Effects of Lethal Levels of Environmental Hypercapnia on Cardiovascular and Blood-Gas Status in Yellowtail, Seriola Quinqueradiata
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Cardiovascular System 9
Chapter Cardiovascular System 9 Learning Outcomes On completion of this chapter, you will be able to: 1. State the description and primary functions of the organs/structures of the car- diovascular system. 2. Explain the circulation of blood through the chambers of the heart. 3. Identify and locate the commonly used sites for taking a pulse. 4. Explain blood pressure. 5. Recognize terminology included in the ICD-10-CM. 6. Analyze, build, spell, and pronounce medical words. 7. Comprehend the drugs highlighted in this chapter. 8. Describe diagnostic and laboratory tests related to the cardiovascular system. 9. Identify and define selected abbreviations. 10. Apply your acquired knowledge of medical terms by successfully completing the Practical Application exercise. 255 Anatomy and Physiology The cardiovascular (CV) system, also called the circulatory system, circulates blood to all parts of the body by the action of the heart. This process provides the body’s cells with oxygen and nutritive ele- ments and removes waste materials and carbon dioxide. The heart, a muscular pump, is the central organ of the system. It beats approximately 100,000 times each day, pumping roughly 8,000 liters of blood, enough to fill about 8,500 quart-sized milk cartons. Arteries, veins, and capillaries comprise the network of vessels that transport blood (fluid consisting of blood cells and plasma) throughout the body. Blood flows through the heart, to the lungs, back to the heart, and on to the various body parts. Table 9.1 provides an at-a-glance look at the cardiovascular system. Figure 9.1 shows a schematic overview of the cardiovascular system. -
Oxygen Concentration of Blood: PO
Oxygen Concentration of Blood: PO2, Co-Oximetry, and More Gary L. Horowitz, MD Beth Israel Deaconess Medical Center Boston, MA Objectives • Define “O2 Content”, listing its 3 major variables • Define the limitations of pulse oximetry • Explain why a normal arterial PO2 at sea level on room air is ~100 mmHg (13.3 kPa) • Describe the major features of methemogobin and carboxyhemglobin O2 Concentration of Blood • not simply PaO2 – Arterial O2 Partial Pressure ~100 mm Hg (~13.3 kPa) • not simply Hct (~40%) – or, more precisely, Hgb (14 g/dL, 140 g/L) • not simply “O2 saturation” – i.e., ~89% O2 Concentration of Blood • rather, a combination of all three parameters • a value labs do not report • a value few medical people even know! O2 Content mm Hg g/dL = 0.003 * PaO2 + 1.4 * [Hgb] * [%O2Sat] = 0.0225 * PaO2 + 1.4 * [Hgb] * [%O2Sat] kPa g/dL • normal value: about 20 mL/dL Why Is the “Normal” PaO2 90-100 mmHg? • PAO2 = (FiO2 x [Patm - PH2O]) - (PaCO2 / R) – PAO2 is alveolar O2 pressure – FiO2 is fraction of inspired oxygen (room air ~0.20) – Patm is atmospheric pressure (~760 mmHg at sea level) o – PH2O is vapor pressure of water (47 mmHg at 37 C) – PaCO2 is partial pressure of CO2 – R is the respiratory quotient (typically ~0.8) – 0.21 x (760-47) - (40/0.8) – ~100 mm Hg • Alveolar–arterial (A-a) O2 gradient is normally ~ 10, so PaO2 (arterial PO2) should be ~90 mmHg NB: To convert mm Hg to kPa, multiply by 0.133 Insights from PAO2 Equation (1) • PaO2 ~ PAO2 = (0.21x[Patm-47]) - (PaCO2 / 0.8) – At lower Patm, the PaO2 will be lower • that’s -
Arterial Blood Gases During Treatment of Congestive Heart Failure
University of Nebraska Medical Center DigitalCommons@UNMC MD Theses Special Collections 5-1-1969 Arterial blood gases during treatment of congestive heart failure John B. Byrd University of Nebraska Medical Center This manuscript is historical in nature and may not reflect current medical research and practice. Search PubMed for current research. Follow this and additional works at: https://digitalcommons.unmc.edu/mdtheses Part of the Medical Education Commons Recommended Citation Byrd, John B., "Arterial blood gases during treatment of congestive heart failure" (1969). MD Theses. 