Synthetic Deslorelin

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k.RECORD ID 11011 Synthetic Deslorelin Catalog No. CRD113A Quantity: 5 mg CRD113B 25 mg CRD113C 100 mg Description: Deslorelin is a potent LHRH/GnRH agonist with a molecular formula of C64H83N17O12, Pyr- His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-NHEt. Deslorelin is being studied in the treatment of cancer as a way to block sex hormones made by the ovaries or testicles. It belongs to the family of drugs called gonadotropin-releasing hormone analogs. It is used for the induction of ovulation in mares. Deslorelin binds to and activates pituitary gonadotropin releasing hormone (GnRH) receptors. Continuous, prolonged administration of goserelin in males results in pituitary GnRH receptor desensitization and inhibition of pituitary secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH), leading to a significant decline in testosterone production; in females, prolonged administration results in a decrease in estradiol production. Molecular Weight: 1.28 kDa Formulation: Lyophilized from a sterile filtered solution without additives Purity: > 99% as determined by RP-HPLC and SDS-PAGE analyses Endotoxin Level: < 0.1 ng/µg of Deslorelin Reconstitution: Centrifuge vial prior to opening. First add sterile distilled water to the vial to fully solubilize the protein to a concentration not less than 100 µg/ml. After complete solubilization of the protein, it can be further diluted to other aqueous solutions. Storage & Stability: Store lyophilized protein at -20°C to -80°C. Reconstituted protein is stable for 1 week at 2-4°C. For long term storage, aliquot and store at -20°C to -80°C with a carrier protein (0.1% HSA or BSA) as a stabilizer. Please note that the addition of any carrier protein into this product may produce unwanted endotoxin. This depends upon the particular application employed. Avoid repeated freeze-thaw cycles. NOT FOR HUMAN USE. FOR RESEARCH ONLY. NOT FOR DIAGNOSTIC OR THERAPEUTIC USE. ® Cell Sciences ® Toll Free: 888-769-1246 E-mail: [email protected] 480 Neponset Street Phone: 781-828-0610 Website: www.cellsciences.com Bldg 12A Fax: 781-828-0542 Canton, MA 02021.

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Hormones and Breeding
IN-DEPTH: REPRODUCTIVE ENDOCRINOLOGY Hormones and Breeding Carlos R.F. Pinto, MedVet, PhD, Diplomate ACT Author’s address: Theriogenology and Reproductive Medicine, Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210; e-mail: [email protected]. © 2013 AAEP. 1. Introduction affected by PGF treatment to induce estrus. In The administration of hormones to mares during other words, once luteolysis takes place, whether breeding management is an essential tool for equine induced by PGF treatment or occurring naturally, practitioners. Proper and timely administration of the events that follow (estrus behavior, ovulation specific hormones to broodmares may be targeted to and fertility) are essentially similar or minimally prevent reproductive disorders, to serve as an aid to affected (eg, decreased signs of behavioral estrus). treating reproductive disorders or hormonal imbal- Duration of diestrus and interovulatory intervals ances, and to optimize reproductive efficiency, for are shortened after PGF administration.1 The example, through induction of estrus or ovulation. equine corpus luteum (CL) is responsive to PGF These hormones, when administered exogenously, luteolytic effects any day after ovulation; however, act to control the duration and onset of the different only CL Ͼ5 days are responsive to one bolus injec- stages of the estrous cycle, specifically by affecting tion of PGF.2,3 Luteolysis or antiluteogenesis can duration of luteal function, hastening ovulation es- be reliably achieved in CL Ͻ5 days only if multiple pecially for timed artificial insemination and stimu- PGF treatments are administered. For that rea- lating myometrial activity in mares susceptible to or son, it became a widespread practice to administer showing delayed uterine clearance.
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SUPRELORIN® F (Deslorelin Acetate) Implant, Contact Your Virbac Sales Representative, Distribution Center, Or Call 1-844-484-7222
Manage pet ferret adrenal cortical disease with a SINGLE ANNUAL IMPLANT NOT APPROVED BY FDA—Legally marketed as an FDA Indexed Product under MIF 900-013. FOR USE IN FERRETS ONLY. Extra-label use is prohibited. This product must not be used in animals intended for use as food for humans or other animals. Help ferrets diagnosed with ACD LIVE HEALTHIER LIVES Reduces clinical signs of ACD with Effective a return to normalcy in 2–8 weeks3,4 4.7-mg dose implant has been shown Safe to be safe with clinical monitoring3 5 reasons to consider the A single subcutaneous implant is Simple recommended once per year3* SUPRELORIN F Implant. Naturally dissolves, so no removal Convenient is necessary3 A novel mechanism of action brought Advanced to you by a company you trust, Virbac Corporation To order the SUPRELORIN® F (deslorelin acetate) Implant, contact your Virbac sales representative, distribution center, or call 1-844-484-7222. *Supplied as 2 or 5 single-use, pre-loaded, individually wrapped implants. Important safety information: For use in ferrets only. Do not use in animals intended for breeding. The safe use of this product has not been evaluated in pregnant or lactating ferrets. Do not use this product in ferrets with known hypersensitivity to deslorelin acetate or other synthetic hormones. DO NOT HANDLE THIS PRODUCT IF YOU ARE PREGNANT OR NURSING OR SUSPECT YOU MAY BE PREGNANT. Accidental administration in humans may lead to disruption of the menstrual cycle. See reverse for complete product information. Potential adverse reaction: Treated ferrets may exhibit signs of soreness and swelling at the implantation site, which should resolve over 1 to 2 weeks.
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