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Cop Supp Maedica.Cdr Under the Auspices of the University of Medicine and Pharmacy CAROL DAVILA Volume 13 (16) Supplement 2018 Supplement Congress of the University of Medicine and Pharmacy CAROL DAVILA (June 7th-9th 2018) ISSN 2501-6903 ISSN-L 2501-6903 Volume 13 Supplement 2018 Editor-in-chief Deputy Editors Mircea CINTEZA (Romania) Dragos VINEREANU (Romania) Bogdan O. POPESCU (Romania) Senior Editors Ioanel SINESCU (Romania) Managing editors Alan G. FRASER (UK) Eliza Elena CINTEZA (Romania) Adriana ILIESIU (Romania) International Editorial Board Scientific Publishing Committee (University of Medicine and Pharmacy 1. Martin BURIAN (Austria) Carol Davila) 2. Gianfranco BUTERA (Italy) 3. Gheorghe CERIN (Italy) 1. Petru ARMEAN 4. Adrian COVIC (Romania) 2. Mihaela BALGRADEAN 5. Maurizio CUTOLO (Italy) 3. Ovidiu BAJENARU 6. Marco DIENA (Italy) 4. Mircea BEURAN 7. Heiner FANGERAU (Germany) 5. Dana BODNAR 8. Antonio FEDERICO (Italy) 6. Miron BOGDAN 9. Nicholas GOURTSOYIANNIS (Greece) 7. Alexandru BUCUR 10. Christopher GRANGER (USA) 8. Emanoil CEAUSU 11. Nicolae HANCU (Romania) 9. Delia CINTEZA 12. Marc HUMBERT (France) 10. Catalin CIRSTOIU 13. Mircea IVAN (USA) 11. Ileana CONSTANTINESCU 14. Vecsei LASZLO (Hungary) 12. Mircea DICULESCU 15. Gerald MAURER (Austria) 13. Ion FULGA 16. Serban MIHAILEANU (France) 14. Daniela FILIPESCU 17. Radu MIHAI (UK) 15. Mihai HINESCU 18. Lucian MIRON (Romania) 16. Ecaterina IONESCU 19. Piero PORTINCASA (Italy) 17. Ruxandra IONESCU 20. Schmidt THORSTEN (Germany) 18. Anca LUPU 21. Emil TOESCU (UK) 19. Dumitru LUPULIASA 22. Selman URANUES (Austria) 20. Dana MINCA 23. Victor VOICU (Romania) 21. Cristina PARVU DINU 22. Doina PLESCA 23. Bogdan A POPESCU 24. Adrian STREINU-CERCEL 25. Radu VLADAREANU IMPORTANT: • The journal is granted with B+ indicative by the CNCSIS. • The annual subscription comes along with a CMR certificate that offers you 5 EMC points. • Attention! The subscription can be solicited starting with any edition of the Medical Journal. For more information, please visit www.maedica.org. COPYRIGHT: All data, information and protocols from the official site www.maedica.org and MÆDICA - a Journal of Clinical Medicine may be reproduced, copied or adapted, freely and unconditionally, under the provision to mention the source as follows: “taken/adapted from MÆDICA - a Journal of Clinical Medicine.” PUBLISHER: MEDIA MED PUBLICIS Address of editorial staff: 10, Petofi Sandor, District 1, Bucharest Phone: +4031 101 13 221 Mædica J Clin Med. www.maedica.org ISSN: 2501-6903 ISSN-L: 2501-6903 MAEDICA - a Journal of Clinical Medicine A valuable Journal of clinical medicine, MAEDICA, has as a main purpose to enrich the quality of the medical practice in Romania through its scientific specialized content. From the summary: – the newest studies, research and discussions in clinical medicine nowadays; – scientific editorials that reflect an up-to-date synthesis of the results in the newest na- tional and international medical papers and research; – a number of clinical Romanian works and also articles from international collaborators; – the content of the Journal is in English only. The Journal has a great peer-review board and its content respects the international stan- dards of certified quality and originality of the articles. Subsequent to the CNCSIS accreditation, the publication was granted B+. At the present moment, MAEDICA - a Journal of Clinical Medicine is part of the inter- national data bases as follows: – PubMed – EBSCO COMITET DE ORGANIZARE / ORGANIZING COMMITTEE Acad. Ioanel SINESCU Congress Chairman, Rector Prof. Dragoş VINEREANU Congress Chairman, Vice-Rector Prof. Mircea BEURAN President of the Senate Prof. Ecaterina IONESCU Vice-Rector Prof. Cătălina POIANĂ Vice-Rector Prof. Viorel JINGA Vice-Rector Prof. Bogdan O. POPESCU Vice-Rector Prof. Dana MINCA Vice-Rector Prof. Dumitru LUPULIASA Director of the Committee for PhD University Studies Prof. Cătălin CÎRSTOIU Dean Prof. Doina DRĂGĂNESCU Dean Conf. Paula PERLEA Dean Conf. Nicoleta MARU Dean of the Faculty of Nurses and Midwives Prof. Ileana CONSTANTINESCU Director of Department for Grants and Scientific Research Prof. Simona RUTA Vice-Dean for Scientific Research Prof. Cristina PÂRVU Vice-Dean for Scientific Research Prof. Andreea DIDILESCU Vice-Dean for Scientific Research Prof. Mircea Ioan POPA Chairman of the Research Ethics Committee Prof. Ovidiu BĂJENARU Chairman of the Senate’s Scientific Research Committee Prof. Victor PURCĂREA Director of Publishing House Carol Davila Prof. Cristian CURCĂ Chairman of the Academic Ethics and Deontology Committee Prof. Octavian BUDA History of Medicine Dr. Silviu PIŢURU General Secretary Ing. Eugenia MIHAI Administrative Director Mædica - a Journal of Clinical Medicine Content Abstracts of