77. https://digitalcommons.unmc.edu/mdtheses/77 This Thesis is brought to you for free and open access by the Special Collections at DigitalCommons@UNMC. It has been accepted for inclusion in MD Theses by an authorized administrator of DigitalCommons@UNMC. For more information, please contact [email protected]. ARTERIAL BLOOD GASES DURING TREATMENT OF CONGESTIVE HEART FAILURE By John B~ Byrd A THESIS Presented to the Faculty of The CollsQs of Medicine in the Universi,!;v of Ne.braska In Partial Fulfillment of Requirements For the Degree of Doctor of Medicine Under the Supervision of John R. Jones, MO Omaha, Nebraska February 3, 1969 CONTENTS Introduction 1 Methods 4 Results 6 Discussion 7 Summary 9 References 10 ARTERIAL BLOOD GASES DURING TREATMENT OF CONGESTIVE HEART FAILURE The congestive syndromes of heart failure are classified as 1) acute pulmonary edema (acute left ventricular failure) and 2) chronic heart failure in Principles of Internal Medicine e d ~'t e d'oy H'arr~son, ea.tIll Acute left ventricular failure is characterized oy paroxysmal dyppnea. It may be caused by an elevated filling load (most common), acute myocardial infarction, ectopic tachycardia or fulminant myocarditis--th8 first causing a high-output syndrome with cardiogenic shock occurring late; the remaining causes characterized by an abrupt declir~in cardiac output. -
Arterial Blood Gases: Their Meaning and Interpretation*
Arterial Blood Gases: Their Meaning and Interpretation* WALTER J. O'DONOHUE, JR., M.D. Assistant Professor of Medicine, Director of Inhalation Therapy, Department of Internal Medicine, Medical College of Virginia, Health Sciences Division of Virginia Commonwealth University, Richmond, Virginia The measurement of arterial blood gases is cause the glass plunger moves more freely and essential in the management of respiratory failure allows easy detection of arterial pulsation. After and in the diagnostic assessment of the nature and the puncture, the artery should be compressed by severity of pulmonary disease. Adequate therapy hand for no less than five minutes. If the blood for patients with acute respiratory insufficiency gas analysis is not done immediately, the capped is often impossible without the information ob syringe should be placed in an iced container. tained from arterial blood gases. These studies must Equipment for blood gas analysis is readily avail be readily available around the clock, including able and relatively easy to operate. The cost of nights, weekends, and holidays and should not have basic equipment is approximately $3,000. An to depend upon a technician called in from home. arterial blood sample of 3-5 cc is sufficient for a A ready knowledge of arterial blood gases in acute complete study. Micromethods are also available respiratory failure is just as important to good for "arterialized" capillary blood obtained by punc medical care as knowing the urine sugar and ace ture of a hyperemic ear or fingertip. Only ar tone in diabetic ketoacidosis or the blood count terial blood is of consistent value in detecting the in an acute infection. -
The Oxygen Saturation of Hemoglobin in the Arterial Blood of Exercising Patients
THE OXYGEN SATURATION OF HEMOGLOBIN IN THE ARTERIAL BLOOD OF EXERCISING PATIENTS Harold E. Himwich, Robert O. Loebel J Clin Invest. 1927;5(1):113-124. https://doi.org/10.1172/JCI100144. Research Article Find the latest version: https://jci.me/100144/pdf THE OXYGEN SATURATION OF HEMOGLOBIN IN TILE ARTERIAL BLOOD OF EXERCISING PATIENTS BY HAROLD E. HIMWICH mm ROBERT 0. LOEBEL (From the Russell Sage Institute of Pathology in Aftiliation with the Second Medical (Cornel) Division and the Pathological Departmen of Bellevue Hospital and the Depart- ment of Medicine, Corndel University Medicd College, New York) (Received for publication August 22, 1927) The following data are presented at the present time even though they are incomplete, since circumstances necessitated an interruption of the work. Observations of Himwich and Barr (1) on the variations in oxygen content and oxygen capacity which occurred in the arterial blood of normal individuals as a result of exercise indicated that the oxygen saturation of the hemoglobin was increased by moderate exercise of short duration. If, however, the exercise was continued to the point of exhaustion, the saturation of hemoglobin might diminish. A simi- lar decrease was noted by Harrop (2) in a convalescent subject, and also in three patients with polycythemia vera (3). A lessened satura- tion was found by Barcroft and others (4) when exercise was per- formed at high altitudes. An explanation of these varying results was attempted. Though the saturation of hemoglobin in the lungs is influenced by many fac- tors, it is in the last analysis determined by two only; the amount of oxygen diffusing through the pulmonary membrane and the volume of blood flow in the pulmonary circuit; the degree of saturation vary- ing directly with the total amount of oxygen diffusing and inversely with the volume of the circulation. -
