Distributions for kingdom level

Primer score mean and SD Genomic GC (%) mean and SD 60 3

2 50

1

Primer score 40

0 Genomic GC (%) Bacteria Bacteria Archaea Archaea kingdom kingdom

16S GC (%) mean and SD Genome size (Mb) mean and SD 65

5 60 4

55 3 16S GC (%) 2 Genome size (Mb) Genome size 50 Bacteria Bacteria Archaea Archaea kingdom kingdom Distributions for phylum level

Primer score mean and SD Genomic GC (%) mean and SD 4 70 3 60 2 50 1 40 30

Primer score 0 Genomic GC (%) Chlorobi Chlorobi Aquificae Aquificae Firmicutes Firmicutes Chloroflexi Chloroflexi Nitrospirae Nitrospirae Caldiserica Caldiserica Tenericutes Tenericutes Dictyoglomi Dictyoglomi unclassified unclassified Chlamydiae Chlamydiae Fusobacteria Fusobacteria Spirochaetes Spirochaetes Elusimicrobia Elusimicrobia Korarchaeota Korarchaeota Thermotogae Thermotogae Synergistetes Synergistetes Acidobacteria Acidobacteria Bacteroidetes Fibrobacteres Bacteroidetes Fibrobacteres Ignavibacteria Ignavibacteria Lentisphaerae Lentisphaerae Actinobacteria Actinobacteria Cyanobacteria Cyanobacteria Euryarchaeota Euryarchaeota Proteobacteria Proteobacteria Crenarchaeota Crenarchaeota Ignavibacteriae Ignavibacteriae Deferribacteres Deferribacteres Nanoarchaeota Nanoarchaeota Chrysiogenetes Chrysiogenetes Planctomycetes Planctomycetes Verrucomicrobia Verrucomicrobia Thaumarchaeota Thaumarchaeota Gemmatimonadetes Gemmatimonadetes Thermodesulfobacteria Thermodesulfobacteria Deinococcus − Thermus Deinococcus − Thermus phylum phylum

16S GC (%) mean and SD Genome size (Mb) mean and SD 10.0 65 7.5 60 55 5.0 50 2.5 16S GC (%) 45 Genome size (Mb) Genome size Chlorobi Chlorobi Aquificae Aquificae Firmicutes Firmicutes Chloroflexi Chloroflexi Nitrospirae Nitrospirae Caldiserica Caldiserica Tenericutes Tenericutes Dictyoglomi Dictyoglomi unclassified unclassified Chlamydiae Chlamydiae Fusobacteria Fusobacteria Spirochaetes Spirochaetes Elusimicrobia Elusimicrobia Korarchaeota Korarchaeota Thermotogae Thermotogae Synergistetes Synergistetes Acidobacteria Acidobacteria Fibrobacteres Fibrobacteres Bacteroidetes Bacteroidetes Ignavibacteria Ignavibacteria Lentisphaerae Lentisphaerae Actinobacteria Actinobacteria Cyanobacteria Cyanobacteria Euryarchaeota Euryarchaeota Proteobacteria Proteobacteria Crenarchaeota Crenarchaeota Ignavibacteriae Ignavibacteriae Deferribacteres Deferribacteres Nanoarchaeota Nanoarchaeota Chrysiogenetes Chrysiogenetes Planctomycetes Planctomycetes Verrucomicrobia Verrucomicrobia Thaumarchaeota Thaumarchaeota Gemmatimonadetes Gemmatimonadetes Thermodesulfobacteria Thermodesulfobacteria Deinococcus − Thermus Deinococcus − Thermus phylum phylum Distributions for class level

Primer score mean and SD Genomic GC (%) mean and SD 4 70 3 60 2 50 1 40

Primer score 0 30 Genomic GC (%) Bacilli Bacilli Opitutae Opitutae Aquificae Aquificae Clostridia Clostridia Nitrospira Nitrospira Chlorobia Chlorobia Mollicutes Mollicutes Chloroflexi Chloroflexi Deinococci Deinococci Chlamydiia Chlamydiia Caldilineae Synergistia Caldilineae Synergistia Bacteroidia Bacteroidia Cytophagia Cytophagia Caldisericia Caldisericia unclassified unclassified Holophagae Holophagae Methanopyri Methanopyri Solibacteres Solibacteres Spirochaetia Spirochaetia Halobacteria Halobacteria Dictyoglomia Dictyoglomia Thermococci Thermococci Archaeoglobi Archaeoglobi Fibrobacteria Fibrobacteria Anaerolineae Anaerolineae Elusimicrobia Elusimicrobia Thermoprotei Thermoprotei Thermotogae Thermotogae Negativicutes Negativicutes Fusobacteriia Fusobacteriia Lentisphaeria Lentisphaeria Methanococci Methanococci Flavobacteriia Flavobacteriia Ignavibacteria Ignavibacteria Gloeobacteria Gloeobacteria Erysipelotrichi Erysipelotrichi Acidobacteriia Acidobacteriia Actinobacteria Actinobacteria Spartobacteria Spartobacteria Planctomycetia Planctomycetia Deferribacteres Deferribacteres Erysipelotrichia Erysipelotrichia Chrysiogenetes Chrysiogenetes Sphingobacteria Sphingobacteria Thermomicrobia Thermomicrobia Ktedonobacteria Ktedonobacteria Dehalococcoidia Dehalococcoidia Methanobacteria Sphingobacteriia Methanobacteria Sphingobacteriia Thermoplasmata Thermoplasmata Methanomicrobia Methanomicrobia Verrucomicrobiae Verrucomicrobiae Zetaproteobacteria Zetaproteobacteria Dehalococcoidetes Dehalococcoidetes Betaproteobacteria Betaproteobacteria Deltaproteobacteria Deltaproteobacteria Alphaproteobacteria Alphaproteobacteria Gemmatimonadetes Gemmatimonadetes Epsilonproteobacteria Epsilonproteobacteria Gammaproteobacteria Gammaproteobacteria Thermodesulfobacteria Thermodesulfobacteria class class

16S GC (%) mean and SD Genome size (Mb) mean and SD

65 10 60 55 5 50 16S GC (%) 45

Genome size (Mb) Genome size 0 Bacilli Bacilli Opitutae Opitutae Aquificae Aquificae Clostridia Clostridia Nitrospira Nitrospira Chlorobia Chlorobia Mollicutes Mollicutes Chloroflexi Chloroflexi Deinococci Deinococci Chlamydiia Chlamydiia Caldilineae Synergistia Caldilineae Synergistia Bacteroidia Bacteroidia Cytophagia Cytophagia Caldisericia Caldisericia unclassified unclassified Holophagae Holophagae Methanopyri Methanopyri Solibacteres Solibacteres Spirochaetia Spirochaetia Halobacteria Halobacteria Dictyoglomia Dictyoglomia Thermococci Thermococci Archaeoglobi Archaeoglobi Fibrobacteria Fibrobacteria Anaerolineae Anaerolineae Elusimicrobia Elusimicrobia Thermoprotei Thermoprotei Thermotogae Thermotogae Negativicutes Negativicutes Fusobacteriia Lentisphaeria Fusobacteriia Lentisphaeria Methanococci Methanococci Flavobacteriia Flavobacteriia Ignavibacteria Ignavibacteria Gloeobacteria Gloeobacteria Erysipelotrichi Erysipelotrichi Acidobacteriia Acidobacteriia Actinobacteria Actinobacteria Spartobacteria Spartobacteria Planctomycetia Planctomycetia Deferribacteres Deferribacteres Erysipelotrichia Erysipelotrichia Chrysiogenetes Chrysiogenetes Sphingobacteria Sphingobacteria Thermomicrobia Thermomicrobia Ktedonobacteria Ktedonobacteria Dehalococcoidia Dehalococcoidia Methanobacteria Sphingobacteriia Methanobacteria Sphingobacteriia Thermoplasmata Thermoplasmata Methanomicrobia Methanomicrobia Verrucomicrobiae Verrucomicrobiae Zetaproteobacteria Zetaproteobacteria Dehalococcoidetes Dehalococcoidetes Betaproteobacteria Betaproteobacteria Deltaproteobacteria Deltaproteobacteria Alphaproteobacteria Alphaproteobacteria Gemmatimonadetes Gemmatimonadetes Epsilonproteobacteria Epsilonproteobacteria Gammaproteobacteria Gammaproteobacteria Thermodesulfobacteria Thermodesulfobacteria class class Distributions for order level

Primer score mean and SD Genomic GC (%) mean and SD

4 70 3 60 2 50 1 40

Primer score 0 30 Genomic GC (%) Bacillales Bacillales Nautiliales Nautiliales Thermales Thermales Aquificales Aquificales Nostocales Nostocales Vibrionales Vibrionales Rhizobiales Rhizobiales unclassified unclassified Acidilobales Acidilobales Sulfolobales Sulfolobales Clostridiales Neisseriales Clostridiales Neisseriales Nitrospirales Nitrospirales Prochlorales Prochlorales Chlorobiales Chlorobiales Rickettsiales Rickettsiales Caldilineales Caldilineales Thiotrichales Thiotrichales Legionellales Legionellales Chromatiales Chromatiales Gallionellales Gallionellales Chlamydiales Chlamydiales Synergistales Synergistales Bacteroidales Bacteroidales Cytophagales Holophagales Cytophagales Holophagales Caldisericales Oscillatoriales Caldisericales Oscillatoriales Pasteurellales Pasteurellales Solibacterales Solibacterales Myxococcales Myxococcales Chloroflexales Chloroflexales Deinococcales Rhodocyclales Deinococcales Rhodocyclales Desulfurellales Lactobacillales Desulfurellales Lactobacillales Chroococcales Chroococcales Anaerolineales Spirochaetales Anaerolineales Spirochaetales Nitriliruptorales Nitriliruptorales Thermotogales Thermotogales Cenarchaeales Cenarchaeales Dictyoglomales Dictyoglomales Desulfarculales Desulfarculales Parvularculales Parvularculales Methylophilales Methylophilales Fibrobacterales Fibrobacterales Fervidicoccales Fervidicoccales Halobacteriales Halobacteriales Burkholderiales Chrysiogenales Burkholderiales Chrysiogenales Aeromonadales Aeromonadales Lentisphaerales Lentisphaerales Fusobacteriales Rhodospirillales Fusobacteriales Rhodospirillales Methanopyrales Methanopyrales Puniceicoccales Puniceicoccales Mariprofundales Mariprofundales Caulobacterales Caulobacterales Acidimicrobiales Elusimicrobiales Acidimicrobiales Elusimicrobiales Halanaerobiales Methanocellales Halanaerobiales Methanocellales Flavobacteriales Flavobacteriales Coriobacteriales Coriobacteriales Actinomycetales Actinomycetales Gloeobacterales Gloeobacterales Rubrobacterales Salinisphaerales Rubrobacterales Salinisphaerales Acidobacteriales Bifidobacteriales Acidobacteriales Bifidobacteriales Methylococcales Thermococcales Methylococcales Thermococcales Haloplasmatales Nitrosopumilales Haloplasmatales Nitrosopumilales Archaeoglobales Archaeoglobales Ignavibacteriales Ignavibacteriales Alteromonadales Alteromonadales Rhodobacterales Rhodobacterales Bdellovibrionales Bdellovibrionales Thermoproteales Thermoproteales Deferribacterales Deferribacterales Natranaerobiales Natranaerobiales Oceanospirillales Oceanospirillales Mycoplasmatales Mycoplasmatales Magnetococcales Methanococcales Magnetococcales Methanococcales Cardiobacteriales Enterobacteriales Cardiobacteriales Enterobacteriales Planctomycetales Planctomycetales Erysipelotrichales Erysipelotrichales Acidithiobacillales Acidithiobacillales Desulfobacterales Desulfobacterales Selenomonadales Selenomonadales Nitrosomonadales Nitrosomonadales Xanthomonadales Xanthomonadales Desulfovibrionales Desulfovibrionales Desulfurococcales Desulfurococcales Hydrogenophilales Hydrogenophilales Pseudomonadales Pseudomonadales Ktedonobacterales Ktedonobacterales Methylacidiphilales Methylacidiphilales Herpetosiphonales Herpetosiphonales Sphaerobacterales Sphaerobacterales Acholeplasmatales Dehalococcoidales Methanosarcinales Acholeplasmatales Dehalococcoidales Methanosarcinales Verrucomicrobiales Verrucomicrobiales Campylobacterales Campylobacterales Sphingobacteriales Sphingobacteriales Thermomicrobiales Thermomicrobiales Sphingomonadales Sphingomonadales Solirubrobacterales Solirubrobacterales Methanobacteriales Methanobacteriales Entomoplasmatales Entomoplasmatales Thermoplasmatales Thermoplasmatales Gemmatimonadales Methanomicrobiales Gemmatimonadales Methanomicrobiales Syntrophobacterales Syntrophobacterales Desulfuromonadales Desulfuromonadales Candidatus Brocadiales Candidatus Brocadiales Thermoanaerobacterales Thermoanaerobacterales Thermodesulfobacteriales Thermodesulfobacteriales Bacteroidetes Order II. Incertae sedis Bacteroidetes Order II. Incertae sedis order order

16S GC (%) mean and SD Genome size (Mb) mean and SD

65 10 60 55 5 50 16S GC (%) 45 0 Genome size (Mb) Genome size Bacillales Bacillales Nautiliales Nautiliales Thermales Thermales Aquificales Aquificales Nostocales Nostocales Vibrionales Vibrionales Rhizobiales Rhizobiales unclassified unclassified Acidilobales Acidilobales Sulfolobales Sulfolobales Clostridiales Neisseriales Clostridiales Neisseriales Nitrospirales Nitrospirales Prochlorales Prochlorales Chlorobiales Chlorobiales Rickettsiales Rickettsiales Caldilineales Caldilineales Thiotrichales Thiotrichales Legionellales Legionellales Chromatiales Chromatiales Gallionellales Gallionellales Chlamydiales Chlamydiales Synergistales Synergistales Bacteroidales Bacteroidales Cytophagales Holophagales Cytophagales Holophagales Caldisericales Oscillatoriales Caldisericales Oscillatoriales Pasteurellales Pasteurellales Solibacterales Solibacterales Myxococcales Myxococcales Chloroflexales Chloroflexales Deinococcales Rhodocyclales Deinococcales Rhodocyclales Desulfurellales Lactobacillales Desulfurellales Lactobacillales Anaerolineales Chroococcales Spirochaetales Anaerolineales Chroococcales Spirochaetales Nitriliruptorales Nitriliruptorales Thermotogales Thermotogales Cenarchaeales Cenarchaeales Dictyoglomales Dictyoglomales Desulfarculales Desulfarculales Parvularculales Parvularculales Methylophilales Methylophilales Fibrobacterales Fibrobacterales Fervidicoccales Fervidicoccales Halobacteriales Halobacteriales Burkholderiales Chrysiogenales Burkholderiales Chrysiogenales Aeromonadales Aeromonadales Lentisphaerales Lentisphaerales Fusobacteriales Methanopyrales Rhodospirillales Fusobacteriales Methanopyrales Rhodospirillales Puniceicoccales Puniceicoccales Mariprofundales Mariprofundales Caulobacterales Caulobacterales Acidimicrobiales Elusimicrobiales Acidimicrobiales Elusimicrobiales Halanaerobiales Methanocellales Halanaerobiales Methanocellales Flavobacteriales Flavobacteriales Coriobacteriales Coriobacteriales Actinomycetales Actinomycetales Gloeobacterales Gloeobacterales Rubrobacterales Salinisphaerales Rubrobacterales Salinisphaerales Acidobacteriales Bifidobacteriales Acidobacteriales Bifidobacteriales Methylococcales Thermococcales Methylococcales Thermococcales Haloplasmatales Nitrosopumilales Haloplasmatales Nitrosopumilales Archaeoglobales Archaeoglobales Ignavibacteriales Ignavibacteriales Alteromonadales Alteromonadales Rhodobacterales Rhodobacterales Bdellovibrionales Bdellovibrionales Thermoproteales Thermoproteales Deferribacterales Deferribacterales Natranaerobiales Natranaerobiales Oceanospirillales Oceanospirillales Mycoplasmatales Mycoplasmatales Magnetococcales Methanococcales Magnetococcales Methanococcales Cardiobacteriales Enterobacteriales Cardiobacteriales Enterobacteriales Planctomycetales Planctomycetales Erysipelotrichales Erysipelotrichales Acidithiobacillales Acidithiobacillales Desulfobacterales Desulfobacterales Selenomonadales Selenomonadales Nitrosomonadales Nitrosomonadales Xanthomonadales Xanthomonadales Desulfovibrionales Desulfovibrionales Desulfurococcales Desulfurococcales Hydrogenophilales Hydrogenophilales Pseudomonadales Pseudomonadales Ktedonobacterales Ktedonobacterales Methylacidiphilales Methylacidiphilales Herpetosiphonales Herpetosiphonales Sphaerobacterales Sphaerobacterales Acholeplasmatales Dehalococcoidales Methanosarcinales Acholeplasmatales Dehalococcoidales Methanosarcinales Verrucomicrobiales Verrucomicrobiales Campylobacterales Sphingobacteriales Campylobacterales Sphingobacteriales Thermomicrobiales Thermomicrobiales Sphingomonadales Sphingomonadales Solirubrobacterales Solirubrobacterales Methanobacteriales Methanobacteriales Entomoplasmatales Entomoplasmatales Thermoplasmatales Thermoplasmatales Gemmatimonadales Methanomicrobiales Gemmatimonadales Methanomicrobiales Syntrophobacterales Syntrophobacterales Desulfuromonadales Desulfuromonadales Candidatus Brocadiales Candidatus Brocadiales Thermoanaerobacterales Thermoanaerobacterales Thermodesulfobacteriales Thermodesulfobacteriales Bacteroidetes Order II. Incertae sedis Bacteroidetes Order II. Incertae sedis order order Distributions for family level

