Okadaic Acid Time-Resolved Absorption and Resonance FT-IR and Raman Biospectroscopy © 2019 Heidari A, Et Al

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Original Article: Open Access One of the primary causes of diarrhetic shellfishshellfish. poi and sponges marine both in accumulate to known is and dinoflagellates, of species several which permitsunrestricteduse, distribution, andreproductioninanymedium,providedtheoriginal authorandsourcearecredited. Copyright: Heidari etal. Accepted: May16,2019 American InternationalStandardsInstitute,Irvine,CA3800, USA author: *Corresponding Introduction 2 1 Alireza Heidari American InternationalStandardsInstitute,USA Faculty ofChemistry, CaliforniaSouthUniversity, USA Okadaic Acid Time-Resolved Absorption and Resonance Functional Theory(DFT)InvestigationofVibronic-Mode and Density Functional Theory (DFT) Investigation of Vibronic-Mode Coupling Structure in Vibrational Spectra Analysis. IntJAnalyt Analysis. Spectra Vibrational in Structure Bioanalyt Methods 1:004 Coupling ofVibronic-Mode Investigation (DFT) Theory Functional Density and Citation: Okadaic acid, C acid, Okadaic Coupling StructureinVibrationalSpectraAnalysis FT-IR andRamanBiospectroscopyDensity Heidari A, Esposito J, Caissutti A (2019) Okadaic Acid Time-Resolved Absorption and Resonance FT-IR and Raman Biospectroscopy © 2019 Heidari A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, Attribution Commons Creative the of terms the under distributed article open-access an is This al. et A, Heidari 2019 © IntJAnalytBioanalytMethods2019, 1:004 VIBGYOR spectrum using density functional theory in levels of HF/6-31G levels in theory functional density using spectrum empirical Raman and spectrum empirical FT-IR and simulation theoretical on based performed the investigate to aimed possibility of simulating the empirical study values. Analysis of vibrational current spectrum of Okadaic Acid is The molecules. adjacent for bonds Hydrogen create to leads it that shown was acid of molecule each from groups carboxyl with crystal in dimers of cycle spectrum vibrational about investigation The results. empirical with compared were Acid Okadaic crystal single for intensities phosphatases in cell growth. Parameters such as FT processes both with respect to dinoflagellate polyketide synthesis as well as the role of protein fatty acid, Okadaic acid and other members of its family have shined light upon many biological known to have a variety of negative effects on cells. A polyketide, is polyether derivative of aC38 and phosphatases protein specific of inhibitor potent a is acid Okadaic poisoning, shellfish diarrhetic of causes primary the of One shellfish. and sponges marine both in accumulate to MP2/6-31++G values confirmhighaccuracyandvalidityofresultsobtainedfromcalculations[ obtained The investigated. separately are cycle phenyl and acid carboxyl methylene, of modes and resonance,FT-IRRamanbiospectroscopy Non-Focal functions of becke, Correlation functions of Lee-Yang-Parr, Time-Resolved absorption acid, Okadaic (DFT), Theory Functional Density analysis, spectra Vibrational structure, Vibronic Keywords C acid, Okadaic Abstract 1,2* ; Published: 44 H Alireza Heidari, Faculty of Chemistry, California South University, 14731 Comet St. Irvine, CA 92604; Irvine, CA St. University, 14731Comet South California Chemistry, of Faculty Heidari, Alireza , JenniferEsposito 68 O ** 13 44 BY/-1, BLYP/6-31++G BLYP/6-31G, , , is a toxin produced by produced toxin a is , H May18,2019 68 O 13 , is a toxin produced by several species of dinoflagellates, and is known is and dinoflagellates, of species several by produced toxin a is , 1 andAngela Caissutti are calculated using density functional theory and theory functional density using calculated are Analytical and Bioanalytical Methods International - ** BLP63G n B3LYP6-31-HEG and B3LYP/6-31G , and other members of its family have shined light shined have family its of members other and acid acid, Okadaic fatty aC38 of derivative ether poly A polyketide, cells. on effects negative of ety vari- a have to known is and phosphatases protein soning, Okadaic acid is a potent inhibitor of specific -IR and Raman vibrational wavelengths and Journal of * , HF/6-31++G , 1 ** 1-42]. , MP2/6-31G, , ** Vibration . - ISSN: 2631-5009

Heidari et al. Int J Analyt Bioanalyt Methods 2019, 1:004 | • Page 2 of 19 • upon many biological processes both with respect applications. In this view, Okadaic acid was taken to dinoflagellate polyketide synthesis as well as the and examined for its phytochemical and active role of protein phosphatases in cell growth. Densi- principles in vitro anti-oxidant models and in silico ty Functional Theory (DFT) is one of the most pow- approach for anti-histamine activity. Free radicals erful calculation methods for electronic structures are atoms with unpaired electrons which can cause [5-7]. Numerous results have been previously stud- various diseases. Intake of vitamin E can reduce the ied and indicate successful use of these methods problems associated with free radicals in the body [8-10]. The theory is one of the most appropriate [201-209]. The unpaired electrons of free-radical methods for simulating the vibrational wavenum- accumulation cause oxidative stress in the body. bers, molecular structure as well as total energy. Oxidative stress causes cell damage leading to var- It may be useful to initially consider the calculated ious health issues such as chronic disease, cancer, results by density functional theory using HF/6- autoimmune disorders, aging, cataract, rheumatoid 31G*, HF/6-31++G**, MP2/6-31G, MP2/6-31++G**, arthritis, cardiovascular diseases, neurodegenera- BLYP/6-31G, BLYP/6-31++G**, B3LYP/6-31G and tive diseases, respiratory disorders [210-218] and B3LYP6-31-HEG** approach [11-16]. It should be also the induced oxidative stress causes bronchial noted that calculations are performed by consid- contraction by the release of cyclooxygenase and ering one degree of quantum interference as well lipoxygenase in the airway that leads to bronchial as polarization effects of 2d orbitals in interaction asthma in human [219-225]. Asthma is a chronic in- [17-47]. flammatory lung disease that happens due to the Okadaic acid is a tropical weed belonging to Tox- respiratory infection triggered by the inhalation of ins family. Amongst Toxins, Okadaic acid contains allergens like tobacco smoke, air pollutants, genet- anti-fungal activity, acetylcholinesterase inhibitory ic and environment factors [226-232] which leads activity, anti-oxidant activity [48-64], mast cell sta- to the release of histamine and leukotrienes from bilization and membrane protection activity [65- the mast cell in the lung. The high release of hista- 92], anti-bacterial activity [93-127] and anti-cancer mine due to allergic reactions is regulated by hista- activity [128-145], anti-hyperglycemic an anti-hy- mine H1 receptor [233-235]. Histamine affects the perlipidemic effects [146-156] and anti-arthritic immune response and related functions in human activity, immunomodulatory activity [157-173] through H1, H2, H3 and H4 receptors activation and anti-diabetic activity [174-187]. Our earlier re- with their intracellular signals [236-238]. The pres- port stated that the Okadaic acid has high anti-ox- ent research work demonstrates the chemotaxon- idant activity [188-200]. The observations show omy of such valuable plant, from the genus of Oka- that Okadaic acid can be used for pharmaceutical daic acid. In addition, pharmaceutical applications

Okadaic acid

Figure 1: Section of the okadaic acid [43-93].

Citation: Heidari A, Esposito J, Caissutti A (2019) Okadaic Acid Time-Resolved Absorption and Resonance FT-IR and Raman Biospectroscopy and Density Functional Theory (DFT) Investigation of Vibronic-Mode Coupling Structure in Vibrational Spectra Analysis. IntJAnalyt Bioanalyt Methods 1:004 ISSN: 2631-5009

