Potassium disulfite sc-253301 Material Safety Data Sheet Hazard Alert Code Key: EXTREME HIGH MODERATE LOW Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION PRODUCT NAME Potassium disulfite STATEMENT OF HAZARDOUS NATURE CONSIDERED A HAZARDOUS SUBSTANCE ACCORDING TO OSHA 29 CFR 1910.1200. NFPA FLAMMABILITY0 HEALTH2 HAZARD INSTABILITY1 SUPPLIER Company: Santa Cruz Biotechnology, Inc. Address: 2145 Delaware Ave Santa Cruz, CA 95060 Telephone: 800.457.3801 or 831.457.3800 Emergency Tel: CHEMWATCH: From within the US and Canada: 877-715-9305 Emergency Tel: From outside the US and Canada: +800 2436 2255 (1-800-CHEMCALL) or call +613 9573 3112 PRODUCT USE ! Reducing agent. As antifermentative in breweries and wineries; bleaching straw; preservative for fruits and vegetables. Not advised for use in foods recognised as a source of Vitamin B-1 or consumed raw. As reducing agent, particularly in dyeing with indigo and vat dyes. Used as a bleach, for soap, straw; removing dyes from dyed fabric. Part of a redox catalyst system for synthetic rubber production. Oxygen scavenger in water treatment, reduction of metals in waste treatment. Brightening groundwood, kraft and other paper pulps; treatment of beet and cane sugar juices; depressant in mining flotations, bleaching textiles, vegetable oils, straw, hemp, vegetable tannins, animal glues. Pulp and paper bleaching. As reducing agent, particularly in dyeing with indigo and vat dyes. Used as a bleach, for soap, straw; removing dyes from dyed fabric. Part of a redox catalyst system for synthetic rubber production. Oxygen scavenger in water treatment, reduction of metals in waste treatment. SYNONYMS K2-S2-O5, "pyrosulfurous acid, dipotassium salt", "potassium metabisulphite", "pyrosulphurous acid, dipotassium salt", "potassium pyrosulphite", "potassium pyrosulfite", "dipotassium disulfite", "dipotassium metabisulfite", "disulfurous acid dipotassium salt" Section 2 - HAZARDS IDENTIFICATION CHEMWATCH HAZARD RATINGS Min Max Flammability: 0 Min/Nil=0 Toxicity: 2 Low=1 Moderate=2 Body Contact: 2 High=3 Extreme=4 1 of 14 Reactivity: 1 Chronic: 2 CANADIAN WHMIS SYMBOLS EMERGENCY OVERVIEW RISK Contact with acids liberates toxic gas. Irritating to eyes, respiratory system and skin. POTENTIAL HEALTH EFFECTS ACUTE HEALTH EFFECTS SWALLOWED ! The material has NOT been classified as "harmful by ingestion". This is because of the lack of corroborating animal or human evidence. The material may still be damaging to the health of the individual, following ingestion, especially where pre-existing organ (e.g. liver, kidney) damage is evident. Present definitions of harmful or toxic substances are generally based on doses producing mortality (death) rather than those producing morbidity (disease, ill-health). Gastrointestinal tract discomfort may produce nausea and vomiting. In an occupational setting however, unintentional ingestion is not thought to be cause for concern. EYE ! This material can cause eye irritation and damage in some persons. SKIN ! This material can cause inflammation of the skin oncontact in some persons. ! The material may accentuate any pre-existing dermatitis condition. ! Skin contact is not thought to have harmful health effects, however the material may still produce health damage following entry through wounds, lesions or abrasions. ! Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may produce systemic injury with harmful effects. Examine the skin prior to the use of the material and ensure that any external damage is suitably protected. INHALED ! The material can cause respiratory irritation in some persons. The body's response to such irritation can cause further lung damage. ! Inhalation of dusts, generated by the material during the course of normal handling, may be damaging to the health of the individual. ! Persons with impaired respiratory function, airway diseases and conditions such as emphysema or chronic bronchitis, may incur further disability if excessive concentrations of particulate are inhaled. ! Sulfur dioxide irritation probably results from the action of sulfurous acid as the highly soluble gas dissolves in mucous fluid. Short-term exposure causes bronchoconstriction measurable as an increase in flow-resistance. The magnitude is concentration-dependent.. Chief effects are upper respiratory tract irritation and severe acute exposure may cause oedema of the lungs and possible respiratory paralysis. These exposures have produced severe obstructive and restrictive defects up to 3 months post-exposure; these have failed to respond to bronchodilators. Such exposures have also, on rare occasions, been associated with moderately severe obstructive illness and persistent, productive cough. Systemic effects of acute poisoning are not known