Primer score mean and SD Genomic GC (%) mean and SD 5 4 70 3 60 2 50 1 40

Primer score 0 30 Genomic GC (%) Bacillaceae Bacillaceae Dietziaceae unclassified Dietziaceae unclassified Opitutaceae Opitutaceae Listeriaceae Listeriaceae Frankiaceae Frankiaceae Nautiliaceae Nautiliaceae Kofleriaceae Kofleriaceae Hahellaceae Hahellaceae Jonesiaceae Jonesiaceae Thermaceae Thermaceae Coxiellaceae Coxiellaceae Aquificaceae Aquificaceae Waddliaceae Waddliaceae Brucellaceae Brucellaceae Nostocaceae Nostocaceae Vibrionaceae Vibrionaceae Moritellaceae Moritellaceae Rhizobiaceae Rhizobiaceae Victivallaceae Victivallaceae Trueperaceae Trueperaceae Jiangellaceae Jiangellaceae Colwelliaceae Colwelliaceae Nocardiaceae Nocardiaceae Acidilobaceae Acidilobaceae Rikenellaceae Rikenellaceae Gordoniaceae Simkaniaceae Gordoniaceae Simkaniaceae Sulfolobaceae Sulfolobaceae Clostridiaceae Neisseriaceae Clostridiaceae Neisseriaceae Sutterellaceae Sutterellaceae Nitrospiraceae Nitrospiraceae Chlorobiaceae Chlorobiaceae Moraxellaceae Moraxellaceae Rickettsiaceae Rickettsiaceae Polyangiaceae Polyangiaceae Caldilineaceae Picrophilaceae Pyrodictiaceae Caldilineaceae Picrophilaceae Pyrodictiaceae Prevotellaceae Prevotellaceae Thiotrichaceae Thiotrichaceae Veillonellaceae Veillonellaceae Bartonellaceae Bartonellaceae Legionellaceae Syntrophaceae Legionellaceae Syntrophaceae Alcaligenaceae Chromatiaceae Alcaligenaceae Chromatiaceae Leptospiraceae Leptospiraceae Gallionellaceae Gallionellaceae Idiomarinaceae Idiomarinaceae Chlamydiaceae Chlamydiaceae Aerococcaceae Synergistaceae Aerococcaceae Synergistaceae Thermofilaceae Thermofilaceae Bacteroidaceae Bacteroidaceae Eubacteriaceae Eubacteriaceae Francisellaceae Francisellaceae Saprospiraceae Saprospiraceae Cytophagaceae Holophagaceae Cytophagaceae Holophagaceae Caldisericaceae Caldisericaceae Pasteurellaceae Pasteurellaceae Segniliparaceae Solibacteraceae Segniliparaceae Solibacteraceae Myxococcaceae Myxococcaceae Chloroflexaceae Chloroflexaceae Micrococcaceae Micrococcaceae Actinospicaceae Actinospicaceae Beijerinckiaceae Beijerinckiaceae Shewanellaceae Shewanellaceae Oscillospiraceae Oscillospiraceae Planococcaceae Planococcaceae Peptococcaceae Peptococcaceae Crenotrichaceae Leptotrichiaceae Crenotrichaceae Leptotrichiaceae Geobacteraceae Geobacteraceae Deinococcaceae Rhodocyclaceae Deinococcaceae Rhodocyclaceae Brachyspiraceae Brachyspiraceae Sporichthyaceae Sporichthyaceae Pelobacteraceae Pelobacteraceae Desulfurellaceae Lactobacillaceae Nannocystaceae Desulfurellaceae Lactobacillaceae Nannocystaceae Marinilabiliaceae Marinilabiliaceae Kineosporiaceae Kineosporiaceae Anaerolineaceae Nocardioidaceae Spirochaetaceae Anaerolineaceae Nocardioidaceae Spirochaetaceae Paenibacillaceae Paenibacillaceae Nitriliruptoraceae Nitriliruptoraceae Thermotogaceae Thermotogaceae Lachnospiraceae Lachnospiraceae Cenarchaeaceae Cenarchaeaceae Dictyoglomaceae Dictyoglomaceae Desulfarculaceae Desulfarculaceae Cryomorphaceae Cryomorphaceae Parvularculaceae Parvularculaceae Enterococcaceae Enterococcaceae Ferroplasmaceae Methylophilaceae Ferroplasmaceae Methylophilaceae Fibrobacteraceae Nakamurellaceae Fibrobacteraceae Nakamurellaceae Fervidicoccaceae Nocardiopsaceae Fervidicoccaceae Nocardiopsaceae Halobacteriaceae Halobacteriaceae Dermacoccaceae Dermacoccaceae Acidothermaceae Acidothermaceae Burkholderiaceae Chrysiogenaceae Burkholderiaceae Chrysiogenaceae Ferrimonadaceae Ferrimonadaceae Halomonadaceae Halomonadaceae Alcanivoracaceae Alcanivoracaceae Aeromonadaceae Aeromonadaceae Glycomycetaceae Glycomycetaceae Lentisphaeraceae Lentisphaeraceae Desulfobulbaceae Patulibacteraceae Desulfobulbaceae Patulibacteraceae Rhodospirillaceae Rhodospirillaceae Fusobacteriaceae Methanopyraceae Fusobacteriaceae Methanopyraceae Methylocystaceae Methylocystaceae Brevibacteriaceae Brevibacteriaceae Anaplasmataceae Streptococcaceae Anaplasmataceae Streptococcaceae Heliobacteriaceae Heliobacteriaceae Acetobacteraceae Caldisphaeraceae Cystobacteraceae Acetobacteraceae Caldisphaeraceae Cystobacteraceae Puniceicoccaceae Puniceicoccaceae Mariprofundaceae Mariprofundaceae Caulobacteraceae Oxalobacteraceae Caulobacteraceae Oxalobacteraceae Acidimicrobiaceae Elusimicrobiaceae Halanaerobiaceae Methanocellaceae Acidimicrobiaceae Elusimicrobiaceae Halanaerobiaceae Methanocellaceae Beutenbergiaceae Beutenbergiaceae Mycobacteriaceae Mycobacteriaceae Dermatophilaceae Flavobacteriaceae Dermatophilaceae Flavobacteriaceae Coriobacteriaceae Coriobacteriaceae Actinomycetaceae Actinomycetaceae Tsukamurellaceae Tsukamurellaceae Microbacteriaceae Microbacteriaceae Rubrobacteraceae Salinisphaeraceae Rubrobacteraceae Salinisphaeraceae Piscirickettsiaceae Piscirickettsiaceae Ruminococcaceae Ruminococcaceae Acidobacteriaceae Bifidobacteriaceae Cyclobacteriaceae Acidobacteriaceae Bifidobacteriaceae Cyclobacteriaceae Methylococcaceae Rhodothermaceae Thermococcaceae Methylococcaceae Rhodothermaceae Thermococcaceae Bradyrhizobiaceae Bradyrhizobiaceae Helicobacteraceae Helicobacteraceae Haloplasmataceae Nitrosopumilaceae Haloplasmataceae Nitrosopumilaceae Blattabacteriaceae Blattabacteriaceae Catenulisporaceae Catenulisporaceae Archaeoglobaceae Archaeoglobaceae Ignavibacteriaceae Ignavibacteriaceae Alicyclobacillaceae Alicyclobacillaceae Alteromonadaceae Leuconostocaceae Alteromonadaceae Leuconostocaceae Phyllobacteriaceae Phyllobacteriaceae Rhodobacteraceae Rhodobacteraceae Bdellovibrionaceae Comamonadaceae Bdellovibrionaceae Comamonadaceae Melioribacteraceae Melioribacteraceae Thermoproteaceae Thermoproteaceae Deferribacteraceae Deferribacteraceae Carnobacteriaceae Flammeovirgaceae Carnobacteriaceae Flammeovirgaceae Natranaerobiaceae Natranaerobiaceae Methanosaetaceae Methanosaetaceae Dermabacteraceae Oceanospirillaceae Dermabacteraceae Oceanospirillaceae Intrasporangiaceae Intrasporangiaceae Spiroplasmataceae Spiroplasmataceae Conexibacteraceae Conexibacteraceae Streptomycetaceae Streptomycetaceae Sanguibacteraceae Sanguibacteraceae Mycoplasmataceae Mycoplasmataceae Staphylococcaceae Staphylococcaceae Xanthobacteraceae Xanthobacteraceae Halothiobacillaceae Hyphomonadaceae Magnetococcaceae Methanococcaceae Halothiobacillaceae Hyphomonadaceae Magnetococcaceae Methanococcaceae Cardiobacteriaceae Oscillochloridaceae Cardiobacteriaceae Oscillochloridaceae Enterobacteriaceae Enterobacteriaceae Planctomycetaceae Planctomycetaceae Parachlamydiaceae Parachlamydiaceae Erythrobacteraceae Erythrobacteraceae Desulfohalobiaceae Desulfohalobiaceae Erysipelotrichaceae Erysipelotrichaceae Acidithiobacillaceae Acidithiobacillaceae Bacteriovoracaceae Bacteriovoracaceae Cellulomonadaceae Hyphomicrobiaceae Methanoregulaceae Cellulomonadaceae Hyphomicrobiaceae Methanoregulaceae Desulfobacteraceae Desulfobacteraceae Halobacteroidaceae Halobacteroidaceae Methanospirillaceae Succinivibrionaceae Methanospirillaceae Succinivibrionaceae Aurantimonadaceae Aurantimonadaceae Nitrosomonadaceae Nitrosomonadaceae Xanthomonadaceae Xanthomonadaceae Corynebacteriaceae Corynebacteriaceae Desulfovibrionaceae Desulfovibrionaceae Desulfurococcaceae Prochlorococcaceae Desulfurococcaceae Prochlorococcaceae Hydrogenophilaceae Pseudomonadaceae Hydrogenophilaceae Pseudomonadaceae Methanothermaceae Methanothermaceae Methylobacteriaceae Methylobacteriaceae Ktedonobacteraceae Ktedonobacteraceae Methylacidiphilaceae Methylacidiphilaceae Herpetosiphonaceae Herpetosiphonaceae Actinopolysporaceae Actinopolysporaceae Sphaerobacteraceae Sphaerobacteraceae Acholeplasmataceae Dehalococcoidaceae Methanosarcinaceae Acholeplasmataceae Dehalococcoidaceae Methanosarcinaceae Desulfomicrobiaceae Desulfomicrobiaceae Verrucomicrobiaceae Verrucomicrobiaceae Pseudonocardiaceae Psychromonadaceae Pseudonocardiaceae Psychromonadaceae Campylobacteraceae Propionibacteriaceae Campylobacteraceae Propionibacteriaceae Sphingobacteriaceae Sphingobacteriaceae Thermomicrobiaceae Thermomicrobiaceae Acidaminococcaceae Acidaminococcaceae Sphingomonadaceae Sphingomonadaceae Cryptosporangiaceae Cryptosporangiaceae Micromonosporaceae Micromonosporaceae Methanobacteriaceae Methanobacteriaceae Entomoplasmataceae Entomoplasmataceae Thermoplasmataceae Thermoplasmataceae Streptosporangiaceae Streptosporangiaceae Porphyromonadaceae Porphyromonadaceae Gemmatimonadaceae Methanomicrobiaceae Gemmatimonadaceae Methanomicrobiaceae Syntrophorhabdaceae Syntrophorhabdaceae Geodermatophilaceae Geodermatophilaceae Desulfurobacteriaceae Desulfurobacteriaceae Syntrophobacteraceae Syntrophobacteraceae Desulfuromonadaceae Desulfuromonadaceae Thermodesulfobiaceae Thermodesulfobiaceae Hydrogenothermaceae Hydrogenothermaceae Syntrophomonadaceae Syntrophomonadaceae Peptostreptococcaceae Peptostreptococcaceae Ectothiorhodospiraceae Ectothiorhodospiraceae Thermomonosporaceae Thermomonosporaceae Methanocorpusculaceae Methanocorpusculaceae Methanocaldococcaceae Methanocaldococcaceae Promicromonosporaceae Promicromonosporaceae Candidatus Brocadiaceae Candidatus Brocadiaceae Thermoactinomycetaceae Thermoactinomycetaceae Pseudoalteromonadaceae Pseudoalteromonadaceae Thermoanaerobacteraceae Thermoanaerobacteraceae Thermodesulfobacteriaceae Thermodesulfobacteriaceae Verrucomicrobia subdivision 3 Verrucomicrobia subdivision 3 Verrucomicrobia Bacillales Family X. Incertae Sedis Bacillales Family X. Incertae Sedis Bacillales Family Clostridiales Family XI. IncertaeClostridiales Sedis Family XI. IncertaeClostridiales Sedis Family Clostridiales Family XIII. IncertaeClostridiales Sedis Family XIII. IncertaeClostridiales Sedis Family Clostridiales Family XVII. IncertaeClostridiales Sedis Family XVII. IncertaeClostridiales Sedis Family Clostridiales Family XVIII. IncertaeClostridiales Sedis Family XVIII. IncertaeClostridiales Sedis Family Thermoanaerobacterales Family IV. Incertae Sedis IV. Thermoanaerobacterales Family Incertae Sedis IV. Thermoanaerobacterales Family Thermoanaerobacterales Family III. IncertaeThermoanaerobacterales Sedis Family III. IncertaeThermoanaerobacterales Sedis Family family family

16S GC (%) mean and SD Genome size (Mb) mean and SD 70 25 65 20 60 15 55 10 50 5 16S GC (%) 45 0 Genome size (Mb) Genome size Bacillaceae Bacillaceae Dietziaceae unclassified Dietziaceae unclassified Opitutaceae Opitutaceae Listeriaceae Listeriaceae Frankiaceae Frankiaceae Nautiliaceae Nautiliaceae Kofleriaceae Kofleriaceae Hahellaceae Hahellaceae Jonesiaceae Jonesiaceae Thermaceae Thermaceae Coxiellaceae Coxiellaceae Aquificaceae Aquificaceae Waddliaceae Waddliaceae Brucellaceae Brucellaceae Nostocaceae Nostocaceae Vibrionaceae Vibrionaceae Moritellaceae Moritellaceae Rhizobiaceae Rhizobiaceae Victivallaceae Victivallaceae Trueperaceae Trueperaceae Jiangellaceae Jiangellaceae Colwelliaceae Colwelliaceae Nocardiaceae Nocardiaceae Acidilobaceae Acidilobaceae Rikenellaceae Rikenellaceae Gordoniaceae Simkaniaceae Gordoniaceae Simkaniaceae Sulfolobaceae Sulfolobaceae Clostridiaceae Neisseriaceae Clostridiaceae Neisseriaceae Sutterellaceae Sutterellaceae Nitrospiraceae Nitrospiraceae Chlorobiaceae Chlorobiaceae Moraxellaceae Moraxellaceae Rickettsiaceae Rickettsiaceae Polyangiaceae Polyangiaceae Caldilineaceae Picrophilaceae Prevotellaceae Pyrodictiaceae Caldilineaceae Picrophilaceae Prevotellaceae Pyrodictiaceae Thiotrichaceae Thiotrichaceae Veillonellaceae Veillonellaceae Bartonellaceae Bartonellaceae Legionellaceae Syntrophaceae Legionellaceae Syntrophaceae Alcaligenaceae Chromatiaceae Alcaligenaceae Chromatiaceae Leptospiraceae Leptospiraceae Gallionellaceae Gallionellaceae Idiomarinaceae Idiomarinaceae Chlamydiaceae Chlamydiaceae Aerococcaceae Synergistaceae Aerococcaceae Synergistaceae Thermofilaceae Thermofilaceae Bacteroidaceae Bacteroidaceae Eubacteriaceae Eubacteriaceae Francisellaceae Saprospiraceae Francisellaceae Saprospiraceae Cytophagaceae Holophagaceae Cytophagaceae Holophagaceae Caldisericaceae Caldisericaceae Pasteurellaceae Pasteurellaceae Segniliparaceae Solibacteraceae Segniliparaceae Solibacteraceae Myxococcaceae Myxococcaceae Chloroflexaceae Chloroflexaceae Micrococcaceae Micrococcaceae Actinospicaceae Actinospicaceae Beijerinckiaceae Beijerinckiaceae Shewanellaceae Shewanellaceae Oscillospiraceae Oscillospiraceae Planococcaceae Planococcaceae Peptococcaceae Peptococcaceae Crenotrichaceae Leptotrichiaceae Crenotrichaceae Leptotrichiaceae Geobacteraceae Geobacteraceae Deinococcaceae Rhodocyclaceae Deinococcaceae Rhodocyclaceae Brachyspiraceae Brachyspiraceae Sporichthyaceae Sporichthyaceae Pelobacteraceae Pelobacteraceae Desulfurellaceae Lactobacillaceae Nannocystaceae Desulfurellaceae Lactobacillaceae Nannocystaceae Kineosporiaceae Marinilabiliaceae Kineosporiaceae Marinilabiliaceae Nocardioidaceae Nocardioidaceae Anaerolineaceae Spirochaetaceae Anaerolineaceae Spirochaetaceae Paenibacillaceae Paenibacillaceae Nitriliruptoraceae Nitriliruptoraceae Thermotogaceae Thermotogaceae Lachnospiraceae Lachnospiraceae Cenarchaeaceae Cenarchaeaceae Dictyoglomaceae Dictyoglomaceae Desulfarculaceae Desulfarculaceae Cryomorphaceae Cryomorphaceae Parvularculaceae Parvularculaceae Enterococcaceae Enterococcaceae Ferroplasmaceae Methylophilaceae Ferroplasmaceae Methylophilaceae Fibrobacteraceae Nakamurellaceae Fibrobacteraceae Nakamurellaceae Fervidicoccaceae Nocardiopsaceae Fervidicoccaceae Nocardiopsaceae Halobacteriaceae Halobacteriaceae Acidothermaceae Dermacoccaceae Acidothermaceae Dermacoccaceae Burkholderiaceae Chrysiogenaceae Burkholderiaceae Chrysiogenaceae Ferrimonadaceae Ferrimonadaceae Halomonadaceae Halomonadaceae Alcanivoracaceae Alcanivoracaceae Aeromonadaceae Aeromonadaceae Glycomycetaceae Glycomycetaceae Lentisphaeraceae Lentisphaeraceae Desulfobulbaceae Patulibacteraceae Desulfobulbaceae Patulibacteraceae Fusobacteriaceae Rhodospirillaceae Fusobacteriaceae Rhodospirillaceae Methanopyraceae Methanopyraceae Methylocystaceae Methylocystaceae Brevibacteriaceae Brevibacteriaceae Anaplasmataceae Streptococcaceae Anaplasmataceae Streptococcaceae Heliobacteriaceae Heliobacteriaceae Caldisphaeraceae Cystobacteraceae Caldisphaeraceae Cystobacteraceae Acetobacteraceae Acetobacteraceae Puniceicoccaceae Puniceicoccaceae Mariprofundaceae Mariprofundaceae Caulobacteraceae Oxalobacteraceae Caulobacteraceae Oxalobacteraceae Acidimicrobiaceae Elusimicrobiaceae Acidimicrobiaceae Elusimicrobiaceae Beutenbergiaceae Halanaerobiaceae Methanocellaceae Beutenbergiaceae Halanaerobiaceae Methanocellaceae Mycobacteriaceae Mycobacteriaceae Dermatophilaceae Dermatophilaceae Flavobacteriaceae Flavobacteriaceae Coriobacteriaceae Coriobacteriaceae Actinomycetaceae Actinomycetaceae Tsukamurellaceae Tsukamurellaceae Microbacteriaceae Microbacteriaceae Rubrobacteraceae Salinisphaeraceae Rubrobacteraceae Salinisphaeraceae Piscirickettsiaceae Piscirickettsiaceae Ruminococcaceae Ruminococcaceae Acidobacteriaceae Bifidobacteriaceae Cyclobacteriaceae Acidobacteriaceae Bifidobacteriaceae Cyclobacteriaceae Methylococcaceae Rhodothermaceae Thermococcaceae Methylococcaceae Rhodothermaceae Thermococcaceae Bradyrhizobiaceae Bradyrhizobiaceae Helicobacteraceae Helicobacteraceae Haloplasmataceae Nitrosopumilaceae Haloplasmataceae Nitrosopumilaceae Blattabacteriaceae Blattabacteriaceae Catenulisporaceae Catenulisporaceae Archaeoglobaceae Archaeoglobaceae Ignavibacteriaceae Ignavibacteriaceae Alicyclobacillaceae Alteromonadaceae Alicyclobacillaceae Alteromonadaceae Leuconostocaceae Leuconostocaceae Phyllobacteriaceae Phyllobacteriaceae Rhodobacteraceae Rhodobacteraceae Bdellovibrionaceae Comamonadaceae Bdellovibrionaceae Comamonadaceae Melioribacteraceae Melioribacteraceae Thermoproteaceae Thermoproteaceae Deferribacteraceae Deferribacteraceae Carnobacteriaceae Flammeovirgaceae Carnobacteriaceae Flammeovirgaceae Natranaerobiaceae Natranaerobiaceae Methanosaetaceae Methanosaetaceae Dermabacteraceae Oceanospirillaceae Dermabacteraceae Oceanospirillaceae Intrasporangiaceae Intrasporangiaceae Spiroplasmataceae Spiroplasmataceae Conexibacteraceae Conexibacteraceae Streptomycetaceae Streptomycetaceae Sanguibacteraceae Sanguibacteraceae Mycoplasmataceae Mycoplasmataceae Staphylococcaceae Staphylococcaceae Xanthobacteraceae Xanthobacteraceae Halothiobacillaceae Hyphomonadaceae Magnetococcaceae Methanococcaceae Halothiobacillaceae Hyphomonadaceae Magnetococcaceae Methanococcaceae Cardiobacteriaceae Enterobacteriaceae Oscillochloridaceae Cardiobacteriaceae Enterobacteriaceae Oscillochloridaceae Planctomycetaceae Planctomycetaceae Parachlamydiaceae Parachlamydiaceae Erythrobacteraceae Erythrobacteraceae Desulfohalobiaceae Desulfohalobiaceae Erysipelotrichaceae Erysipelotrichaceae Acidithiobacillaceae Acidithiobacillaceae Bacteriovoracaceae Bacteriovoracaceae Hyphomicrobiaceae Hyphomicrobiaceae Cellulomonadaceae Methanoregulaceae Cellulomonadaceae Methanoregulaceae Desulfobacteraceae Desulfobacteraceae Halobacteroidaceae Halobacteroidaceae Aurantimonadaceae Methanospirillaceae Succinivibrionaceae Aurantimonadaceae Methanospirillaceae Succinivibrionaceae Nitrosomonadaceae Nitrosomonadaceae Xanthomonadaceae Xanthomonadaceae Corynebacteriaceae Corynebacteriaceae Desulfovibrionaceae Desulfovibrionaceae Desulfurococcaceae Prochlorococcaceae Desulfurococcaceae Prochlorococcaceae Hydrogenophilaceae Pseudomonadaceae Hydrogenophilaceae Pseudomonadaceae Methanothermaceae Methanothermaceae Methylobacteriaceae Methylobacteriaceae Ktedonobacteraceae Ktedonobacteraceae Methylacidiphilaceae Methylacidiphilaceae Herpetosiphonaceae Herpetosiphonaceae Actinopolysporaceae Sphaerobacteraceae Actinopolysporaceae Sphaerobacteraceae Acholeplasmataceae Dehalococcoidaceae Methanosarcinaceae Acholeplasmataceae Dehalococcoidaceae Methanosarcinaceae Desulfomicrobiaceae Desulfomicrobiaceae Verrucomicrobiaceae Verrucomicrobiaceae Psychromonadaceae Psychromonadaceae Pseudonocardiaceae Pseudonocardiaceae Campylobacteraceae Propionibacteriaceae Sphingobacteriaceae Campylobacteraceae Propionibacteriaceae Sphingobacteriaceae Thermomicrobiaceae Thermomicrobiaceae Acidaminococcaceae Acidaminococcaceae Sphingomonadaceae Sphingomonadaceae Cryptosporangiaceae Cryptosporangiaceae Micromonosporaceae Micromonosporaceae Methanobacteriaceae Methanobacteriaceae Entomoplasmataceae Entomoplasmataceae Thermoplasmataceae Thermoplasmataceae Streptosporangiaceae Streptosporangiaceae Porphyromonadaceae Porphyromonadaceae Gemmatimonadaceae Methanomicrobiaceae Syntrophorhabdaceae Gemmatimonadaceae Methanomicrobiaceae Syntrophorhabdaceae Geodermatophilaceae Geodermatophilaceae Desulfurobacteriaceae Desulfurobacteriaceae Syntrophobacteraceae Syntrophobacteraceae Desulfuromonadaceae Desulfuromonadaceae Thermodesulfobiaceae Thermodesulfobiaceae Hydrogenothermaceae Hydrogenothermaceae Syntrophomonadaceae Syntrophomonadaceae Peptostreptococcaceae Peptostreptococcaceae Ectothiorhodospiraceae Ectothiorhodospiraceae Thermomonosporaceae Thermomonosporaceae Methanocorpusculaceae Methanocorpusculaceae Methanocaldococcaceae Methanocaldococcaceae Promicromonosporaceae Promicromonosporaceae Candidatus Brocadiaceae Candidatus Brocadiaceae Thermoactinomycetaceae Thermoactinomycetaceae Pseudoalteromonadaceae Pseudoalteromonadaceae Thermoanaerobacteraceae Thermoanaerobacteraceae Thermodesulfobacteriaceae Thermodesulfobacteriaceae Verrucomicrobia subdivision 3 Verrucomicrobia subdivision 3 Verrucomicrobia Bacillales Family X. Incertae Sedis Bacillales Family X. Incertae Sedis Bacillales Family Clostridiales Family XI. IncertaeClostridiales Sedis Family XI. IncertaeClostridiales Sedis Family Clostridiales Family XIII. IncertaeClostridiales Sedis Family XIII. IncertaeClostridiales Sedis Family Clostridiales Family XVII. IncertaeClostridiales Sedis Family XVII. IncertaeClostridiales Sedis Family Clostridiales Family XVIII. IncertaeClostridiales Sedis Family XVIII. IncertaeClostridiales Sedis Family Thermoanaerobacterales Family IV. Incertae Sedis IV. Thermoanaerobacterales Family Incertae Sedis IV. Thermoanaerobacterales Family Thermoanaerobacterales Family III. IncertaeThermoanaerobacterales Sedis Family III. IncertaeThermoanaerobacterales Sedis Family family family Distributions for genus level