Heidari et al. Int J Analyt Bioanalyt Methods 2019, 1:004 | • Page 3 of 19 • such as in vitro anti-oxidant and in silico anti-his- methylene, carboxyl acid and phenyl cycle are tamine activity of their active principles as natural separately investigated. remedy was examined. C-H stretching vibrations in single replacement Details of Calculations of benzene cycles are usually seen in band range of 3225-3475 cm-1. Weak Raman bands are at 3214 cm-1 All calculations of molecular orbital in the base and 3227 cm-1. C-C stretching mode is a strong Raman of ab are performed by Gaussian 09. In calculation mode at 1199 cm-1. Raman weak band is seen at 1673 process, the structure of Okadaic Acid molecule cm-1, too. Bending mode of C-H is emerged as a weak (Figure 1) is optimized and FT-IR and Raman wav- mode at 1423 cm-1 and 1222 cm-1 and a strong band at enumbers are calculated using HF/6-31G*, HF/6- 1306 cm-1 in Raman spectrum. Raman is considerably 31++G**, MP2/6-31G, MP2/6-31++G**, BLYP/6-31G, active in the range of 1225-1475 cm-1 which 1218 cm-1 BLYP/6-31++G**, B3LYP/6-31G and B3LYP6-31- indicates this issue. HEG** base. All optimized structures are adjusted with minimum energy. Harmonic vibrational wav- C-H skew-symmetric stretching mode of methy- enumbers are calculated using second degree of lene group is expected at 3210 cm-1 and its symmet- derivation to adjust convergence on potential sur- ric mode is expected at 3024 cm-1. Skew-symmetric face as good as possible and to evaluate vibration- stretching mode of CH2 in Okadaic Acid has a mode al energies at zero point. In optimized structures in mid-range of Raman spectrum at 3125-3245 considered in the current study, virtual frequency cm-1. When this mode is symmetric, it is at 3120 modes are not observed which indicates that the cm-1 and is sharp. The calculated wavenumbers of minimum potential energy surface is correctly cho- higher modes are at 3088 cm-1 and 3118 cm-1 for sen. The optimized geometry is calculated by mini- symmetric and skew-symmetric stretching mode of mizing the energy relative to all geometrical quan- methylene, respectively. tities without forcing any constraint on molecular Scissoring vibrations of CH2 are usually seen at symmetry. Calculations were performed by Gauss- the range of 1555-1606 cm-1 which often includes ian 09. The current calculation is aimed to maxi- mid-range bands. Weak bands at 1565 cm-1 are mize structural optimization using density func- scissoring modes of CH2 in Raman spectrum. Moving tional theory. The calculations of density functional vibrations of methylene are usually seen at 1494 * ** theory is performed by HF/6-31G , HF/6-31++G , cm-1. For the investigated chemical in the current ** MP2/6-31G, MP2/6-31++G , BLYP/6-31G, BLY- study, these vibrations are at 1364-1 cm were ** ** P/6-31++G , B3LYP/6-31G and B3LYP6-31-HEG calculated using density functional theory. Twisting function in which non-focal functions of Becke and and rocking vibrations of 2 CH are seen in Raman correlation functions of Lee-Yang-Parr beyond the spectrum at 940 cm-1 and 1214 cm-1, respectively, Franck-Condon approximation are used. After com- which are in good accordance with the results at pletion of optimization process, the second order 924 cm-1 and 1189 cm-1, respectively. derivation of energy is calculated as a function of In a non-ionized carboxyl group (COOH), stretch- core coordination and is investigated to evaluate ing vibrations of carbonyl [C=O] are mainly ob- whether the structure is accurately minimized. Vi- served at the range of 1865-1913 cm-1. If dimer is brational frequencies used to simulate spectrums considered as an intact constituent, two stretching presented in the current study are derived from vibrations of carbonyl for symmetric stretching are these second order derivatives. All calculations are at 1765-1810 cm-1 in Raman spectrum. In the cur- performed for room temperature of 414 (K). rent paper, stretching vibration of carbonyl mode is Vibration Analysis at 1822 cm-1 which is a mid-range value. Analysis of vibrational spectrum of Okadaic Acid Stretching and bending bands of hydroxyl can be is performed based on theoretical simulation and identified by width and band intensity which in turn FT-IR empirical spectrum and Raman empirical is dependent on bond length of Hydrogen. In dimer spectrum using density functional theory in levels form of Hydrogen bond, stretching band of O-H is of HF/6-31G*, HF/6-31++G**, MP2/6-31G, MP2/6- of a strong Raman peak at 1392 cm-1 which is due to 31++G**, BLYP/6-31G, BLYP/6-31++G**, B3LYP/6- in-plain metamorphosis mode. Out-of-plain mode 31G and B3LYP6-31-HEG**. Vibration modes of of O-H group is a very strong mode of peak at 1074

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38.0 37.5 37.0 36.5 36.0 119.0 118.5 35.5 118.0 117.5 117.0 35.0 116.5 116.0

1500 1400 1300 1200 800 1100 700 600 1000 500 400 900 300 Figure 2: 3D Simulation of a) FT-IR spectrum and b) Raman spectrum of Okadaic Acid. It should be noted that in the Figure a x-axis shows wavenumbers (cm-1), y-axis shows percent transmission (T%) and z-axis shows time(s). Also, in the Figure b x-axis shows Raman shifts (cm-1), y-axis shows intensity and z-axis shows time(s). cm-1 of Raman spectrum. The stretching mode of are frequently stronger than transferring ones. C-O (H) emerges as a mid-band of Raman spectrum Intra-molecular vibrations with low wavenumbers at 1272 cm-1. involving two-bands O-H …O dimer at 113 cm-1, 218 -1 -1 Lattice vibrations are usually seen at the range of cm and 274 cm are attributed to a rotary moving 0-575 cm-1. These modes are induced by rotary and of two molecules involving in-plain rotation of transferring vibrations of molecules and vibrations molecules against each other. and are including Hydrogen bond. Bands with low Conclusion and Summary wavenumbers of Hydrogen bond vibrations in FT-IR and Raman spectrum (Figure 2) are frequently weak, Calculations of density functional theory using * ** width and unsymmetrical. Rotary lattice vibrations HF/6-31G , HF/6-31++G , MP2/6-31G, MP2/6-

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31++G**, BLYP/6-31G, BLYP/6-31++G**, B3LYP/6- 7. A Heidari (2016) Study of irradiations to enhance the 31G and B3LYP6-31-HEG** levels were used to induces the dissociation of hydrogen bonds between obtain vibrational wavenumbers and intensities peptide chains and transition from helix structure to in single crystal of Okadaic Acid. Investigation and random coil structure using ATR-FTIR, Raman and 1 consideration of vibrational spectrum confirm the HNMR spectroscopies. J Biomol Res Ther 5: e146. formation of dimer cycles in the investigated crystal 8. A Heidari (2016) Future prospects of point fluorescence with carboxyl groups from each Hydrogen molecule spectroscopy, fluorescence imaging and fluorescence of acid protected from adjacent molecules. The endoscopy in photodynamic therapy (PDT) for cancer calculated vibrational spectrum which obtains from cells. J Bioanal Biomed 8: e135. calculations of density functional theory is in good 9. A Heidari (2016) A bio-spectroscopic study of DNA accordance with recorded empirical values which density and color role as determining factor for indicates successful simulation of the problem. The absorbed irradiation in cancer cells. Adv Cancer Prev obtained results indicate that the results obtained 1: e102. from theoretical calculations are valid through 10. A Heidari (2016) Manufacturing process of solar cells comparing with empirical recorded results. using cadmium oxide (CdO) and rhodium (III) oxide

Acknowledgements (Rh2O3) nanoparticles. J Biotechnol Biomater 6: e125. Authors are supported by an American Interna- 11. A Heidari (2016) A novel experimental and tional Standards Institute (AISI) Future Fellowship computational approach to photobiosimulation Grant FT1201009373517. We acknowledge Ms. Is- of telomeric DNA/RNA: A biospectroscopic and abelle Villena for instrumental support and Dr. Mi- photobiological study. J Res Development 4: 144. chael N. Cocchi for constructing graphical abstract 12. A Heidari (2016) Biochemical and pharmacodynamical figure. We gratefully acknowledge Prof. Dr. Chris- study of microporous molecularly imprinted polymer topher Brown for proofreading the manuscript. selective for vancomycin, teicoplanin, oritavancin, telavancin and dalbavancin binding. Biochem Physiol References 5: e146. 1. A Heidari, C Brown (2015) Study of composition and 13. A Heidari (2016) Anti-cancer effect of UV irradiation morphology of cadmium oxide (cdo) nanoparticles at presence of cadmium oxide (CdO) nanoparticles for eliminating cancer cells. J Nanomed Res 2: 20. on dna of cancer cells: A photodynamic therapy 2. A Heidari, C Brown (2015) Study of surface study. Arch Cancer Res 4: 1. morphological, phytochemical and structural 14. A Heidari (2016) Biospectroscopic study on multi- characteristics of Rhodium (III) Oxide (Rh2O3) component reactions (MCRs) in two a-type and nanoparticles. International Journal of Pharmacology, b-type conformations of nucleic acids to determine Phytochemistry and Ethnomedicine 1: 15-19. ligand binding modes, binding constant and 3. A Heidari (2016) An experimental biospectroscopic stability of nucleic acids in cadmium oxide (CdO) study on seminal plasma in determination of semen nanoparticles-nucleic acids complexes as anti-cancer quality for evaluation of male infertility. Int JAdv drugs. Arch Cancer Res 4: 2. Technol 7: e007. 15. A Heidari (2016) Simulation of temperature 4. A Heidari (2016) Extraction and preconcentration of distribution of DNA/RNA of human cancer cells using N-Tolyl-Sulfonyl-Phosphoramid-Saeure-Dichlorid as time-dependent bio-heat equation and Nd: YAG an anti-cancer drug from plants: A pharmacognosy lasers. Arch Cancer Res 4: 2. study. J Pharmacogn Nat Prod 2: e103. 16. A Heidari (2016) Quantitative structure-activity 5. A Heidari (2016) A thermodynamic study on relationship (QSAR) approximation for Cadmium

