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Deficiency of the Zinc Finger Protein ZFP106 Causes Motor and Sensory
Human Molecular Genetics, 2016, Vol. 25, No. 2 291–307 doi: 10.1093/hmg/ddv471 Advance Access Publication Date: 24 November 2015 Original Article ORIGINAL ARTICLE Deficiency of the zinc finger protein ZFP106 causes Downloaded from https://academic.oup.com/hmg/article/25/2/291/2384594 by guest on 23 September 2021 motor and sensory neurodegeneration Peter I. Joyce1, Pietro Fratta2,†, Allison S. Landman1,†, Philip Mcgoldrick2,†, Henning Wackerhage3, Michael Groves2, Bharani Shiva Busam3, Jorge Galino4, Silvia Corrochano1, Olga A. Beskina2, Christopher Esapa1, Edward Ryder4, Sarah Carter1, Michelle Stewart1, Gemma Codner1, Helen Hilton1, Lydia Teboul1, Jennifer Tucker1, Arimantas Lionikas3, Jeanne Estabel5, Ramiro Ramirez-Solis5, Jacqueline K. White5, Sebastian Brandner2, Vincent Plagnol6, David L. H. Bennet4,AndreyY.Abramov2,LindaGreensmith2,*, Elizabeth M. C. Fisher2,* and Abraham Acevedo-Arozena1,* 1MRC Mammalian Genetics Unit, Harwell, Oxfordshire OX11 0RD, UK, 2UCL Institute of Neurology and MRC Centre for Neuromuscular Disease, Queen Square, London WC1N 3BG, UK, 3Health Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK, 4Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK, 5Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK and 6UCL Genetics Institute, London WC1E 6BT, UK *To whom correspondence should be addressed. Email: [email protected] (A.A.)/e.fi[email protected] (E.M.C.F.)/[email protected] (L.G.) Abstract Zinc finger motifs are distributed amongst many eukaryotic protein families, directing nucleic acid–protein and protein–protein interactions. Zinc finger protein 106 (ZFP106) has previously been associated with roles in immune response, muscle differentiation, testes development and DNA damage, although little is known about its specific function. -
Nuachtlitiraibreán 2017
APRIL 2017 NUACHTLITIRAIBREÁN 2017 FOR NEWS, VIDEOS AND FIXTURES www.gaa.ie Football Hurling Club General LÁ NA gCLUBANNA The importance of YOUR GAA club in YOUR community will be highlighted on the first weekend in May as ‘Lá na gClubanna’ takes place on 6/7th May. Cumann Lúthchleas Gael is making prizes available to clubs who participate in Lá na gClubanna including the chance to win an overnight stay and match tickets to an All-Ireland senior semi-final of their choice. As well as that, ‘Lá na gClubanna’ events will be captured by professional photography and video for two lucky clubs. For YOUR club to be in with a chance of winning, clubs can submit their plans by email to [email protected] detailing why it is they should win and what lengths they have gone to in order to organise their Lá na gClubanna events. The GAA is encouraging every member to mark this special day of celebration by participating at events in their club in recognition of the vital role that our clubs and members play at the heart of the GAA. For full information, visit www.gaa.ie/lanagclubanna Football Hurling Club General CROKE PARK DREAM FULFILLED FOR 7,000 KIDS AT GAA GO GAMES or 7,000 lucky children from across the 32 counties the recent Easter holidays had a bigger treat in store than just Fchocolate. That’s because they and their clubs got the precious opportunity to play at Croke Park as part of the Littlewoods Ireland GAA GO Games festival over eight unforgettable days at HQ. -
Abstracts of Papers Presented at the Tenth Mammalian Genetics And
