University of South Florida Scholar Commons Graduate Theses and Dissertations Graduate School 3-16-2016 Metabolic Therapy for Age-Dependent Impaired Wound Healing Shannon Lynn Kesl Follow this and additional works at: http://scholarcommons.usf.edu/etd Part of the Physiology Commons Scholar Commons Citation Kesl, Shannon Lynn, "Metabolic Therapy for Age-Dependent Impaired Wound Healing" (2016). Graduate Theses and Dissertations. http://scholarcommons.usf.edu/etd/6104 This Dissertation is brought to you for free and open access by the Graduate School at Scholar Commons. It has been accepted for inclusion in Graduate Theses and Dissertations by an authorized administrator of Scholar Commons. For more information, please contact
[email protected]. Metabolic Therapy for Age-Dependent Impaired Wound Healing by Shannon Lynn Kesl A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy Department of Molecular Physiology and Pharmacology Morsani College of Medicine University of South Florida Co-Major Professor: Dominic D’Agostino, Ph.D. Co-Major Professor: Mack Wu, M.D. Lisa Gould, M.D., Ph.D. Thomas Taylor-Clark, Ph.D. Paula Bickford, Ph.D. Kenneth Ugen, Ph.D. Date of Approval: December 09, 2015 Keywords: Aging, Chronic Wounds, Ketosis, Exogenous Ketone Supplementation Copyright © 2016, Shannon Lynn Kesl ACKNOWLEDGEMENTS The research included in this dissertation was made possible by support from our funding sources, including the James A. Haley Veterans Hospital’s Merit Review, the Department of Molecular Pharmacology and Physiology, Scivation Inc., and the Office of Naval Research (ONR). I would like to express my heartfelt gratitude to everyone who has supported me in my pursuit of my doctoral degree.