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5: 5. standard dna/rna-binding molecules identified in many types of solid and liquid tumors oncology in 57. A Heidari (2016) Chemotherapy a last resort for human body for advancing cancer immunotherapy cancer treatment. Chemo Open Access 5: 4. using computer simulations and data analysis: 58. A Heidari (2016) Separation and pre-concentration of Number of mutations in a synchronous tumor varies metal cations-dna/rna chelates using molecular beam by age and type of synchronous cancer. J Appl mass spectrometry with tunable vacuum ultraviolet Bioinforma Comput Biol 6: 1. (VUV) synchrotron radiation and various analytical 68. A Heidari (2017) Electronic coupling among the five methods. Mass Spectrom Purif Tech 2: e101. nanomolecules shuts down quantum tunneling in 59. A Heidari (2016) Yoctosecond quantitative structure- the presence and absence of an applied magnetic activity relationship (QSAR) and quantitative field for indication of the dimer or other provide structure-property relationship (QSPR) under different influences on the magnetic behavior of synchrotron radiations studies for prediction of single molecular magnets (SMMs) as qubits for solubility of anti-cancer nano drugs in aqueous quantum computing. Glob J Res Rev 4: 2. solutions using genetic function approximation 69. A Heidari (2017) Polymorphism in nano-sized (GFA) algorithm. Insight Pharm Res 1: 1. graphene ligand-induced transformation of 38 Au - 60. A Heidari (2016) Cancer risk prediction and xAgx/xCux(SPh-tBu)24 to Au36-xAgx/xCux(SPh-tBu)24 (x assessment in human cells under synchrotron = 1-12) nanomolecules for synthesis of Au144-xAgx/ radiations using quantitative structure activity xCux[(SR)60, (SC4)60, (SC6)60, (SC12)60, (PET)60, (p-MBA)60, relationship (QSAR) and quantitative structure (F)60, (Cl)60, (Br)60, (I)60, (At)60, (Uus)60 and (SC6H13)60] properties relationship (QSPR) studies. Int J Clin Med nano clusters as anti-cancer nano drugs. J Nanomater Imaging 3: 516. Mol Nanotechnol 6: 3. 61. A Heidari (2016) A novel approach to biology. 70. A Heidari (2017) Biomedical resource oncology and Electronic J Biol 12: 4. data mining to enable resource discovery in medical, 62. A Heidari (2016) Innovative biomedical equipment’s medicinal, clinical, pharmaceutical, chemical and for diagnosis and treatment. J Bioengineer & translational research and their applications in Biomedical Sci 6: 2. cancer research. Int J Biomed Data Min 6: e103. 63. A Heidari (2016) Integrating precision cancer 71. A Heidari (2017) Study of synthesis, pharmacokinetics, medicine into healthcare, medicare reimbursement pharmacodynamics, dosing, stability, safety and changes and the practice of oncology: Trends in efficacy of olympiadane nanomolecules as agent oncology medicine and practices. J Oncol Med & for cancer enzymotherapy, immunotherapy, Pract 1: 2. chemotherapy, radiotherapy, hormone therapy and targeted therapy under synchrotorn radiation. J Dev 64. A Heidari (2016) Promoting convergence in Drugs 6: e154. biomedical and biomaterials sciences and silk proteins for biomedical and biomaterials 72. A Heidari (2017) A novel approach to future horizon applications: An introduction to materials in medicine of top seven biomedical research topics to watch and bioengineering perspectives. J Bioengineer & in 2017: Alzheimer's, ebola, hypersomnia, human Biomedical Sci 6: 3. immunodeficiency virus (HIV), tuberculosis (TB), microbiome/antibiotic resistance and endovascular 65. A Heidari (2017) X-Ray fluorescence and X-Ray stroke. J Bioengineer & Biomedical Sci 7: e127. diffraction analysis on discrete element modeling of nano powder metallurgy processes in optimal 73. A Heidari (2017) Opinion on computational fluid container design. J Powder Metall Min 6: 1. dynamics (cfd) technique. Fluid Mech Open Acc 4: 157. 66. A Heidari (2017) Biomolecular spectroscopy and dynamics of nano-sized molecules and clusters as 74. A Heidari (2017) Concurrent diagnosis of oncology cross-linking-induced anti-cancer and immune- influence outcomes in emergency general surgery oncology nano drugs delivery in DNA/RNA of for colorectal cancer and multiple sclerosis (MS) human cancer cells’ membranes under synchrotron treatment using magnetic resonance imaging (MRI) radiations: A payload-based perspective. Arch Chem and Au329(SR)84, Au329-xAgx(SR)84, Au144(SR)60, Au68(SR)36, Res 1: 2. Au30(SR)18, Au102(SPh)44, Au38(SPh)24, Au38(SC2H4Ph)24, Au S(SAdm) , Au (pMBA) and Au (pMBA) nano 67. A Heidari (2017) Deficiencies in repair of double- 21 15 36 24 25 18

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clusters. J Surgery Emerg Med 1: 21. metastases through a targeted nanomolecule drug delivery system based on dopamine functionalized 75. A Heidari (2017) Developmental cell biology in multi-wall carbon nanotubes (MWCNTs) coated adult stem cells death and autophagy to trigger a with nano graphene oxide (GO) and protonated preventive allergic reaction to common airborne polyaniline (PANI) in situ during the polymerization allergens under synchrotron radiation using of aniline autogenic nanoparticles for the delivery of nanotechnology for therapeutic goals in particular anti-cancer nano drugs under synchrotron radiation. allergy shots (immunotherapy). Cell Biol (Henderson, Br J Res 4: 16. NV) 6: 1. 83. A Heidari (2017) Sedative, analgesic and ultrasound- 76. A Heidari (2017) Changing metal powder characteristics mediated gastrointestinal nano drugs delivery for for elimination of the heavy metals toxicity and gastrointestinal endoscopic procedure, nano drug- diseases in disruption of extracellular matrix (ECM) induced gastrointestinal disorders and nano drug proteins adjustment in cancer metastases induced by treatment of gastric acidity. Res Rep Gastroenterol osteosarcoma, chondrosarcoma, carcinoid, carcinoma, 1: 1. ewing’s sarcoma, fibrosarcoma and secondary hematopoietic solid or soft tissue tumors. J Powder 84. A Heidari (2017) Synthesis, pharmacokinetics, phar- Metall Min 6: 170. macodynamics, dosing, stability, safety and efficacy of orphan nano drugs to treat high cholesterol and 77. A Heidari (2017) Nanomedicine-based combination related conditions and to prevent cardiovascular dis- anti-cancer therapy between nucleic acids and anti- ease under synchrotron radiation. J Pharm Sci Emerg cancer nano drugs in covalent nano drugs delivery Drugs 5: 1. systems for selective imaging and treatment of human brain tumors using hyaluronic acid, alguronic 85. A Heidari (2017) Non-Linear compact proton acid and sodium hyaluronate as anti-cancer nano synchrotrons to improve human cancer cells drugs and nucleic acids delivery under synchrotron and tissues treatments and diagnostics through radiation. Am J Drug Deliv 5: 2. particle therapy accelerators with monochromatic microbeams. Cell Immunol Serum Biol 3: 115-119. 78. A Heidari (2017) Clinical trials of dendritic cell therapies for cancer exposing vulnerabilities in 86. A Heidari (2017) Design of targeted metal chelation human cancer cells’ metabolism and metabolomics: therapeutics nanocapsules as colloidal carriers and New discoveries, unique features inform new blood-brain barrier (BBB) translocation to targeted therapeutic opportunities, biotech's bumpy road to deliver anti-cancer nano drugs into the human brain the market and elucidating the biochemical programs to treat alzheimer’s disease under synchrotron that support cancer initiation and progression. J Biol radiation. J Nanotechnol Material Sci 4: 1-5. Med Science 1: e103. 87. R Gobato, A Heidari (2017) Calculations using 79. A Heidari (2017) The design graphene-based quantum chemistry for inorganic molecule simulation

nanosheets as a new nanomaterial in anti-cancer BeLi2SeSi. Science Journal of Analytical Chemistry 5: therapy and delivery of chemotherapeutics and 76-85. biological nano drugs for liposomal anti-cancer nano 88. A Heidari (2017) Different high-resolution simulations drugs and gene delivery. Br Biomed Bull 5: 305. of medical, medicinal, clinical, pharmaceutical 80. A Heidari (2017) Integrative approach to biological and therapeutics oncology of human lung cancer networks for emerging roles of proteomics, genomics translational anti-cancer nano drugs delivery and transcriptomics in the discovery and validation treatment process under synchrotron and x-ray of human colorectal cancer biomarkers from DNA/ radiations. J Med Oncol 1: 1. RNA sequencing data under synchrotron radiation. 89. A Heidari (2017) A modern ethnomedicinal technique Transcriptomics 5: e117. for transformation, prevention and treatment of 81. A Heidari (2017) Elimination of the heavy metals human malignant gliomas tumors into human benign toxicity and diseases in disruption of extracellular gliomas tumors under synchrotron radiation. Am J matrix (ECM) proteins and cell adhesion intelligent Ethnomed 4: 1-10. nanomolecules adjustment in cancer metastases 90. A Heidari (2017) Active targeted nanoparticles for using metalloenzymes and under synchrotron anti-cancer nano drugs delivery across the blood- radiation. Lett Health Biol Sci 2: 1-4. brain barrier for human brain cancer treatment, 82. A Heidari (2017) Treatment of breast cancer brain multiple sclerosis (MS) and alzheimer's diseases