but regular exposure may deaden the sense of smell. Symptoms include throat irritation, coughing, tightness of chest, difficulty with breathing, tear formation (lachrymation), eye smarting and suffocating feeling. Substantial exposures produce direct respiratory tract irritation, cough, burning, lachrymation, conjunctival injection, difficulty in swallowing, and otopharyngeal erythema. Other symptoms may include vomiting, diarrhoea, abdominal pain, fever, headache, vertigo, agitation, tremor, convulsions, and peripheral neuritis. High dose acute exposure may produce immediate bronchospasm and pulmonary oedema with respiratory failure/ paralysis, inflammation of the conjunctivae and inflammation of the tongue. CHRONIC HEALTH EFFECTS ! Long-term exposure to respiratory irritants may result in disease of the airways involving difficult breathing and related systemic problems. There has been some concern that this material can cause cancer or mutations but there is not enough data to make an assessment. Limited evidence suggests that repeated or long-term occupational exposure may produce cumulative health effects involving organs or biochemical systems. There is some evidence that inhaling this product is more likely to cause a sensitization reaction in some persons compared to the general population. There is limited evidence that, skin contact with this product is more likely to cause a sensitization reaction in some persons compared to the general population. Long term exposure to high dust concentrations may cause changes in lung function i.e. pneumoconiosis; caused by particles less than 0.5 micron penetrating and remaining in the lung. Prime symptom is breathlessness; lung shadows show on X-ray. Repeated exposure of animals to airborne sulfur dioxide (SO2) can produce a thickening of the mucous layer in the trachea and an increase in goblet cells and mucous glands similar to pathological changes found in chronic human bronchitis. Chronic exposure to sulfur dioxide (SO2) particulate complexes, present in polluted air, have been associated with the aggravation of chronic cardiovascular diseases such as asthma, chronic pulmonary disease, and coronary artery disease (this may occur at levels of 6-10 ug/m3 for 24 hours), An association exists between persistent cough and sputum production, particularly in women and non-smokers. A 10-year follow study on workers exposed to a mean sulfur dioxide concentration of up to 33 ppm did not reveal an increased prevalence of chronic respiratory disease or decreased pulmonary function. 2 of 14 By contrast, studies of smelter workers, exposed to concentrations below 2 ppm, suggest that chronic respiratory disease may develop and that workers exposed at concentrations exceeding 1 ppm show accelerated loss of pulmonary function. Although SO2 is not a carcinogen, the apparent increases in mortalities amongst arsenic-exposed smelter workers was greater when exposures included both high arsenic concentrations and moderate to high SO2 exposures, suggesting that SO2 might act as a promoter. Intermittent exposure of rats to benz[a]pyrene along with inhalation of SO2 at 4-10 ppm, 1-6 hours per day, 5 days per week, produced substantial increases in respiratory tract squamous cell carcinomas compared to that associated with exposure to B[a]P or SO2 alone. Sulfites and bisulfites can cause narrowing of the airways, stomach upset, flushing, low blood pressure. tingling sensation, itchy wheal, swelling and shock, and asthmatics are especially prone. They induce allergic-like reactions which can occur on first contact with the material. Section 3 - COMPOSITION / INFORMATION ON INGREDIENTS NAME CAS RN % potassium metabisulfite 16731-55-8 >95 decomposes to produce sulfur dioxide 7446-09-5 Section 4 - FIRST AID MEASURES SWALLOWED ! Immediately give a glass of water. First aid is not generally required. If in doubt, contact a Poisons Information Center or a doctor. EYE ! If this product comes in contact with the eyes: Wash out immediately with fresh running water. Ensure complete irrigation of the eye by keeping eyelids apart and away from eye and moving the eyelids by occasionally lifting the upper and lower lids. If pain persists or recurs seek medical attention. Removal of contact lenses after an eye injury should only be undertaken by skilled personnel. SKIN ! If skin contact occurs: Immediately remove all contaminated clothing, including footwear Flush skin and hair with running water (and soap if available). Seek medical attention in event of irritation. INHALED ! If fumes or combustion products are inhaled remove from contaminated area. Lay patient down. Keep warm and rested. Prostheses such as false teeth, which may block airway, should be removed, where possible, prior to