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CT-Based Mediastinal Compartment Classifications and Differential Japanese Journal of Radiology (2019) 37:117–134 https://doi.org/10.1007/s11604-018-0777-5 INVITED REVIEW CT‑based mediastinal compartment classifcations and diferential diagnosis of mediastinal tumors Takahiko Nakazono1 · Ken Yamaguchi1 · Ryoko Egashira1 · Yukari Takase2 · Junichi Nojiri1 · Masanobu Mizuguchi1 · Hiroyuki Irie1 Received: 16 July 2018 / Accepted: 10 September 2018 / Published online: 20 September 2018 © Japan Radiological Society 2018 Abstract Division of the mediastinum into compartments is used to help narrow down the diferential diagnosis of mediastinal tumors, assess tumor growth, and plan biopsies and surgical procedures. There are several traditional mediastinal compartment classifcation systems based upon anatomical landmarks and lateral chest radiograph. Recently, the Japanese Association of Research of the Thymus (JART) and the International Thymic Malignancy Interest Group (ITMIG) proposed new mediastinal compartment classifcation systems based on transverse CT images. These CT-based classifcation systems are useful for more consistent and exact diagnosis of mediastinal tumors. In this article, we review these CT-based mediastinal compart- ment classifcations in relation to the diferential diagnosis of mediastinal tumors. Keywords Mediastinum · Compartment · Computed tomography · Magnetic resonance imaging Introduction have resulted in confusion among physicians. In addition, the traditional models are based on lateral chest radiographs, The mediastinum is anatomically bound on the lateral side and thus some mediastinal lesions cannot be reliably local- by the parietal pleural refections along the medial aspects ized to a specifc compartment, since considerable overlap of both lungs, superiorly by the thoracic inlet, inferiorly by exists among the radiographically imaged compartments. the diaphragm, anteriorly by the sternum, and posteriorly Because mediastinal lesions are optimally evaluated with by the thoracic vertebral bodies. Various tumors and tumor- cross-sectional imaging techniques, computed tomography like lesions occur in the mediastinum. It is thus clinically (CT) is currently the main practical clinical examination for important to have a standardized system that can classify the assessing the existence, origin and extension of mediasti- mediastinum into several compartments in order to assess nal tumors. The Japanese Association of Research of the the origin and extension of mediastinal lesions. There are Thymus (JART) proposed a CT-based 4-compartment medi- several traditional mediastinal classifications based on astinal classifcation system [7]. The International Thymic anatomy and chest radiographs [1–6]. Felson proposed Malignancy Interest Group (ITMIG) subsequently modi- 3-mediastinal compartment classifcation method based fed the JART classifcation system to produce a CT-based on the lateral chest radiographs [2], resulting in a widely 3-compartment mediastinal classifcation system [8]. In this used classifcation that is both simple and diagnostically article, we review the new CT-based mediastinal compart- useful. However, diferences in terminology and methods ment classifcations and discuss their use in the diferential diagnosis of mediastinal tumors. * Takahiko Nakazono [email protected]‑u.ac.jp CT‑based mediastinum compartment 1 Department of Radiology, Faculty of Medicine, Saga classifcations University, Nabeshima 5‑1‑1, Saga City, Saga 849‑8501, Japan Sone et al. [9] evaluated CT images from 15 patients after 2 Departments of Pathology & Microbiology, Faculty pneumomediastinography and described two potential of Medicine, Saga University, Nabeshima 5‑1‑1, mediastinal spaces. The anterior (precardiovascular) zone Saga City, Saga 849‑8501, Japan Vol.:(0123456789)1 3 118 Japanese Journal of Radiology (2019) 37:117–134 is anterior to the superior vena cava, brachiocephalic artery, pulmonary veins). The posterior boundary of the anterior aorta, left common carotid artery, left subclavian artery, and mediastinum is formed by the pericardium (including a heart. The anterior zone is described as extending laterally horizontal line at the posterior rim of the heart), anterior to surround the heart. The central (retrocardiovascular) zone rims of the left brachiocephalic vein, superior vena cava, is an area around the trachea and esophagus and anterior to superior and inferior pulmonary veins, ascending aorta, the vertebrae [9]. and lateral rim of the aortic arch. The anterior bound- Fujimoto et al. [7] from JART proposed a new CT- ary of the middle mediastinum consists of the posterior based 4-compartment mediastinal classifcation system rim of the left brachiocephalic vein, superior vena cava, that included the superior portion of the