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using chemical modifications of anti-cancer nano and naprosyn) and dextromethamphetamine drugs or drug-nanoparticles through zika virus (ZIKV) nanocapsules with surface conjugated dna/rna nanocarriers under synchrotron radiation. J Med to targeted nano drugs for enhanced anti-cancer Chem Toxicol 2: 1-5. efficacy and targeted cancer therapy using nano drugs delivery systems. Ann Adv Chem 1: 061-069. 91. A Heidari (2017) Investigation of medical, medicinal, clinical and pharmaceutical applications of estradiol, 98. A Heidari (2017) High-resolution simulations of mestranol (norlutin), norethindrone (NET), norethis- human brain cancer translational nano drugs delivery terone acetate (NETA), norethisterone enanthate treatment process under synchrotron radiation. J (NETE) and testosterone nanoparticles as biologi- Transl Res 1: 1-3. cal imaging, cell labeling, anti-microbial agents and 99. A Heidari (2017) Investigation of anti-cancer nano anti-cancer nano drugs in nanomedicines based drugs’ effects’ trend on human pancreas cancer cells drug delivery systems for anti-cancer targeting and and tissues prevention, diagnosis and treatment treatment. Parana Journal of Science and Education process under synchrotron and X-ray radiations with (PJSE) 3: 10-19. the passage of time using mathematica. Current 92. A Heidari (2017) A comparative computational and Trends Anal Bioanal Chem 1: 36-41. experimental study on different vibrational bio- 100. A Heidari (2017) Pros and cons controversy on spectroscopy methods, techniques and applications molecular imaging and dynamics of double- for human cancer cells in tumor tissues simulation, standard DNA/RNA of human preserving stem cells- modeling, research, diagnosis and treatment. Open binding nano molecules with androgens/anabolic J Anal Bioanal Chem 1: 014-020. steroids (AAS) or testosterone derivatives through 93. A Heidari (2017) Combination of DNA/RNA ligands tracking of helium-4 nucleus (Alpha Particle) using and linear/non-linear visible-synchrotron radiation- synchrotron radiation. Arch Biotechnol Biomed 1: driven n-doped ordered mesoporous cadmium 067-0100. oxide (CdO) nanoparticles photocatalysts channels 101. A Heidari (2017) Visualizing metabolic changes in resulted in an interesting synergistic effect enhancing probing human cancer cells and tissues metabolism catalytic anti-cancer activity. Enz Eng 6: 1. using vivo 1H or Proton NMR, 13C NMR, 15N NMR and 94. A Heidari (2017) Modern approaches in designing 31P NMR spectroscopy and self-organizing maps ferritin, ferritin light chain, transferrin, beta-2 under synchrotron radiation. SOJ Mater Sci Eng 5: transferrin and bacterioferritin-based anti-cancer 1-6. nano drugs encapsulating nanosphere as dna-binding 102. A Heidari (2017) Cavity ring-down spectroscopy proteins from starved cells (DPS). Mod Appro Drug (CRDS), circular dichroism spectroscopy, cold Des 1: 1-5. vapour atomic fluorescence spectroscopy and 95. A Heidari (2017) Potency of human interferon β-1a correlation spectroscopy comparative study on and human interferon β-1b in enzymotherapy, malignant and benign human cancer cells and immunotherapy, chemotherapy, radiotherapy, tissues with the passage of time under synchrotron hormone therapy and targeted therapy of radiation. Enliven: Challenges Cancer Detect Ther encephalomyelitis disseminate/multiple sclerosis 4: e001. (ms) and hepatitis A, B, C, D, E, F and G virus enter 103. A Heidari (2017) Laser spectroscopy, laser-induced and targets liver cells. J Proteomics Enzymol 6: 1. breakdown spectroscopy and laser-induced plasma 96. A Heidari (2017) Transport therapeutic active spectroscopy comparative study on malignant and targeting of human brain tumors enable anti-cancer benign human cancer cells and tissues with the nanodrugs delivery across the blood-brain barrier passage of time under synchrotron radiation. Int J (BBB) to treat brain diseases using nanoparticles and Hepatol Gastroenterol 3: 079-084. nanocarriers under synchrotron radiation. J Pharm 104. A Heidari (2017) Time-resolved spectroscopy and Pharmaceutics 4: 1-5. time-stretch spectroscopy comparative study on 97. A Heidari, C Brown (2017) Combinatorial therapeutic malignant and benign human cancer cells and approaches to DNA/RNA and benzylpenicillin tissues with the passage of time under synchrotron (penicillin g), fluoxetine hydrochloride (prozac radiation. Enliven: Pharmacovigilance and Drug and sarafem), propofol (diprivan), acetylsalicylic Safety 4: e001. acid (ASA) (Aspirin), naproxen sodium (aleve 105. A Heidari (2017) Overview of the role of vitamins in

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reducing negative effect of Decapeptyl (Triptorelin fluorescence spectroscopy comparative study Acetate or Pamoate Salts) on prostate cancer on malignant and benign human cancer cells and cells and tissues in prostate cancer treatment tissues with the passage of time under synchrotron process through transformation of malignant radiation. EC Cancer 2: 239-246. prostate tumors into benign prostate tumors under 113. A Heidari (2017) Photoacoustic spectroscopy, synchrotron radiation. Open J Anal Bioanal Chem 1: photoemission spectroscopy and photothermal 021-026. spectroscopy comparative study on malignant and 106. A Heidari (2017) Electron Phenomenological benign human cancer cells and tissues with the Spectroscopy, Electron Paramagnetic Resonance passage of time under synchrotron radiation. BAOJ (EPR) Spectroscopy and Electron Spin Resonance Cancer Res Ther 3: 045-052. (ESR) Spectroscopy comparative study on malignant 114. A Heidari (2017) J-Spectroscopy, Exchange and benign human cancer cells and tissues with Spectroscopy (EXSY), Nuclear Overhauser Effect the passage of time under synchrotron radiation. Spectroscopy (NOESY) and Total Correlation Austin J Anal Pharm Chem 4: 1091. Spectroscopy (TOCSY) comparative study on 107. A Heidari (2017) Therapeutic nanomedicine malignant and benign human cancer cells and different high-resolution experimental images and tissues under synchrotron radiation. EMS Eng Sci J computational simulations for human brain cancer 1: 006-013. cells and tissues using nanocarriers deliver DNA/ 115. A Heidari (2017) Neutron spin echo spectroscopy RNA to brain tumors under synchrotron radiation and spin noise spectroscopy comparative study with the passage of time using mathematica and on malignant and benign human cancer cells and MATLAB. Madridge J Nano Tech Sci 2: 77-83. tissues with the passage of time under synchrotron 108. A Heidari (2017) A consensus and prospective study radiation. Int J Biopharm Sci 1: 103-107. on restoring Cadmium Oxide (CdO) nanoparticles 116. A Heidari (2017) Vibrational Decahertz (daHz), sensitivity in recurrent ovarian cancer by extending Hectohertz (hHz), Kilohertz (kHz), Megahertz (MHz), the Cadmium Oxide (CdO) nanoparticles-free Gigahertz (GHz), Terahertz (THz), Petahertz (PHz), interval using synchrotron radiation therapy as Exahertz (EHz), Zettahertz (ZHz) and Yottahertz antibody-drug conjugate for the treatment of (YHz) imaging and spectroscopy comparative study limited-stage small cell diverse epithelial cancers. on malignant and benign human cancer cells and Cancer Clin Res Rep 1: e001. tissues under synchrotron radiation. Madridge J 109. A Heidari (2017) A novel and modern experimental Anal Sci Instrum 2: 41-46. imaging and spectroscopy comparative study on 117. A Heidari (2018) Two-dimensional infrared malignant and benign human cancer cells and correlation spectroscopy, linear two-dimensional tissues with the passage of time under white infrared spectroscopy and non-linear two- synchrotron radiation. Cancer Sci Res Open Access dimensional infrared spectroscopy comparative 4: 1-8. study on malignant and benign human cancer cells 110. A Heidari (2017) Different high-resolution and tissues under synchrotron radiation with the simulations of medical, medicinal, clinical, passage of time. J Mater Sci Nanotechnol 6: 101. pharmaceutical and therapeutics oncology of 118. A Heidari (2018) Fourier Transform Infrared (FTIR) human breast cancer translational nano drugs Spectroscopy, Near-Infrared Spectroscopy (NIRS) delivery treatment process under synchrotron and and Mid-Infrared Spectroscopy (MIRS) comparative X-Ray radiations. J Oral Cancer Res 1: 12-17. study on malignant and benign human cancer cells 111. A Heidari (2017) Vibrational Decihertz (dHz), and tissues under synchrotron radiation with the Centihertz (cHz), Millihertz (mHz), Microhertz (μHz), passage of time. Int J Nanotechnol Nanomed 3: 1-6. Nanohertz (nHz), Picohertz (pHz), Femtohertz (fHz), 119. A Heidari (2018) Infrared photo dissociation Attohertz (aHz), Zeptohertz (zHz) and Yoctohertz spectroscopy and infrared correlation table (yHz) imaging and spectroscopy comparative study spectroscopy comparative study on malignant on malignant and benign human cancer cells and and benign human cancer cells and tissues under tissues under synchrotron radiation. International synchrotron radiation with the passage of time. Journal of Biomedicine 7: 335-340. Austin Pharmacol Pharm 3: 1011. 112. A Heidari (2017) Force spectroscopy and 120. A Heidari (2017) Novel and transcendental

