Custom Peptide Synthesis 2

Biologically Active Peptides Catalogue 2013-2014 The Companies of the ChinaPeptides Laboratories Group 1 Custom Peptide Synthesis 2 Catalogue Peptides 3 Technical Details 3 Confidentiality, Quoting, Sequence, Counterion, Quantity Purity, Lead time, Cost, Certification of Analysis, Peptide Purity Peptide Content, Additional Analysis, Reconstitution Storage, Shipment, Ordering Prices List for Custom Peptide Synthesis 7 Modification Prices for Custom Peptide Synthesis 8 Contact Addresses 8 Overview of Catalogue Peptides 9 Biologically Functional Peptides 11 Glossary 67 Appendix 69 Sample Certification of Analysis 2 The Companies of the ChinaPeptides Laboratories Group The ChinaPeptides Laboratories Group is a Further information can be obtained from our privately-owned network of companies located web site http://www.chinapeptides.com or by in Zhangjiang High-Tech Park, Shanghai contacting us directly. ChinaPeptides China, specializing in the manufacture of Laboratories is committed to close customer peptides for basic research and for contact. We believe that every project is a therapeutic applications. The companies of partnership and that valuable time and money the Group are specifically equipped to can be saved by discussing the chemistry and complement each other both in terms of scale biology of the project before starting the and focus, allowing ChinaPeptides synthesis. We are dedicated to serving our Laboratories to keep pace with peptide customers. peptide needs and would welcome projects as quantity, synthetic strategy and your input for new products, your comments regulatory requirements change. We can on our products and services, or simply an respond quickly, competently and cost exchange of views on topics related to effectively to customers. needs whether these peptides. Please do not hesitate to write, are for milligrams of peptide for research or for phone, fax or e-mail ChinaPeptides tens to hundreds of grams of of peptide for Laboratories. therapeutic applications. The need of each customer is unique. With many years of experience in small-scale ChinaPeptides Laboratories is uniquely and large-scale peptide manufacturing, equipped to fulfill that need. ChinaPeptides Laboratories is the most dependable resource available for catalogue or custom peptides, regardless of the scale of the project or the complexity of the peptide. We can satisfy both the requirements of customers from academic institutions and from the generic, biotechnological and emerging pharmaceutical industries as well as customers from major pharmaceutical companies targeting peptide development for the human and animal health care markets. i Custom Peptide Synthesis ChinaPeptides Laboratories products and main product, these peptide contaminants services support the development and supply must be viewed as potential agonists or of new peptide drug substances and generics antagonists. Although the presence of a small as well as bulk peptides for other uses such amount of related peptides is generally as chromogenic substrates or enzyme unlikely to cause problems, the literature inhibitors. We also supply catalogue peptides documents many examples of analogues and small-scale custom synthesis services for acting as biologically potent agonists and basic research, in particular for antagonists. Finding (and publishing) effects pharmacological investigations which require which later have to be exceptionally pure substances. attributed to (unidentifiable) contaminants is a recognized risk if purity is low. Peptides may At ChinaPeptides Laboratories, research seem to expensive items in terms of money grade peptides(usually quantities between 5 per mg, but their relative cost compared to the milligrams and 50 grams)are routinely total cost of an investigation is low. Sacrificing synthesized to at least 97% purity. In attainable peptide purity for reasons of exceptional cases, where structure or lability economy can be an expensive mistake. The of the peptide makes this genuinely 2% difference between 97% and 95% purity unattainable, a lower limit may be set. These may be seen as 2% more peptide, but it may stringent specifications become increasingly also be regarded as a 40% decrease in difficult to maintain for longer peptides unless impurities (from 5% to 3%) and their possible extremely efficient synthetic strategies are interference. used to maintain high yields. At ChinaPeptides Laboratories, research grade peptides are handmade by skilled technicians. Manual synthesis means that we can carefully control each step, repeating reactions where necessary. Each peptide is made individually by a dedicated technician who is responsible for the whole synthesis - from weighing the individual amino acids through to the final