treatment of several metabolic disorders including pre-testicular, testicular, post- obesity. This review aims at looking the effect of natural products on obesity at pre-testicular, testicular, and post- testicular, male reproductive testicular levels of the male reproductive system which will be discussed.
    [Show full text]
  • CHAPTER 18 Nutrition and Reproduction
    CHAPTER 18 Nutrition and Reproduction Nanette Santoro Alex J. Polotsky Jessica Rieder Laxmi A. Kondapalli In males, pulsatile gonadotropin-releasing hormone (GnRH) characterized molecule to date is leptin. It has been shown and gonadotropin secretion occurs at a mean interval of in both animal models10 and in humans that inadequate leptin every 2 hours,1 a frequency sufficient to maintain testosterone is associated with lack of GnRH secretion, and that leptin secretion, normal virilization, and spermatogenesis. In females, replacement can restore normal cycles in women who have a more complex series of gonadal tasks must be accomplished, hypothalamic amenorrhea and hypoleptinemia.11 However, which include maturation of a single follicle, follicular rupture leptin alone is insufficient to initiate pubertal maturation of and ovulation, and corpus luteum formation. The mature the hypothalamic-pituitary-gonadal (HPG) axis and a specific female hypothalamic-pituitary-ovarian (HPO) axis must leptin concentration or threshold, above which maturation respond dynamically with negative and then positive (bimodal) occurs, has not been identified.12 feedback to rising estradiol, which is secreted by the develop- One of the final common pathways that appears to activate ing follicle.2 The positive feedback response, in the form of GnRH-LH secretion during puberty involves kisspeptin a luteinizing hormone (LH) surge, must be sufficient to and its cognate receptor, G-protein coupled receptor-54 initiate the molecular events of follicle rupture and subsequent (GPR54).13 Kisspeptin appears to act directly on GnRH luteinization. Optimal functioning of the female reproductive neurons and amplifies GnRH and consequently LH and system requires more versatility of the HPO axis, and this follicle-stimulating hormone (FSH) secretion.
    [Show full text]
  • Impact of Body Mass Index on Female Fertility and ART Outcomes
    •C 2018 EDIZIONIMil\1lRVAMED!CA PanmincrvaMcdica 2019 March:61{1):58-67 Online version at http:/!\,.\,.\,·.111111ervi1med1ca.1t DOI 10.21716/SOOl l-OROR.18.01490-0 REVIEW HOT TOPICS IN FEMALE INFERTILITY Impact of Body Mass Index on female fertility and ART outcomes Majdi IMTERAT 1, Ashok AGARWAL 2, Sandro C. ESTEVES\ Jenna MEYER 4, Avi HARLEY 1, 2 * JDepanmenL of Obstetrics and Gynecology. Soroka University Medical Center, Ben-Gurion University of the Negev. Beer-Sheva, Israel; 2American Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, CSA; 3Andrology and Human Reproduction Clinic, Al\-nROFERT. Referral CenLer for :Viale Reproduction, Campinas. Brazil; 4f'aculty of Health Sciences, Ben-Gurion University of Lhe Negev, Beer-Sheva, Israel �conesponding author: Avi Harlev, Depa1tment of Obstetricsand Gynecolq,,y, Soroka University rv!edical Center, l 5 l l7ak H.ager Ave. Heer-Sheva 84101, Israel. E-mail: harlev(fi;b1,'l1ac. il ABSTRACT As the global mean Body l\fass Index (B!l:fI) is on the rise, the importance of understanding exactly how female fertility is impacted by once outlier BMl values, becomes ever more important. Studies have 1mphcatcd abnormal BMl on the female reproductive system by contributing to anovulatio11, irregular menses, adverse oocyte quality, endometrial alterations,and hormonal imbalances. These well ultimately result in female infertility, which could complicate natural conception efforts and request considcrmg assisted reproductrve technology ( ART) in such couples. vVitl1 an increase in the demand for ART, it is crucial to understand what factors can be alteredby the female BMI in order to maximize tl1e op­ porn1nityfor successfulpregmmcy. The current manuscnpt aimed to review the information about the effectof Bl\:11 on the female fertilityand ART out.rnmes.
    [Show full text]
  • The Obesity-Fertility Protocol
    Duval et al. BMC Obesity (2015) 2:47 DOI 10.1186/s40608-015-0077-x STUDY PROTOCOL Open Access The Obesity-Fertility Protocol: a randomized controlled trial assessing clinical outcomes and costs of a transferable interdisciplinary lifestyle intervention, before and during pregnancy, in obese infertile women Karine Duval1,2, Marie-France Langlois1,2, Belina Carranza-Mamane1,3,4, Marie-Hélène Pesant1,2, Marie-France Hivert1,2, Thomas G. Poder1,5,6, Hélène B. Lavoie4,7, Youssef Ainmelk3, Denise St-Cyr Tribble8, Sheila Laredo9, Ellen Greenblatt10, Margaret Sagle11, Guy Waddell3, Serge Belisle12, Daniel Riverin13, Farrah Jean-Denis1, Matea Belan1,2 and Jean-Patrice Baillargeon1,2* Abstract Background: Obesity in infertile women increases the costs of fertility treatments, reduces their effectiveness and increases significantly the risks of many complications of pregnancy and for the newborn. Studies suggest that even a modest loss of 5–10 % of body weight can restore ovulation. However, there are gaps in knowledge regarding the benefits and cost-effectiveness of a lifestyle modification program targeting obese infertile women and integrated into the fertility clinics. This study will evaluate clinical outcomes and costs of a transferable interdisciplinary lifestyle intervention, before and during pregnancy, in obese infertile women. We hypothesize that the intervention will: 1) improve fertility, efficacy of fertility treatments, and health of mothers and their children; and 2) reduce the cost per live birth, including costs of fertility treatments and pregnancy outcomes. Methods/Design: Obese infertile women (age: 18–40 years; BMI ≥30 kg/m2 or ≥27 kg/m2 with polycystic ovary syndrome) will be randomised to either a lifestyle intervention followed by standard fertility treatments after 6 months if no conception has been achieved (intervention group) or standard fertility treatments only (control group).
