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Homeostasis Model Assessment Closely Mirrors the Glucose Clamp

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Homeostasis Model Assessment Closely Mirrors the Glucose Clamp Emerging Treatments and T e c h n o l o g i e s ORIGINAL AR T I C L E Homeostasis Model Assessment Closely Mirrors the Glucose Clamp Technique in the Assessment of Insulin Se n s i t i v i t y Studies in subjects with various degrees of glucose tolerance and insulin se n s i t i v i t y ENZO BONORA, MD, PHD FRANCESCA SAGGIANI, MD sulin sensitivity (7). However, this method GIOVANNI TARGHER, MD MARINA B. ZENERE, MD is laborious, expensive, and theref o r e un- MARIA ALBERICHE, MD TIZIANO MONAUNI, MD suitable for large-scale or epidemiological RICCARDO C. BONADONNA, MD MICHELE MUGGEO, MD studies. Several alternative methods to evaluate insulin sensitivity have been pro- posed during the last two decades (8–13), but, although generally less complex and less troublesome than the glucose clamp OB J E C T I V E — To evaluate whether the homeostasis model assessment (HOMA) is a rel i - technique, none of them is as simple as is able surrogate measure of in vivo insulin sensitivity in humans. ne c e s s a r y in large-scale studies involving RESEARCH DESIGN AND METHODS — In the present study, we compared insulin hu n d r eds or thousands of subjects. sensitivity as assessed by a 4-h euglycemic ( 5 mmol/l) hyperinsulinemic ( 300 pmol/l) clamp Homeostasis model assessment (HOMA) with HOMA in 115 subjects with various degrees of glucose tolerance and insulin sensitivity. of insulin sensitivity was proposed about 10 years ago as a simple and inexpensive alter- RE S U LT S — We found a strong correlation between clamp-measured total glucose disposal native to more sophisticated techniques and HOMA-estimated insulin sensitivity (r = 0.820, P 0.0001), with no substantial dif- (14). Such a method derives an estimate of fe r ences between men (r = 0.800) and women (r = 0.796), younger (aged 50 years, r = insulin sensitivity from the mathematical 0.832) and older (r = 0.800) subjects, nonobese (BMI 27 kg/m2, r = 0.800) and obese modeling of fasting plasma glucose and in- (r = 0.765) subjects, nondiabetic (r = 0.754) and diabetic (r = 0.695) subjects, and nor- sulin concentrations. Although the HOMA motensive ( r = 0.786) and hypertensive (r = 0.762) subjects. Also, we found good agree - has been recently used in several clinical ment between the two methods in the categorization of subjects according to insulin sensitiv- ity (weighted k = 0.63). and epidemiological studies (15–24), it has not been definitely validated. Indeed, few CO N C L U S I O N S — We conclude that the HOMA can be reliably used in large-scale or data are available that compare insulin sen- epidemiological studies in which only a fasting blood sample is available to assess in- sitivity estimated by the HOMA with that sulin sensitivity. me a s u r ed by the glucose clamp technique (1 2 , 2 5 , 2 6 ) . Diabetes Care 23 :5 7 –63, 2000 In the present study, we perf o rm e d euglycemic hyperinsulinemic clamp stud- ies in combination with tracer glucose in- everal studies consistently demon- investigational and clinical relevance in fusion to measure insulin-stimulated glu- strated that insulin resistance is a identifying subjects at high risk of type 2 cose disposal in 115 individuals with Ss t rong predictor of type 2 diabetes diabetes and/or cardiovascular disease. various degrees of glucose tolerance and (1,2). More rec e n t l y , insulin resistance has Insulin resistance can be measured by insulin sensitivity and compared the been shown to be associated with prev a - using the glucose clamp technique (6), clamp studies with the estimate of insulin lent atheros c l e r osis (3–5). Thus, the rec o g - which is reg a r ded as the ref e r ence method sensitivity derived by the HOMA. nition of insulin resistance seems to have for an accurate assessment of in vivo in- RESEARCH DESIGN AND ME T H O D S F rom the Division of Endocrinology and Metabolic Diseases, University of Ve rona Medical School, Ve rona, Italy. Ad d r ess correspondence and reprint requests to Prof. Enzo Bonora, Endocrinologia e Malattie del Me- Subjects tabolismo, Ospedale Civile Maggiore, Piazzale Stefani, 