Genet. Res., Camb. (2000), 76, pp. 199–214. Printed in the United Kingdom # 2000 Cambridge University Press 199 Abstracts of papers presented at the tenth Mammalian Genetics and Deelopment Workshop (Incorporating the Promega Young Geneticists’ Meeting) held at the Institute of Child Health, Uniersity College London on 17–19Noember 1999 " # Edited by: ANDREW J. COPP AND ELIZABETH M. C. FISHER 1Institute of Child Health, Uniersity College London, 30 Guilford Street, London WC1N 1EH, UK # Neurogenetics Unit, Imperial College School of Medicine, St Mary’s Hospital, Norfolk Place, London W2 1PG, UK Sponsored by: The Genetical Society, Promega (UK) Ltd and B&K Universal Group Ltd Evidence for imprinting in type 2 diabetes: detection of Identification of a locus for primary ciliary dyskinesia parent-of-origin effects at the insulin gene on chromosome 19 " " " STEWART HUXTABLE, PHILIP SAKER, LEMA S. L. SPIDEN , M. MEEKS , A. J. WALNE ,H. # # HADDAD, ANDREW HATTERSLEY, MARK BLAU , H. MUSSAFFI-GEORGY ,H. $ % % WALKER and MARK McCARTHY SIMPSON , M. EL FEHAID , M. CHEEBAB ,M. % % Section of Endocrinology, Imperial College School of AL-DABBAGH , H. D. HAMMUM ,R.M. " " Medicine, St Mary’s Hospital, London, UK GARDINER , E. M. K. CHUNG and H. M. " MITCHISON " Variation at the insulin gene (INS) VNTR is impli- Department of Paediatrics, Royal Free and Uniersity cated in type 1 diabetes, polycystic ovarian syndrome College Medical School, Uniersity College London, # and birthweight. Case-control studies inconsistently UK; Schneider Children’s Medical Center of Israel, $ show class III VNTR association with type 2 diabetes, Petech Tika, Israel; School of Medical Sciences, but may result from population stratification. -
Campaigners to Fly Drone with Abortion Pills Site Web Enter Your Search Across Irish Border Like Follow by REUTERS Daily Mail @Mailonline
Campaigners to fly drone with abortion pills across Irish border | Daily Mail Online 16/06/16 21:42 Follow @MailOnline Thursday, Jun 16th 2016 11PM 14°C 2AM 13°C 5-Day Forecast Home News U.S. Sport TV&Showbiz Australia Femail Health Science Money Video Travel Fashion Finder Wires Home Login YOU MIGHT LIKE Sponsored Links by Taboola Jonc Cancun 95 € - lexception.com What Little Hercules Looks Like Now is Shocking (Photos) MyFirstClassLife Isabella Dress - Champagne WantMyLook 7 tricks to learn ANY language in 7 days Babbel [TOP 10] 10 Stars With A PhD News For Ants World's Most Haunting Abandoned Places CrazeCentral Campaigners to fly drone with abortion pills Site Web Enter your search across Irish border Like Follow By REUTERS Daily Mail @MailOnline PUBLISHED: 18:26 GMT, 16 June 2016 | UPDATED: 18:26 GMT, 16 June 2016 Follow +1 Daily Mail Daily Mail DON'T MISS By Umberto Bacchi Tom Hiddleston LONDON, June 16 (Thomson Reuters Foundation) - Pro-choice groups plan to fly a drone carrying gushes over 'charming' Taylor Swift in recent abortion pills from Ireland to Northern Ireland in protest against restrictions on terminations on both interview... as picture sides of the border, activists said on Thursday. emerges of couple Organisers said the move was intended as a show of solidarity between women facing some of the together WEEKS ago Did it all start then? strictest abortion laws in Europe. In Ireland and Northern Ireland, abortion is permitted if the mother's life is in danger. In Northern That didn't last long! Ireland, it is also allowed if there is a permanent or serious risk to a woman's mental or physical health. -
Forget Retail! Buy Wholesale Direct! Over $10.6 Million Inventory Available Same Day
