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Fibrin and Thrombosis in the Central Nervous System in Children with Particular Reference to Congenital Hydrocephalus

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Fibrin and Thrombosis in the Central Nervous System in Children with Particular Reference to Congenital Hydrocephalus J Clin Pathol: first published as 10.1136/jcp.17.3.348 on 1 May 1964. Downloaded from J. clin. Path. (1964), 17, 348 Fibrin and thrombosis in the central nervous system in children with particular reference to congenital hydrocephalus JOHN L. EMERY From the Department ofPathology, The Children's Hospital, Sheffield While rare metabolic and degenerative diseases of scanty and a simple fibrin clot is rarely seen. the central nervous system in children are reported Surrounding the small veins there are often clear at great length, the much commoner diseases vacuolated spaces but there is no evidence of relating to vascular incidents are rarely discussed. inflammation of the vein wall or of reaction in the Only those aspects of disease of the central surrounding glia. Occasionally there are small local nervous system related to thrombosis and the haemorrhages. There are three clinical states in deposition of fibrin will be discussed here; diseases which thrombi are most likely to be encountered. related to general vasculitis and aneurysm are omitted. The conditions discussed here fall into two SEVERE DEHYDRATION AND INANITION This situation main categories: first, the presence of thrombosis in is liable to occur associated with vomiting or small blood vessels or in the large superficial veins diarrhoea. There is frequently massive thrombosis, draining the brain, and second, the deposition of often involving the longitudinal sinus and well fibrin either in the ventricles or on the membranes known in the past as 'marantic thrombosis'. overlying the brain in association with thrombotic The second condition is liable to occur in young lesions, haemorrhage, or infiltration. infants associated with states of hypoxia. These can be associated with birth or, what is probably most http://jcp.bmj.com/ PRIMARY THROMBOSES commonly and most frequently overlooked, with hypoxia related to acute tracheo-bronchitis. The Thrombosis of small blood vessels, particularly of third group is associated with peripheral vascular veins, forms an important part of the general failure from many causes, including post-operative pathology of infants. These lesions are easily shock and septicaemia. diagnosed and recorded in viscera such as the The clinical effects associated with massive kidneys but their importance in the brain is often thrombosis are usually gross convulsive states overlooked. Thrombi in the brain can be found in leading to death. Associated with the microscopic on September 26, 2021 by guest. Protected copyright. two main forms, the first being massive thrombi in clots, symptoms may be minimal. Many instances of either the longitudinal sinus, the lateral sinus, or so-called febrile convulsions are probably associated more commonly, one or other of the large veins with these lesions. Such clots are frequently found in coursing into the longitudinal sinus from the children found unexpectedly dead who have inhaled, surface of the hemispheres. These thrombi are and it is not uncommon for a child to die unexpect- usually associated with cerebral symptoms, usually edly in this way. Such children also frequently show severe convulsions, and are rarely an incidental the presence of agonal intussusceptions in the small finding at necropsy. The more common finding intestine, suggesting that there has been a terminal when routine microscopy of the brain is done on all derangement of the function of the nervous system. children is the finding of unequivocal ante-mortem thrombi in small vessels, particularly in the small HAEMORRHAGES vessels of the thalamus and of the cortex. Thrombi in the medulla and in the region of the olives are, in INTRAVENTRICULAR HAEMORRHAGES Gross haemor- my experience, less common. These minute thrombi rhage with clotted blood filling the ventricles, usually contain coagulated fibrin and a relatively particularly in the lateral and third ventricles, is a few immeshed red blood cells. Occasionally many not uncommon association with the newborn state. platelets appear to be incorporated but these are The sites of these haemorrhages are not always 348 J Clin Pathol: first published as 10.1136/jcp.17.3.348 on 1 May 1964. Downloaded from Fibrin and thrombosis in the central nervous system in children with reference to congenital hydrocephalus 349 identifiable but the frequent finding of small areas of MENINGITIS AND ENCEPHALITIS thrombosis on the choroid plexus in children who have died from haemorrhages elsewhere in the body It is doubtful if meningitis is ever a primary disease suggests that the site of origin of the intracranial in a child. Since so many ill children show the haemorrhage is probably the choroid plexus. The presence of small haemorrhages or small thrombi, other most common site is in the highly vascular the impression gained is that a child with a septi- mass of primitive neuroblasts lying beneath the caemia who has any such lesions is liable to develop lining of the lateral ventricles in the premature