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prevention, diagnosis and treatment strategies for therapy. Open Acc J Oncol Med 1. investigation of interaction among human blood 129. A Heidari (2018) Heteronuclear Correlation Experi- cancer cells, tissues, tumors and metastases with ments such as Heteronuclear Single-Quantum Cor- synchrotron radiation under anti-cancer nano relation Spectroscopy (HSQC), Heteronuclear Mul- drugs delivery efficacy using MATLAB modeling and tiple-Quantum Correlation Spectroscopy (HMQC) simulation. Madridge J Nov Drug Res 1: 18-24. and Heteronuclear Multiple-Bond Correlation Spec- 121. A Heidari (2018) Comparative study on malignant troscopy (HMBC) comparative study on malignant and benign human cancer cells and tissues with the and benign human endocrinology and thyroid can- passage of time under synchrotron radiation. Open cer cells and tissues under synchrotron radiation. J Access J Trans Med Res 2: 4-9. Endocrinol Thyroid Res 3: 555603. 122. MRR Gobato, R Gobato, A Heidari (2018) Planting of 130. A Heidari (2018) Nuclear Resonance Vibrational jaboticaba trees for landscape repair of degraded Spectroscopy (NRVS), Nuclear Inelastic Scattering area. Landscape Architecture and Regional Planning Spectroscopy (NISS), Nuclear Inelastic Absorption 3: 1-9. Spectroscopy (NIAS) and Nuclear Resonant Inelastic X-Ray Scattering Spectroscopy (NRIXSS) 123. A Heidari (2018) Fluorescence spectroscopy, comparative study on malignant and benign phosphorescence spectroscopy and luminescence human cancer cells and tissues under synchrotron spectroscopy comparative study on malignant radiation. Int J Bioorg Chem Mol Biol 6: 1-5. and benign human cancer cells and tissues under synchrotron radiation with the passage of time. SM 131. A Heidari (2018) A novel and modern experimental J Clin Med Imaging 4: 1018. approach to vibrational circular dichroism spectroscopy and video spectroscopy comparative 124. A Heidari (2018) Nuclear Inelastic Scattering study on malignant and benign human cancer cells Spectroscopy (NISS) and Nuclear Inelastic and tissues with the passage of time under white Absorption Spectroscopy (NIAS) comparative study and monochromatic synchrotron radiation. Glob J on malignant and benign human cancer cells and Endocrinol Metab 1. tissues under synchrotron radiation. Int J Pharm Sci 2: 1-14. 132. A Heidari (2018) Pros and Cons Controversy on heteronuclear correlation experiments such as Hetero- 125. A Heidari (2018) X-Ray Diffraction (XRD), Powder nuclear Single-Quantum Correlation Spectroscopy X-Ray Diffraction (PXRD) and Energy-Dispersive (HSQC), Heteronuclear Multiple-Quantum Cor- X-Ray Diffraction (EDXRD) comparative study on relation Spectroscopy (HMQC) and Heteronuclear malignant and benign human cancer cells and Multiple-Bond Correlation Spectroscopy (HMBC) tissues under synchrotron radiation. J Oncol Res 2: comparative study on malignant and benign human 1-14. cancer cells and tissues under synchrotron radia- 126. A Heidari (2018) Correlation two-dimensional tion. EMS Pharma J 1: 002-008. Nuclear Magnetic Resonance (NMR) (2D-NMR) 133. A Heidari (2018) A modern comparative and (COSY) imaging and spectroscopy comparative comprehensive experimental biospectroscopic study on malignant and benign human cancer cells study on different types of infrared spectroscopy and tissues under synchrotron radiation. EMS Can of malignant and benign human cancer cells and Sci. tissues with the passage of time under synchrotron 127. A Heidari (2018) Thermal spectroscopy, photo- radiation. J Analyt Molecul Tech 3: 8. thermal spectroscopy, thermal microspectroscopy, 134. A Heidari (2018) Investigation of cancer types using photothermal microspectroscopy, thermal mac- synchrotron technology for proton beam therapy: rospectroscopy and photothermal macrospectros- An experimental biospectroscopic comparative copy comparative study on malignant and benign study. European Modern Studies Journal 2: 13-29. human cancer cells and tissues with the passage of time under synchrotron radiation. SM J Biometrics 135. A Heidari (2018) Saturated spectroscopy and Biostat 3: 1024. unsaturated spectroscopy comparative study on malignant and benign human cancer cells and 128. A Heidari (2018) A modern and comprehensive tissues with the passage of time under synchrotron experimental biospectroscopic comparative study radiation. Imaging J Clin Medical Sci 5: 001-007. on human common cancers’ cells, tissues and tumors before and after synchrotron radiation 136. A Heidari (2018) Small-Angle Neutron Scattering

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(SANS) and Wide-Angle X-Ray Diffraction (WAXD) 144. A Heidari (2018) Grazing-Incidence Small-Angle comparative study on malignant and benign Neutron Scattering (GISANS) and Grazing-Incidence human cancer cells and tissues under synchrotron X-Ray Diffraction (GIXD) comparative study on radiation. Int J Bioorg Chem Mol Biol 6: 1-6. malignant and benign human cancer cells, tissues and tumors under synchrotron radiation. Ann 137. A Heidari (2018) Investigation of bladder cancer, Cardiovasc Surg 1: 1006. breast cancer, colorectal cancer, endometrial cancer, kidney cancer, leukemia, liver, lung cancer, 145. A Heidari (2018) Adsorption Isotherms and Kinetics melanoma, non-hodgkin lymphoma, pancreatic of Multi-Walled Carbon Nanotubes (MWCNTs), cancer, prostate cancer, thyroid cancer and Boron Nitride Nanotubes (BNNTs), Amorphous non-melanoma skin cancer using synchrotron Boron Nitride Nanotubes (a-BNNTs) and Hexagonal technology for proton beam therapy: An Boron Nitride Nanotubes (h-BNNTs) for eliminating experimental biospectroscopic comparative study. carcinoma, sarcoma, lymphoma, leukemia, germ Ther Res Skin Dis 1. cell tumor and blastoma cancer cells and tissues. Clin Med Rev Case Rep 5: 201. 138. A Heidari (2018) Attenuated Total Reflectance Fourier Transform Infrared (ATR-FTIR) Spectroscopy, 146. A Heidari (2018) Correlation Spectroscopy (COSY), Micro-Attenuated Total Reflectance Fourier Exclusive Correlation Spectroscopy (ECOSY), Total Transform Infrared (Micro-ATR-FTIR) Spectroscopy Correlation Spectroscopy (TOCSY), Incredible and Macro-Attenuated Total Reflectance Fourier Natural-Abundance Double-Quantum Transfer Transform Infrared (Macro-ATR-FTIR) spectroscopy Experiment (INADEQUATE), Heteronuclear comparative study on malignant and benign human Single-Quantum Correlation Spectroscopy cancer cells and tissues under synchrotron radiation (HSQC), Heteronuclear Multiple-Bond Correlation with the passage of time. International Journal of Spectroscopy (HMBC), Nuclear Overhauser Chemistry Papers 2: 1-12. Effect Spectroscopy (NOESY) and Rotating Frame Nuclear Overhauser Effect Spectroscopy (ROESY) 139. A Heidari (2018) Mössbauer spectroscopy, comparative study on malignant and benign mössbauer emission spectroscopy and 57Fe human cancer cells and tissues under synchrotron mössbauer spectroscopy comparative study on radiation. Acta Scientific Pharmaceutical Sciences malignant and benign human cancer cells and 2: 30-35. tissues under synchrotron radiation. Acta Scientific Cancer Biology 2.3: 17-20. 147. A Heidari (2018) Small-Angle X-Ray Scattering (SAXS), Ultra-Small Angle X-Ray Scattering (USAXS), 140. A Heidari (2018) Comparative study on malignant Fluctuation X-Ray Scattering (FXS), Wide-Angle and benign human cancer cells and tissues under X-Ray Scattering (WAXS), Grazing-Incidence Small- synchrotron radiation with the passage of time. Angle X-Ray Scattering (GISAXS), Grazing-Incidence Organic & Medicinal Chem IJ 6: 555676. Wide-Angle X-Ray Scattering (GIWAXS), Small- 141. A Heidari (2018) Correlation spectroscopy, exclusive Angle Neutron Scattering (SANS), Grazing-Incidence correlation spectroscopy and total correlation Small-Angle Neutron Scattering (GISANS), X-Ray spectroscopy comparative study on malignant Diffraction (XRD), Powder X-Ray Diffraction (PXRD), and benign human aids-related cancers cells and Wide-Angle X-Ray Diffraction (WAXD), Grazing- tissues with the passage of time under synchrotron Incidence X-Ray Diffraction (GIXD) and Energy- radiation. Int J Bioanal Biomed 2: 001-007. Dispersive X-Ray Diffraction (EDXRD) comparative 142. A Heidari (2018) Biomedical instrumentation study on malignant and benign human cancer cells and applications of biospectroscopic methods and tissues under synchrotron radiation. Oncol Res and techniques in malignant and benign human Rev 1: 1-10. cancer cells and tissues studies under synchrotron 148. A Heidari (2018) Pump-probe spectroscopy and radiation and anti-cancer nano drugs delivery. Am J transient grating spectroscopy comparative study Nanotechnol Nanomed 1: 001-009. on malignant and benign human cancer cells and 143. A Heidari (2018) Vivo 1H or Proton NMR, 13C NMR, tissues with the passage of time under synchrotron 15N NMR and 31P NMR spectroscopy comparative radiation. Adv Material Sci Engg 2: 1-7. study on malignant and benign human cancer 149. A Heidari (2018) Grazing-Incidence Small-Angle cells and tissues under synchrotron radiation. Ann X-Ray Scattering (GISAXS) and Grazing-Incidence Biomet Biostat 1: 1001. Wide-Angle X-Ray Scattering (GIWAXS) comparative