3364-136-07-09 Ventilator Management Protocol
Name of Policy: Ventilator Management Protocol Policy Number: 3364-136-07-09 Department: Respiratory Care Approving Chief Nursing Officer Officer: Responsible Director, Respiratory Care Agent: Scope: Effective Date: 2/1/2020 The University of Toledo Medical Initial Effective Date: 2/1/2020 Center Respiratory Care Department X New policy proposal Minor/technical revision of existing policy Major revision of existing policy Reaffirmation of existing policy Policy Statement Initiating mechanical ventilator settings, ventilator assessments, and establishing ventilator alarm settings, shall be in accordance to the following procedure. Purpose of Policy To provide guidelines for the assembly and function testing of mechanical ventilators, and to establish guide lines for initial ventilation, ongoing management and weaning. The Respiratory Care Practitioner (RCP) will utilize the following Therapist Driven Protocol (TDP) to assess the patient on mechanical ventilation for “Readiness to Wean” with a daily Spontaneous Breathing Trial (SBT) to be performed daily as appropriate, for the purpose of expediting weaning and extubation from mechanical ventilation. A physician must order “Ventilator Management, Weaning & Extubation Protocol” or simply “Ventilator Protocol”. Upon the physician’s order for the Ventilator Protocol, the RCP will follow the procedure described and outlined in this document to facilitate a safe and timely removal of the endotracheal tube (ETT) at the earliest possible and appropriate time. Procedure A. Mechanical Ventilator Initiation 1. Physician will order “Ventilator Management, Weaning & Extubation Protocol” or simply “Ventilator Protocol” and “Ventilator Sedation Protocol”. 2. Patient will be on ETCO2 monitoring along with the mechanical ventilator, a cardiac monitor and continuous pulse oximetry. 3. The RCP will document all initial ventilator parameters and parameter changes in the electronic medical record. -
The Chemoreflex Control of Breathing and Its Measurement
933 Continuing Medical Education The chemoreflex control of breathing James Duffin PhD and measurement The chemoreflex control of breathing is described in terms of a Le contrrle chimiorEflexe de la respiration est dEcrit comme un graphical model. The central chemoreflex, the ventilatory modEle graphique. Le centre chimiordflexe, #1 rEponse respira- response to carbon dioxide mediated by the central chemorecep- toire au C02 mEdiEe par les chEmorEcepteurs centrmLr sont tors, is modelled as a straight-line relation between the dEcrits comme une relation directe entre la rEponse respira- ventilatory response and the arterial level of carbon dioxide. toire et les niveaux de C02 artdriels. Le chimior~flexe ptariph~- The peripheral chemoreflex, the ventilatory response to carbon rique, la r~ponse ventilatoire au C02 et I'hypoxie mddi~s par les dioxide and hypoxia mediated by the peripheral chemorecep- chEmorEcepteurs p~riph~riques sont subdivis~es en deux rela- tors, is broken into two relations. First, a straight.line relation tions. PremiErement, une relation directe entre la rdponse between the ventilatory response and the arterial level of carbon ventilatoire et le niveau artEriel de COz dont la pente (sensiti- dioxide whose slope (sensitivity) increases as the oxygen level vitE) augmente a vec les variations du niveau d' oxygEne d' hyper- varies from hyperoxic to hypoxic. Second, a rectangular oxique c} hypoxique. Deuxidmement, une relation hyperbolique hyperbolic relation between the ventilatory response and the rectangulaire entre la rdponse respiratoire et le niveau artEriel arterial level of oxygen with ventilation increasing with increas- d' oxygOne avecla ventilation augmentant avec I' augmentation ing hypoxia. The three ventilatory response relations (one de l'hypoxie. -
Regulation of Ventilation