child. infection at these sites spreading to the rest of the It is commonly believed that hydrocephalus due meninges. to blocked aqueducts is often due to scarring after The presence of pus itself, either within the subclinical intraventricular haemorrhage but in our ventricles or surrounding the brain, appears to have experience this has been extremely rare, and, while very little effect either on the circulation of the cere- we have found thrombi in these sites, I personally do brospinal fluid or on the function of the brain or not believe that clots within the ventricular system indeed often on the general health of the child. The are of any great importance in the aetiology of symptoms and complications are, in our experience, hydrocephalus. invariably associated with vascular lesions, either vasculitis affecting the small arteries or thrombosis SUBDURAL HAEMORRHAGES Subdural haemorrhages of the veins. This is particularly notable in tubercu- are extremely common and probably an almost lous meningitis in which the complications and final invariable concomitant of normal birth. Haemor- sequelae are directly related to the vascular damage. rhages over the surface of the hemispheres are a very In this type of meningitis. masses of fibrin can be frequent incidental finding in the newborn period seen spreading outside the small arteries into the and evidence of old haemorrhages common findings subarachnoid space and these are associated with in children dying in infancy. The majority of such inflammatory change in the walls of the blood vessels haemorrhages appear to be completely asympto- (Fig. 1). By the time any obstructive lesion has been matic and are of no clinical importance. The blood found in the ventricular system, the obstructive forms in these sites what appear to be simple clots structure itself has, in our experience, always been which are eventually completely eliminated. collagenous and not fibrinous. The only haemorrhages that appear to persist and There is often a complete dissociation between produce any symptoms are those which occur over ventriculitis and meningitis and this is particularly the upper and lateral surfaces of the cerebral seen in children with hydrocephalus associated with http://jcp.bmj.com/ hemispheres. In these sites, the haemorrhages the Arnold-Chiari deformity. In these children, liquefy and form the so-called chronic subdural meningitis is virtually non-existent even in the haematoma. In our experience, every such case that presence of gross ventriculitis. In the cases of chronic has come to necropsy has shown the presence of ventriculitis often associated with E. coli and thrombi of long standing in some of the traversing Pseudomonas pyocyanea, the ventricles are lined by a blood vessels. Since the essential difference between layer of coagulated fibrin and degenerate leucocytes these persisting cystic cavities and the apparent but the presence of this membrane is always on September 26, 2021 by guest. Protected copyright. dissolution of clots elsewhere is the presence of the associated with areas ofthrombosis and haemorrhage traversing vessel it seems likely that the thrombosed in the underlying brain tissue. traversing vessels are the essential factor in main- The ventriculitis and the 'fibrin' membrane in taining the chronicity of these subdural effusions. cases showing minimal ventriculitis is frequently localized to the choroid plexuses, these often being TRAUMA completely surrounded by a greyish zone of fibrinous tissue. The underlying choroid plexus in such cases We have been able to study the effects of simple invariably shows thrombosis and inflammatory trauma from such procedures as ventricular puncture change in the vessel wall. The 'fibrin' membrane at considerable length in children with congenital referred to here contains thick masses of coagulated hydrocephalus, and in none of these cases have we material and it seems that the presence of ventricul- seen fibrin deposited in the injured area in the itis is invariably associated with vascular lesions absence of chronic infection or gross haemorrhage. either of the choroid plexus or of the brain tissue and The tip of the Spitz-Holter catheter penetrating the follows a lesion of the choroid plexus. side of the brain quite frequently impinges on the In cases of ventriculitis that have been treated by medial surface of the hemispheres and this can the instillation of corticosteroids, the fibrin zone, cause considerable damage to this area without the previously described, is absent and the ventricle is finding of any local tissue reaction. lined by an irregular mass of degenerated nerve cells J Clin Pathol: first published as 10.1136/jcp.17.3.348 on 1 May 1964. Downloaded from 350 John L. Emery FIG. 1. Photograph ofa section from below the base of the brain of a child with tuberculous meningitis. Near the centre of the picture is a small blood vessel almost completely occluded by swelling of the intimal cells. The surrounding subarachnoid space contains an extensive network offibrin. (Masson x 120). and leucocytes, there being no definite line of auricle of the heart for two years in which not a http://jcp.bmj.com/ demarcation between the ventricular cavity and the vestige of fibrin was attached to the surface.
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