Farewell Symposium Erich Nigg, Director Biozentrum

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Farewell Symposium Erich Nigg, Director Biozentrum

Thursday, Farewell February 1, 2018 Lecture Hall 1, Pharmazentrum Klingelbergstrasse 50/70 Symposium Basel Erich Nigg, Director Biozentrum. Farewell Symposium Erich Nigg. 09.00 – 09.05 Welcome address 15.05 – 15.40 Time of change – change over time Erich Nigg, Director Biozentrum, University of Basel Katharina Sonnen, European Molecular Biology Laboratory, Heidelberg 09.05 – 09.40 Chromosomal dynamics during spermatogenesis in Drosophila melanogaster 15.40 – 16.15 Studies on NEK family kinases: From molecular Christian Lehner, Institute of Molecular Life Sciences, mechanisms to cancer therapies University of Zurich Andrew Fry, Department of Molecular and Cell Biology, University of Leicester 09.40 – 10.15 How do cells count centrosomes? Luca Fava, Centre for Integrative Biology, University of 16.15 – 16.45 Coffee Break Trento 16.45 – 17.20 Structure and function of the kinetochore 10.15 – 10.50 Checkpoint kinases: Beyond cell cycle control Andrea Musacchio, Max Planck Institute of Molecular Susan Gasser, Director of Friedrich Miescher Institute for Physiology, Dortmund Biomedical Research, Basel 17.20 – 17.55 Centrosome function and dynamics 10.50 – 11.15 Coffee Break Jordan Raff, Department of Biochemistry, University of Oxford 11.15 – 11.50 Regulation of cell growth and division Matthias Peter, Institute of Biochemistry, ETH Zurich 17.55 – 18.15 Short Break 11.50 – 12.25 The biology of hypoxia response pathways in cancer Wilhelm Krek, Molecular Health Sciences, ETH Zurich 18.15 – 18.25 Erich Nigg: Director of the Biozentrum Andrea Schenker-Wicki, Rector of the University of Basel 12.25 – 13.00 How cancer respond and become resistant to microtubule-targeting drugs 18.25 – 18.35 Erich Nigg: A life in science Patrick Meraldi, Department of Cell Physiology and Susan Gasser, Director of Friedrich Miescher Institute for Metabolism, University of Geneva Biomedical Research, Basel 18.35 – 19.15 Farewell Lecture 13.00 – 14.30 Lunch 40 years of exploration come to an end – time to say “thank you” 14.30 – 15.05 “Should I stay or should I go” – the fate of cytosolic Erich Nigg, Director Biozentrum, University of Basel misfolded proteins Thibault Mayor, Department of Biochemistry and Molecular 19.15 Apéro Biology, University of British Columbia Please register online by January 22, 2018: www.biozentrum.unibas.ch/symposium_nigg Biozentrum, University of Basel Klingelbergstrasse 50/70 4056 Basel Switzerland www.biozentrum.unibas.ch.