Primer score mean and SD Genomic GC (%) mean and SD

5.0 60

2.5 40 Primer score

0.0 Genomic GC (%) 20 Afipia Afipia Vibrio Vibrio Dorea Dorea Basfia Basfia Delftia Delftia Kordia Kordia Agreia Hafnia Rothia Agreia Hafnia Rothia Xylella Xylella Orenia Orenia Labrys Labrys Dietzia Dietzia Blautia Blautia Ensifer Ensifer Nisaea Nostoc Nisaea Nostoc Hippea Hippea Slackia Slackia Listeria Listeria Aquifex Aquifex Erwinia Sodalis Erwinia Sodalis Frankia Frankia Nautilia Oligella Nautilia Oligella Kocuria Kocuria Hahella Hahella Bacillus Belliella Borrelia Hoeflea Jonesia Proteus Bacillus Belliella Borrelia Hoeflea Jonesia Proteus Yersinia Yersinia Serratia Serratia Dickeya Dickeya Bizionia Mahella Bizionia Mahella Orientia Orientia Coxiella Coxiella Pirellula Pirellula Kingella Shigella Kingella Shigella Waddlia Waddlia Kyrpidia Kyrpidia Dialister Hirschia Dialister Hirschia Niabella Niabella Brucella Brucella Dasania Nautella Dasania Nautella Pantoea Pantoea Lyngbya Lyngbya Thauera Thauera Alistipes Gemella Opitutus Alistipes Gemella Opitutus Aliivibrio Aliivibrio Filifactor Filifactor Bilophila Bulleidia Bilophila Bulleidia Moritella Moritella Moorella Solitalea Moorella Solitalea Ehrlichia Thiothrix Ehrlichia Thiothrix Azospira Azospira Balneola Kribbella Sagittula Balneola Kribbella Sagittula Starkeya Starkeya Ahrensia Cohnella Jiangella Joostella Rahnella Truepera Ahrensia Cohnella Jiangella Joostella Rahnella Truepera Nitritalea Thermus Nitritalea Thermus Flexithrix Flexithrix Colwellia Colwellia Emticicia Nocardia Emticicia Nocardia Frateuria Leifsonia Frateuria Leifsonia Natrialba Natrialba Wolinella Wolinella Eikenella Eikenella Gramella Gramella Myroides Myroides Ruegeria Ruegeria Victivallis Wenxinia Victivallis Wenxinia Rikenella Rikenella Gordonia Kangiella Salisaeta Simkania Gordonia Kangiella Salisaeta Simkania Cellvibrio Marivirga Cellvibrio Marivirga Lewinella Lewinella Azoarcus Azoarcus Fluviicola Lautropia Olsenella Ralstonia Fluviicola Lautropia Olsenella Ralstonia Caldithrix Neisseria Taylorella Caldithrix Neisseria Taylorella Lawsonia Reinekea Lawsonia Reinekea Catonella Dokdonia Sutterella Catonella Dokdonia Sutterella Endoriftia Haloferax Endoriftia Haloferax Weissella Weissella Buchnera Buchnera Halopiger Klebsiella Halopiger Klebsiella Lacinutrix Petrotoga Lacinutrix Petrotoga Halovivax Moraxella Nodularia Halovivax Moraxella Nodularia Ilyobacter Rickettsia Ilyobacter Rickettsia Acidianus Acidianus Brenneria Grimontia Brenneria Grimontia Martelella Martelella Caldilinea Citreicella Gemmata Indibacter Labrenzia Mesotoga Prevotella Caldilinea Citreicella Gemmata Indibacter Labrenzia Mesotoga Prevotella Leptothrix Leptothrix Pyrolobus Pyrolobus Scardovia Scardovia Caldivirga Thiocystis Ulvibacter Caldivirga Thiocystis Ulvibacter Laribacter Laribacter Veillonella Veillonella Micavibrio Micavibrio Beggiatoa Bordetella Facklamia Rudanella Beggiatoa Bordetella Facklamia Rudanella Maricaulis Maricaulis Acidilobus Acidilobus Bartonella Bartonella Roseburia Roseburia Anabaena Collinsella Echinicola Legionella Loktanella Anabaena Collinsella Echinicola Legionella Loktanella Weeksella Weeksella Janibacter Microvirga Janibacter Microvirga Leisingera Tannerella Leisingera Tannerella Finegoldia Thiocapsa Finegoldia Thiocapsa Sulfolobus Sulfolobus Acetivibrio Crenothrix Natrinema Acetivibrio Crenothrix Natrinema Wolbachia Wolbachia Turneriella Turneriella Leptospira Rubrivivax Leptospira Rubrivivax Microscilla Microscilla Gallionella Geobacter Glaciecola Sebaldella Gallionella Geobacter Glaciecola Sebaldella Variovorax Variovorax Idiomarina Marinitoga Idiomarina Marinitoga Flexistipes Flexistipes Chlamydia Rhizobium Chlamydia Rhizobium Ignicoccus Ignicoccus Pelobacter Pelobacter Maribacter Maribacter Atopobium Haloarcula Riemerella Spirosoma Atopobium Haloarcula Riemerella Spirosoma Francisella Saprospira Sorangium Tolumonas Francisella Saprospira Sorangium Tolumonas Arcobacter Cytophaga Holophaga Arcobacter Cytophaga Holophaga Flexibacter Flexibacter Nitriliruptor Nitriliruptor Aeropyrum Terriglobus Aeropyrum Terriglobus Citrobacter Histophilus Nitrobacter Picrophilus Citrobacter Histophilus Nitrobacter Picrophilus Acidovorax Pelagibaca Acidovorax Pelagibaca Aquiflexum Arthrospira Aquiflexum Arthrospira Salinispora Salinispora Ammonifex Isosphaera Ammonifex Isosphaera Collimonas Microcystis Salmonella Stigmatella Thiomonas Collimonas Microcystis Salmonella Stigmatella Thiomonas Oscillatoria Oscillatoria Pasteurella Pasteurella Alkaliflexus Barnesiella Alkaliflexus Barnesiella Butyrivibrio Butyrivibrio Clavibacter Clavibacter Haloplanus Treponema Haloplanus Treponema Alkaliphilus Haliangium Alkaliphilus Haliangium Anaplasma Leptonema Meganema Oceanicola Rhodocista Anaplasma Leptonema Meganema Oceanicola Rhodocista Pontibacter Pontibacter Clostridium Clostridium Aequorivita Kosmotoga Aequorivita Kosmotoga Methylopila Methylopila Cyanobium Ferrimonas Jannaschia Cyanobium Ferrimonas Jannaschia Sulfurovum Sulfurovum Abiotrophia Acetonema Baumannia Fibrobacter Halomonas Mobiluncus Syntrophus Abiotrophia Acetonema Baumannia Fibrobacter Halomonas Mobiluncus Syntrophus Kytococcus Pedobacter Kytococcus Pedobacter Eggerthella Pelodictyon Eggerthella Pelodictyon Actinospica Aeromonas Chlorobium Jonquetella Simonsiella Actinospica Aeromonas Chlorobium Jonquetella Simonsiella Beijerinckia Isoptericola Rhodoferax Beijerinckia Isoptericola Rhodoferax Alcanivorax Shewanella Alcanivorax Shewanella Roseiflexus Roseiflexus Bdellovibrio Oligotropha Pyrococcus Bdellovibrio Oligotropha Pyrococcus Paracoccus Paracoccus Escherichia Fulvimarina Leptotrichia Escherichia Fulvimarina Leptotrichia Providencia Providencia Ignisphaera Ignisphaera Aerococcus Gardnerella Geobacillus Plesiocystis Salinibacter Synergistes unclassified Aerococcus Gardnerella Geobacillus Plesiocystis Salinibacter Synergistes unclassified Brachyspira Nitratiruptor Brachyspira Nitratiruptor Odoribacter Patulibacter Odoribacter Patulibacter Sporichthya Sporichthya Halorubrum Halorubrum Granulicella Granulicella Parvimonas Parvimonas Cupriavidus Cupriavidus Bacteroides Desulfurella Haloplasma Sciscionella Thiobacillus Bacteroides Desulfurella Haloplasma Sciscionella Thiobacillus Ferroglobus Ferroglobus Polaribacter Tropheryma Polaribacter Tropheryma Methylibium Methylibium Cyanothece Rickettsiella Cyanothece Rickettsiella Azotobacter Azotobacter Nitrosospira Nitrosospira Acetobacter Acidiphilium Anaerolinea Johnsonella Microcoleus Ramlibacter Rhodovibrio Spirochaeta Acetobacter Acidiphilium Anaerolinea Johnsonella Microcoleus Ramlibacter Rhodovibrio Spirochaeta Succinispira Succinispira Azospirillum Caulobacter Halobacillus Oxalobacter Ureaplasma Azospirillum Caulobacter Halobacillus Oxalobacter Ureaplasma Thermotoga Thermotoga Nitratifractor Nitratifractor Deferrisoma Glycomyces Deferrisoma Glycomyces Allobaculum Mannheimia Oscillibacter Allobaculum Mannheimia Oscillibacter Gloeobacter Gloeobacter Hylemonella Myxococcus Zymomonas Hylemonella Myxococcus Zymomonas Cronobacter Limnobacter Megamonas Rubrobacter Xylanibacter Cronobacter Limnobacter Megamonas Rubrobacter Xylanibacter Paludibacter Segniliparus Paludibacter Segniliparus Thermincola Thermincola Chloroflexus Desulfotalea Methylocella Chloroflexus Desulfotalea Methylocella Roseovarius Roseovarius Arthrobacter Arthrobacter Parvularcula Parvularcula Micrococcus Micrococcus Anaerofustis Helicobacter Lactococcus Oenococcus Spiroplasma Sulfitobacter Anaerofustis Helicobacter Lactococcus Oenococcus Spiroplasma Sulfitobacter Thermofilum Thermofilum Brevibacillus Ferroplasma Sulfobacillus Brevibacillus Ferroplasma Sulfobacillus Nakamurella Nakamurella Alteromonas Denitrovibrio Mycoplasma Pusillimonas Segetibacter Alteromonas Denitrovibrio Mycoplasma Pusillimonas Segetibacter Pediococcus Pediococcus Thermovirga Thermovirga Eubacterium Eubacterium Burkholderia Burkholderia Dyadobacter Dyadobacter Actinomyces Edwardsiella Vulcanisaeta Actinomyces Edwardsiella Vulcanisaeta Desmospora Desmospora Alicycliphilus Comamonas Croceibacter Dethiobacter Halorhabdus Helcococcus Kineococcus Leuconostoc Mesoplasma Microlunatus Phaeobacter Planococcus Roseobacter Alicycliphilus Comamonas Croceibacter Dethiobacter Halorhabdus Helcococcus Kineococcus Leuconostoc Mesoplasma Microlunatus Phaeobacter Planococcus Roseobacter Actinoplanes Deinococcus Enterobacter Mobilicoccus Oceanicaulis Raphidiopsis Rhodobacter Xylanimonas Actinoplanes Deinococcus Enterobacter Mobilicoccus Oceanicaulis Raphidiopsis Rhodobacter Xylanimonas Melioribacter Melioribacter Desulfovibrio Desulfovibrio Oribacterium Oribacterium Nonomuraea Nonomuraea Deferribacter Deferribacter Lentisphaera Lentisphaera Neorickettsia Neorickettsia Ancylobacter Asticcacaulis Lactobacillus Nocardiopsis Pseudovibrio Robiginitalea Ancylobacter Asticcacaulis Lactobacillus Nocardiopsis Pseudovibrio Robiginitalea Akkermansia Akkermansia Caldisericum Meiothermus Methylosinus Thermicanus Thermosinus Caldisericum Meiothermus Methylosinus Thermicanus Thermosinus Thermocrinis Thermocrinis Gracilimonas Gracilimonas Anaerostipes Cellulophaga Coprococcus Haemophilus Nocardioides Pyrobaculum Sphingobium Anaerostipes Cellulophaga Coprococcus Haemophilus Nocardioides Pyrobaculum Sphingobium Polaromonas Polaromonas Algoriphagus Marinobacter Paenibacillus Sulfurimonas Algoriphagus Marinobacter Paenibacillus Sulfurimonas Conexibacter Lysinibacillus Methanofollis Thermobifida Thermosipho Thermovibrio Conexibacter Lysinibacillus Methanofollis Thermobifida Thermosipho Thermovibrio Caldisphaera Caldisphaera Blastococcus Caminibacter Hyphomonas Lamprocystis Macrococcus Methylovorus Pedosphaera Sporosarcina Blastococcus Caminibacter Hyphomonas Lamprocystis Macrococcus Methylovorus Pedosphaera Sporosarcina Chitinophaga Sanguibacter Chitinophaga Sanguibacter Oscillochloris Oscillochloris Sphingopyxis Sphingopyxis Aromatoleum Aromatoleum Beutenbergia Dehalobacter Methanocella Xanthobacter Xenorhabdus Beutenbergia Dehalobacter Methanocella Xanthobacter Xenorhabdus Peptoniphilus Peptoniphilus Methyloferula Methyloferula Dictyoglomus Methylocystis Dictyoglomus Methylocystis Granulibacter Granulibacter Tsukamurella Tsukamurella Anaerophaga Flavonifractor Methanolinea Anaerophaga Flavonifractor Methanolinea Haloterrigena Haloterrigena Acaryochloris Acaryochloris Azorhizobium Desulfarculus Desulfobacca Sideroxydans Azorhizobium Desulfarculus Desulfobacca Sideroxydans Erythrobacter Erythrobacter Erysipelothrix Erysipelothrix Salinisphaera Salinisphaera Cellulomonas Coprobacillus Enterococcus Eremococcus Flectobacillus Rhodococcus Cellulomonas Coprobacillus Enterococcus Eremococcus Flectobacillus Rhodococcus Marinomonas Oceanibulbus Marinomonas Oceanibulbus Alishewanella Bacteriovorax Chelativorans Alishewanella Bacteriovorax Chelativorans Anoxybacillus Methylophilus Anoxybacillus Methylophilus Granulicatella Granulicatella Streptomyces Streptomyces Kitasatospora Megasphaera Kitasatospora Megasphaera Acinetobacter Actinobacillus Cloacibacillus Dichelobacter Fervidicoccus Selenomonas Acinetobacter Actinobacillus Cloacibacillus Dichelobacter Fervidicoccus Selenomonas Parasutterella Parasutterella Methylovulum Methylovulum Acidothermus Aurantimonas Methanotorris Acidothermus Aurantimonas Methanotorris Dermacoccus Methylocapsa Dermacoccus Methylocapsa Catenulispora Polymorphum Catenulispora Polymorphum Sulfuricurvum Sulfuricurvum Krokinobacter Nitrosomonas Oceanimonas Xanthomonas Krokinobacter Nitrosomonas Oceanimonas Xanthomonas Fructobacillus Palaeococcus Fructobacillus Palaeococcus Psychroflexus Psychroflexus Owenweeksia Owenweeksia Planctomyces Planctomyces Blastopirellula Photorhabdus Blastopirellula Photorhabdus Adhaeribacter Adhaeribacter Methylobacter Methylophaga Methylobacter Methylophaga Desulfobulbus Desulfobulbus Corallococcus Crocosphaera Teredinibacter Corallococcus Crocosphaera Teredinibacter Acholeplasma Alkalilimnicola Cenarchaeum Geminicoccus Nitrosococcus Sedimenticola Acholeplasma Alkalilimnicola Cenarchaeum Geminicoccus Nitrosococcus Sedimenticola Maritimibacter Methylotenera Maritimibacter Methylotenera Desulfomonile Desulfomonile Methanopyrus Sinorhizobium Methanopyrus Sinorhizobium Parascardovia Parascardovia Hyperthermus Hyperthermus Anaerococcus Gordonibacter Leadbetterella Methanosaeta Streptococcus Anaerococcus Gordonibacter Leadbetterella Methanosaeta Streptococcus Paraprevotella Persephonella Shuttleworthia Paraprevotella Persephonella Shuttleworthia Ochrobactrum Ochrobactrum Desulfurivibrio Marinithermus Desulfurivibrio Marinithermus Psychrobacter Rhodopirellula Synechocystis Psychrobacter Rhodopirellula Synechocystis Pseudomonas Pseudomonas Gallibacterium Herbaspirillum Mariprofundus Solobacterium Gallibacterium Herbaspirillum Mariprofundus Solobacterium Calditerrivibrio Calditerrivibrio Nesterenkonia Nesterenkonia Amycolatopsis Amycolatopsis Halobacterium Renibacterium Halobacterium Renibacterium Desulfococcus Enhydrobacter Methylomonas Desulfococcus Enhydrobacter Methylomonas Melissococcus Melissococcus Gluconobacter Hymenobacter Ktedonobacter Gluconobacter Hymenobacter Ktedonobacter Agrobacterium Anaerotruncus Agrobacterium Anaerotruncus Herpetosiphon Herpetosiphon Thiomicrospira Zunongwangia Thiomicrospira Zunongwangia Parachlamydia Parachlamydia Halostagnicola Natronomonas Ruminococcus Sphaerobacter Streptobacillus Halostagnicola Natronomonas Ruminococcus Sphaerobacter Streptobacillus Rhodothermus Rhodothermus Methylococcus Thermococcus Methylococcus Thermococcus Chlamydophila Marvinbryantia Chlamydophila Marvinbryantia Singulisphaera Singulisphaera Acetohalobium Nitrosopumilus Psychromonas Acetohalobium Nitrosopumilus Psychromonas Desulfonispora Fusobacterium Rhodospirillum Thioalkalivibrio Desulfonispora Fusobacterium Rhodospirillum Thioalkalivibrio Stackebrandtia Stackebrandtia Archaeoglobus Verrucosispora Archaeoglobus Verrucosispora Brevibacterium Brevibacterium Thiorhodospira Thiorhodospira Halomicrobium Methanoregula Natronococcus Sphingomonas Halomicrobium Methanoregula Natronococcus Sphingomonas Heliobacterium Heliobacterium Campylobacter Herminiimonas Methylocaldum Methylosarcina Thermoplasma Campylobacter Herminiimonas Methylocaldum Methylosarcina Thermoplasma Aeromicrobium Alicyclobacillus Chlorobaculum Citromicrobium Elizabethkingia Hydrogenivirga Aeromicrobium Alicyclobacillus Chlorobaculum Citromicrobium Elizabethkingia Hydrogenivirga Trichodesmium Trichodesmium Thermobispora Thermobispora Natronorubrum Natronorubrum Mesorhizobium Mesorhizobium Halorhodospira Halorhodospira Achromobacter Acidimicrobium Chthoniobacter Elusimicrobium Halanaerobium Achromobacter Acidimicrobium Chthoniobacter Elusimicrobium Halanaerobium Sphaerochaeta Sphaerochaeta Mycobacterium Oceanithermus Mycobacterium Oceanithermus Flavobacterium Methylobacillus Thermobacillus Thermoproteus Flavobacterium Methylobacillus Thermobacillus Thermoproteus Coriobacterium Wigglesworthia Coriobacterium Wigglesworthia Thioflavicoccus Thioflavicoccus Haloquadratum Metallosphaera Natranaerobius Haloquadratum Metallosphaera Natranaerobius Methanoplanus Methanoplanus Actinosynnema Nanoarchaeum Oceanobacillus Actinosynnema Nanoarchaeum Oceanobacillus Pelotomaculum Rhodanobacter Pelotomaculum Rhodanobacter Microbacterium Sulfurospirillum Microbacterium Sulfurospirillum Allochromatium Cellulosilyticum Halalkalicoccus Thiorhodovibrio Allochromatium Cellulosilyticum Halalkalicoccus Thiorhodovibrio Ethanoligenens Ethanoligenens Acidobacterium Bifidobacterium Cyclobacterium Acidobacterium Bifidobacterium Cyclobacterium Pectobacterium Pectobacterium Bradyrhizobium Brevundimonas Bradyrhizobium Brevundimonas Chloroherpeton Dolosigranulum Chloroherpeton Dolosigranulum Dysgonomonas Dysgonomonas Acetobacterium Blattabacterium Acetobacterium Blattabacterium Staphylococcus Staphylococcus Thermocrispum Thermocrispum Pyramidobacter Pyramidobacter Anaerobaculum Caldanaerobius Dechloromonas Halothiobacillus Magnetococcus Methanococcus Methanoculleus Synechococcus Anaerobaculum Caldanaerobius Dechloromonas Halothiobacillus Magnetococcus Methanococcus Methanoculleus Synechococcus Porphyromonas Porphyromonas Photobacterium Photobacterium Ignavibacterium Ignavibacterium Aggregatibacter Gemmatimonas Methanosalsum Octadecabacter Succinatimonas Aggregatibacter Gemmatimonas Methanosalsum Octadecabacter Succinatimonas Thermosphaera Thermosphaera Ornithinibacillus Ornithinibacillus Halothermothrix Halothermothrix Actinopolyspora Actinopolyspora Acidithiobacillus Methanosarcina Acidithiobacillus Methanosarcina Pelagibacterium Pelagibacterium Carnobacterium Carnobacterium Marichromatium Marichromatium Intrasporangium Intrasporangium Halobacteroides Mucilaginibacter Halobacteroides Mucilaginibacter Parabacteroides Pseudonocardia Parabacteroides Pseudonocardia Aminobacterium Aminobacterium Thermobaculum Thermobaculum Haloglycomyces Haloglycomyces Cyanobacterium Cyanobacterium Desulfuromonas Desulfuromonas Catenibacterium Catenibacterium Amycolicicoccus Methyloversatilis Amycolicicoccus Methyloversatilis Dinoroseobacter Dinoroseobacter Syntrophobacter Syntrophobacter Cardiobacterium Cardiobacterium Dethiosulfovibrio Dethiosulfovibrio Cryptobacterium Cryptobacterium Desulfurococcus Prochlorococcus Desulfurococcus Prochlorococcus Coraliomargarita Coraliomargarita Prosthecochloris Prosthecochloris Desulfohalobium Desulfohalobium Micromonospora Micromonospora Exiguobacterium Exiguobacterium Brachybacterium Brachybacterium Subdoligranulum Subdoligranulum Staphylothermus Staphylothermus Methanosphaera Methanosphaera Hyphomicrobium Hyphomicrobium Saccharophagus Saccharophagus Methanothermus Methanothermus Desulfatibacillum Desulfatibacillum Tetragenococcus Tetragenococcus Capnocytophaga Rhodomicrobium Syntrophomonas Capnocytophaga Rhodomicrobium Syntrophomonas Arcanobacterium Magnetospirillum Methanospirillum Arcanobacterium Magnetospirillum Methanospirillum Faecalibacterium Faecalibacterium Polynucleobacter Polynucleobacter Dehalococcoides Thiorhodococcus Dehalococcoides Thiorhodococcus Desulfurispirillum Desulfurispirillum Corynebacterium Corynebacterium Caldalkalibacillus Hydrogenobacter Caldalkalibacillus Hydrogenobacter Thermaerobacter Thermaerobacter Ornithobacterium Ornithobacterium Aciduliprofundum Aciduliprofundum Fervidobacterium Symbiobacterium Fervidobacterium Symbiobacterium Desulfobacterium Desulfobacterium Acidaminococcus Acidaminococcus Syntrophobotulus Syntrophobotulus Halogeometricum Halogeometricum Methylobacterium Methylobacterium Methylacidiphilum Methylacidiphilum Caldanaerobacter Methanohalobium Caldanaerobacter Methanohalobium Chromobacterium Chromobacterium Natronobacterium Novosphingobium Natronobacterium Novosphingobium Desulfomicrobium Desulfomicrobium Leeuwenhoekiella Leeuwenhoekiella Phenylobacterium Phenylobacterium Verrucomicrobium Verrucomicrobium Candidatus Sulcia Dehalogenimonas Candidatus Sulcia Dehalogenimonas Propionibacterium Sphingobacterium Propionibacterium Sphingobacterium Thermomicrobium Thermomicrobium Methylomicrobium Methylomicrobium Candidatus Riesia Candidatus Riesia Chryseobacterium Chryseobacterium Janthinobacterium Janthinobacterium Syntrophorhabdus Syntrophorhabdus Desulfosporosinus Syntrophothermus Desulfosporosinus Syntrophothermus Cryptosporangium Cryptosporangium Geodermatophilus Geodermatophilus Candidatus Ruthia Chromohalobacter Candidatus Ruthia Chromohalobacter Desulfotomaculum Desulfotomaculum Tepidanaerobacter Tepidanaerobacter Desulfitobacterium Methanobacterium Desulfitobacterium Methanobacterium Methanosphaerula Methanosphaerula Ectothiorhodospira Ectothiorhodospira Commensalibacter Commensalibacter Methanococcoides Methanococcoides Anaeromyxobacter Anaeromyxobacter Gluconacetobacter Methanohalophilus Gluconacetobacter Methanohalophilus Thermanaerovibrio Thermanaerovibrio Carboxydothermus Carboxydothermus Catelliglobosispora Streptosporangium Catelliglobosispora Streptosporangium Stenotrophomonas Verminephrobacter Stenotrophomonas Verminephrobacter Caldicellulosiruptor Caldicellulosiruptor Thermomonospora Thermomonospora Actinomycetospora Actinomycetospora Saccharopolyspora Saccharopolyspora Haliscomenobacter Haliscomenobacter Coprothermobacter Coprothermobacter Candidatus Frankia Candidatus Frankia Thermodesulfatator Thermodesulfatator Hydrogenobaculum Hydrogenobaculum Desulfurobacterium Ketogulonicigenium Desulfurobacterium Ketogulonicigenium Peptostreptococcus Peptostreptococcus Cylindrospermopsis Cylindrospermopsis Methanobrevibacter Methanobrevibacter Candidatus Portiera Candidatus Portiera Candidatus Serratia Thermodesulfobium Candidatus Serratia Thermodesulfobium Thioalkalimicrobium Thioalkalimicrobium Pseudoalteromonas Pseudoalteromonas Desulfonatronospira Desulfonatronospira Candidatus Regiella Candidatus Regiella Candidatus Zinderia Candidatus Zinderia Promicromonospora Promicromonospora Pseudogulbenkiania Pseudogulbenkiania Thermanaeromonas Thermanaeromonas Thermodesulfovibrio Thermodesulfovibrio Saccharomonospora Saccharomonospora Candidatus Aquiluna Rhodopseudomonas Candidatus Aquiluna Rhodopseudomonas Pseudoxanthomonas Thermoanaerobacter Pseudoxanthomonas Thermoanaerobacter Sulfurihydrogenibium Sulfurihydrogenibium Methanocaldococcus Methanocaldococcus Candidatus Kuenenia Candidatus Kuenenia Methanocorpusculum Methanocorpusculum Candidatus Nitrospira Candidatus Nitrospira Candidatus Rickettsia Candidatus Rickettsia Candidatus Moranella Candidatus Moranella Candidatus Hodgkinia Candidatus Solibacter Candidatus Hodgkinia Candidatus Solibacter Methanothermobacter Methanothermobacter Candidatus Koribacter Candidatus Tremblaya Candidatus Koribacter Candidatus Tremblaya Thermosediminibacter Thermosediminibacter Candidatus Carsonella Candidatus Carsonella Candidatus Midichloria Candidatus Midichloria Methanothermococcus Methanothermococcus Candidatus Chlorothrix Phascolarctobacterium Candidatus Chlorothrix Phascolarctobacterium Thermosynechococcus Thermosynechococcus Methanomethylovorans Methanomethylovorans Candidatus Arthromitus Candidatus Arthromitus Candidatus Liberibacter Candidatus Liberibacter Candidatus Hamiltonella Candidatus Hamiltonella Candidatus Pelagibacter Candidatus Pelagibacter Candidatus Desulforudis Candidatus Desulforudis Candidatus Mycoplasma Candidatus Mycoplasma Thermoanaerobacterium Thermoanaerobacterium Thermodesulfobacterium Thermodesulfobacterium Candidatus Phytoplasma Candidatus Phytoplasma Candidatus Blochmannia Candidatus Blochmannia Candidatus Korarchaeum Candidatus Korarchaeum Candidatus Cloacamonas Candidatus Cloacamonas Candidatus Amoebophilus Candidatus Amoebophilus Candidatus Methanoregula Candidatus Methanoregula Candidatus Caldiarchaeum Candidatus Caldiarchaeum Candidatus Accumulibacter Candidatus Accumulibacter Candidatus Azobacteroides Candidatus Protochlamydia Candidatus Azobacteroides Candidatus Protochlamydia Candidatus Endomicrobium Candidatus Endomicrobium Candidatus Puniceispirillum Candidatus Puniceispirillum − like Candidatus Pelagibacter − like Candidatus Pelagibacter Candidatus Vesicomyosocius Candidatus Vesicomyosocius Candidatus Nitrosoarchaeum Candidatus Nitrosoarchaeum Candidatus Chloracidobacterium Candidatus Chloracidobacterium genus genus