CHAPTER 1 Regulation of Ventilation © IT Stock/Polka Dot/ inkstock Chapter Objectives By studying this chapter, you should be able to do 5. Describe the chemoreceptor input to the brain the following: stem and how it modifi es the rate and depth of breathing. 1. Describe the brain stem structures that regulate 6. Explain why it is that the arterial gases and pH respiration. do not signifi cantly change during moderate 2. Defi ne central and peripheral chemoreceptors. exercise. 3. Explain what eff ect a decrease in blood pH or 7. Discuss the respiratory muscles at rest and carbon dioxide has on respiratory rate. during exercise. How are they infl uenced by 4. Describe the Hering–Breuer reflex and its endurance training? function. 8. Describe respiratory adaptations that occur in response to athletic training. Chapter Outline Passive and Active Expiration Eff ects of Blood PCO 2 and pH on Ventilation Respiratory Areas in the Brain Stem Proprioceptive Refl exes Dorsal Respiratory Group Other Factors Ventral Respiratory Group Hering–Breuer Refl ex Apneustic Center Ventilation Response During Exercise Pneumotaxic Center Ventilation Equivalent for Oxygen () V/EOV 2 Chemoreceptors Ventilation Equivalent for Carbon Dioxide Central Chemoreceptors ()V/ECV O2 Peripheral Chemoreceptors Ventilation Limitations to Exercise Eff ects of Blood PO 2 on Ventilation Energy Cost of Breathing Ventilation Control During Exercise Chemical Factors Copyright ©2014 Jones & Bartlett Learning, LLC, an Ascend Learning Company Content not final. Not for sale or distribution. 17097_CH01_Pass4.indd 3 10/12/12 2:13 PM 4 Chapter 1 Regulation of Ventilation Passive and Active Expiration Ventilation is controlled by a complex cyclic neural process within the respiratory Brain stem Th e lower part centers located in the medulla oblongata of the brain stem . -
Arterial Puncture Procedures Chapter 14
Objectives 1. Define the key terms and abbreviations listed at the beginning of this chapter. 2. State the primary reason for performing arterial punctures and identify the personnel who may be Chapter 14: Arterial Puncture required to perform them. Procedures 3. Explain the purpose of collecting arterial blood gas (ABG) specimens and identify and describe commonly measured ABG parameters. 4. Identify the sites that can be used for arterial puncture, the criteria used for selection of the site, and the advantages and disadvantages of each site. Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins Objectives (cont’d) Objectives (cont’d) 5. List equipment and supplies needed for arterial 8. Describe the procedure for collecting radial arterial puncture. blood gases and the role of the phlebotomist in other site collections. 6. Identify typical required and supplemental requisition information and describe patient assessment and 9. List hazards and complications of arterial puncture, preparation procedures, including the administration of identify sampling errors that may affect the integrity of local anesthetic, prior to performing arterial blood an arterial sample, and describe the criteria for gases. specimen rejection. 7. Explain the purpose of the modified Allen test, describe how it is performed, define what constitutes a positive or negative result, and give the procedure to follow for either result. Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins 1 Overview: Video (Arterial blood gas sampling) ABGs • Disadvantages of Arterial Puncture • Used in diagnosis & management of respiratory disorders – Technically difficult • Provide valuable info. -
Anatomy and Physiology of the Cardiovascular System
Chapter © Jones & Bartlett Learning, LLC © Jones & Bartlett Learning, LLC 5 NOT FOR SALE OR DISTRIBUTION NOT FOR SALE OR DISTRIBUTION Anatomy© Jonesand & Physiology Bartlett Learning, LLC of © Jones & Bartlett Learning, LLC NOT FOR SALE OR DISTRIBUTION NOT FOR SALE OR DISTRIBUTION the Cardiovascular System © Jones & Bartlett Learning, LLC © Jones & Bartlett Learning, LLC NOT FOR SALE OR DISTRIBUTION NOT FOR SALE OR DISTRIBUTION © Jones & Bartlett Learning, LLC © Jones & Bartlett Learning, LLC NOT FOR SALE OR DISTRIBUTION NOT FOR SALE OR DISTRIBUTION OUTLINE Aortic arch: The second section of the aorta; it branches into Introduction the brachiocephalic trunk, left common carotid artery, and The Heart left subclavian artery. Structures of the Heart Aortic valve: Located at the base of the aorta, the aortic Conduction System© Jones & Bartlett Learning, LLCvalve has three cusps and opens© Jonesto allow blood & Bartlett to leave the Learning, LLC Functions of the HeartNOT FOR SALE OR DISTRIBUTIONleft ventricle during contraction.NOT FOR SALE OR DISTRIBUTION The Blood Vessels and Circulation Arteries: Elastic vessels able to carry blood away from the Blood Vessels heart under high pressure. Blood Pressure Arterioles: Subdivisions of arteries; they are thinner and have Blood Circulation muscles that are innervated by the sympathetic nervous Summary© Jones & Bartlett Learning, LLC system. © Jones & Bartlett Learning, LLC Atria: The upper chambers of the heart; they receive blood CriticalNOT Thinking FOR SALE OR DISTRIBUTION NOT FOR SALE OR DISTRIBUTION Websites returning to the heart. Review Questions Atrioventricular node (AV node): A mass of specialized tissue located in the inferior interatrial septum beneath OBJECTIVES the endocardium; it provides the only normal conduction pathway between the atrial and ventricular syncytia. -