    [Show full text]
  • Original Article Correlation Between Body Mass Index of Chinese Males and Assisted Reproductive Technology Outcome
    Int J Clin Exp Med 2015;8(11):21472-21476 www.ijcem.com /ISSN:1940-5901/IJCEM0011432 Original Article Correlation between body mass index of Chinese males and assisted reproductive technology outcome Zhengmu Wu, Xiang Lu, Min Wang, Huaijin Cheng Reproductive Medical Center, International Peace Maternity and Child Health Hospital Affiliated, Shanghai Jiao Tong University, Shanghai, China Received June 14, 2015; Accepted November 2, 2015; Epub November 15, 2015; Published November 30, 2015 Abstract: Objective: To investigate the relationship between male’s body mass index (BMI) and the outcome of as- sisted reproductive technology (ART). In this retrospective study, we analyzed the data from 729 cycles of female patients aged 38 years or less, with normal BMI and who received IVF treatments between January, 2013 and June, 2014. The patients were divided into normal weight (n = 358), overweight (n = 267), and obese (n = 104) groups according to the BMI of their male partners. Embryonic development and pregnancy outcomes in these three groups were compared. Results: With increasing BMI, fertilization rates decreased proportionately (P < 0.05); but embry- onic cleavage rates and effective embryo rates were not significantly affected (P > 0.05). There was no significant difference in implantation rates, pregnancy rates, or early miscarriage rates (P > 0.05) among the three groups. Conclusions: High male BMI affects fertilization rate with ART; and we recommend that men of reproductive age adjust their lifestyles accordingly and make efforts to control their weight. Keywords: Obesity, infertility, assisted reproductive technology, pregnancy outcome Introduction between male body weight and ART outcomes in China has not been examined extensively.
    [Show full text]
  • Effect of Obesity on Fertility
    Review Bezmialem Science 2015; 3: 78-82 DOI: 10.14235/bs.2015.532 Effect of Obesity on Fertility Nilay KARACA, Gonca BATMAZ, Serdar AYDIN Department of Obstetrics and Gynecology, Bezmialem Vakif University School of Medicine, İstanbul, Turkey ABSTRACT Prior studies have shown that obesity causes many gynecologic and obstetric disorders, including anovulation, irregular periods, sub- fertility, abortion, and adverse pregnancy outcomes. Obesity-related infertility or reduced fertility problems were influenced by any step from follicular recruitment to implantation. Adverse effects in reproductive health were not subjected out of entire obese women. Physical activity and nutrition were shown to be the probable determining factors. Assisted reproductive techniques provide obese women with an opportunity to investigate the relationship with pregestational status and reproductive outcomes as well. Although there is a lack of epidemiological data, an association between obesity and abortion is already known in obese women who had spontaneous pregnancy. This study aimed to investigate the effects of obesity among various stages of the reproductive process in recent studies, to summarize multidisciplinary strategies, and to facilitate reproductive outcomes in obese women. Keywords: Obesity, infertility, body mass index, assisted reproductive technology Introduction The term “obesity” comes from the Latin word “obere (obesusu),” which means “over eat,” and it is defined as the presence of an extreme amount of fat tissue in the body (1). Body mass index (BMI) is classified consider- ing the ratio of human body weight in kilograms to squared height in meters. According to this classification, a BMI of 18.5–24.9 kg/m2 is accepted as normal. People with BMI values between 25 and 29.9 kg/m2are over- weight, those with BMI values between 30 and 39.9 kg/m2 are obese, and those with values of 40 kg/m2 and above are accepted as morbid obese (2).
    [Show full text]
  • The Effect of Obesity on Sperm Disorders and Male Infertility Stefan S
    REVIEWS The effect of obesity on sperm disorders and male infertility Stefan S. Du Plessis, Stephanie Cabler, Debra A. McAlister, Edmund Sabanegh and Ashok Agarwal Abstract | The results of several studies point to an increased likelihood of abnormal semen parameters among overweight men, and an elevated risk for subfertility among couples in which the male partner is obese. Obesity is, therefore, associated with a higher incidence of male factor infertility. Several mechanisms might account for the effect of obesity on male infertility, both directly and indirectly, by inducing sleep apnea, alterations in hormonal profiles (reduced inhibin B and androgen levels accompanied by elevated estrogen levels) and increased scrotal temperatures, ultimately manifesting as impaired semen parameters (decreased total sperm count, concentration and motility; increased DNA fragmentation index). Neither the reversibility of obesity-associated male infertility with weight loss nor effective therapeutic interventions have been studied in- depth. The increasing prevalence of obesity calls for greater clinical awareness of its effects on fertility, better understanding of underlying mechanisms, and exploration into avenues of treatment. Du Plessis, S. S. et al. Nat. Rev. Urol. 7, 153–161 (2010); published online 16 February 2010; doi:10.1038/nrurol.2010.6 Introduction Obesity is a medical condition in which excess body fat, Western countries have also been reported.4 Notably, or white adipose tissue, accumulates in the body to the such decreases have not been reported in regions where extent that this accumulation of fat might adversely affect obesity is less prevalent.4 Because this decline in fertility health, potentially reducing life expectancy. An indivi­ has occurred in parallel with increasing rates of obesity, dual can be defined as being overweight if their BMI is the possibility that obesity is a cause of male infertility 25–30 kg/m2, and obese if their BMI exceeds 30 kg/m2.
    [Show full text]