16S GC (%) mean and SD Genome size (Mb) mean and SD 70 25

20 60 15

50 10

16S GC (%) 5 40 Genome size (Mb) Genome size 0 Afipia Afipia Vibrio Vibrio Dorea Dorea Basfia Basfia Delftia Delftia Kordia Kordia Agreia Hafnia Rothia Agreia Hafnia Rothia Xylella Xylella Orenia Orenia Labrys Labrys Blautia Dietzia Blautia Dietzia Ensifer Ensifer Nisaea Nostoc Nisaea Nostoc Hippea Hippea Slackia Slackia Listeria Listeria Aquifex Aquifex Erwinia Sodalis Erwinia Sodalis Frankia Frankia Nautilia Oligella Nautilia Oligella Kocuria Kocuria Hahella Hahella Bacillus Belliella Borrelia Hoeflea Jonesia Proteus Bacillus Belliella Borrelia Hoeflea Jonesia Proteus Yersinia Yersinia Serratia Serratia Dickeya Dickeya Bizionia Mahella Bizionia Mahella Orientia Orientia Coxiella Coxiella Kingella Pirellula Shigella Kingella Pirellula Shigella Waddlia Waddlia Kyrpidia Kyrpidia Dialister Hirschia Niabella Dialister Hirschia Niabella Brucella Brucella Dasania Nautella Dasania Nautella Pantoea Pantoea Lyngbya Lyngbya Thauera Thauera Alistipes Gemella Opitutus Alistipes Gemella Opitutus Aliivibrio Aliivibrio Filifactor Filifactor Bilophila Bulleidia Bilophila Bulleidia Moritella Moritella Moorella Solitalea Moorella Solitalea Ehrlichia Thiothrix Ehrlichia Thiothrix Azospira Azospira Balneola Sagittula Balneola Sagittula Kribbella Kribbella Starkeya Starkeya Truepera Truepera Ahrensia Cohnella Jiangella Joostella Rahnella Ahrensia Cohnella Jiangella Joostella Rahnella Nitritalea Thermus Nitritalea Thermus Flexithrix Flexithrix Colwellia Colwellia Emticicia Leifsonia Nocardia Emticicia Leifsonia Nocardia Frateuria Frateuria Natrialba Natrialba Wolinella Wolinella Eikenella Eikenella Gramella Gramella Myroides Myroides Ruegeria Ruegeria Wenxinia Wenxinia Victivallis Victivallis Rikenella Rikenella Simkania Simkania Gordonia Kangiella Salisaeta Gordonia Kangiella Salisaeta Cellvibrio Marivirga Cellvibrio Marivirga Lewinella Lewinella Azoarcus Azoarcus Fluviicola Fluviicola Lautropia Olsenella Ralstonia Lautropia Olsenella Ralstonia Caldithrix Neisseria Caldithrix Neisseria Taylorella Taylorella Lawsonia Reinekea Lawsonia Reinekea Catonella Dokdonia Sutterella Catonella Dokdonia Sutterella Endoriftia Haloferax Endoriftia Haloferax Weissella Weissella Buchnera Buchnera Halopiger Klebsiella Halopiger Klebsiella Lacinutrix Petrotoga Lacinutrix Petrotoga Halovivax Moraxella Nodularia Halovivax Moraxella Nodularia Ilyobacter Rickettsia Ilyobacter Rickettsia Acidianus Acidianus Brenneria Grimontia Brenneria Grimontia Martelella Martelella Caldilinea Citreicella Gemmata Indibacter Labrenzia Mesotoga Prevotella Caldilinea Citreicella Gemmata Indibacter Labrenzia Mesotoga Prevotella Leptothrix Leptothrix Pyrolobus Pyrolobus Scardovia Scardovia Caldivirga Thiocystis Ulvibacter Caldivirga Thiocystis Ulvibacter Laribacter Laribacter Veillonella Veillonella Micavibrio Micavibrio Bordetella Rudanella Bordetella Rudanella Beggiatoa Facklamia Beggiatoa Facklamia Maricaulis Maricaulis Acidilobus Acidilobus Bartonella Bartonella Roseburia Roseburia Collinsella Echinicola Collinsella Echinicola Anabaena Legionella Loktanella Anabaena Legionella Loktanella Weeksella Weeksella Janibacter Microvirga Janibacter Microvirga Leisingera Tannerella Leisingera Tannerella Finegoldia Thiocapsa Finegoldia Thiocapsa Sulfolobus Sulfolobus Acetivibrio Crenothrix Natrinema Acetivibrio Crenothrix Natrinema Wolbachia Wolbachia Turneriella Turneriella Rubrivivax Rubrivivax Leptospira Leptospira Microscilla Microscilla Gallionella Geobacter Glaciecola Sebaldella Gallionella Geobacter Glaciecola Sebaldella Variovorax Variovorax Idiomarina Marinitoga Idiomarina Marinitoga Flexistipes Flexistipes Chlamydia Rhizobium Chlamydia Rhizobium Ignicoccus Ignicoccus Pelobacter Pelobacter Maribacter Maribacter Atopobium Haloarcula Riemerella Spirosoma Atopobium Haloarcula Riemerella Spirosoma Francisella Saprospira Sorangium Tolumonas Francisella Saprospira Sorangium Tolumonas Arcobacter Cytophaga Holophaga Arcobacter Cytophaga Holophaga Flexibacter Flexibacter Nitriliruptor Nitriliruptor Aeropyrum Terriglobus Aeropyrum Terriglobus Citrobacter Histophilus Nitrobacter Picrophilus Citrobacter Histophilus Nitrobacter Picrophilus Acidovorax Pelagibaca Acidovorax Pelagibaca Aquiflexum Aquiflexum Arthrospira Arthrospira Isosphaera Salinispora Isosphaera Salinispora Ammonifex Ammonifex Collimonas Microcystis Salmonella Stigmatella Thiomonas Collimonas Microcystis Salmonella Stigmatella Thiomonas Oscillatoria Pasteurella Oscillatoria Pasteurella Alkaliflexus Barnesiella Alkaliflexus Barnesiella Butyrivibrio Butyrivibrio Clavibacter Clavibacter Haloplanus Haloplanus Treponema Treponema Alkaliphilus Anaplasma Haliangium Meganema Oceanicola Rhodocista Alkaliphilus Anaplasma Haliangium Meganema Oceanicola Rhodocista Leptonema Leptonema Pontibacter Pontibacter Aequorivita Clostridium Aequorivita Clostridium Kosmotoga Kosmotoga Methylopila Methylopila Cyanobium Cyanobium Ferrimonas Jannaschia Sulfurovum Ferrimonas Jannaschia Sulfurovum Fibrobacter Halomonas Mobiluncus Fibrobacter Halomonas Mobiluncus Abiotrophia Acetonema Baumannia Syntrophus Abiotrophia Acetonema Baumannia Syntrophus Kytococcus Pedobacter Kytococcus Pedobacter Eggerthella Pelodictyon Eggerthella Pelodictyon Chlorobium Simonsiella Chlorobium Simonsiella Actinospica Aeromonas Jonquetella Actinospica Aeromonas Jonquetella Beijerinckia Beijerinckia Isoptericola Rhodoferax Isoptericola Rhodoferax Alcanivorax Shewanella Alcanivorax Shewanella Roseiflexus Roseiflexus Bdellovibrio Oligotropha Pyrococcus Bdellovibrio Oligotropha Pyrococcus Paracoccus Paracoccus Fulvimarina Fulvimarina Escherichia Leptotrichia Escherichia Leptotrichia Providencia Providencia Ignisphaera Ignisphaera Aerococcus Gardnerella Geobacillus Plesiocystis Salinibacter Synergistes unclassified Aerococcus Gardnerella Geobacillus Plesiocystis Salinibacter Synergistes unclassified Brachyspira Nitratiruptor Brachyspira Nitratiruptor Odoribacter Patulibacter Odoribacter Patulibacter Sporichthya Sporichthya Halorubrum Halorubrum Granulicella Granulicella Parvimonas Parvimonas Cupriavidus Cupriavidus Bacteroides Desulfurella Haloplasma Sciscionella Thiobacillus Bacteroides Desulfurella Haloplasma Sciscionella Thiobacillus Ferroglobus Ferroglobus Polaribacter Tropheryma Polaribacter Tropheryma Methylibium Methylibium Cyanothece Rickettsiella Cyanothece Rickettsiella Azotobacter Azotobacter Nitrosospira Nitrosospira Acetobacter Acidiphilium Anaerolinea Johnsonella Microcoleus Ramlibacter Rhodovibrio Spirochaeta Acetobacter Acidiphilium Anaerolinea Johnsonella Microcoleus Ramlibacter Rhodovibrio Spirochaeta Succinispira Succinispira Azospirillum Caulobacter Halobacillus Oxalobacter Ureaplasma Azospirillum Caulobacter Halobacillus Oxalobacter Ureaplasma Thermotoga Thermotoga Nitratifractor Nitratifractor Deferrisoma Glycomyces Deferrisoma Glycomyces Allobaculum Gloeobacter Mannheimia Oscillibacter Allobaculum Gloeobacter Mannheimia Oscillibacter Cronobacter Hylemonella Limnobacter Megamonas Myxococcus Rubrobacter Xylanibacter Zymomonas Cronobacter Hylemonella Limnobacter Megamonas Myxococcus Rubrobacter Xylanibacter Zymomonas Segniliparus Segniliparus Paludibacter Paludibacter Chloroflexus Methylocella Thermincola Chloroflexus Methylocella Thermincola Desulfotalea Roseovarius Desulfotalea Roseovarius Arthrobacter Arthrobacter Parvularcula Parvularcula Helicobacter Micrococcus Spiroplasma Helicobacter Micrococcus Spiroplasma Anaerofustis Lactococcus Oenococcus Sulfitobacter Anaerofustis Lactococcus Oenococcus Sulfitobacter Brevibacillus Ferroplasma Thermofilum Brevibacillus Ferroplasma Thermofilum Sulfobacillus Sulfobacillus Nakamurella Nakamurella Denitrovibrio Mycoplasma Pusillimonas Denitrovibrio Mycoplasma Pusillimonas Alteromonas Segetibacter Alteromonas Segetibacter Pediococcus Thermovirga Pediococcus Thermovirga Eubacterium Eubacterium Burkholderia Burkholderia Dyadobacter Dyadobacter Actinomyces Edwardsiella Vulcanisaeta Actinomyces Edwardsiella Vulcanisaeta Desmospora Desmospora Alicycliphilus Alicycliphilus Comamonas Croceibacter Dethiobacter Halorhabdus Helcococcus Kineococcus Leuconostoc Mesoplasma Microlunatus Phaeobacter Planococcus Roseobacter Comamonas Croceibacter Dethiobacter Halorhabdus Helcococcus Kineococcus Leuconostoc Mesoplasma Microlunatus Phaeobacter Planococcus Roseobacter Actinoplanes Deinococcus Enterobacter Mobilicoccus Oceanicaulis Raphidiopsis Rhodobacter Xylanimonas Actinoplanes Deinococcus Enterobacter Mobilicoccus Oceanicaulis Raphidiopsis Rhodobacter Xylanimonas Melioribacter Melioribacter Desulfovibrio Desulfovibrio Oribacterium Oribacterium Nonomuraea Nonomuraea Deferribacter Deferribacter Lentisphaera Lentisphaera Neorickettsia Neorickettsia Ancylobacter Asticcacaulis Lactobacillus Nocardiopsis Pseudovibrio Robiginitalea Ancylobacter Asticcacaulis Lactobacillus Nocardiopsis Pseudovibrio Robiginitalea Akkermansia Akkermansia Caldisericum Meiothermus Methylosinus Thermicanus Thermosinus Caldisericum Meiothermus Methylosinus Thermicanus Thermosinus Thermocrinis Thermocrinis Gracilimonas Gracilimonas Anaerostipes Cellulophaga Coprococcus Haemophilus Nocardioides Pyrobaculum Sphingobium Anaerostipes Cellulophaga Coprococcus Haemophilus Nocardioides Pyrobaculum Sphingobium Polaromonas Polaromonas Algoriphagus Marinobacter Paenibacillus Sulfurimonas Algoriphagus Marinobacter Paenibacillus Sulfurimonas Conexibacter Lysinibacillus Methanofollis Thermobifida Thermosipho Thermovibrio Conexibacter Lysinibacillus Methanofollis Thermobifida Thermosipho Thermovibrio Caldisphaera Caldisphaera Blastococcus Caminibacter Chitinophaga Hyphomonas Lamprocystis Macrococcus Methylovorus Pedosphaera Sanguibacter Sporosarcina Blastococcus Caminibacter Chitinophaga Hyphomonas Lamprocystis Macrococcus Methylovorus Pedosphaera Sanguibacter Sporosarcina Oscillochloris Oscillochloris Sphingopyxis Sphingopyxis Aromatoleum Dehalobacter Methanocella Aromatoleum Dehalobacter Methanocella Beutenbergia Xanthobacter Xenorhabdus Beutenbergia Xanthobacter Xenorhabdus Methyloferula Peptoniphilus Methyloferula Peptoniphilus Dictyoglomus Methylocystis Dictyoglomus Methylocystis Granulibacter Granulibacter Tsukamurella Tsukamurella Flavonifractor Flavonifractor Anaerophaga Methanolinea Anaerophaga Methanolinea Haloterrigena Haloterrigena Acaryochloris Azorhizobium Desulfarculus Acaryochloris Azorhizobium Desulfarculus Desulfobacca Erythrobacter Sideroxydans Desulfobacca Erythrobacter Sideroxydans Erysipelothrix Erysipelothrix Salinisphaera Salinisphaera Cellulomonas Coprobacillus Eremococcus Flectobacillus Cellulomonas Coprobacillus Eremococcus Flectobacillus Enterococcus Rhodococcus Enterococcus Rhodococcus Marinomonas Marinomonas Oceanibulbus Oceanibulbus Alishewanella Bacteriovorax Chelativorans Alishewanella Bacteriovorax Chelativorans Anoxybacillus Methylophilus Anoxybacillus Methylophilus Granulicatella Granulicatella Streptomyces Streptomyces Kitasatospora Megasphaera Kitasatospora Megasphaera Cloacibacillus Fervidicoccus Cloacibacillus Fervidicoccus Acinetobacter Actinobacillus Dichelobacter Selenomonas Acinetobacter Actinobacillus Dichelobacter Selenomonas Parasutterella Parasutterella Methylovulum Methylovulum Acidothermus Aurantimonas Methanotorris Acidothermus Aurantimonas Methanotorris Dermacoccus Dermacoccus Methylocapsa Methylocapsa Catenulispora Polymorphum Catenulispora Polymorphum Sulfuricurvum Sulfuricurvum Krokinobacter Nitrosomonas Oceanimonas Xanthomonas Krokinobacter Nitrosomonas Oceanimonas Xanthomonas Fructobacillus Palaeococcus Fructobacillus Palaeococcus Psychroflexus Psychroflexus Owenweeksia Owenweeksia Planctomyces Planctomyces Blastopirellula Photorhabdus Blastopirellula Photorhabdus Adhaeribacter Adhaeribacter Methylobacter Methylophaga Methylobacter Methylophaga Desulfobulbus Desulfobulbus Corallococcus Crocosphaera Teredinibacter Corallococcus Crocosphaera Teredinibacter Acholeplasma Alkalilimnicola Cenarchaeum Geminicoccus Nitrosococcus Sedimenticola Acholeplasma Alkalilimnicola Cenarchaeum Geminicoccus Nitrosococcus Sedimenticola Maritimibacter Methylotenera Maritimibacter Methylotenera Desulfomonile Desulfomonile Methanopyrus Sinorhizobium Methanopyrus Sinorhizobium Parascardovia Parascardovia Anaerococcus Gordonibacter Hyperthermus Leadbetterella Methanosaeta Streptococcus Anaerococcus Gordonibacter Hyperthermus Leadbetterella Methanosaeta Streptococcus Paraprevotella Persephonella Paraprevotella Persephonella Shuttleworthia Shuttleworthia Ochrobactrum Ochrobactrum Desulfurivibrio Marinithermus Desulfurivibrio Marinithermus Pseudomonas Psychrobacter Rhodopirellula Synechocystis Pseudomonas Psychrobacter Rhodopirellula Synechocystis Gallibacterium Herbaspirillum Mariprofundus Solobacterium Gallibacterium Herbaspirillum Mariprofundus Solobacterium Calditerrivibrio Calditerrivibrio Nesterenkonia Nesterenkonia Amycolatopsis Amycolatopsis Halobacterium Renibacterium Halobacterium Renibacterium Desulfococcus Methylomonas Desulfococcus Methylomonas Enhydrobacter Enhydrobacter Hymenobacter Melissococcus Hymenobacter Melissococcus Gluconobacter Ktedonobacter Gluconobacter Ktedonobacter Agrobacterium Agrobacterium Anaerotruncus Anaerotruncus Herpetosiphon Herpetosiphon Thiomicrospira Zunongwangia Thiomicrospira Zunongwangia Parachlamydia Parachlamydia Ruminococcus Ruminococcus Halostagnicola Natronomonas Sphaerobacter Streptobacillus Halostagnicola Natronomonas Sphaerobacter Streptobacillus Rhodothermus Rhodothermus Thermococcus Thermococcus Methylococcus Methylococcus Marvinbryantia Marvinbryantia Chlamydophila Chlamydophila Singulisphaera Singulisphaera Nitrosopumilus Nitrosopumilus Acetohalobium Psychromonas Acetohalobium Psychromonas Rhodospirillum Thioalkalivibrio Rhodospirillum Thioalkalivibrio Desulfonispora Fusobacterium Desulfonispora Fusobacterium Stackebrandtia Stackebrandtia Archaeoglobus Verrucosispora Archaeoglobus Verrucosispora Brevibacterium Brevibacterium Thiorhodospira Thiorhodospira Halomicrobium Halomicrobium Methanoregula Natronococcus Sphingomonas Methanoregula Natronococcus Sphingomonas Heliobacterium Heliobacterium Herminiimonas Herminiimonas Campylobacter Methylocaldum Methylosarcina Thermoplasma Campylobacter Methylocaldum Methylosarcina Thermoplasma Citromicrobium Citromicrobium Aeromicrobium Alicyclobacillus Chlorobaculum Elizabethkingia Hydrogenivirga Aeromicrobium Alicyclobacillus Chlorobaculum Elizabethkingia Hydrogenivirga Trichodesmium Trichodesmium Thermobispora Thermobispora Natronorubrum Natronorubrum Mesorhizobium Mesorhizobium Halorhodospira Halorhodospira Achromobacter Acidimicrobium Chthoniobacter Elusimicrobium Halanaerobium Sphaerochaeta Achromobacter Acidimicrobium Chthoniobacter Elusimicrobium Halanaerobium Sphaerochaeta Mycobacterium Oceanithermus Mycobacterium Oceanithermus Flavobacterium Methylobacillus Thermobacillus Thermoproteus Flavobacterium Methylobacillus Thermobacillus Thermoproteus Coriobacterium Wigglesworthia Coriobacterium Wigglesworthia Thioflavicoccus Thioflavicoccus Haloquadratum Metallosphaera Methanoplanus Natranaerobius Haloquadratum Metallosphaera Methanoplanus Natranaerobius Actinosynnema Nanoarchaeum Oceanobacillus Rhodanobacter Actinosynnema Nanoarchaeum Oceanobacillus Rhodanobacter Pelotomaculum Pelotomaculum Microbacterium Sulfurospirillum Microbacterium Sulfurospirillum Allochromatium Cellulosilyticum Halalkalicoccus Thiorhodovibrio Allochromatium Cellulosilyticum Halalkalicoccus Thiorhodovibrio Ethanoligenens Ethanoligenens Acidobacterium Bifidobacterium Cyclobacterium Acidobacterium Bifidobacterium Cyclobacterium Pectobacterium Pectobacterium Brevundimonas Brevundimonas Bradyrhizobium Chloroherpeton Bradyrhizobium Chloroherpeton Dolosigranulum Dolosigranulum Dysgonomonas Dysgonomonas Acetobacterium Blattabacterium Acetobacterium Blattabacterium Staphylococcus Staphylococcus Thermocrispum Thermocrispum Pyramidobacter Pyramidobacter Dechloromonas Halothiobacillus Dechloromonas Halothiobacillus Anaerobaculum Caldanaerobius Magnetococcus Methanococcus Methanoculleus Synechococcus Anaerobaculum Caldanaerobius Magnetococcus Methanococcus Methanoculleus Synechococcus Porphyromonas Porphyromonas Photobacterium Photobacterium Gemmatimonas Ignavibacterium Gemmatimonas Ignavibacterium Aggregatibacter Methanosalsum Octadecabacter Succinatimonas Aggregatibacter Methanosalsum Octadecabacter Succinatimonas Thermosphaera Thermosphaera Ornithinibacillus Ornithinibacillus Halothermothrix Halothermothrix Actinopolyspora Actinopolyspora Acidithiobacillus Methanosarcina Acidithiobacillus Methanosarcina Pelagibacterium Pelagibacterium Carnobacterium Carnobacterium Marichromatium Marichromatium Intrasporangium Intrasporangium Halobacteroides Mucilaginibacter Pseudonocardia Halobacteroides Mucilaginibacter Pseudonocardia Parabacteroides Parabacteroides Aminobacterium Aminobacterium Thermobaculum Thermobaculum Haloglycomyces Haloglycomyces Cyanobacterium Cyanobacterium Desulfuromonas Desulfuromonas Catenibacterium Catenibacterium Amycolicicoccus Methyloversatilis Amycolicicoccus Methyloversatilis Dinoroseobacter Syntrophobacter Dinoroseobacter Syntrophobacter Cardiobacterium Cardiobacterium Dethiosulfovibrio Dethiosulfovibrio Cryptobacterium Cryptobacterium Desulfurococcus Prochlorococcus Desulfurococcus Prochlorococcus Coraliomargarita Coraliomargarita Prosthecochloris Prosthecochloris Desulfohalobium Desulfohalobium Micromonospora Micromonospora Exiguobacterium Exiguobacterium Brachybacterium Brachybacterium Subdoligranulum Subdoligranulum Staphylothermus Staphylothermus Methanosphaera Methanosphaera Hyphomicrobium Hyphomicrobium Saccharophagus Saccharophagus Methanothermus Methanothermus Desulfatibacillum Desulfatibacillum Tetragenococcus Tetragenococcus Rhodomicrobium Rhodomicrobium Capnocytophaga Syntrophomonas Capnocytophaga Syntrophomonas Magnetospirillum Methanospirillum Magnetospirillum Methanospirillum Arcanobacterium Arcanobacterium Faecalibacterium Faecalibacterium Polynucleobacter Polynucleobacter Dehalococcoides Thiorhodococcus Dehalococcoides Thiorhodococcus Desulfurispirillum Desulfurispirillum Corynebacterium Corynebacterium Caldalkalibacillus Hydrogenobacter Caldalkalibacillus Hydrogenobacter Thermaerobacter Thermaerobacter Ornithobacterium Ornithobacterium Aciduliprofundum Aciduliprofundum Fervidobacterium Symbiobacterium Fervidobacterium Symbiobacterium Desulfobacterium Desulfobacterium Acidaminococcus Syntrophobotulus Acidaminococcus Syntrophobotulus Halogeometricum Halogeometricum Methylobacterium Methylobacterium Methylacidiphilum Methylacidiphilum Caldanaerobacter Methanohalobium Caldanaerobacter Methanohalobium Chromobacterium Natronobacterium Chromobacterium Natronobacterium Novosphingobium Novosphingobium Desulfomicrobium Desulfomicrobium Leeuwenhoekiella Leeuwenhoekiella Phenylobacterium Phenylobacterium Verrucomicrobium Verrucomicrobium Candidatus Sulcia Dehalogenimonas Candidatus Sulcia Dehalogenimonas Propionibacterium Sphingobacterium Propionibacterium Sphingobacterium Methylomicrobium Thermomicrobium Methylomicrobium Thermomicrobium Candidatus Riesia Candidatus Riesia Chryseobacterium Chryseobacterium Janthinobacterium Janthinobacterium Syntrophorhabdus Syntrophorhabdus Desulfosporosinus Syntrophothermus Desulfosporosinus Syntrophothermus Cryptosporangium Cryptosporangium Geodermatophilus Geodermatophilus Candidatus Ruthia Chromohalobacter Candidatus Ruthia Chromohalobacter Desulfotomaculum Desulfotomaculum Tepidanaerobacter Tepidanaerobacter Desulfitobacterium Methanobacterium Methanosphaerula Desulfitobacterium Methanobacterium Methanosphaerula Ectothiorhodospira Ectothiorhodospira Commensalibacter Methanococcoides Commensalibacter Methanococcoides Anaeromyxobacter Anaeromyxobacter Gluconacetobacter Methanohalophilus Gluconacetobacter Methanohalophilus Thermanaerovibrio Thermanaerovibrio Carboxydothermus Carboxydothermus Catelliglobosispora Catelliglobosispora Streptosporangium Streptosporangium Stenotrophomonas Verminephrobacter Stenotrophomonas Verminephrobacter Caldicellulosiruptor Thermomonospora Caldicellulosiruptor Thermomonospora Actinomycetospora Actinomycetospora Saccharopolyspora Saccharopolyspora Haliscomenobacter Haliscomenobacter Coprothermobacter Coprothermobacter Candidatus Frankia Candidatus Frankia Thermodesulfatator Thermodesulfatator Hydrogenobaculum Hydrogenobaculum Desulfurobacterium Ketogulonicigenium Desulfurobacterium Ketogulonicigenium Peptostreptococcus Peptostreptococcus Cylindrospermopsis Methanobrevibacter Cylindrospermopsis Methanobrevibacter Candidatus Portiera Candidatus Portiera Candidatus Serratia Candidatus Serratia Thermodesulfobium Thermodesulfobium Thioalkalimicrobium Thioalkalimicrobium Pseudoalteromonas Pseudoalteromonas Desulfonatronospira Desulfonatronospira Candidatus Regiella Candidatus Regiella Candidatus Zinderia Candidatus Zinderia Promicromonospora Promicromonospora Pseudogulbenkiania Pseudogulbenkiania Thermanaeromonas Thermanaeromonas Thermodesulfovibrio Thermodesulfovibrio Saccharomonospora Saccharomonospora Candidatus Aquiluna Rhodopseudomonas Candidatus Aquiluna Rhodopseudomonas Thermoanaerobacter Thermoanaerobacter Pseudoxanthomonas Pseudoxanthomonas Sulfurihydrogenibium Sulfurihydrogenibium Methanocaldococcus Methanocaldococcus Candidatus Kuenenia Candidatus Kuenenia Methanocorpusculum Methanocorpusculum Candidatus Nitrospira Candidatus Nitrospira Candidatus Rickettsia Candidatus Rickettsia Candidatus Moranella Candidatus Moranella Candidatus Hodgkinia Candidatus Solibacter Candidatus Hodgkinia Candidatus Solibacter Methanothermobacter Methanothermobacter Candidatus Koribacter Candidatus Tremblaya Candidatus Koribacter Candidatus Tremblaya Thermosediminibacter Thermosediminibacter Candidatus Carsonella Candidatus Carsonella Candidatus Midichloria Candidatus Midichloria Methanothermococcus Methanothermococcus Candidatus Chlorothrix Phascolarctobacterium Candidatus Chlorothrix Phascolarctobacterium Thermosynechococcus Thermosynechococcus Methanomethylovorans Methanomethylovorans Candidatus Arthromitus Candidatus Arthromitus Candidatus Liberibacter Candidatus Liberibacter Candidatus Hamiltonella Candidatus Hamiltonella Candidatus Pelagibacter Candidatus Pelagibacter Candidatus Desulforudis Candidatus Desulforudis Candidatus Mycoplasma Candidatus Mycoplasma Thermoanaerobacterium Thermoanaerobacterium Thermodesulfobacterium Thermodesulfobacterium Candidatus Phytoplasma Candidatus Phytoplasma Candidatus Blochmannia Candidatus Blochmannia Candidatus Korarchaeum Candidatus Korarchaeum Candidatus Cloacamonas Candidatus Cloacamonas Candidatus Amoebophilus Candidatus Amoebophilus Candidatus Methanoregula Candidatus Methanoregula Candidatus Caldiarchaeum Candidatus Caldiarchaeum Candidatus Accumulibacter Candidatus Accumulibacter Candidatus Protochlamydia Candidatus Protochlamydia Candidatus Azobacteroides Candidatus Azobacteroides Candidatus Endomicrobium Candidatus Endomicrobium Candidatus Puniceispirillum Candidatus Puniceispirillum − like Candidatus Pelagibacter − like Candidatus Pelagibacter Candidatus Vesicomyosocius Candidatus Vesicomyosocius Candidatus Nitrosoarchaeum Candidatus Nitrosoarchaeum Candidatus Chloracidobacterium Candidatus Chloracidobacterium genus genus Distributions for species level