the posters exposed at the Congress of the University of Medicine and Pharmacy Carol Davila, Bucharest (June 7th-9th 2018) Young Investigator Award 3 Surgical Specialities 3 Medical Specialities 6 Pharmacy 9 Preclinical Specialities 12 Dental Medicine 17 Pharmacy 33 Preclinical Specialities 47 Surgical Specialities 49 Medical Specialities 97 Maedica A Journal of Clinical Medicine, Volume 12, Supplement, 2017 1 Mædica - a Journal of Clinical Medicine YOOUNGUNG INNVESTIGATORVESTIGATOR AWWARDARD SURGICAL SPECIALITIES (ID 132) The importance of the intrauterine environment on (ID 108) Matrix longevity - gestational obesity as metalloproteinases: a possible prediction factor for reduced new marker of the effectiveness lifespan in descendants of bariatric surgery Diana-Elena Comandasu1, Bogdana Virgolici2, Radu Mihail Mirica1,2, Mihai Ionescu1, Alexandra Maria Mohora2, Claudia Mehedintu3, Costin Mirica5, Octav Ginghina1,3, Razvan Iosifescu1,3, Berceanu4, Mihai Mitran1, Elvira Bratila1 Adrian Rosca2, Laura Gaman4, Bogdan Marinescu6, Nicolae Iordache1,3, Leon Zagrean2 1Department of Obstetrics and Gynecology, University of Medicine and Pharmacy Carol Davila, Bucharest, 1 Emergency Hospital St. John, Bucharest, Romania Romania, Panait Sarbu Clinical Obstetrics Gynecology 2 Department of Physiology and Neuroscience, Hospital, Bucharest, Romania University of Medicine and Pharmacy Carol Davila, 2Department Biochemistry, University of Medicine and Bucharest, Romania Pharmacy Carol Davila, Bucharest, Romania 3 University of Medicine and Pharmacy Carol Davila, 3Department of Obstetrics and Gynecology, Nicolae Bucharest, Romania, Department of General Surgery, Malaxa Clinical Emergency Hospital, University of St. John Hospital, Bucharest, Romania Medicine and Pharmacy Carol Davila, Bucharest, 4 Department of Biochemistry, University of Medicine Romania and Pharmacy Carol Davila, Bucharest, Romania 4Department of Obstetrics and Gynecology, University 5 National Institute of Endocrinology C.I. Parhon, of Medicine and Pharmacy, Craiova County Hospital, Bucharest, Romania Craiova, Romania 6Faculty of Veterinary medicine, University of agronomic sciences and veterinary medicine, Objective: Obesity represents a common pregnan- Bucharest, Romania cy comorbidity causing obstetrical, neonatal and long- term complications. We aim to present the conse- quences of gestational obesity on lifespan prognosis of Introduction: Matrix metalloproteinases (MMPs) the descendants, showing that longevity is highly cor- are known ezymes involved in the modulation of extra- related with the quality of the intrauterine environ- cellular matrix (ECM) and adipocyte and preadipocytes ment. differentiation. Obesity implies a more or less rapid but Method: We studied the effects of maternal obesi- generalized increase in adipose tissue (adipocyte and ty on descendants’ health in adulthood using 30 obese preadipocytes) and these processes generate abnormal female Wistar rats. We induced rats the obesity by ECM metabolism. high-calorie high-fat diet administered by gavage and Aim: This study purpose was to determine if we bread them. The pregnant females were then divided can consider MMPs as a marker of effectiveness in bar- into a group receiving normal diet and another one that continued the fat alimentation during gestation. iatric surgery. Results: Obese rat females were followed through- Materials and methods: The experimental study out gestation and sacrificed at term, along with part of used 20 obese wistar rats (10 in control group and 10 their pups, while another part were followed until nat- in Study group).The study group had gastric by-pass for ural death. We analysed the secretion of adipokines obesity, and there were analyzed the pre and post- op- from maternal blood (leptin and adiponectin), lipid erative MMP-2 and MMP-9. We compared the results peroxidation levels by malonyl-dialdehyde and gluta- in order to see if bariatric surgery modifies the MMPs tion as antioxidant factor from placental homogenates status and if there is a correlation between the weight and maternal blood. Low levels of adiponectin and in- loss and the values of MMPs. creased of leptin positively correlated with placental Results: lipid peroxidation measured by elevated MDA and low The MMP-2 and MMP-9 activities were levels of GSH. Placental histology showed dysplastic detectable, but MMP-2 activity was significantly higher epithelial and mesoderm cells in the yolk sac, a higher than MMP-9. MMP-9 was strongly correlated with density of inflammatory cells and congested vessels body weight parameters before surgery, as well as after with thrombotic areas and glycogen trophoblast depos- significant body weight reduction as a result of bariatric its in the fat group. Following the pups
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