Reviews the Control of Breathing in Clinical Practice*
Reviews The Control of Breathing in Clinical Practice* Brendan Caruana-Montaldo, MD; Kevin Gleeson, MD; and Clifford W. Zwillich, MD, FCCP The control of breathing results from a complex interaction involving the respiratory centers, which feed signals to a central control mechanism that, in turn, provides output to the effector muscles. In this review, we describe the individual elements of this system, and what is known about their function in man. We outline clinically relevant aspects of the integration of human ventilatory control system, and describe altered function in response to special circumstances, disorders, and medications. We emphasize the clinical relevance of this topic by employing case presentations of active patients from our practice. (CHEST 2000; 117:205–225) Key words: carotid body; chemoreceptors; control of ventilation; pulmonary receptors Abbreviations: CPAP 5 continuous positive airway pressure; CSF 5 cerebrospinal fluid; CSR 5 Cheyne-Stokes 5 1 5 2 5 respiration; DRG dorsal respiratory group; [H ] hydrogen ion concentration; HCO3 bicarbonate; MVV 5 maximal voluntary ventilation; OSA 5 obstructive sleep apnea; pHa 5 arterial pH; PIIA 5 postinspiration inspiratory activity; PImax 5 maximal inspiratory pressure; RAR 5 rapidly adapting receptor; REM 5 rapid eye 5 5 5 ˙ 5 movement; Sao2 arterial oxygen saturation; SAR slowly adapting receptor; VC vital capacity; Ve minute ˙ 5 ˙ ˙ 5 5 5 ventilation; Vo2 oxygen uptake; V/Q ventilation/perfusion; VRG ventral respiratory group; Vt tidal volume; WOB 5 work of breathing his review is intended as an overview of human response to changes in blood chemistry, mechanical T respiratory control. The first section will briefly load, metabolic rate, and respiratory neural receptors describe the physiology of respiratory control includ- enables the respiratory system to adapt to special ing the sensors, the central controllers, and the physiologic circumstances such as sleep, exercise, effector systems. -
Blood and Cardiovascular-Respiratory Properties of the Common Carp Cyprinus Carpio Under Resting Conditions
本論文 Journal of National Fisheries University 62 (1) 19-29 (2013) Blood and Cardiovascular-Respiratory Properties of the Common Carp Cyprinus carpio under Resting Conditions Takeshi Handa 1 † and Ken-ichi Yamamoto 1 Abstract : We investigated the variations and the interrelationships among heart rate, blood pressure, ventilation frequency, blood gases, electrolytes, and catecholamine concentrations in the common carp Cyprinus carpio under resting conditions. The mean values of blood parameters and cardiovascular-respiratory properties were not signifi cantly different between males and females. No significant sexual differences in correlation coeffi cients were observed. Therefore, the sexual difference hardly affected these properties of the common carp, which had immature gonad, under resting conditions. Blood Na+ and Cl- concentrations and pH of the common carp were strictly controlled under resting conditions since the coeffi cient variations of Na+, Cl- and pH were much lower than those of the other properties. Some blood properties of the resting carp were found to correlate with each other: heart rate, dorsal aortic blood pressure, ventilation frequency, blood pH, O2 partial pressure, and catecholamine concentrations. The variations in blood pH, O2 partial pressure, and catecholamines of the resting carp little effect on the heart rate and the blood pressure. Key words : Cyprinus carpio ; resting condition; blood gas and electrolyte ; catecholamine ; heart rate ; blood pressure Introduction carp under resting conditions. Therefore, we measured arterial blood gases, blood chemical properties, ventilation The Cyprinidae is the largest family of freshwater frequency, heart rate, and dorsal aortic blood pressure, and fish, and the cyprinids are the most diverse in Southeast investigated the variations and the interrelationships of Asia, followed by Africa, North America, and Europe.1) blood parameters and cardiovascular-respiratory properties The common carp Cyprinus carpio is widely distributed of the resting carp.