Primer score mean and SD Genomic GC (%) mean and SD 80 6 60 4 40 2

Primer score 20

0 Genomic GC (%) uli uli sp sp − 1 − 1 etli loti etli loti sp. sp. lari lari xyli xyli coli soli coli soli alni ceti alni ceti zea zea oris oris illini illini bilis vitis bilis vitis felis felis ovis ovis junii suis junii suis mali mali alba equi oeni alba equi oeni antri antri bellii hallii jostii lienii bellii hallii jostii lienii exile exile alvei alvei bivia mitis bivia mitis grylli grylli fulva fulva aceti sputi typhi aceti sputi typhi grayi grayi fetus fetus zeae zeae clara clara iners lenta lutea vafer iners lenta lutea vafer akari petrii akari petrii ferus ferus dorei harei dorei harei aeria aeria lactis lytica sicca tarda velox lactis lytica sicca tarda velox sakei sakei bovis novyi bovis novyi sinus sinus canis casei jejuni lacus lupini canis casei jejuni lacus lupini ciceri ruber ciceri ruber fontis noxia fontis noxia nivea nivea albus albus pylori pylori oralis oralis fusca mahii fusca mahii micra micra breve gadei inhae longa orenii setae tenax tetani breve gadei inhae longa orenii setae tenax tetani maris ruddii maris ruddii lwoffii lwoffii major minor morbi rosea major minor morbi rosea parva parva prima rimae risticii wolfei prima rimae risticii wolfei baylyi infelix baylyi infelix afzelii afzelii alocis bescii gilvus italica kunzii alocis bescii gilvus italica kunzii ureae ureae viridis viridis boydii iowae boydii iowae flavus flavus terrae terrae limnia mallei limnia mallei fluxus fulvus indica linens pestis plautii shahii tiedjei fluxus fulvus indica linens pestis plautii shahii tiedjei criceti criceti brevis brevis avium avium mazei mazei tenuis tenuis koseri koseri acnes alhagi anatis hippei lautus luteus ordalii pelagi somni virosa acnes alhagi anatis hippei lautus luteus ordalii pelagi somni virosa clarus garinii clarus garinii flexilis flexilis album album vortex vortex bromii dispar gleum putida rectus salicis bromii dispar gleum putida rectus salicis larvae larvae uberis uberis lovleyi lovleyi pernix pernix fibrata leprae fibrata leprae clausii philipii rohdei clausii philipii rohdei florum mirum urinae florum mirum urinae arvum arvum abyssi staleyi abyssi staleyi woodii woodii capitis elkanii katesii leachii mossii smithii capitis elkanii katesii leachii mossii smithii reuteri reuteri biflexa biflexa caviae flavida caviae flavida curtisii curtisii fragilis fragilis baltica brockii caldus camini gilvum pallida segnis simiae spadix baltica brockii caldus camini gilvum pallida segnis simiae spadix ignava ignava ictaluri ovatus ictaluri ovatus exigua forsetii exigua forsetii veronii veronii baarsii brookii comes glauca igneus kingae laneus microti mobile oceani sedula shibae sonnei baarsii brookii comes glauca igneus kingae laneus microti mobile oceani sedula shibae sonnei cibaria conorii cibaria conorii curvus foetida curvus foetida albertii stuartii albertii stuartii varium varium cereus concilii leptum luteum rectale roseus torquis tropica cereus concilii leptum luteum rectale roseus torquis tropica boonei natans potens ubique boonei natans potens ubique africae fumarii olearia africae fumarii olearia frigoris oryzae frigoris oryzae invisus invisus deserti deserti xylinus xylinus caprae caprae kimchii kimchii aureus azurea difficile ebreus italicus magna moorei obeum shilonii subtilis aureus azurea difficile ebreus italicus magna moorei obeum shilonii subtilis barkeri parkeri barkeri parkeri arboris marina peroris pigrum arboris marina peroris pigrum drewsii salivae drewsii salivae curtum curtum gracilis litoralis gracilis litoralis woesei woodyi woesei woodyi meliloti mobilis suillum meliloti mobilis suillum defluvii disiens gladioli indicus psittaci scabiei defluvii disiens gladioli indicus psittaci scabiei sibirica sibirica novella novella infantis infantis azollae downei azollae downei atypica caccae calvum canettii cinaedi eligens irgensii jeotgali larsenii micans pallens paludis prevotii saltans SAR11 stellata timidus tusciae atypica caccae calvum canettii cinaedi eligens irgensii jeotgali larsenii micans pallens paludis prevotii saltans SAR11 stellata timidus tusciae fischeri lactaris urinalis fischeri lactaris urinalis rubrum vagans rubrum vagans avidum buccae cyanea ducreyi gnavus avidum buccae cyanea ducreyi gnavus flexneri harveyi flexneri harveyi butzleri butzleri bifidum duttonii marshii opacus persica stutzeri wittichii bifidum duttonii marshii opacus persica stutzeri wittichii avenae bryantii avenae bryantii gasseri griseus orientis primitia ruminis gasseri griseus orientis primitia ruminis walsbyi walsbyi boevrei hermsii boevrei hermsii fervens fervens bispora grandis mutans bispora grandis mutans bolteae cinerea citreum freundii glumae longum villosus vulgare wiegelii bolteae cinerea citreum freundii glumae longum villosus vulgare wiegelii burnetii curvata orisratti burnetii curvata orisratti cuprina ivanovii cuprina ivanovii burtonii burtonii warneri warneri parvula volcanii parvula volcanii biforme biforme agreste limicola necator roseum torques agreste limicola necator roseum torques bongori penneri slovaca torridus bongori penneri slovaca torridus faecalis faecalis parvum parvum keddieii keddieii abortus bovienii watsoni abortus bovienii watsoni kluyveri kluyveri algicida algicola elsdenii hollisae intestini jensenii merdae pacifica satelles zhilinae algicida algicola elsdenii hollisae intestini jensenii merdae pacifica satelles zhilinae cattleya cattleya furnissii oxytoca showae furnissii oxytoca showae bouvetii bouvetii tokodaii tokodaii arcticus auensis cepacia cloacae dentalis fulgidus fuscans giardinii hilgardii hominis indicum linguale melonis okutanii oshimai pumilus usitatus arcticus auensis cepacia cloacae dentalis fulgidus fuscans giardinii hilgardii hominis indicum linguale melonis okutanii oshimai pumilus usitatus mulieris mulieris vulgaris vulgaris faecium faecium laidlawii vaginae laidlawii vaginae conradii mucosa conradii mucosa equinus equinus fervidus gelidum magadii maxima fervidus gelidum magadii maxima dadantii elegans flueggei globosa innocua muelleri tunicata uenonis xanthus dadantii elegans flueggei globosa innocua muelleri tunicata uenonis xanthus caldaria furiosus kandleri meridiei caldaria furiosus kandleri meridiei barnesii barnesii defensa defensa bartlettii bartlettii extructa infernus siraeum extructa infernus siraeum centrale centrale dentium endobia gordonii robiniae tepidum dentium endobia gordonii robiniae tepidum marinus marinus striatum striatum africana enterica rugosus africana enterica rugosus silvanus silvanus cryptum vannielii cryptum vannielii buccalis buccalis watsonii watsonii aurantia rickettsii aurantia rickettsii indolifex indolifex anthropi histicola kansasii saliphila vincentii whipplei anthropi histicola kansasii saliphila vincentii whipplei frappieri frappieri sibiricus sibiricus cetorum oulorum cetorum oulorum morbifer morbifer gregoryi gregoryi jeikeium jeikeium mirabilis novicida mirabilis novicida variicola variicola aeolicus animalis aquatilis efficiens gallicum kujiense occultus pinensis pipientis placidus violacea aeolicus animalis aquatilis efficiens gallicum kujiense occultus pinensis pipientis placidus violacea stewartii stewartii subflava subflava farcinica oxydans taffensis farcinica oxydans taffensis australis variabile australis variabile atlantica balticum datiscae eiseniae halobius hansenii hofstadii inhibens japonica limosum pallidum pelagius stomatis vinosum vulgatus atlantica balticum datiscae eiseniae halobius hansenii hofstadii inhibens japonica limosum pallidum pelagius stomatis vinosum vulgatus cristatus ehrlichei palustris seeligeri turnerae cristatus ehrlichei palustris seeligeri turnerae veroralis veroralis versutus versutus mccartyi mccartyi diminuta parasuis porcinus ulcerans diminuta parasuis porcinus ulcerans ananatis benthica citroniae equitans eutactus languida lettingae luteolum medicae nodosus pilosicoli tanakaei ananatis benthica citroniae equitans eutactus languida lettingae luteolum medicae nodosus pilosicoli tanakaei aestuarii merionis princeps stercoris syringae aestuarii merionis princeps stercoris syringae cholerae grahamii minutum silvestris tetradius cholerae grahamii minutum silvestris tetradius buchneri coxensis buchneri coxensis cyclicum elongata hungatei pendens quintana tiamatea viscosus cyclicum elongata hungatei pendens quintana tiamatea viscosus wenyonii wenyonii infirmum maritima pullorum turicatae infirmum maritima pullorum turicatae garvieae vaginalis versatilis garvieae vaginalis versatilis butylicus butylicus eggerthii eggerthii variabilis variabilis asiaticus billingiae concisus indiensis indolicus rotundus turgidum asiaticus billingiae concisus indiensis indolicus rotundus turgidum marinum marinum pecorum pecorum odorifera vadensis odorifera vadensis synoviae synoviae tannerae terangae tannerae terangae accolens cholodnii crocodyli finegoldii johnsonii pimensis platensis scindens suebicus tropicalis accolens cholodnii crocodyli finegoldii johnsonii pimensis platensis scindens suebicus tropicalis defectiva eutropha hyorhinis profunda defectiva eutropha hyorhinis profunda pyrifoliae pyrifoliae sibiricum sibiricum flavigena flavigena mucosus terrenum mucosus terrenum composti dolichum pulmonis resistens composti dolichum pulmonis resistens adiacens denticola halophila plutonius adiacens denticola halophila plutonius crispatus orientalis crispatus orientalis termitidis termitidis geofontis geofontis purpurea purpurea pertussis pertussis anthracis mucosae mustelae ragsdalei uniformis anthracis mucosae mustelae ragsdalei uniformis distributa distributa arenicola henselae inopinata macacae postgatei sennetsu tibetense arenicola henselae inopinata macacae postgatei sennetsu tibetense africanus africanus restrictus restrictus balearica fructosus obscurus balearica fructosus obscurus carnosus pomeroyi carnosus pomeroyi gingivalis gingivalis cavernae cavernae ambifaria azorense lipoferum yayanosii ambifaria azorense lipoferum yayanosii mathranii ochracea tractuosa mathranii ochracea tractuosa arthritidis arthritidis aerophila loihiensis nodosum pealeana reducens sakazakii sprentiae vulnificus aerophila loihiensis nodosum pealeana reducens sakazakii sprentiae vulnificus iheyensis racemifer thioparus iheyensis racemifer thioparus parvulum parvulum araneosa igniterrae ramosum salivarius araneosa igniterrae ramosum salivarius biformata biformata acidiphila delafieldii hospitalis mallensis massiliae nitrofigilis peacockii piscolens sediminis tergarcus vinelandii violaceus vulcanius acidiphila delafieldii hospitalis mallensis massiliae nitrofigilis peacockii piscolens sediminis tergarcus vinelandii violaceus vulcanius lacrimalis lacrimalis perforans perforans farciminis fastidiosa hydrossis farciminis fastidiosa hydrossis veneficus veneficus evryensis subflavus evryensis subflavus mycoides polymyxa wasabiae mycoides polymyxa wasabiae iraqiensis iraqiensis horikoshii horikoshii atlanticus batsensis coelicolor coleocola europaea gobiensis hispanica hopiensis japonicus lactamica macleodii mitsuokai sanguinis atlanticus batsensis coelicolor coleocola europaea gobiensis hispanica hopiensis japonicus lactamica macleodii mitsuokai sanguinis alligatoris pomorum turicensis alligatoris pomorum turicensis erythraea erythraea koreensis koreensis alexandrii rhizophila alexandrii rhizophila multocida multocida fusiformis fusiformis aegyptius anophelis aquaticus coprosuis crossotus gibsoniae hepaticus leiognathi maculosa magnifica spinosum tularensis ureolytica utahensis zucineum aegyptius anophelis aquaticus coprosuis crossotus gibsoniae hepaticus leiognathi maculosa magnifica spinosum tularensis ureolytica utahensis zucineum pyogenes pyogenes trichoides trichoides fergusonii fergusonii botulinum mucosum murdochii paracasei polyspora botulinum mucosum murdochii paracasei polyspora butyricum funiformis butyricum funiformis aquaeolei bergensis cinnamea columbae coprocola damselae elongatus glycolicus hafniense lipolyticus putredinis sputigena sticklandii aquaeolei bergensis cinnamea columbae coprocola damselae elongatus glycolicus hafniense lipolyticus putredinis sputigena sticklandii floridanus maritimus floridanus maritimus caeruleus salinarum tundricola caeruleus salinarum tundricola marisnigri panacarvi marisnigri panacarvi pharaonis pharaonis aromatica basilensis capillosus cicadicola claussenii islandicus marginale petrophila rhodesiae salsuginis aromatica basilensis capillosus cicadicola claussenii islandicus marginale petrophila rhodesiae salsuginis africanum heparinus africanum heparinus diaphorus diaphorus helveticus valaisiana helveticus valaisiana avermitilis avermitilis hathewayi penetrans hathewayi penetrans campbellii coccoides corrodens distasonis hellenicus jannaschii ljungdahlii melitensis rodentium spielmanii campbellii coccoides corrodens distasonis hellenicus jannaschii ljungdahlii melitensis rodentium spielmanii neotomae profundus retbaense neotomae profundus retbaense mortivallis plantarum mortivallis plantarum volcanium volcanium piezophila prausnitzii raciborskii piezophila prausnitzii raciborskii formicicus formicicus liminatans violaceum liminatans violaceum aggregata aphidicola dorotheae flagellatus halophilus hollandica naeslundii piechaudii saanensis ultunensis aggregata aphidicola dorotheae flagellatus halophilus hollandica naeslundii piechaudii saanensis ultunensis agarilytica nigrificans agarilytica nigrificans amorphae amorphae amylovora brasilense contractile amylovora brasilense contractile acidilactici acidipiscis acidilactici acidipiscis agalactiae anginosus coagulans columbina genitalium influenzae japonicum ubonensis agalactiae anginosus coagulans columbina genitalium influenzae japonicum ubonensis moribillum ruminicola moribillum ruminicola hydrophila hydrophila melliferum melliferum infantarius infantarius ingrahamii nucleatum ingrahamii nucleatum aurescens baculatum barophilus baumannii catarrhalis methanica oguniense oremlandii pittmaniae polytropus sinaiiensis testaceum aurescens baculatum barophilus baumannii catarrhalis methanica oguniense oremlandii pittmaniae polytropus sinaiiensis testaceum gallinarum paradoxus gallinarum paradoxus calidifontis ferrophilus phymatum calidifontis ferrophilus phymatum alaskensis alaskensis aurantiaca glomerans saphenum aurantiaca glomerans saphenum acidiphilus angulatum cohaerens columnare glossinidia glycolicum insecticola intestinalis lipocalidus neptunium violascens xylaniphila acidiphilus angulatum cohaerens columnare glossinidia glycolicum insecticola intestinalis lipocalidus neptunium violascens xylaniphila ferrivorans ferrivorans flavescens prowazekii rhizoxinica flavescens prowazekii rhizoxinica beijerinckii centenaria viscericola beijerinckii centenaria viscericola intermedia salexigens intermedia salexigens drancourtii universalis drancourtii universalis byssophila byssophila uzoniensis uzoniensis degradans labreanum degradans labreanum disciformis spiroforme disciformis spiroforme abscessus acetiphilus adhaerens aerogenes aggregans albilineans cellulosum chejuensis islandicum recurrentis symbiotica ulceribovis abscessus acetiphilus adhaerens aerogenes aggregans albilineans cellulosum chejuensis islandicum recurrentis symbiotica ulceribovis parauberis shayeganii toyohensis welshimeri parauberis shayeganii toyohensis welshimeri savastanoi savastanoi arilaitensis crunogena narugense arilaitensis crunogena narugense tribocorum tribocorum blandensis saburreum blandensis saburreum coralloides municipale plymuthica radiovictrix vesicatoria coralloides municipale plymuthica radiovictrix vesicatoria clariflavum fermentum clariflavum fermentum bronchialis capsulatus hassiacum lagunensis lotononidis maltophilia oneidensis posidonica profundum splendidus thalassium bronchialis capsulatus hassiacum lagunensis lotononidis maltophilia oneidensis posidonica profundum splendidus