purification. Only the final quality control is performed independently. It is a matter of personal pride for each technician that the best result is obtained. The combination of high yields obtained using manual technology This argument can, of course, be inverted to and proprietary purification procedures is explain why peptides used to raise antibodies, particularly adaptable for scaling-up to do not need to have the same high purity as multigram and larger quantities. those used for pharmacological research. The concentration of any given partial sequence Because higher peptide purity costs more, (e.g. the relevant epitope) will always be one of the questions which many customers higher than that of the complete sequence. ask is how pure a peptide should be. This is There is, for example, no reason why a not an easy question to answer, but the peptide with only 85% HPLC purity may not investigator should be aware of the following contain 97% of the relevant epitope. Although facts. Solid phase strategy dictates that the our peptides are routinely manufactured to ≥ side-products of peptide synthesis are mainly 97% HPLC purity for pharmacological N-terminal deletants of the main product. By research, we will manufacture to lower (and very nature of their close homology to the higher) specifications if required. 2 It goes without saying that within the company please send us your sequence, the quantity group, we have the ability to scale up from and (if other than ≥ 97%) the HPLC purity milligrams to multi-kilogram and multi-10 required. We can normally provide a quotation kilogram quantities if the need arises. If you within 24 hours. would like a quotation on a custom synthesis, Catalogue Peptides ChinaPeptides Laboratories also offers over confirming the identity and purity of the 2000 different biologically functional peptides material. as catalogue items. These peptides are made to even more stringent specifications than our The peptides are packaged in small quantities custom syntheses and most have a >97% (normally 0.5 mg and 1 mg) that are designed HPLC purity. Because this is our lower limit of for dissolution in the vial. Larger quantities acceptability, most of our peptides exceed this (5mg and above) are supplied with a slight specification. This can be seen in the HPLC excess of material. trace(s) provided with the certificate of analysis. In rare cases, either the nature of the All catalogue items can be supplied as bulk amino acids or the tertiary structure of the material at considerable reduced unit cost. peptide prevents this purity being attained at a commercially acceptable price. In such cases, We regularly check representative catalogue this will be clearly stated in the certificate of peptides for chiral purity (see Appendix). analysis. Experience shows that the synthetic methods we use (for both catalogue peptides and Catalogue peptides are supplied with a custom syntheses) do not permit significant Certificate of Analysis (see Appendix) racemization. Technical Details Quoting and establishing specifications for can be provided upon request. Large Scale Contract Manufacture, Feasibility Studies, Development Projects, Supply Quoting Agreements, and GMP Projects has to be We quote promptly, usually within 24 - 48 h. dealt with on a case-by-case basis. Please We only quote delivery times that we consider contact ChinaPeptides Laboratories for further realistic. details. On custom syntheses, we will quote a price The information provided below refers to that directly relates to the sequence, purity small-scale custom syntheses, catalogue and quantity of the required peptide after and generic peptides. reviewing the structure. Confidentiality Sequence All information provided to us by customers is We will normally quote on any linear or cyclic considered confidential. However, we would sequence between 3 and 40 amino acids. be pleased to sign a Confidentiality Disclosure Quotations on longer peptides will be Agreement (CDA) if required. ChinaPeptides considered in exceptional circumstances. Laboratories has its own standard CDA that 3 Non-proteogenic residues, exotic amino acids, applications, we can supply peptides with biotin, chromogenic, fluorogenic or protective higher or lower purity on request. The cost groups as well as isosteric bonds can be varies accordingly. incorporated at extra cost. Please enquire about phosphorylated peptides. The specifications of peptide generics are available from ChinaPeptides Laboratories. Lead Time Most catalogue items and peptide generics are in warehouse stock. For small-scale custom syntheses, the time between order and delivery depends on the quantity, purity and sequence of the peptide ordered as well as the number of orders being currently processed. However,

Load more