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PDW CV March 2014
Curriculum Vitae Dr. ir. Peter De Wulf Contact information European Institute of Oncology Department of Experimental Oncology Via Adamello 16 20139 Milan, Italy E-mail: [email protected] Tel: (++39) 0294375036 Fax: (++39) 0294375990 Position 08/2005 - present Principal Investigator Director Kinetochore and Chromosome Segregation Research Unit Department of Experimental Oncology European Institute of Oncology Milan, Italy Education and training 11/1999 - 06/2005 Post-Doctoral Research in Yeast Kinetochore Biology Department of Biology Massachusetts Institute of Technology 77 Massachusetts Avenue 02139 Cambridge (MA), USA Mentor: Prof. Dr. Peter K. Sorger (now at Harvard Medical School, Department of Systems Biology) 07/1996 - 10/1999 Post-Doctoral Research in Bacterial Two-Component Signal Transduction Department of Microbiology and Molecular Genetics Harvard Medical School 210 Longwood Avenue 02115 Boston (MA), USA Mentor: Prof. Dr. Edmund C.C. Lin (deceased) 04-20/07/1999 Course in Protein Purification and Characterization Cold Spring Harbor Laboratory. Cold Spring Harbor (NY), USA Instructors: Dr. Richard Burgess, Dr. Albert Courey, Dr. Sue-Hwa Lin, Dr. Sheenah Mische 06-20/06/1997 Course in Advanced Bacterial Genetics Cold Spring Harbor Laboratory. Cold Spring Harbor (NY), USA Instructors: Dr. Bonnie Bassler, Dr. Colin Manoil, Dr. James Slauch 06/1995 - 06/1996 Training in Yeast Cell Biology Department of Applied Biochemistry University of Milan via Celoria 26 20133 Milan, Italy Mentor: Prof. Dr. Lilia Alberghina (now at the University of Milan-Bicocca, Department of Biotechnology and Biosciences) 1 01/1992-05/1995 Ph.D. in Industrial Microbiology and Biocatalysis Department of Biochemical and Microbial Technology School of Bioengineering University of Ghent Coupure Links 653 B-9000 Ghent, Belgium Mentor: Prof.
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Molecular Determinants of the Ska-Ndc80 Interaction and Their
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Structure of Human Mad1 C-Terminal Domain Reveals Its Involvement in Kinetochore Targeting
Structure of human Mad1 C-terminal domain reveals its involvement in kinetochore targeting Soonjoung Kima,b,1, Hongbin Suna,1,2, Diana R. Tomchickc, Hongtao Yua,b,3, and Xuelian Luoa,3 aDepartment of Pharmacology, bHoward Hughes Medical Institute, and cDepartment of Biochemistry, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390 Edited by Edward D. Salmon, University of North Carolina, Chapel Hill, NC, and accepted by the Editorial Board February 28, 2012 (received for review November 4, 2011) The spindle checkpoint prevents aneuploidy by delaying anaphase and sufficient for its kinetochore localization and checkpoint func- onset until all sister chromatids achieve proper microtubule attach- tion (18). By contrast, an N-terminal fragment of Xenopus Mad1 ment. The kinetochore-bound checkpoint protein complex Mad1- lacking the CTD has been shown to localize to kinetochores (19). Mad2 promotes the conformational activation of Mad2 and serves Finally, mutation of T680, a residue within the CTD and a poten- as a catalytic engine of checkpoint signaling. How Mad1 is targeted tial Plk1 phosphorylation site, in human Mad1 has been reported to kinetochores is not understood. Here, we report the crystal to diminish its kinetochore localization (20). It is thus unclear structure of the conserved C-terminal domain (CTD) of human whether Mad1 has conserved kinetochore-targeting domains. Mad1. Mad1 CTD forms a homodimer and, unexpectedly, has a fold The kinetochore receptor or receptors of Mad1 are also unknown. similar to those of the kinetochore-binding domains of Spc25 and In this study, we have determined the crystal structure of the Csm1.
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Growtharrestinyeastwithaberrant
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A Molecular Basis for the Differential Roles of Bub1 and Bubr1 In
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Research Interests – Prof. Dr. Andrea Musacchio
Research Interests – Prof. Dr. Andrea Musacchio The main focus of Andrea Musacchio’s laboratory is the study of the molecular mechanisms supporting chromosome inheritance. As carriers of the genetic information stored in DNA (deoxyribonucleic acid), chromosomes play a crucial role in cellular and organismal heredity. Collectively, the 23 pairs of chromosomes present in each human cell carry almost exact copies of the three billion nucleotides of the human genome. In addition to be DNA carriers, chromosomes provide a protein-based scaffold that allows the genetic information contained in DNA to be decoded. Furthermore, and equally importantly, chromosomes act as units for the replication of the DNA in a mother cell and for its subsequent segregation into its two daughters. This foundational process in genetic heredity, which repeats itself in our bodies billions of times every day, is astonishingly accurate, with essentially negligible natural rates of chromosome gain or loss. However, this process goes often awry in tumours, generating imbalances in chromosome number that have dire consequences for cell physiology. Defects in this process are also observed in sexual reproduction, especially as a consequence of organismal aging, and represent prominent causes of infertility, miscarriage and birth de- fects. The series of events that allow a mother cell to replicate itself to generate two identical daughters is known as the cell cycle. This process is responsible for inter-generational prop- agation or organisms and for their development. In adult organisms, the cell cycle also pro- motes the continued, rapid renewal of many tissues, such as the intestine, the skin and the blood.
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Spindly Attachments
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Edoardo (Born 03/02/2006) and Tommaso (Born 14/12/2008) Italian Citizenship
Andrea Musacchio ORCID ID: 0000-0003-2362-8784 August 2019 Prof. Andrea Musacchio, PhD Director, Department of Mechanistic Cell Biology Max Planck Institute of Molecular Physiology, Dortmund, Germany Curriculum vitae Personal Born in Rome, 11 July 1964 Married to Roberta Palumbo Two kids: Edoardo (born 03/02/2006) and Tommaso (born 14/12/2008) Italian citizenship Education 1985-90 Degree in Biology, University of Rome-Tor Vergata (summa cum laude), Rome (Italy). Advisor: Prof Giovanni Cesareni 1991-95 PhD in Biochemistry at EMBL-University of Heidelberg (summa cum laude), Heidelberg (Germany). Advisor: Dr Matti Saraste Postdoctoral 1995-98 Postdoctoral Fellow at Harvard Medical School, Boston (USA). Advisor: Prof Stephen C. Harrison Appointments 1999-03 Assistant Professor, Department of Experimental Oncology, European Institute of Oncology, Milan (Italy) 2003-06 Associate Professor, Department of Experimental Oncology, European Institute of Oncology, Milan (Italy) 2006-2011 Full Professor, Department of Experimental Oncology, European Institute of Oncology, Milan (Italy) 2011- Director, Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, Dortmund (Germany) Honors § Human Frontier Science Program postdoctoral fellow (1995-1997) § American Cancer Society Senior postdoctoral fellow (1997-1998) § Scholar of the Italian Foundation for Cancer Research (1999-2004) § EMBO Young Investigator (2000-2004) § Scientific Director of the Milan branch of SEMM (European School of Molecular Medicine) (2003-2006) § Chiara
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Contents Will Come Baden-Württemberg Ministry of (OIPA) Several Times a Year
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The Molecular Biology of Spindle Assembly Checkpoint Signaling Dynamics
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