thalassium infernorum infernorum delbrueckii delbrueckii burgdorferi muridarum burgdorferi muridarum haemofelis mortiferum haemofelis mortiferum multiformis multiformis praevalens praevalens formicicum formicicum crescentus cynodegmi johnsoniae microfusus nigrescens smegmatis taeanensis crescentus cynodegmi johnsoniae microfusus nigrescens smegmatis taeanensis oleovorans oleovorans campestris capricolum sphaericus campestris capricolum sphaericus hylemonae hylemonae cryptofilum cryptofilum granulosus multivorum granulosus multivorum chubuense rhizogenes thermarum chubuense rhizogenes thermarum ventriosum ventriosum alkaliphilus gallolyticus lactolyticus mendocina spumigena alkaliphilus gallolyticus lactolyticus mendocina spumigena canariense matruchotii turkmenica canariense matruchotii turkmenica genomosp. genomosp. extorquens multipartita extorquens multipartita kuznetsovii kuznetsovii arabaticum brasiliensis ochraceum arabaticum brasiliensis ochraceum buryatense formigenes halodurans buryatense formigenes halodurans aerophilum colihominis indistinctus obsidiansis rhamnosus upsaliensis aerophilum colihominis indistinctus obsidiansis rhamnosus upsaliensis anaerobius harbinense pamelaeae anaerobius harbinense pamelaeae onnurineus onnurineus aquimarina vallismortis aquimarina vallismortis aeruginosa diphtheriae aeruginosa diphtheriae vestibularis vestibularis pellirubrum pellirubrum muciniphila muciniphila argentinum graevenitzii argentinum graevenitzii fermentans limnophilus fermentans limnophilus acidophilus atrophaeus interrogans negevensis acidophilus atrophaeus interrogans negevensis kristensenii kristensenii perfringens perfringens chaffeensis chaffeensis vanbaalenii vanbaalenii excentricus solfataricus sulfurifontis excentricus solfataricus sulfurifontis symbiosum symbiosum canadensis denticolens ethanolicus gansuensis gelatinosus lentocellum rhipicephali salanitronis canadensis denticolens ethanolicus gansuensis gelatinosus lentocellum rhipicephali salanitronis multivorans multivorans amylovorus amylovorus acetivorans erythraeum yellowstonii acetivorans erythraeum yellowstonii deleyianum deleyianum xenovorans xenovorans australicum thoraltensis australicum thoraltensis aerosaccus axonopodis canimorsus capsulatum coprophilus fluorescens glutamicum helcogenes longicatena magneticus propionicus spiritivorum urealyticum urogenitalis aerosaccus axonopodis canimorsus capsulatum coprophilus fluorescens glutamicum helcogenes longicatena magneticus propionicus spiritivorum urealyticum urogenitalis maripaludis maripaludis fungivorans purpuratum fungivorans purpuratum aerofaciens epidermidis mukohataei aerofaciens epidermidis mukohataei dassonvillei fructivorans dassonvillei fructivorans aurantiacus trachomatis aurantiacus trachomatis halifaxensis halifaxensis antarcticum aphrophilus audaxviator glossinidius neapolitana phagedenis testosteroni antarcticum aphrophilus audaxviator glossinidius neapolitana phagedenis testosteroni goodfellowii goodfellowii anguillarum clarridgeiae dysenteriae sedentarius anguillarum clarridgeiae dysenteriae sedentarius acidifaciens acidifaciens erythropolis owensensis erythropolis owensensis flavefaciens thermoflava flavefaciens thermoflava acinonychis taiwanensis acinonychis taiwanensis suwonensis suwonensis bacilliformis punctiforme bacilliformis punctiforme akajimensis aromaticum castenholzii massiliense pediculicola sporogenes stadtmanae unclassified akajimensis aromaticum castenholzii massiliense pediculicola sporogenes stadtmanae unclassified petrolearius wadsworthii petrolearius wadsworthii bizzozeronii hormaechei thermophila bizzozeronii hormaechei thermophila polymorpha polymorpha radiodurans sinusarabici radiodurans sinusarabici balhimycina balhimycina clavuligerus clavuligerus asymbiotica carbinolicus constellatus cylindroides haloplanktis hutchinsonii marismortui meningitidis persephone propinquum salmonicida asymbiotica carbinolicus constellatus cylindroides haloplanktis hutchinsonii marismortui meningitidis persephone propinquum salmonicida amblyommii megaterium amblyommii megaterium acetoxidans forsythensis thiooxydans acetoxidans forsythensis thiooxydans pleomorpha pleomorpha moniliformis moniliformis acidophilum caulinodans evestigatum haemolytica lugdunensis scotoductus tuberculosis acidophilum caulinodans evestigatum haemolytica lugdunensis scotoductus tuberculosis denitrificans necessarius denitrificans necessarius tumefaciens tumefaciens amycolatum amycolatum australiense columbinum philomiragia australiense columbinum philomiragia flavithermus nubinhibens flavithermus nubinhibens haemocanis massiliensis haemocanis massiliensis frederiksenii marianensis mitochondrii frederiksenii marianensis mitochondrii alcalifaciens coryniformis okinawensis pennivorans alcalifaciens coryniformis okinawensis pennivorans anatipestifer putrefaciens anatipestifer putrefaciens amylolyticus amylolyticus chlororaphis chlororaphis catenulatum O1 cholerae halotolerans catenulatum O1 cholerae halotolerans alginolyticus arsenaticum caseolyticus ferrooxidans magneticum alginolyticus arsenaticum caseolyticus ferrooxidans magneticum catacumbae entomophila mongolense nematophila neutrophilus profundicola seropedicae sphaeroides catacumbae entomophila mongolense nematophila neutrophilus profundicola seropedicae sphaeroides gallolyticus= gallolyticus= sublithincola sublithincola bemidjiensis imshenetskii neofelifaecis bemidjiensis imshenetskii neofelifaecis autotrophica coahuilensis pinnipedialis pneumoniae sulfidophilus xylanophilus autotrophica coahuilensis pinnipedialis pneumoniae sulfidophilus xylanophilus ruminantium ruminantium borinquense laterosporus roseosporus borinquense laterosporus roseosporus intermedium intermedium carotovorum conjunctivae carotovorum conjunctivae australiensis licheniformis mediterranei panaciterrae australiensis licheniformis mediterranei panaciterrae adolescentis alkenivorans benevestitus chliarophilus dysgalactiae equigenitalis kaustophilus luminescens nassauensis saxobsidens adolescentis alkenivorans benevestitus chliarophilus dysgalactiae equigenitalis kaustophilus luminescens nassauensis saxobsidens wadsworthia wadsworthia alkanivorans alkanivorans coralliilyticus moutnovskia szegediense coralliilyticus moutnovskia szegediense aespoeensis cellulolyticus cenocepacia colombiense proteolyticus psychrophila shabanensis xanaduensis aespoeensis cellulolyticus cenocepacia colombiense proteolyticus psychrophila shabanensis xanaduensis stercoricanis thuringiensis stercoricanis thuringiensis hydrogenalis hydrogenalis casseliflavus casseliflavus intracellulare neapolitanus intracellulare neapolitanus donghaensis endodontalis gonorrhoeae montanensis oligotrophica pentosaceus donghaensis endodontalis gonorrhoeae montanensis oligotrophica pentosaceus borkumensis borkumensis peraridilitoris peraridilitoris xylosoxidans xylosoxidans scabrisporus scabrisporus ferrooxydans phytofirmans ferrooxydans phytofirmans amoebophila asinigenitalis atrosepticum chondrophila gallaeciensis halalkaliphila pneumophila vestfoldensis xinjiangensis amoebophila asinigenitalis atrosepticum chondrophila gallaeciensis halalkaliphila pneumophila vestfoldensis xinjiangensis longbeachae naphthophila pasteurianus longbeachae naphthophila pasteurianus acidarmanus bermudensis dentocariosa kristjanssonii acidarmanus bermudensis dentocariosa kristjanssonii geothermalis thermophilus geothermalis thermophilus radiotolerans radiotolerans smaragdinae winogradskyi smaragdinae winogradskyi gallisepticum lactoaceticus splanchnicus gallisepticum lactoaceticus splanchnicus cellulovorans ethenogenes cellulovorans ethenogenes cf. prausnitzii cf. prausnitzii cf. ferrireducens ferrireducens mucilaginosa subterraneus valericigenes mucilaginosa subterraneus valericigenes subvibrioides subvibrioides alkalicellulosi cellulosilytica coleohominis haemolyticus odontolyticus pectinophilus tasmaniensis thailandensis vietnamensis alkalicellulosi cellulosilytica coleohominis haemolyticus odontolyticus pectinophilus tasmaniensis thailandensis vietnamensis intracellularis intracellularis miyakonense perideroedes miyakonense perideroedes kodakarensis kodakarensis mediterranea mediterranea enterocolitica haemolysans lithotrophicus minatonensis pseudomallei enterocolitica haemolysans lithotrophicus minatonensis pseudomallei bethesdensis tataouinensis bethesdensis tataouinensis desulfuricans maricopensis necrophorum desulfuricans maricopensis necrophorum xylanisolvens xylanisolvens piezotolerans piezotolerans metallidurans metallidurans cellulolyticum cellulolyticum argentinensis lacusprofundi argentinensis lacusprofundi metschnikovii metschnikovii fumaroxidans fumaroxidans odoratimimus odoratimimus bacteriovorus bacteriovorus xylanolyticum xylanolyticum aurimucosum autotrophicus biprosthecum calcoaceticus freudenreichii rhusiopathiae aurimucosum autotrophicus biprosthecum calcoaceticus freudenreichii rhusiopathiae newyorkensis newyorkensis pseudofirmus pseudofirmus thermocellum thermocellum trichosporium trichosporium parapertussis parapertussis marburgensis marburgensis benzoatilytica benzoatilytica nitroreducens vietnamiensis nitroreducens vietnamiensis missouriensis missouriensis harundinacea harundinacea thermophilum thermophilum dioxanivorans dioxanivorans aciditrophicus oklahomensis succinogenes aciditrophicus oklahomensis succinogenes cryohalolentis cryohalolentis saprophyticus saprophyticus subterraneum thiodismutans subterraneum thiodismutans obscuriglobus obscuriglobus ammonificans cicadellinicola haemolyticum ammonificans cicadellinicola haemolyticum succinifaciens succinifaciens cellulosolvens cellulosolvens stuttgartiensis stuttgartiensis parasanguinis radioresistens parasanguinis radioresistens kroppenstedtii petroleiphilum kroppenstedtii petroleiphilum peptidovorans peptidovorans formatexigens formatexigens phosphovorus phosphovorus hamburgensis hamburgensis genosp. SA − 4 genosp. SA − 4 genosp. haloalkaliphila haloalkaliphila dehalogenans dehalogenans periodonticum salmoninarum solanacearum periodonticum salmoninarum solanacearum thermoacetica thermoacetica mucilaginosus rhinotracheale mucilaginosus rhinotracheale aleyrodidarum aleyrodidarum autotrophicum borgpetersenii cellulosilyticus melanesiensis michiganensis vitaminophilus winghamensis autotrophicum borgpetersenii cellulosilyticus melanesiensis michiganensis vitaminophilus winghamensis tundripaludum tundripaludum hygroscopicus hygroscopicus versmoldensis versmoldensis asparagiforme opportunistum asparagiforme opportunistum mediatlanticus violaceusniger mediatlanticus violaceusniger papyrosolvens papyrosolvens acidocaldarius acidocaldarius diazotrophicus diazotrophicus doebereinerae tsutsugamushi doebereinerae tsutsugamushi bronchiseptica gasicomitatum psychrophilum bronchiseptica gasicomitatum psychrophilum caribbenthicus caribbenthicus micraerophilus micraerophilus azotonutricium azotonutricium nitrogenifigens succinatiphilus nitrogenifigens succinatiphilus clostridioforme clostridioforme fructosovorans fructosovorans benzoatilyticus benzoatilyticus nitratireducens parainfluenzae uraniireducens nitratireducens parainfluenzae uraniireducens hydrothermalis hydrothermalis mesenteroides sulfurreducens mesenteroides sulfurreducens kamchatkensis kronotskyensis lipophiloflavum kamchatkensis kronotskyensis lipophiloflavum curdlanolyticus maquilingensis curdlanolyticus maquilingensis photometricum photometricum acetobutylicum acetobutylicum roseosalivarius roseosalivarius kefiranofaciens kefiranofaciens paurometabola paurometabola cyriacigeorgica thermotolerans cyriacigeorgica thermotolerans arsenitoxydans arsenitoxydans hongkongensis hongkongensis brennaborense chthonoplastes metalliredigens modesticaldum brennaborense chthonoplastes metalliredigens modesticaldum phyllosphaerae stercorihominis phyllosphaerae stercorihominis hyodysenteriae hyodysenteriae ovipneumoniae ovipneumoniae branchiophilum branchiophilum chlorochromatii glucosetrophus chlorochromatii glucosetrophus yellowstonense yellowstonense nigripulchritudo pennsylvanicus nigripulchritudo pennsylvanicus paraluiscuniculi paraluiscuniculi gonidiaformans gonidiaformans ammoniagenes saccharolyticus ammoniagenes saccharolyticus leguminosarum leguminosarum gammatolerans haemominutum gammatolerans haemominutum asaccharolytica chiangmaiensis asaccharolytica chiangmaiensis arsenicoxydans thiosulfatigenes arsenicoxydans thiosulfatigenes carboxidivorans carboxidivorans yellowstonensis yellowstonensis micronuciformis micronuciformis melaninogenica metallireducens phaeovibrioides propionicigenes proteoclasticum saccharophilum melaninogenica metallireducens phaeovibrioides propionicigenes proteoclasticum saccharophilum saccharovorans saccharovorans aromaticivorans aromaticivorans pseudoporcinus psychrotolerans pseudoporcinus psychrotolerans microaerophilus monocytogenes microaerophilus monocytogenes brassicacearum hyopneumoniae brassicacearum hyopneumoniae formicigenerans formicigenerans aminoaromatica proteamaculans aminoaromatica proteamaculans thiocyanoxidans thiocyanoxidans wadsworthensis wadsworthensis thermohalophila thermohalophila malefermentans malefermentans acanthamoebae saccharolyticum acanthamoebae saccharolyticum psychrerythraea psychrerythraea carboxydivorans carboxydivorans selenitireducens selenitireducens carboxidovorans carboxidovorans methylpentosum methylpentosum manganoxydans manganoxydans aeruginosavorus sanfranciscensis aeruginosavorus sanfranciscensis asaccharolyticus asaccharolyticus paurometabolica thetaiotaomicron paurometabolica thetaiotaomicron lacuscaerulensis lacuscaerulensis phytofermentans phytofermentans pseudomycoides pseudomycoides bingchenggensis chlorophenolicus glucuronolyticum bingchenggensis chlorophenolicus glucuronolyticum acidaminovorans acidaminovorans phagocytophilum selenatireducens phagocytophilum selenatireducens magnetotacticum magnetotacticum capsiferriformans capsiferriformans heilongjiangensis heilongjiangensis dichloroeliminans dichloroeliminans pseudethanolicus pseudethanolicus parahaemolyticus parahaemolyticus chlorophenolicum chlorophenolicum pseudogenitalium pseudogenitalium heliotrinireducens heliotrinireducens griseoaurantiacus griseoaurantiacus amyloliquefaciens amyloliquefaciens aminisulfidivorans aminisulfidivorans methylaminiphilus methylaminiphilus pseudintermedius pseudintermedius parascrofulaceum parascrofulaceum phaeobacteroides phaeobacteroides naphthalenivorans naphthalenivorans thermocatenulatus thermocatenulatus multisaccharivorax multisaccharivorax hydrogenotrophica hydrogenotrophica pleuropneumoniae pleuropneumoniae polyisoprenivorans polyisoprenivorans excrementihominis hydrogenoformans excrementihominis hydrogenoformans succiniciproducens succiniciproducens tuberculostearicum tuberculostearicum thermodenitrificans thermodenitrificans paramesenteroides paramesenteroides thermautotrophicus thermopropionicum thermautotrophicus thermopropionicum pseudotuberculosis pseudotuberculosis thermolithotrophum thermolithotrophum phosphatis Type IIA phosphatis Type pseudocatenulatum IIA phosphatis Type pseudocatenulatum methylohalidivorans methylohalidivorans pseudopneumoniae pseudopneumoniae phenanthrenivorans phenanthrenivorans phaeoclathratiforme phaeoclathratiforme polysaccharolyticum polysaccharolyticum weihenstephanensis weihenstephanensis thermoglucosidasius thermoglucosidasius lykanthroporepellens lykanthroporepellens thuringiensisfinitimus thuringiensisfinitimus thermosulfidooxidans thermosulfidooxidans pseudotrichonymphae pseudotrichonymphae thermosaccharolyticum thermosaccharolyticum actinomycetemcomitans actinomycetemcomitans endosymbiont of Drosophila ananassae endosymbiont of Drosophila ananassae endosymbiont of Culex quinquefasciatus endosymbiont of Culex quinquefasciatus endosymbiont of Culex endosymbiont of Drosophila melanogaster endosymbiont of Drosophila melanogaster species species