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study on malignant and benign human cancer cells and miraculin nano molecules incorporation into and tissues under synchrotron radiation. Insights the Nano Polymeric Matrix (NPM) by Immersion Pharmacol Pharm Sci 1: 1-8. of the Nano Polymeric Modified Electrode (NPME) as molecular enzymes and drug targets for human 150. A Heidari (2018) Acoustic spectroscopy, acoustic cancer cells, tissues and tumors treatment under resonance spectroscopy and auger spectroscopy synchrotron and synchrocyclotron radiations. Med comparative study on anti-cancer nano drugs & Analy Chem Int J 2: 000111. delivery in malignant and benign human cancer cells and tissues with the passage of time under 158. A Heidari (2018) Gamma Linolenic Methyl Ester, synchrotron radiation. Nanosci Technol 5: 1-9. 5-Heptadeca-5,8,11-Trienyl 1,3,4-Oxadiazole-2- Thiol, Sulphoquinovosyl Diacyl Glycerol, Ruscogenin, 151. A Heidari (2018) Niobium, Technetium, Ruthenium, Nocturnoside B, Protodioscine B, Parquisoside-B, Rhodium, Hafnium, Rhenium, Osmium and Iridium Leiocarposide, Narangenin, 7-Methoxy Hespertin, Ions Incorporation into the Nano Polymeric Matrix Lupeol, Rosemariquinone, Rosmanol and (NPM) by Immersion of the Nano Polymeric Modified Rosemadiol Nano Molecules Incorporation into Electrode (NPME) as molecular enzymes and drug the Nano Polymeric Matrix (NPM) by Immersion targets for human cancer cells, tissues and tumors of the Nano Polymeric Modified Electrode (NPME) treatment under synchrotron and synchrocyclotron as molecular enzymes and drug targets for human radiations. Nanomed Nanotechnol 3: 000138. cancer cells, tissues and tumors treatment under 152. A Heidari (2018) Homonuclear Correlation synchrotron and synchrocyclotron radiations. Int J Experiments such as Homonuclear Single-Quantum Pharma Anal Acta 2: 007-014. Correlation Spectroscopy (HSQC), Homonuclear 159. A Heidari (2018) Fourier Transform Infrared (FTIR) Multiple-Quantum Correlation Spectroscopy Spectroscopy, Attenuated Total Reflectance Fourier (HMQC) and Homonuclear Multiple-Bond Transform Infrared (ATR-FTIR) Spectroscopy, Micro- Correlation Spectroscopy (HMBC) comparative Attenuated Total Reflectance Fourier Transform study on malignant and benign human cancer cells Infrared (Micro-ATR-FTIR) Spectroscopy, Macro- and tissues under synchrotron radiation. Austin J Attenuated Total Reflectance Fourier Transform Proteomics Bioinform & Genomics 5: 1024. Infrared (Macro-ATR-FTIR) Spectroscopy, two- 153. A Heidari (2018) Atomic Force Microscopy Based dimensional infrared correlation spectroscopy, Infrared (AFM-IR) spectroscopy and nuclear linear two-dimensional infrared spectroscopy, resonance vibrational spectroscopy comparative non-linear two-dimensional infrared spectroscopy, study on malignant and benign human cancer cells Atomic Force Microscopy Based Infrared (AFM- and tissues under synchrotron radiation with the IR) spectroscopy, infrared photodissociation passage of time. J Appl Biotechnol Bioeng 5: 142- spectroscopy, infrared correlation table 148. spectroscopy, Near-Infrared Spectroscopy (NIRS), 154. A Heidari (2018) Time-dependent vibrational Mid-Infrared Spectroscopy (MIRS), nuclear spectral analysis of malignant and benign human resonance vibrational spectroscopy, thermal cancer cells and tissues under synchrotron infrared spectroscopy and photothermal infrared radiation. J Cancer Oncol 2: 000124. spectroscopy comparative study on malignant and benign human cancer cells and tissues under 155. A Heidari (2018) Palauamine and olympiadane nano synchrotron radiation with the passage of time. molecules incorporation into the Nano Polymeric Glob Imaging Insights 3: 1-14. Matrix (NPM) by immersion of the Nano Polymeric Modified Electrode (NPME) as molecular enzymes 160. A Heidari (2018) Heteronuclear Single-Quantum and drug targets for human cancer cells, tissues Correlation Spectroscopy (HSQC) and Heteronuclear and tumors treatment under synchrotron and Multiple-Bond Correlation Spectroscopy (HMBC) synchrocyclotron radiations. Arc Org Inorg Chem comparative study on malignant and benign human Sci 3. cancer cells, tissues and tumors under synchrotron and synchrocyclotron radiations. Chronicle of 156. R Gobato, A Heidari (2018) Infrared spectrum Medicine and Surgery 2: 144-156. and sites of action of sanguinarine by molecular mechanics and ab initio methods. International 161. A Heidari (2018) Tetrakis [3, 5-bis (Trifluoromethyl) Journal of Atmospheric and Oceanic Sciences 2: 1-9. Phenyl] Borate (BARF)-Enhanced Precatalyst Prepa- ration Stabilization and Initiation (EPPSI) Nano Mol- 157. A Heidari (2018) Angelic acid, diabolic acids, draculin ecules. Medical Research and Clinical Case Reports

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2: 113-126. 171. A Heidari (2018) Biomedical systematic and emerging technological study on human malignant 162. A Heidari (2018) Sydnone, münchnone, and benign cancer cells and tissues biospectroscopic montréalone, mogone, montelukast, quebecol and analysis under synchrotron radiation. Glob Imaging palau’amine-Enhanced Precatalyst Preparation Insights 3: 1-7. Stabilization and Initiation (EPPSI) Nano Molecules. Sur Cas Stud Op Acc J 1. 172. A Heidari (2018) Deep-level transient spectroscopy and X-Ray Photoelectron Spectroscopy (XPS) 163. A Heidari (2018) Fornacite, orotic acid, rhamnetin, comparative study on malignant and benign human Sodium Ethyl Xanthate (SEX) and spermine cancer cells and tissues with the passage of time (spermidine or polyamine) nanomolecules under synchrotron radiation. Res Dev Material Sci incorporation into the Nanopolymeric Matrix 7. (NPM). International Journal of Biochemistry and Biomolecules 4: 1-19. 173. A Heidari (2018) C70-Carboxyfullerenes nano molecules incorporation into the Nano Polymeric 164. A Heidari, R Gobato (2018) Putrescine, cadaverine, Matrix (NPM) by Immersion of the Nano Polymeric spermine and Spermidine-Enhanced Precatalyst Modified Electrode (NPME) as molecular enzymes Preparation Stabilization and Initiation (EPPSI) nano and drug targets for human cancer cells, tissues molecules. Parana Journal of Science and Education and tumors treatment under synchrotron and (PJSE) 4: 1-14. synchrocyclotron radiations. Glob Imaging Insights 165. A Heidari (2018) Cadaverine (1,5-Pentanediamine 3: 1-7. or Pentamethylenediamine), Diethyl Azodicar- 174. A Heidari (2018) The effect of temperature on boxylate (DEAD or DEADCAT) and Putrescine (Te- Cadmium Oxide (CdO) nanoparticles produced tramethylenediamine) Nano Molecules Incorpora- by synchrotron radiation in the human cancer tion into the Nano Polymeric Matrix (NPM) by Im- cells, tissues and tumors. International Journal of mersion of the Nano Polymeric Modified Electrode Advanced Chemistry 6: 140-156. (NPME) as Molecular Enzymes and Drug Targets for Human Cancer Cells, Tissues and Tumors Treat- 175. A Heidari (2018) A Clinical and Molecular Pathology ment under Synchrotron and Synchrocyclotron Ra- Investigation of Correlation Spectroscopy (COSY), diations. Hiv and Sexual Health Open Access Open Exclusive Correlation Spectroscopy (ECOSY), Total Journal 1: 4-11. Correlation Spectroscopy (TOCSY), Heteronuclear Single-Quantum Correlation Spectroscopy (HSQC) 166. A Heidari (2018) Improving the performance of and Heteronuclear Multiple-Bond Correlation Spec- nano-endofullerenes in polyaniline nanostructure- troscopy (HMBC) comparative study on malignant based biosensors by covering californium colloidal and benign human cancer cells, tissues and tumors nanoparticles with multi-walled carbon nanotubes. under synchrotron and synchrocyclotron radiations Journal of Advances in Nanomaterials 3: 1-28. using cyclotron versus synchrotron, synchrocyclo- 167. R Gobato, A Heidari (2018) Molecular mechanics tron and the Large Hadron Collider (LHC) for de- and quantum chemical study on sites of action of livery of proton and helium ion (charged particle) sanguinarine using vibrational spectroscopy based beams for oncology radiotherapy. European Jour- on molecular mechanics and quantum chemical nal of Advances in Engineering and Technology 5: calculations. Malaysian Journal of Chemistry 20: 414-426. 1-23. 176. A Heidari (2018) Nano Molecules Incorporation into 168. A Heidari (2018) Vibrational biospectroscopic the Nano Polymeric Matrix (NPM) by Immersion of studies on anti-cancer nanopharmaceuticals (Part the Nano Polymeric Modified Electrode (NPME) I). Malaysian Journal of Chemistry 20: 33-73. as molecular enzymes and drug targets for human 169. A Heidari (2018) Vibrational biospectroscopic cancer cells, tissues and tumors treatment under studies on anti-cancer nanopharmaceuticals (Part synchrotron and synchrocyclotron radiations. J II). Malaysian Journal of Chemistry 20: 74-117. Oncol Res 1: 1-20. 170. A Heidari (2018) Uranocene (U(C H ) ) and 177. A Heidari (2018) Use of molecular enzymes in the 8 8 2 treatment of chronic disorders. Canc Oncol Open Bis(Cyclooctatetraene)Iron (Fe(C8H8)2 or Fe(COT)2)- Enhanced Precatalyst Preparation Stabilization Access J 1: 12-15. and Initiation (EPPSI) Nano Molecules. Chemistry 178. A Heidari (2018) Vibrational biospectroscopic study Reports 1: 1-16.