mediastinum, ascending aorta, bilateral main pulmonary arteries, and the anterior mediastinum (prevascular zone), middle mediasti- heart. The posterior boundary of the middle mediastinum num (peritracheoesophageal zone), and posterior medi- consists of the anterior rim of the descending aorta and a astinum (paravertebral zone) (Fig. 1). The boundaries of vertical line connecting a point on each thoracic vertebral each compartment are shown in Table 1 [7]. The inferior body at 1 cm behind its anterior margin [middle-posterior boundary of the superior portion of the mediastinum is a boundary line (M-PBL), red dotted lines in Fig. 1]. The horizontal plane at the intersection of the caudal margin middle mediastinum includes mainly the trachea, bilateral of the brachiocephalic vein with the trachea. Classifying main bronchi and esophagus. The posterolateral bounda- the superior portion of the mediastinum has the advantage ries of the superior portion of the mediastinum and the of making it easy to diferentiate an intrathoracic goiter or posterior mediastinum are vertical lines against the poste- neurogenic tumor of the thoracic inlet from other medi- rior rim of the chest wall at the lateral rim of the thoracic astinal tumors [7]. The lateral boundaries of the anterior vertebral transverse process (yellow solid lines in Fig. 1) mediastinum are the parietal (mediastinal) pleural refec- [7]. Fujimoto et al. [7] evaluated the JART CT-based tions (including the lateral rims of the bilateral internal classifcation method by using it to assess 445 mediasti- thoracic arteries and veins, and the superior and inferior nal mass lesions and reported that the classifcation was ITAV ITAV LBCV SVC M-PBL ITAV ITAV RSPV LSPV RIPV LIPV M-PBL 䕔㻌 Superior portion of the mediastinum 䕔㻌 Anterior mediastinum (prevascular zone) 䕔㻌 Middle mediastinum (peritracheoesophageal zone) 䕔㻌 Posterior mediastinum (paravertebral zone) Fig. 1 Axial contrast-enhanced CT images representing the JART superior pulmonary vein; RIPV, right inferior pulmonary vein; LIPV, CT-based mediastinal compartment classifcation [7]. JART: The left inferior pulmonary vein; M-PBL, middle-posterior boundary line Japanese Association for Research on the Thymus; LBCV, left bra- (a vertical line connecting a point on each thoracic vertebral body at chiocephalic vein; ITAV, internal thoracic arteries and veins; SVC, 1 cm behind its anterior margin) superior vena cava; RSPV, right superior pulmonary vein; LSPV, left 1 3 Japanese Journal of Radiology (2019) 37:117–134 119 Table 1 Anatomical boundaries of the JART CT-based mediastinal compartment classifcation [7] Compartments Boundaries Superior portion of the mediastinum Superior: thoracic inlet Inferior: horizontal plane at the intersection of the caudal margin of the LBCV with the trachea Posterior: anterior rim of the thoracic vertebral body Posterior-lateral: vertical line against the posterior rim of the chest wall at the lateral rim of the thoracic vertebral process Anterior mediastinum (prevascular zone) Superior: inferior boundary of the superior portion of the mediastinum Inferior: diaphragm Lateral: parietal (mediastinal) pleural refections, ITAV, RSPV, LSPV, RIPV, and LIPV Posterior: pericardium, anterior rims of the LBCV, SVC, RSPV, LSPV, RIPV, LIPV, ascending aorta, and lateral rim of the aortic arch Middle mediastinum (peritracheoesophageal zone) Superior: inferior boundary of the superior portion of the mediastinum Inferior: diaphragm Anterior: posterior rim of the LBCV, SVC, ascending aorta, bilateral main pulmonary arteries, and heart Posterior: anterior rim of the descending aorta and M-PBL Posterior mediastinum (paravertebral zone) Superior: inferior boundary of the superior portion of the mediastinum Inferior: diaphragm Anterior: M-PBL Posterior-lateral: vertical line against the posterior rim of the chest wall at the lateral rim of the thoracic vertebral process JART, The Japanese Association for Research on the Thymus, LBCV, left brachiocephalic vein; ITAVs, internal thoracic arteries and veins; SVC, superior vena cava; RSPV, right superior pulmonary vein; LSPV, left superior pulmonary vein; RIPV, right inferior pulmonary vein; LIPV, left inferior pulmonary vein; M-PBL, middle-posterior boundary line (a vertical line connecting a point on each thoracic vertebral body at 1 cm behind its anterior margin) sufciently user-friendly and potentially useful for the dif- contents of the visceral compartment include two main ferential diagnosis of mediastinal lesions. components: (1) a vascular component (i.e., the heart, ITMIG modifed and simplifed the JART classifca- superior vena cava, ascending thoracic aorta, aortic arch, tion to produce a CT-based 3-compartment classifca- and descending thoracic aorta, intrapericardial pulmonary tion that has the
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