16S GC (%) mean and SD Genome size (Mb) mean and SD 70 25

20 60 15

50 10

16S GC (%) 5 40 Genome size (Mb) Genome size 0 uli uli sp sp − 1 − 1 etli loti etli loti sp. sp. lari lari xyli xyli coli soli coli soli alni ceti alni ceti zea zea oris oris illini illini bilis vitis bilis vitis felis felis ovis ovis junii suis junii suis mali mali alba equi oeni alba equi oeni antri antri bellii hallii jostii lienii bellii hallii jostii lienii exile exile alvei alvei bivia mitis bivia mitis fulva grylli fulva grylli aceti sputi typhi aceti sputi typhi grayi grayi fetus fetus clara zeae clara zeae iners iners lenta lutea vafer lenta lutea vafer akari petrii akari petrii ferus ferus dorei harei dorei harei aeria aeria lactis lytica sicca tarda velox lactis lytica sicca tarda velox sakei sakei bovis novyi bovis novyi sinus sinus canis casei jejuni lacus lupini canis casei jejuni lacus lupini ciceri ruber ciceri ruber fontis noxia fontis noxia nivea nivea albus albus pylori pylori oralis oralis fusca mahii fusca mahii micra micra breve gadei inhae longa orenii setae tenax tetani breve gadei inhae longa orenii setae tenax tetani maris ruddii maris ruddii lwoffii lwoffii major minor morbi rosea major minor morbi rosea parva parva prima rimae risticii wolfei prima rimae risticii wolfei baylyi infelix baylyi infelix afzelii afzelii alocis bescii gilvus italica kunzii ureae alocis bescii gilvus italica kunzii ureae viridis viridis boydii iowae boydii iowae flavus flavus terrae terrae fluxus fulvus indica limnia linens mallei pestis plautii shahii tiedjei fluxus fulvus indica limnia linens mallei pestis plautii shahii tiedjei criceti criceti brevis brevis avium avium mazei mazei koseri tenuis koseri tenuis ordalii somni virosa ordalii somni virosa acnes alhagi anatis hippei lautus luteus pelagi acnes alhagi anatis hippei lautus luteus pelagi clarus garinii clarus garinii flexilis flexilis album album vortex vortex bromii salicis bromii salicis dispar gleum putida rectus dispar gleum putida rectus larvae larvae uberis uberis lovleyi lovleyi pernix pernix fibrata leprae fibrata leprae clausii philipii rohdei clausii philipii rohdei mirum mirum florum urinae florum urinae arvum arvum abyssi staleyi abyssi staleyi woodii woodii capitis elkanii katesii leachii mossii smithii capitis elkanii katesii leachii mossii smithii reuteri reuteri biflexa biflexa caviae flavida caviae flavida curtisii curtisii fragilis fragilis baltica brockii caldus camini gilvum pallida segnis simiae spadix baltica brockii caldus camini gilvum pallida segnis simiae spadix ignava ignava ictaluri ovatus ictaluri ovatus exigua forsetii exigua forsetii veronii veronii baarsii brookii comes glauca igneus kingae laneus microti mobile oceani sedula shibae sonnei baarsii brookii comes glauca igneus kingae laneus microti mobile oceani sedula shibae sonnei cibaria conorii cibaria conorii foetida foetida curvus curvus albertii stuartii albertii stuartii varium varium boonei cereus concilii leptum luteum natans potens rectale roseus torquis tropica ubique boonei cereus concilii leptum luteum natans potens rectale roseus torquis tropica ubique africae fumarii olearia africae fumarii olearia frigoris oryzae frigoris oryzae invisus invisus deserti deserti caprae xylinus caprae xylinus aureus azurea difficile ebreus italicus kimchii magna moorei obeum shilonii subtilis aureus azurea difficile ebreus italicus kimchii magna moorei obeum shilonii subtilis barkeri parkeri barkeri parkeri arboris marina peroris pigrum arboris marina peroris pigrum salivae salivae drewsii drewsii curtum curtum gracilis litoralis woesei woodyi gracilis litoralis woesei woodyi defluvii disiens gladioli indicus meliloti mobilis psittaci scabiei suillum defluvii disiens gladioli indicus meliloti mobilis psittaci scabiei suillum sibirica sibirica novella novella infantis infantis azollae downei azollae downei calvum irgensii larsenii micans timidus calvum irgensii larsenii micans timidus atypica caccae canettii cinaedi eligens jeotgali pallens paludis prevotii saltans SAR11 stellata tusciae atypica caccae canettii cinaedi eligens jeotgali pallens paludis prevotii saltans SAR11 stellata tusciae fischeri lactaris urinalis fischeri lactaris urinalis rubrum rubrum vagans vagans avidum buccae cyanea ducreyi gnavus avidum buccae cyanea ducreyi gnavus flexneri harveyi flexneri harveyi butzleri marshii wittichii butzleri marshii wittichii bifidum duttonii opacus persica stutzeri bifidum duttonii opacus persica stutzeri avenae bryantii primitia ruminis avenae bryantii primitia ruminis gasseri griseus orientis gasseri griseus orientis hermsii walsbyi hermsii walsbyi boevrei boevrei fervens fervens bispora grandis mutans bispora grandis mutans bolteae cinerea citreum freundii glumae longum villosus vulgare wiegelii bolteae cinerea citreum freundii glumae longum villosus vulgare wiegelii burnetii curvata orisratti burnetii curvata orisratti cuprina ivanovii cuprina ivanovii burtonii burtonii warneri warneri parvula volcanii parvula volcanii biforme biforme agreste limicola necator roseum torques agreste limicola necator roseum torques bongori penneri slovaca torridus bongori penneri slovaca torridus faecalis faecalis parvum parvum keddieii keddieii abortus bovienii watsoni abortus bovienii watsoni kluyveri kluyveri algicida algicola elsdenii hollisae intestini jensenii merdae pacifica satelles zhilinae algicida algicola elsdenii hollisae intestini jensenii merdae pacifica satelles zhilinae cattleya cattleya furnissii oxytoca showae furnissii oxytoca showae bouvetii bouvetii tokodaii tokodaii arcticus auensis cepacia cloacae dentalis fulgidus fuscans giardinii hilgardii hominis indicum linguale melonis okutanii oshimai pumilus usitatus arcticus auensis cepacia cloacae dentalis fulgidus fuscans giardinii hilgardii hominis indicum linguale melonis okutanii oshimai pumilus usitatus mulieris mulieris vulgaris vulgaris faecium faecium vaginae vaginae laidlawii laidlawii conradii equinus mucosa conradii equinus mucosa dadantii elegans fervidus flueggei gelidum globosa innocua magadii maxima tunicata uenonis xanthus dadantii elegans fervidus flueggei gelidum globosa innocua magadii maxima tunicata uenonis xanthus muelleri muelleri caldaria furiosus kandleri meridiei caldaria furiosus kandleri meridiei barnesii barnesii defensa defensa bartlettii extructa infernus bartlettii extructa infernus centrale siraeum centrale siraeum dentium gordonii robiniae tepidum dentium gordonii robiniae tepidum endobia marinus endobia marinus africana enterica rugosus striatum africana enterica rugosus striatum silvanus silvanus cryptum vannielii cryptum vannielii buccalis buccalis watsonii watsonii aurantia rickettsii aurantia rickettsii histicola indolifex kansasii saliphila vincentii whipplei histicola indolifex kansasii saliphila vincentii whipplei anthropi frappieri anthropi frappieri cetorum oulorum sibiricus cetorum oulorum sibiricus morbifer morbifer gregoryi gregoryi jeikeium jeikeium mirabilis novicida variicola mirabilis novicida variicola animalis gallicum animalis gallicum aeolicus aquatilis efficiens kujiense occultus pinensis pipientis placidus stewartii violacea aeolicus aquatilis efficiens kujiense occultus pinensis pipientis placidus stewartii violacea subflava subflava farcinica oxydans taffensis farcinica oxydans taffensis australis variabile australis variabile limosum limosum atlantica balticum datiscae eiseniae halobius hansenii hofstadii inhibens japonica pallidum pelagius stomatis vinosum vulgatus atlantica balticum datiscae eiseniae halobius hansenii hofstadii inhibens japonica pallidum pelagius stomatis vinosum vulgatus cristatus ehrlichei palustris seeligeri turnerae cristatus ehrlichei palustris seeligeri turnerae veroralis veroralis versutus versutus mccartyi mccartyi diminuta parasuis porcinus ulcerans diminuta parasuis porcinus ulcerans ananatis benthica citroniae equitans eutactus languida lettingae luteolum medicae nodosus pilosicoli tanakaei ananatis benthica citroniae equitans eutactus languida lettingae luteolum medicae nodosus pilosicoli tanakaei aestuarii merionis princeps stercoris syringae aestuarii merionis princeps stercoris syringae cholerae grahamii minutum silvestris tetradius cholerae grahamii minutum silvestris tetradius buchneri coxensis buchneri coxensis cyclicum elongata hungatei pendens quintana tiamatea viscosus cyclicum elongata hungatei pendens quintana tiamatea viscosus wenyonii wenyonii infirmum maritima pullorum turicatae infirmum maritima pullorum turicatae garvieae vaginalis versatilis garvieae vaginalis versatilis butylicus butylicus eggerthii eggerthii variabilis variabilis asiaticus billingiae concisus indiensis indolicus rotundus turgidum asiaticus billingiae concisus indiensis indolicus rotundus turgidum marinum marinum pecorum pecorum odorifera vadensis odorifera vadensis synoviae synoviae tannerae terangae tannerae terangae accolens cholodnii crocodyli defectiva eutropha finegoldii johnsonii pimensis platensis profunda scindens suebicus tropicalis accolens cholodnii crocodyli defectiva eutropha finegoldii johnsonii pimensis platensis profunda scindens suebicus tropicalis hyorhinis hyorhinis pyrifoliae pyrifoliae sibiricum sibiricum flavigena flavigena mucosus terrenum mucosus terrenum adiacens composti denticola dolichum halophila plutonius pulmonis resistens adiacens composti denticola dolichum halophila plutonius pulmonis resistens crispatus orientalis crispatus orientalis termitidis termitidis geofontis purpurea geofontis purpurea pertussis pertussis anthracis mucosae mustelae ragsdalei anthracis mucosae mustelae ragsdalei distributa uniformis distributa uniformis arenicola macacae arenicola macacae africanus henselae inopinata postgatei sennetsu tibetense africanus henselae inopinata postgatei sennetsu tibetense balearica fructosus obscurus restrictus balearica fructosus obscurus restrictus carnosus pomeroyi carnosus pomeroyi gingivalis gingivalis ambifaria cavernae lipoferum ambifaria cavernae lipoferum azorense mathranii yayanosii azorense mathranii yayanosii ochracea tractuosa ochracea tractuosa arthritidis loihiensis sakazakii vulnificus arthritidis loihiensis sakazakii vulnificus aerophila nodosum pealeana reducens sprentiae aerophila nodosum pealeana reducens sprentiae racemifer racemifer iheyensis thioparus iheyensis thioparus parvulum parvulum ramosum salivarius ramosum salivarius araneosa igniterrae araneosa igniterrae biformata mallensis massiliae nitrofigilis sediminis biformata mallensis massiliae nitrofigilis sediminis acidiphila delafieldii hospitalis peacockii piscolens tergarcus vinelandii violaceus vulcanius acidiphila delafieldii hospitalis peacockii piscolens tergarcus vinelandii violaceus vulcanius lacrimalis lacrimalis perforans perforans farciminis farciminis fastidiosa hydrossis fastidiosa hydrossis veneficus veneficus evryensis subflavus evryensis subflavus mycoides polymyxa wasabiae mycoides polymyxa wasabiae iraqiensis iraqiensis horikoshii horikoshii atlanticus batsensis coelicolor coleocola europaea gobiensis hispanica hopiensis japonicus lactamica macleodii mitsuokai sanguinis atlanticus batsensis coelicolor coleocola europaea gobiensis hispanica hopiensis japonicus lactamica macleodii mitsuokai sanguinis alligatoris pomorum turicensis alligatoris pomorum turicensis erythraea erythraea koreensis koreensis alexandrii rhizophila alexandrii rhizophila multocida multocida fusiformis fusiformis aegyptius anophelis aquaticus coprosuis crossotus gibsoniae hepaticus leiognathi maculosa magnifica spinosum tularensis ureolytica utahensis zucineum aegyptius anophelis aquaticus coprosuis crossotus gibsoniae hepaticus leiognathi maculosa magnifica spinosum tularensis ureolytica utahensis zucineum pyogenes pyogenes trichoides trichoides fergusonii fergusonii botulinum mucosum murdochii paracasei polyspora botulinum mucosum murdochii paracasei polyspora butyricum funiformis butyricum funiformis aquaeolei bergensis cinnamea columbae coprocola damselae elongatus glycolicus hafniense lipolyticus putredinis sputigena sticklandii aquaeolei bergensis cinnamea columbae coprocola damselae elongatus glycolicus hafniense lipolyticus putredinis sputigena sticklandii floridanus maritimus floridanus maritimus caeruleus salinarum tundricola caeruleus salinarum tundricola marisnigri panacarvi marisnigri panacarvi pharaonis pharaonis aromatica basilensis capillosus cicadicola claussenii islandicus marginale petrophila rhodesiae salsuginis aromatica basilensis capillosus cicadicola claussenii islandicus marginale petrophila rhodesiae salsuginis africanum heparinus africanum heparinus diaphorus diaphorus helveticus valaisiana helveticus valaisiana avermitilis avermitilis hathewayi penetrans hathewayi penetrans campbellii coccoides corrodens distasonis hellenicus jannaschii ljungdahlii melitensis neotomae profundus retbaense rodentium spielmanii campbellii coccoides corrodens distasonis hellenicus jannaschii ljungdahlii melitensis neotomae profundus retbaense rodentium spielmanii mortivallis plantarum mortivallis plantarum volcanium volcanium piezophila piezophila prausnitzii raciborskii prausnitzii raciborskii formicicus formicicus aphidicola flagellatus halophilus hollandica liminatans naeslundii piechaudii saanensis ultunensis violaceum aphidicola flagellatus halophilus hollandica liminatans naeslundii piechaudii saanensis ultunensis violaceum aggregata dorotheae aggregata dorotheae agarilytica nigrificans agarilytica nigrificans amorphae amorphae amylovora brasilense contractile amylovora brasilense contractile acidilactici acidipiscis columbina genitalium japonicum acidilactici acidipiscis columbina genitalium japonicum agalactiae anginosus coagulans influenzae ubonensis agalactiae anginosus coagulans influenzae ubonensis moribillum ruminicola moribillum ruminicola hydrophila hydrophila melliferum melliferum infantarius ingrahamii infantarius ingrahamii nucleatum nucleatum catarrhalis oremlandii sinaiiensis catarrhalis oremlandii sinaiiensis aurescens baculatum barophilus baumannii methanica oguniense pittmaniae polytropus testaceum aurescens baculatum barophilus baumannii methanica oguniense pittmaniae polytropus testaceum gallinarum gallinarum paradoxus paradoxus calidifontis ferrophilus phymatum calidifontis ferrophilus phymatum alaskensis alaskensis aurantiaca glomerans saphenum aurantiaca glomerans saphenum glycolicum glycolicum acidiphilus angulatum cohaerens columnare glossinidia insecticola intestinalis lipocalidus neptunium violascens xylaniphila acidiphilus angulatum cohaerens columnare glossinidia insecticola intestinalis lipocalidus neptunium violascens xylaniphila ferrivorans ferrivorans beijerinckii flavescens prowazekii rhizoxinica viscericola beijerinckii flavescens prowazekii rhizoxinica viscericola centenaria centenaria intermedia salexigens intermedia salexigens drancourtii universalis drancourtii universalis byssophila byssophila uzoniensis uzoniensis degradans disciformis labreanum degradans disciformis labreanum spiroforme spiroforme abscessus acetiphilus adhaerens aerogenes aggregans albilineans cellulosum chejuensis islandicum recurrentis symbiotica ulceribovis welshimeri abscessus acetiphilus adhaerens aerogenes aggregans albilineans cellulosum chejuensis islandicum recurrentis symbiotica ulceribovis welshimeri parauberis shayeganii toyohensis parauberis shayeganii toyohensis savastanoi savastanoi arilaitensis crunogena narugense arilaitensis crunogena narugense tribocorum tribocorum blandensis saburreum blandensis saburreum coralloides municipale plymuthica radiovictrix vesicatoria coralloides municipale plymuthica radiovictrix vesicatoria clariflavum fermentum clariflavum fermentum bronchialis capsulatus hassiacum lagunensis lotononidis maltophilia oneidensis posidonica profundum splendidus thalassium bronchialis capsulatus hassiacum lagunensis lotononidis maltophilia oneidensis posidonica profundum