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and chemical structure analysis of unsaturated Molecules Incorporation into the Nano Polymeric polyamides nanoparticles as anti-cancer polymeric Matrix (NPM) by Immersion of the Nano Polymeric nanomedicines using synchrotron radiation. Modified Electrode (NPME) as molecular enzymes International Journal of Advanced Chemistry 6: and drug targets for human cancer cells, tissues 167-189. and tumors treatment under synchrotron and synchrocyclotron radiations. Glob Imaging Insights 179. A Heidari (2018) Adamantane, irene, naftazone 3: 1-8. and pyridine-enhanced precatalyst Preparation Stabilization and Initiation (PEPPSI) nano molecules. 187. E Dadvar, A Heidari (2018) A review on separation Madridge J Nov Drug Res 2: 61-67. techniques of Graphene Oxide (GO)/base on hybrid polymer membranes for eradication of dyes and 180. A Heidari (2018) Heteronuclear Single-Quantum oil compounds: Recent progress in Graphene Correlation Spectroscopy (HSQC) and Heteronuclear Oxide (GO)/base on polymer membranes-related Multiple-Bond Correlation Spectroscopy (HMBC) nanotechnologies. Clin Med Rev Case Rep 5: 228. comparative study on malignant and benign human cancer cells and tissues with the passage of time 188. A Heidari, R Gobato (2018) First-Time Simulation under synchrotron radiation. Madridge J Nov Drug of Deoxyuridine Monophosphate (dUMP) (Deoxyu- Res 2: 68-74. ridylic Acid or Deoxyuridylate) and Vomitoxin (De- oxynivalenol (DON)) ((3α,7α)-3,7,15-Trihydroxy- 181. A Heidari, R Gobato (2018) A novel approach to 12,13-Epoxytrichothec-9-En-8-One)-Enhanced reduce toxicities and to improve bioavailabilities of Precatalyst Preparation Stabilization and Initiation DNA/RNA of Human Cancer Cells-Containing Cocaine (EPPSI) Nano Molecules Incorporation into the (Coke), Lysergide (Lysergic Acid Diethyl Amide or Nano Polymeric Matrix (NPM) by Immersion of the LSD), Δ9-Tetrahydrocannabinol (THC) [(-)-trans-Δ9- Nano Polymeric Modified Electrode (NPME) as mo- Tetrahydrocannabinol], Theobromine (Xantheose), lecular enzymes and drug targets for human cancer Caffeine, Aspartame (APM) (NutraSweet) and cells, tissues and tumors treatment under synchro- Zidovudine (ZDV) [Azidothymidine (AZT)] as anti- tron and synchrocyclotron radiations. Parana Jour- cancer nano drugs by coassembly of dual anti- nal of Science and Education 4: 46-67. cancer nano drugs to Inhibit DNA/RNA of human cancer cells drug resistance. Parana Journal of 189. A Heidari (2018) Buckminsterfullerene (Fullerene), Science and Education 4: 1-17. Bullvalene, Dickite and Josiphos Ligands Nano Molecules Incorporation into the Nano Polymeric 182. A Heidari, R Gobato (2018) Ultraviolet Photoelectron Matrix (NPM) by Immersion of the Nano Polymeric Spectroscopy (UPS) and Ultraviolet-Visible (UV- Modified Electrode (NPME) as molecular enzymes Vis) spectroscopy comparative study on malignant and drug targets for human hematology and and benign human cancer cells and tissues with thromboembolic diseases prevention, diagnosis and the passage of time under synchrotron radiation. treatment under synchrotron and synchrocyclotron Parana Journal of Science and Education 4: 18-33. radiations. Glob Imaging Insights 3: 1-7. 183. R Gobato, A Heidari, A Mitra (2018) The creation 190. A Heidari (2018) Fluctuation X-Ray Scattering of C H BeLi SeSi. The proposal of a bio-inorganic 13 20 2 (FXS) and Wide-Angle X-Ray Scattering (WAXS) molecule, using Ab initio methods for the genesis of comparative study on malignant and benign a nano membrane. Arc Org Inorg Chem Sci 3. human cancer cells and tissues under synchrotron 184. R Gobato, A Heidari (2018) Using the quantum radiation. Glob imaging insights 3: 1-7. chemistry for genesis of a nano biomembrane with 191. A Heidari (2018) A novel approach to Correlation a combination of the elements Be, Li, Se, Si, C and Spectroscopy (COSY), Exclusive Correlation Spec- H. J Nanomed Res 7: 241-252. troscopy (ECOSY), Total Correlation Spectrosco- 185. A Heidari (2018) Bastadins and Bastaranes- py (TOCSY), Incredible Natural-Abundance Dou- Enhanced Precatalyst Preparation Stabilization and ble-Quantum Transfer Experiment (INADEQUATE), Initiation (EPPSI) nano molecules. Glob Imaging Heteronuclear Single-Quantum Correlation Spec- Insights 3: 1-7. troscopy (HSQC), Heteronuclear Multiple-Bond 186. A Heidari (2018) Fucitol, Pterodactyladiene, Correlation Spectroscopy (HMBC), Nuclear - Over DEAD or DEADCAT (DiEthyl AzoDiCArboxylaTe), hauser Effect Spectroscopy (NOESY) and Rotating Skatole, the NanoPutians, Thebacon, Pikachurin, Frame Nuclear Overhauser Effect Spectroscopy Tie Fighter, Spermidine and Mirasorvone Nano (ROESY) comparative study on malignant and be-

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nign human cancer cells and tissues under synchro- pVTZ and 6-311G**(3df, 3pd). Arc Org Inorg Chem tron radiation. Glob Imaging Insights 3: 1-9. Sci 3: 402-409.

