The Σ-Receptor Antagonist BD-1063 Decreases
Neuropsychopharmacology (2009) 34, 1482–1493 & 2009 Nature Publishing Group All rights reserved 0893-133X/09 $32.00 www.neuropsychopharmacology.org The s-Receptor Antagonist BD-1063 Decreases Ethanol Intake and Reinforcement in Animal Models of Excessive Drinking ,1,2,7 1,2,7 1 3 4 5 Valentina Sabino* , Pietro Cottone , Yu Zhao , Malliga R Iyer , Luca Steardo Jr , Luca Steardo , 3 2,6 1 ,1,2 Kenner C Rice , Bruno Conti , George F Koob and Eric P Zorrilla* 1 2 Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA, USA; Harold L. Dorris Neurological 3 Research Institute, The Scripps Research Institute, La Jolla, CA, USA; Chemical Biology Research Branch, National Institute on Drug Abuse and the National Institute on Alcohol Abuse and Alcoholism, Rockville, MD, USA; 4Department of Psychiatry, University of Naples SUN, Naples, Italy; 5Department of Human Physiology and Pharmacology, University of Rome La Sapienza, Rome, Italy; 6Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA, USA s-Receptors (SigRs) have been implicated in behavioral and appetitive effects of psychostimulants and may also modulate the motivating properties of ethanol. This study tested the hypothesis that SigRs modulate ethanol reinforcement and contribute to excessive ethanol intake. The effects of subcutaneous treatment with the potent, selective Sig-1R antagonist BD-1063 on operant ethanol self- administration were studied in two models of excessive drinkingFSardinian alcohol-preferring (sP) rats and acutely withdrawn ethanol- dependent Wistar ratsFand compared to ethanol self-administration in nondependent Wistar controls. To assess the specificity of action, the effects of BD-1063 on self-administration of an equally reinforcing saccharin solution were determined in Wistar and sP rats.
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