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Reducing Treatment Burden in Neovascular AMD Visit https://tinyurl.com/newgroundAMD for CME Monograph online testing and instant CME certificate. Reducing Treatment Burden in Neovascular AMD Original Release: November 1, 2020 Expiration: November 30, 2021 FACULTY Arshad M. Baruch D. Christina Y. Khanani, MD, MA Kuppermann, MD, PhD Weng, MD, MBA (CHAIR) This continuing medical education activity is provided by New York Eye and Ear Infirmary of Mount Sinai. This educational activity was developed and implemented in collaboration with MedEdicus LLC. This continuing medical education activity is supported through an unrestricted educational grant from Allergan. Distributed with LEARNING METHOD AND MEDIUM AMA CREDIT DESIGNATION STATEMENT IVERIC bio; jCyte; Novartis Pharmaceuticals This educational activity consists of a The New York Eye and Ear Infirmary of Corporation; and Regeneron Pharmaceuticals, supplement and ten (10) study questions. Mount Sinai designates this enduring material Inc. Honoraria from promotional, advertising The participant should, in order, read the for a maximum of 1.5 AMA PRA Category 1 or non-CME services received directly from learning objectives contained at the beginning Credits™. Physicians should claim only the commercial interests or their Agents (eg, of this supplement, read the supplement, credit commensurate with the extent of their Speakers Bureaus): Allergan. answer all questions in the post test, and participation in the activity. Christina Y. Weng, MD, MBA, had a financial complete the Activity Evaluation/Credit agreement or affiliation during the past year Request form. To receive credit for this activity, GRANTOR STATEMENT This continuing medical education activity is with the following commercial interests in the please follow the instructions provided on form of Consultant/Advisory Board: Alcon; the post test and Activity Evaluation/Credit supported through an unrestricted educational grant from Allergan. Alimera Sciences; Allergan; D.O.R.C. Dutch Request form. This educational activity should Ophthalmic Research Center (International) take a maximum of 1.5 hours to complete. DISCLOSURE POLICY STATEMENT B.V.; Novartis Pharmaceuticals Corporation; ACTIVITY DESCRIPTION It is the policy of New York Eye and Ear and Regeneron Pharmaceuticals, Inc. By 2030, it is estimated that 3.7 million people Infirmary of Mount Sinai that the faculty and NEW YORK EYE AND EAR INFIRMARY OF anyone in a position to control activity content in the United States will have advanced age- MOUNT SINAI PEER REVIEW DISCLOSURE related macular degeneration (AMD), disclose any real or apparent conflicts of interest relating to the topics of the Gennady Landa, MD, has no relevant including neovascular AMD (nAMD) and commercial relationships to disclose. geographic atrophy, yet current treatments educational activity in which they are for nAMD leave much to be desired in terms participating. They are also required to disclose EDITORIAL SUPPORT DISCLOSURES of efficacy, safety, and treatment burden. A discussions of unlabeled/unapproved uses of Erika Langsfeld, PhD; Cynthia Tornallyay, RD, growing body of research on newly approved drugs or devices during their presentations. MBA, CHCP; Barbara Aubel; and Michelle Ong or investigational “next-generation” therapies New York Eye and Ear Infirmary of have no relevant commercial relationships to Mount Sinai is committed to providing its suggests that novel mechanisms of action may disclose. learners with quality CME activities and related lessen treatment burden for nAMD. These materials that promote improvements in DISCLOSURE ATTESTATION include an antibody fragment, a DARPin healthcare and not the proprietary interests of (designed ankyrin repeat protein), a bispecific The contributing physicians listed above have a commercial interest and, thus, has established attested to the following: antibody, and viral gene delivery and policies and procedures in place that identify 1) that the relationships/affiliations noted will expression. Importantly, no 2 patients are and resolve all conflicts of interest prior to the not bias or otherwise influence their alike in their degree of disease activity and execution or release of its educational activities. involvement in this activity; severity, leading experts to question if an Full disclosure of faculty/planners and their 2) that practice recommendations given individualized approach to treatment with commercial relationships, if any, follows. relevant to the companies with whom they current modalities—along with careful disease have relationships/affiliations will be activity monitoring—is a viable approach to DISCLOSURES supported by the best available evidence save vision while reducing treatment burden. Arshad M. Khanani, MD, MA, had a financial