192. A Heidari (2018) Terphenyl-Based Reversible Re- 198. A Heidari (2018) C60 and C70-Encapsulating Carbon ceptor with Rhodamine, Rhodamine-Based Mo- Nanotubes Incorporation into the Nano Polymeric lecular Probe, Rhodamine-Based Using the Spi- Matrix (NPM) by Immersion of the Nano Polymeric rolactam Ring Opening, Rhodamine B with Ferro- Modified Electrode (NPME) as molecular enzymes cene Substituent, Calix[4]Arene-Based Receptor, and drug targets for human cancer cells, tissues Thioether + Aniline-Derived Ligand Framework and tumors treatment under synchrotron and Linked to a Fluorescein Platform, Mercuryfluor-1 synchrocyclotron radiations. Integr Mol Med 5: 1-9. (Flourescent Probe), N,N’-Dibenzyl-1,4,10,13-Tetr- 199. A Heidari (2018) Two-Dimensional (2D) 1H or Proton araoxa-7,16-Diazacyclooctadecane and Terphe- NMR, 13C NMR, 15N NMR and 31P NMR spectroscopy nyl-Based Reversible Receptor with Pyrene and comparative study on malignant and benign human Quinoline as the Fluorophores-Enhanced Precata- cancer cells and tissues under synchrotron radiation lyst Preparation Stabilization and Initiation (EPPSI) with the passage of time. Glob Imaging Insights 3: nano molecules. Glob Imaging Insights 3: 1-9. 1-8. 193. A Heidari (2018) Small-Angle X-Ray Scattering 200. A Heidari (2018) FT-Raman Spectroscopy, Coherent (SAXS), Ultra-Small Angle X-Ray Scattering (USAXS), Anti-Stokes Raman Spectroscopy (CARS) and Raman Fluctuation X-Ray Scattering (FXS), Wide-Angle Optical Activity Spectroscopy (ROAS) comparative X-Ray Scattering (WAXS), Grazing-Incidence Small- study on malignant and benign human cancer Angle X-Ray Scattering (GISAXS), Grazing-Incidence cells and tissues with the passage of time under Wide-Angle X-Ray Scattering (GIWAXS), Small- synchrotron radiation. Glob Imaging Insights 3: 1-8. Angle Neutron Scattering (SANS), Grazing-Incidence Small-Angle Neutron Scattering (GISANS), X-Ray 201. A Heidari (2018) A modern and comprehensive Diffraction (XRD), Powder X-Ray Diffraction (PXRD), investigation of Inelastic Electron Tunneling Wide-Angle X-Ray Diffraction (WAXD), Grazing- Spectroscopy (IETS) and scanning tunneling Incidence X-Ray Diffraction (GIXD) and Energy- spectroscopy on malignant and benign human Dispersive X-Ray Diffraction (EDXRD) Comparative cancer cells, tissues and tumors through optimizing study on malignant and benign human cancer cells synchrotron microbeam radiotherapy for human and tissues under synchrotron radiation. Glob cancer treatments and diagnostics: An experimental Imaging Insights 3: 1-10. biospectroscopic comparative study. Glob Imaging Insights 3: 1-8. 194. A Heidari (2018) Nuclear Resonant Inelastic X-Ray Scattering Spectroscopy (NRIXSS) and Nuclear 202. A Heidari (2018) A hypertension approach to thermal Resonance Vibrational Spectroscopy (NRVS) infrared spectroscopy and photothermal infrared comparative study on malignant and benign spectroscopy comparative study on malignant human cancer cells and tissues under synchrotron and benign human cancer cells and tissues under radiation. Glob Imaging Insights 3: 1-7. synchrotron radiation with the passage of time. Glob Imaging Insights 3: 1-8. 195. A Heidari (2018) Small-Angle X-Ray Scattering (SAXS) and Ultra-Small Angle X-Ray Scattering 203. A Heidari (2018) Incredible Natural-Abundance (USAXS) comparative study on malignant and Double-Quantum Transfer Experiment (INADE- benign human cancer cells and tissues under QUATE), Nuclear Overhauser Effect Spectroscopy synchrotron radiation. Glob Imaging Insights 3: 1-7. (NOESY) and Rotating Frame Nuclear Overhauser Effect Spectroscopy (ROESY) Comparative study 196. A Heidari (2018) Curious Chloride (CmCl ) and Titanic 3 on malignant and benign human cancer cells and Chloride (TiCl )-Enhanced Precatalyst Preparation 4 tissues under synchrotron radiation. Glob Imaging Stabilization and Initiation (EPPSI) nano molecules Insights 3: 1-8. for cancer treatment and cellular therapeutics. J Cancer Research and Therapeutic Interventions 1: 204. A Heidari (2018) 2-Amino-9-((1S, 3R, 4R)-4-Hy- 01-10. droxy-3-(Hydroxymethyl)-2-Methylenecyclopen- tyl)-1H-Purin-6(9H)-One, 2-Amino-9-((1R, 3R, 4R)- 197. R Gobato, MRR Gobato, A Heidari, A Mitra (2018) 4-Hydroxy-3-(Hydroxymethyl)-2-Methylenecyclo- Spectroscopy and dipole moment of the molecule pentyl)-1H-Purin-6(9H)-One, 2-Amino-9-((1R, 3R, C H BeLi SeSi via quantum chemistry using Ab 13 20 2 4S)-4-Hydroxy-3-(Hydroxymethyl)-2-Methylenecy- Initio, Hartree-Fock Method in the Base Set CC-

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clopentyl)-1H-Purin-6(9H)-One and 2-Amino-9-((1S, Trends in Res 2: 1-8. 3R, 4S)-4-Hydroxy-3-(Hydroxymethyl)-2-Methy- 214. A Heidari, R Gobato (2019) Pros and cons lenecyclopentyl)-1H-Purin-6(9H)-One-enhanced controversy on malignant human cancer cells, precatalyst preparation stabilization and initiation tissues and tumors transformation process to nano molecules. Glob Imaging Insights 3: 1-9. benign human cancer cells, tissues and tumors. 205. R Gobato, MRR Gobato, A Heidari, A Mitra (2018) Trends in Res 2: 1-8. Spectroscopy and dipole moment of the molecule 215. A Heidari, R Gobato (2019) Three-Dimensional C13H20BeLi2SeSi via quantum chemistry using Ab (3D) simulations of human cancer cells, tissues and initio, Hartree-Fock method in the base set CC- tumors for using in human cancer cells, tissues and pVTZ and 6-311G**(3df, 3pd). American Journal of tumors diagnosis and treatment as a powerful tool Quantum Chemistry and Molecular Spectroscopy 2: in human cancer cells, tissues and tumors research 9-17. and anti-cancer nano drugs sensitivity and delivery 206. A Heidari (2018) Production of Electrochemilumi- area discovery and evaluation. Trends in Res 2: 1-8. nescence (ECL) Biosensor Using Os-Pd/HfC nano- 216. A Heidari, R Gobato (2019) Investigation of energy composites for detecting and tracking of human production by synchrotron, synchrocyclotron and gastroenterological cancer cells, tissues and tu- LASER radiations in human cancer cells, tissues and mors. Int J Med Nano Res 5. tumors and evaluation of their effective on human 207. A Heidari (2018) Enhancing the raman scattering cancer cells, tissues and tumors treatment trend. for diagnosis and treatment of human cancer cells, Trends in Res 2: 1-8. tissues and tumors using Cadmium Oxide (CdO) 217. A Heidari, R Gobato (2019) High-Resolution nanoparticles. J Toxicol Risk Assess 4. Mapping of DNA/RNA hypermethylation and 208. A Heidari (2018) Human malignant and benign hypomethylation process in human cancer cells, human cancer cells and tissues biospectroscopic tissues and tumors under synchrotron radiation. analysis under synchrotron radiation using anti- Trends in Res 2: 1-9. cancer nano drugs delivery. Integr Mol Med 5: 1-13. 218. A Heidari (2019) A novel and comprehensive study 209. A Heidari (2018) Analogous nano compounds of on manufacturing and fabrication nanoparticles

the form M(C8H8)2 Exist for M = (Nd, Tb, Pu, Pa, methods and techniques for processing Cadmium Np, Th, and Yb)-Enhanced Precatalyst Preparation Oxide (CdO) nanoparticles colloidal solution. Glob Stabilization and Initiation (EPPSI) nano molecules. Imaging Insights 4: 1-8. Integr Mol Med 5: 1-8. 219. A Heidari (2019) A combined experimental and 210. A Heidari (2018) Hadron spectroscopy, baryon computational study on the catalytic effect of Alu- spectroscopy and meson spectroscopy comparative minum Nitride Nanocrystal (AlN) on the polym- study on malignant and benign human cancer cells erization of benzene, naphthalene, anthracene, and tissues under synchrotron radiation. Integr Mol phenanthrene, chrysene and tetracene. Glob Imag- Med 5: 1-8. ing Insights 4: 1-8. 211. R Gobato, MRR Gobato, A Heidari (2019) Raman 220. A Heidari (2019) Novel Experimental and Three- spectroscopy study of the nano molecule Dimensional (3D) multiphysics computational

C13H20BeLi2SeSi using Ab initio and Hartree-Fock framework of michaelis-menten kinetics for catalyst Methods in the Basis Set CC-pVTZ and 6-311G** processes innovation, characterization and carrier (3df, 3pd). International Journal of Advanced applications. Glob Imaging Insights 4: 1-8. Engineering and Science 7: 14-35. 221. A Heidari (2019) The Hydrolysis Constants of 212. A Heidari, R Gobato (2019) Evaluating the effect Copper (I) (Cu+) and Copper (II) (Cu2+) in aqueous of anti-cancer nano drugs dosage and reduced solution as a function of pH using a combination leukemia and polycythemia vera levels on trend of of ph measurement and biospectroscopic methods the human blood and bone marrow cancers under and techniques. Glob Imaging Insights 4: 1-8. synchrotron radiation. Trends Res 2: 1-8. 222. A Heidari (2019) Vibrational biospectroscopic study 213. A Heidari, R Gobato (2019) Assessing the variety of of ginormous virus-sized macromolecule and poly- synchrotron, synchrocyclotron and LASER radiations peptide macromolecule as mega macromolecules and their roles and applications in human cancer using Attenuated Total Reflectance-Fourier Trans- cells, tissues and tumors diagnosis and treatment. form Infrared (ATR-FTIR) spectroscopy and mathe-

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