splendidus thalassium infernorum infernorum delbrueckii delbrueckii burgdorferi muridarum burgdorferi muridarum haemofelis mortiferum haemofelis mortiferum multiformis multiformis praevalens praevalens formicicum formicicum crescentus cynodegmi johnsoniae microfusus nigrescens smegmatis taeanensis crescentus cynodegmi johnsoniae microfusus nigrescens smegmatis taeanensis oleovorans oleovorans campestris capricolum sphaericus campestris capricolum sphaericus hylemonae hylemonae cryptofilum cryptofilum chubuense granulosus multivorum chubuense granulosus multivorum rhizogenes thermarum rhizogenes thermarum ventriosum ventriosum alkaliphilus gallolyticus lactolyticus mendocina spumigena alkaliphilus gallolyticus lactolyticus mendocina spumigena canariense matruchotii turkmenica canariense matruchotii turkmenica genomosp. genomosp. extorquens extorquens multipartita multipartita kuznetsovii kuznetsovii arabaticum brasiliensis buryatense halodurans ochraceum arabaticum brasiliensis buryatense halodurans ochraceum formigenes formigenes aerophilum anaerobius colihominis harbinense indistinctus obsidiansis pamelaeae rhamnosus upsaliensis aerophilum anaerobius colihominis harbinense indistinctus obsidiansis pamelaeae rhamnosus upsaliensis onnurineus onnurineus aeruginosa aquimarina diphtheriae vallismortis aeruginosa aquimarina diphtheriae vallismortis vestibularis vestibularis pellirubrum pellirubrum argentinum graevenitzii muciniphila argentinum graevenitzii muciniphila fermentans fermentans acidophilus interrogans limnophilus acidophilus interrogans limnophilus atrophaeus negevensis atrophaeus negevensis kristensenii perfringens kristensenii perfringens chaffeensis chaffeensis vanbaalenii vanbaalenii excentricus solfataricus sulfurifontis excentricus solfataricus sulfurifontis lentocellum rhipicephali salanitronis symbiosum lentocellum rhipicephali salanitronis symbiosum canadensis denticolens ethanolicus gansuensis gelatinosus canadensis denticolens ethanolicus gansuensis gelatinosus multivorans multivorans amylovorus amylovorus erythraeum yellowstonii erythraeum yellowstonii acetivorans acetivorans deleyianum deleyianum xenovorans xenovorans australicum australicum thoraltensis thoraltensis canimorsus glutamicum urealyticum canimorsus glutamicum urealyticum aerosaccus axonopodis capsulatum coprophilus fluorescens helcogenes longicatena magneticus propionicus spiritivorum urogenitalis aerosaccus axonopodis capsulatum coprophilus fluorescens helcogenes longicatena magneticus propionicus spiritivorum urogenitalis maripaludis maripaludis epidermidis fungivorans purpuratum epidermidis fungivorans purpuratum aerofaciens mukohataei aerofaciens mukohataei dassonvillei fructivorans dassonvillei fructivorans aurantiacus trachomatis aurantiacus trachomatis halifaxensis halifaxensis antarcticum aphrophilus audaxviator glossinidius neapolitana phagedenis testosteroni antarcticum aphrophilus audaxviator glossinidius neapolitana phagedenis testosteroni goodfellowii goodfellowii anguillarum clarridgeiae dysenteriae sedentarius anguillarum clarridgeiae dysenteriae sedentarius acidifaciens acidifaciens erythropolis owensensis erythropolis owensensis flavefaciens thermoflava flavefaciens thermoflava acinonychis taiwanensis acinonychis taiwanensis bacilliformis suwonensis bacilliformis suwonensis punctiforme punctiforme akajimensis aromaticum castenholzii massiliense pediculicola sporogenes stadtmanae unclassified akajimensis aromaticum castenholzii massiliense pediculicola sporogenes stadtmanae unclassified petrolearius wadsworthii petrolearius wadsworthii bizzozeronii hormaechei thermophila bizzozeronii hormaechei thermophila polymorpha polymorpha radiodurans sinusarabici radiodurans sinusarabici balhimycina balhimycina clavuligerus marismortui clavuligerus marismortui asymbiotica carbinolicus constellatus cylindroides haloplanktis hutchinsonii meningitidis persephone propinquum salmonicida asymbiotica carbinolicus constellatus cylindroides haloplanktis hutchinsonii meningitidis persephone propinquum salmonicida amblyommii megaterium amblyommii megaterium acetoxidans forsythensis thiooxydans acetoxidans forsythensis thiooxydans pleomorpha pleomorpha moniliformis moniliformis acidophilum caulinodans evestigatum haemolytica lugdunensis scotoductus tuberculosis acidophilum caulinodans evestigatum haemolytica lugdunensis scotoductus tuberculosis denitrificans necessarius denitrificans necessarius tumefaciens tumefaciens amycolatum amycolatum australiense columbinum nubinhibens philomiragia australiense columbinum nubinhibens philomiragia flavithermus flavithermus haemocanis massiliensis haemocanis massiliensis frederiksenii marianensis mitochondrii frederiksenii marianensis mitochondrii pennivorans pennivorans alcalifaciens anatipestifer coryniformis okinawensis putrefaciens alcalifaciens anatipestifer coryniformis okinawensis putrefaciens amylolyticus amylolyticus catenulatum chlororaphis O1 cholerae halotolerans catenulatum chlororaphis O1 cholerae halotolerans ferrooxidans ferrooxidans alginolyticus arsenaticum caseolyticus catacumbae entomophila magneticum mongolense nematophila neutrophilus profundicola seropedicae sphaeroides alginolyticus arsenaticum caseolyticus catacumbae entomophila magneticum mongolense nematophila neutrophilus profundicola seropedicae sphaeroides gallolyticus= gallolyticus= sublithincola sublithincola bemidjiensis coahuilensis imshenetskii neofelifaecis pinnipedialis sulfidophilus xylanophilus bemidjiensis coahuilensis imshenetskii neofelifaecis pinnipedialis sulfidophilus xylanophilus autotrophica pneumoniae autotrophica pneumoniae laterosporus roseosporus ruminantium laterosporus roseosporus ruminantium borinquense borinquense intermedium intermedium carotovorum carotovorum conjunctivae conjunctivae australiensis mediterranei australiensis mediterranei licheniformis panaciterrae licheniformis panaciterrae chliarophilus luminescens chliarophilus luminescens adolescentis alkenivorans benevestitus dysgalactiae equigenitalis kaustophilus nassauensis saxobsidens adolescentis alkenivorans benevestitus dysgalactiae equigenitalis kaustophilus nassauensis saxobsidens wadsworthia wadsworthia alkanivorans alkanivorans coralliilyticus moutnovskia szegediense coralliilyticus moutnovskia szegediense cellulolyticus cellulolyticus aespoeensis cenocepacia colombiense proteolyticus psychrophila shabanensis xanaduensis aespoeensis cenocepacia colombiense proteolyticus psychrophila shabanensis xanaduensis stercoricanis stercoricanis thuringiensis thuringiensis hydrogenalis hydrogenalis casseliflavus casseliflavus intracellulare neapolitanus intracellulare neapolitanus donghaensis endodontalis gonorrhoeae montanensis oligotrophica pentosaceus donghaensis endodontalis gonorrhoeae montanensis oligotrophica pentosaceus borkumensis peraridilitoris borkumensis peraridilitoris xylosoxidans xylosoxidans scabrisporus scabrisporus ferrooxydans phytofirmans ferrooxydans phytofirmans amoebophila asinigenitalis atrosepticum chondrophila gallaeciensis halalkaliphila longbeachae naphthophila pneumophila vestfoldensis xinjiangensis amoebophila asinigenitalis atrosepticum chondrophila gallaeciensis halalkaliphila longbeachae naphthophila pneumophila vestfoldensis xinjiangensis pasteurianus pasteurianus acidarmanus bermudensis dentocariosa kristjanssonii acidarmanus bermudensis dentocariosa kristjanssonii geothermalis thermophilus geothermalis thermophilus radiotolerans radiotolerans smaragdinae winogradskyi smaragdinae winogradskyi ethenogenes gallisepticum lactoaceticus splanchnicus ethenogenes gallisepticum lactoaceticus splanchnicus cellulovorans cellulovorans cf. prausnitzii cf. prausnitzii cf. ferrireducens ferrireducens mucilaginosa subterraneus valericigenes mucilaginosa subterraneus valericigenes subvibrioides subvibrioides alkalicellulosi cellulosilytica coleohominis haemolyticus odontolyticus pectinophilus tasmaniensis thailandensis vietnamensis alkalicellulosi cellulosilytica coleohominis haemolyticus odontolyticus pectinophilus tasmaniensis thailandensis vietnamensis intracellularis intracellularis miyakonense perideroedes miyakonense perideroedes kodakarensis kodakarensis mediterranea mediterranea bethesdensis enterocolitica haemolysans lithotrophicus minatonensis pseudomallei tataouinensis bethesdensis enterocolitica haemolysans lithotrophicus minatonensis pseudomallei tataouinensis desulfuricans maricopensis necrophorum desulfuricans maricopensis necrophorum piezotolerans xylanisolvens piezotolerans xylanisolvens metallidurans metallidurans argentinensis cellulolyticum lacusprofundi argentinensis cellulolyticum lacusprofundi metschnikovii metschnikovii fumaroxidans fumaroxidans odoratimimus odoratimimus bacteriovorus bacteriovorus biprosthecum calcoaceticus freudenreichii xylanolyticum biprosthecum calcoaceticus freudenreichii xylanolyticum aurimucosum autotrophicus rhusiopathiae aurimucosum autotrophicus rhusiopathiae newyorkensis newyorkensis pseudofirmus pseudofirmus thermocellum thermocellum parapertussis trichosporium parapertussis trichosporium marburgensis marburgensis benzoatilytica benzoatilytica vietnamiensis vietnamiensis nitroreducens nitroreducens missouriensis missouriensis harundinacea harundinacea thermophilum thermophilum dioxanivorans dioxanivorans aciditrophicus oklahomensis succinogenes aciditrophicus oklahomensis succinogenes cryohalolentis cryohalolentis saprophyticus saprophyticus subterraneum thiodismutans subterraneum thiodismutans obscuriglobus obscuriglobus ammonificans cicadellinicola haemolyticum ammonificans cicadellinicola haemolyticum succinifaciens succinifaciens cellulosolvens cellulosolvens stuttgartiensis stuttgartiensis parasanguinis radioresistens parasanguinis radioresistens kroppenstedtii petroleiphilum kroppenstedtii petroleiphilum peptidovorans peptidovorans formatexigens formatexigens phosphovorus phosphovorus hamburgensis hamburgensis genosp. SA − 4 genosp. SA − 4 genosp. dehalogenans haloalkaliphila dehalogenans haloalkaliphila periodonticum salmoninarum solanacearum periodonticum salmoninarum solanacearum thermoacetica thermoacetica mucilaginosus rhinotracheale mucilaginosus rhinotracheale aleyrodidarum aleyrodidarum autotrophicum borgpetersenii cellulosilyticus melanesiensis michiganensis vitaminophilus winghamensis autotrophicum borgpetersenii cellulosilyticus melanesiensis michiganensis vitaminophilus winghamensis tundripaludum tundripaludum hygroscopicus hygroscopicus versmoldensis versmoldensis asparagiforme opportunistum asparagiforme opportunistum mediatlanticus papyrosolvens violaceusniger mediatlanticus papyrosolvens violaceusniger acidocaldarius acidocaldarius diazotrophicus diazotrophicus tsutsugamushi tsutsugamushi doebereinerae doebereinerae bronchiseptica gasicomitatum psychrophilum bronchiseptica gasicomitatum psychrophilum caribbenthicus caribbenthicus azotonutricium micraerophilus azotonutricium micraerophilus succinatiphilus succinatiphilus nitrogenifigens nitrogenifigens clostridioforme clostridioforme fructosovorans fructosovorans benzoatilyticus benzoatilyticus hydrothermalis nitratireducens parainfluenzae uraniireducens hydrothermalis nitratireducens parainfluenzae uraniireducens mesenteroides sulfurreducens mesenteroides sulfurreducens kamchatkensis kronotskyensis lipophiloflavum kamchatkensis kronotskyensis lipophiloflavum curdlanolyticus maquilingensis curdlanolyticus maquilingensis photometricum photometricum acetobutylicum acetobutylicum roseosalivarius roseosalivarius kefiranofaciens kefiranofaciens paurometabola paurometabola cyriacigeorgica thermotolerans cyriacigeorgica thermotolerans arsenitoxydans arsenitoxydans hongkongensis hongkongensis brennaborense chthonoplastes metalliredigens modesticaldum brennaborense chthonoplastes metalliredigens modesticaldum phyllosphaerae stercorihominis phyllosphaerae stercorihominis hyodysenteriae hyodysenteriae ovipneumoniae ovipneumoniae branchiophilum branchiophilum chlorochromatii glucosetrophus chlorochromatii glucosetrophus yellowstonense yellowstonense nigripulchritudo pennsylvanicus nigripulchritudo pennsylvanicus paraluiscuniculi paraluiscuniculi gonidiaformans gonidiaformans ammoniagenes saccharolyticus ammoniagenes saccharolyticus leguminosarum leguminosarum gammatolerans haemominutum gammatolerans haemominutum asaccharolytica chiangmaiensis asaccharolytica chiangmaiensis arsenicoxydans arsenicoxydans thiosulfatigenes thiosulfatigenes carboxidivorans carboxidivorans yellowstonensis yellowstonensis micronuciformis micronuciformis metallireducens proteoclasticum saccharophilum metallireducens proteoclasticum saccharophilum melaninogenica phaeovibrioides propionicigenes melaninogenica phaeovibrioides propionicigenes saccharovorans saccharovorans aromaticivorans aromaticivorans pseudoporcinus psychrotolerans pseudoporcinus psychrotolerans microaerophilus microaerophilus brassicacearum monocytogenes brassicacearum monocytogenes hyopneumoniae hyopneumoniae formicigenerans formicigenerans aminoaromatica proteamaculans aminoaromatica proteamaculans thiocyanoxidans thiocyanoxidans wadsworthensis wadsworthensis thermohalophila thermohalophila malefermentans malefermentans acanthamoebae saccharolyticum acanthamoebae saccharolyticum psychrerythraea psychrerythraea carboxydivorans carboxydivorans selenitireducens selenitireducens carboxidovorans carboxidovorans manganoxydans methylpentosum manganoxydans methylpentosum aeruginosavorus aeruginosavorus sanfranciscensis sanfranciscensis asaccharolyticus paurometabolica thetaiotaomicron asaccharolyticus paurometabolica thetaiotaomicron lacuscaerulensis lacuscaerulensis phytofermentans phytofermentans pseudomycoides pseudomycoides glucuronolyticum glucuronolyticum bingchenggensis chlorophenolicus bingchenggensis chlorophenolicus acidaminovorans acidaminovorans phagocytophilum selenatireducens phagocytophilum selenatireducens magnetotacticum magnetotacticum capsiferriformans capsiferriformans heilongjiangensis heilongjiangensis dichloroeliminans dichloroeliminans pseudethanolicus pseudethanolicus parahaemolyticus parahaemolyticus chlorophenolicum pseudogenitalium chlorophenolicum pseudogenitalium heliotrinireducens heliotrinireducens griseoaurantiacus griseoaurantiacus amyloliquefaciens amyloliquefaciens aminisulfidivorans aminisulfidivorans methylaminiphilus pseudintermedius methylaminiphilus pseudintermedius parascrofulaceum parascrofulaceum phaeobacteroides phaeobacteroides naphthalenivorans naphthalenivorans thermocatenulatus thermocatenulatus hydrogenotrophica multisaccharivorax hydrogenotrophica multisaccharivorax pleuropneumoniae pleuropneumoniae hydrogenoformans polyisoprenivorans hydrogenoformans polyisoprenivorans excrementihominis excrementihominis succiniciproducens succiniciproducens tuberculostearicum tuberculostearicum thermodenitrificans thermodenitrificans paramesenteroides paramesenteroides thermautotrophicus thermopropionicum thermautotrophicus thermopropionicum pseudotuberculosis pseudotuberculosis thermolithotrophum thermolithotrophum pseudocatenulatum pseudocatenulatum phosphatis Type IIA phosphatis Type IIA phosphatis Type methylohalidivorans methylohalidivorans pseudopneumoniae pseudopneumoniae phenanthrenivorans phenanthrenivorans phaeoclathratiforme phaeoclathratiforme polysaccharolyticum polysaccharolyticum weihenstephanensis weihenstephanensis thermoglucosidasius thermoglucosidasius lykanthroporepellens lykanthroporepellens thuringiensisfinitimus thuringiensisfinitimus thermosulfidooxidans thermosulfidooxidans pseudotrichonymphae pseudotrichonymphae thermosaccharolyticum thermosaccharolyticum actinomycetemcomitans actinomycetemcomitans endosymbiont of Drosophila ananassae endosymbiont of Drosophila ananassae endosymbiont of Culex quinquefasciatus endosymbiont of Culex quinquefasciatus endosymbiont of Culex endosymbiont of Drosophila melanogaster endosymbiont of Drosophila melanogaster species species