or, absent evidence, will be consistent with This monograph, based on a roundtable agreement or affiliation during the past year generally accepted medical practice; and discussion among 3 leading retina specialists, with the following commercial interests in the 3) that all reasonable clinical alternatives will will review new developments and cutting- form of Consultant/Advisory Board: Adverum; be discussed when making practice edge data on next-generation treatments and Allergan; Bausch & Lomb Incorporated; recommendations. individualized, patient-centered management. Chengdu Kanghong Pharmaceutical Group A series of challenging cases will also be Co Ltd; D.O.R.C. Dutch Ophthalmic Research OFF-LABEL DISCUSSION discussed. The desired results of this Center (International) B.V.; EyePoint This CME activity includes discussion of educational activity are for retina specialists Pharmaceuticals; Gemini Therapeutics; unlabeled and/or investigative uses of drugs. and other ophthalmologists to evaluate Genentech, Inc; GrayBug, Inc; Gyroscope; Please refer to the official prescribing emerging treatments, with the aim to reduce Novartis Pharmaceuticals Corporation; Opthea; information for each drug discussed in this the treatment burden of nAMD while Oxurion NV; PolyPhotonix; Recens Medical; activity for FDA-approved dosing, indications, comparing their potential clinical use against and Regenxbio Inc; Contracted Research: and warnings. the current standard of care. Adverum; Allergan; Chengdu Kanghong Pharmaceutical Group Co Ltd; Gemini New York Eye and Ear Infirmary of TARGET AUDIENCE Therapeutics; Genentech, Inc; GrayBug, Inc; Mount Sinai Privacy & Confidentiality Policies This educational activity is intended for retina Gyroscope; Novartis Pharmaceuticals https://www.nyee.edu/education/cme specialists and other ophthalmologists caring Corporation; Opthea; Oxurion NV; CME Provider Contact Information for patients with nAMD. PolyPhotonix; Recens Medical; and Regenxbio For questions about this activity, call Inc; Honoraria from promotional, advertising 917-270-7571. LEARNING OBJECTIVES or non-CME services received directly from Upon completion of this activity, participants commercial interests or their Agents TO OBTAIN AMA PRA CATEGORY 1 CREDIT™ will be better able to: (eg, Speakers Bureaus): Allergan; Genentech, Inc, To obtain AMA PRA Category 1 Credit™ for • Contrast the mechanism of extended and Novartis Pharmaceuticals Corporation. this activity, read the material in its entirety and therapeutic effect for investigational and consult referenced sources as necessary. Please current treatments for nAMD Baruch D. Kuppermann, MD, PhD, had a take this post test and evaluation online by • Describe recent clinical trial data for financial agreement or affiliation during the going to https://tinyurl.com/newgroundAMD. approved and emerging treatments for nAMD past year with the following commercial Upon passing, you will receive your certificate • Develop re-treatment plans for patients with interests in the form of Consultant/Advisory immediately. You must score 70% or higher to nAMD that consider observed disease activity Board: Allegro Ophthalmics, LLC; Allergan; receive credit for this activity, and may take the and treatment burden Aprea Therapeutics; Cell Care Therapeutics; test up to 2 times. Upon registering and Eyedaptic Inc; Galimedix Therapeutics, Inc; successfully completing the post test, your ACCREDITATION STATEMENT Genentech, Inc; Glaukos Corporation; Interface certificate will be made available online and The New York Eye and Ear Infirmary Biologics, Inc; IVERIC bio; jCyte; Novartis you can print it or file it. of Mount Sinai is accredited by the Pharmaceuticals Corporation; Oculis SA, Inc; Accreditation Council for Continuing Regeneron Pharmaceuticals, Inc; Re-Vana DISCLAIMER Medical Education (ACCME) to provide Therapeutics; Ripple Therapeutics; and The views and opinions expressed in this continuing medical education for physicians. Theravance Biopharma; Contracted Research: educational activity are those of the faculty and This educational activity was developed Alcon, Inc; Allegro Ophthalmics, LLC; Allergan; do not necessarily represent the views of and implemented in collaboration with Apellis Pharmaceuticals; Genentech, Inc; New York Eye and Ear Infirmary of Mount Sinai, MedEdicus LLC. GlaxoSmithKline plc; Ionis Pharmaceuticals, Inc; MedEdicus LLC, Allergan, or Retina Specialist. FOR INSTANT CME CERTIFICATE PROCESSING, COMPLETE THE POST TEST ONLINE AT 2 FACULTY Reducing Treatment Burden Arshad M. Khanani, MD, MA (CHAIR) in Neovascular AMD Managing Partner Director of Clinical Research Director of Fellowship Sierra Eye Associates Clinical Associate Professor University of Nevada, Reno School of Medicine Reno, Nevada Baruch D. Kuppermann,
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