1, I-37126 Ver ona, Italy. E-mail: [email protected]. The study included 115 subjects who all Received for publication 22 March 1999 and accepted in revised form 13 September 1999. un d e r went a glucose clamp with the for- Ab b re v i a t i o n s : CV , coefficient of variation; GIR, glucose infusion rate; HOMA, homeostasis model as- sessment; IVGTT, intravenous glucose tolerance test; TGD, total glucose disposal. mat described below in our laboratory in A table elsewhere in this issue shows conventional and Système International (SI) units and conversion 1995 and 1996. A total of 53 subjects with factors for many substances. type 2 diabetes was rec r uited among those DIABETES CARE, VOLUME 23, NUMBER 1, JANUARY 2000 57 HOMA in the assessment of insulin sensitivity Table 1—Main clinical characteristics of subjects under study ef ficient of variation [CV]) was 5% in all subjects. At 2 h after the beginning of the Su b j e c t s glucose clamp, a prime constant infusion of 3-[3H ] -D-glucose was initiated at the No n d i a b e t i c Type 2 diabetic rate of 0.45 µCi/min and was continued Sex (M/F) 12 / 5 0 37 / 1 6 until the end of the study. The prime dose Age (years) 41.3 ± 1.4 (19 to 63) 55.6 ± 1.0 (31 to 67) of labeled glucose was calculated by divid- Body weight (kg) 76.9 ± 2.2 (53 to 115) 75.9 ± 1.4 (52 to 104) ing the glucose pool (plasma glucose con- BMI (kg/m2) 27.8 ± 0.7 (19 to 45) 27.7 ± 0.6 (20 to 51) centration glucose distribution volume Waist-to-hip ratio 0.88 ± 0.01 (0.73 to 1.04) 0.97 ± 0.01 (0.83 to 1.01) assumed to be 25% of body weight) by Fasting insulin (pmol/l) 63 ± 4 (21 to 182) 96 ± 7 (14 to 224) the product of 1.1 by the glucose infusion Fasting glucose (mmol/l) 5.0 ± 0.05 (4.3 to 6.0) 9.72 ± 0.35 (4.4 to 16.2) rate (GIR) from 100 to 120 min of the Hb A 1c (%) — 6.6 ± 0.2 (4.2 to 9.0) study and then multiplying the result by HOMA score 2.06 ± 0.14 (0.7 to 6.5) 5.98 ± 0.48 (1.1 to 13.9) the tracer infusion rate. GIR was multi- TGD during clamp (µmol 34.6 ± 1.6 (17.4 to 75.9) 21.0 ± 1.1 (7.8 to 52.5) plied by 1.1 to take into account the ex- mi n –1 kg –1 fa t - f r ee mass) pected 10% average increase in GIR from Glucose rate of appearance 0.92 ± 0.50 ( 6.39 to 8.28) 4.1 ± 0.7 ( 5.4 to 13.4) 100–120 to 180–240 min of the glucose during clamp (µmol mi n –1 clamp. As previously rep o r ted (29), with kg –1 fa t - f r ee mass) this methodological approach, a steady Hy p e r tension (%) ( 160/95 25 . 8 56 . 6 state of tritiated glucose specific activity is mmHg or trea t m e n t ) obtained from 180 to 240 min of the Obesity (%) 41 . 9 37 . 7 clamp. In fact, in the entire group we ex- Data are means ± SEM (range) or %. amined, mean specific activity at 180 min and at 240 min averaged 843 ± 32 and 821 ± 33 dpm/µmol, res p e c t i v e l y , with a regularly attending the Diabetes Clinic at was perf o rmed in combination with CV of 2.5 ± 0.3% from 180 to 240 min. the University of Ver ona who were willing 3- [ 3H] - D-glucose infusion, as prev i o u s l y During this period, blood was drawn to participate in the study. Of these pa- rep o r ted in detail (28), to assess total glu- ev e r y 10 min to measure plasma levels of tients, 10 were treated with diet only, and cose disposal (TGD) accurately. glucose, serum insulin, and plasma triti- 43 were taking oral hypoglycemic agents All studies began at 8:00 A.M. Sub- ated glucose specific activity. Insulin-me- (22 were taking sulfonylureas, 21 were jects were admitted to the hospital after a diated TGD rate was calculated by divid- taking sulfonylureas plus metformin). Pa- 10- to 12-h overnight fast. Briefly, two ing the 3-[3H] - D-glucose infusion rate by tients taking insulin were excluded from Teflon cannulas were inserted: one was the steady-state 3-[3H] - D-glucose specific the study, and 62 nondiabetic subjects in s e r ted into an antecubital vein for infu- ac t i v i t y . More details have been rep o rt e d w e re re c ruited by an advertisement. All sion of insulin, glucose (20% dextrose), and el s e w h e r e (28). pa r ticipants underwent a physical exami- 3- [ 3H] - D-glucose, and the other was in- nation and routine blood chemistry evalu- se r ted into a contralateral heated ( 60 ° C ) Analytical determinations ation.
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