Forget Retail! Buy Wholesale Direct! Over $10.6 million inventory available same day. Family owned for more than 40 years. Value to premium parts available. 902-423-7127 | WWW.CANDRAUTOSUPPLY.CA | 2513 AGRICOLA ST., HALIFAX 144518 Monday, June 25, 2018 Volume 52, Issue 13 www.tridentnewspaper.com CAF members send Canada Day greetings from the flight deck of HMCS St. John’s during Op REASSURANCE. CPL TONY CHAND, FIS Happy Canada Day from HMCS St. John’s RCAF Honorary Colonel HMCS Haida designated Kayak trip supports Atlantic Regional conference Pg. 7 RCN Flagship Pg. 9 HMCS Sackville Pg. 12 Powerlifting Pg. 20 CAF Veterans who completed Basic Training and are Honorably Discharged are eligible for the CANEX No Interest Credit Plan. (OAC) CANADA’S MILITARY STORE LE MAGASIN MILITAIRE DU CANADA Canex Windsor Park | 902-465-5414 152268 2 TRIDENT NEWS JUNE 25, 2018 Former NESOPs welcomed back to RCN through Skilled Re-enrollment Initiative By Ryan Melanson, ance in some cases, was a factor in Trident Staff bringing him back to the Navy. “It was something I was consider- The RCN has been making an extra ing, but I was still enjoying my time effort to bring recently retired sailors with my family and I wasn’t sure back to the organization, and the two about it. When I got the letter and first members to take advantage of heard about this, that definitely had this Skilled Re-enrollment Initiative an impact on my decision.” have now made it official. In addressing the brand new re- LS Kenneth Squibb and LS Steven cruits at the ceremony, RAdm Baines Auchu, both NESOPs with sailing recalled his own enrollment in the experience, who each retired from CAF nearly 31 years ago, and the un- the Navy less than two years ago, will certainty that came with it. -
15-12596-Mg Doc 202 Filed 11/24/15 Entered 11/24/15 14:18:16 Main Document Pg 1 Of
15-12596-mg Doc 202 Filed 11/24/15 Entered 11/24/15 14:18:16 Main Document Pg 1 of 260 15-12596-mg Doc 202 Filed 11/24/15 Entered 11/24/15 14:18:16 Main Document Pg 2 of 260 Quirky, Inc.,-Service15-12596-mg List to Doc e-mail 202 Recipients Filed 11/24/15 Entered 11/24/15 14:18:16 Main Document Served 11-19-15 Pg 3 of 260 Name Not Provided Name Not Provided Name Not Provided Name Not Provided Email Address Redacted Email Address Redacted Email Address Redacted Email Address Redacted Name Not Provided Name Not Provided Name Not Provided Name Not Provided Email Address Redacted Email Address Redacted Email Address Redacted Email Address Redacted Name Not Provided Name Not Provided Name Not Provided Name Not Provided Email Address Redacted Email Address Redacted Email Address Redacted Email Address Redacted Name Not Provided Name Not Provided Name Not Provided Name Not Provided Email Address Redacted Email Address Redacted Email Address Redacted Email Address Redacted Name Not Provided Name Not Provided Name Not Provided Name Not Provided Email Address Redacted Email Address Redacted Email Address Redacted Email Address Redacted Name Not Provided Name Not Provided Name Not Provided Name Not Provided Email Address Redacted Email Address Redacted Email Address Redacted Email Address Redacted Name Not Provided Name Not Provided Name Not Provided Name Not Provided Email Address Redacted Email Address Redacted Email Address Redacted Email Address Redacted Name Not Provided Name Not Provided Name Not Provided Name Not Provided Email Address Redacted -
Broadcast Bulletin Issue Number 150 25/01/10
Ofcom Broadcast Bulletin Issue number 150 25 January 2010 1 Ofcom Broadcast Bulletin, Issue 150 25 January 2010 Contents Introduction 3 Standards cases In Breach Steve Power at Breakfast Wave 105 (Solent and surrounding area), 3 December 2009, 05:30 4 Ruhaniat and Tib-e-Nabvi [this decision has now been removed from this Bulletin – see note at page 6] Venus TV, 9 September 2009, 12:05 6 The X Factor Results Show ITV 1, 25 October 2009, 20:00 7 Really Caught in the Act ITV4, 1 December 2009, 13:25 9 Yvette and Karl: Down on One Knee Living, 7 November 2009, 20:00 10 Retention of recordings ABS-CBN News Channel, 6 November 2009 11 Resolved The Early Morning Breakfast Show Pirate FM, 14 November 2009, 09:00 12 Fairness & Privacy cases There are no Fairness and Privacy Adjudications in this Bulletin. Other programmes not in breach 14 2 Ofcom Broadcast Bulletin, Issue 150 25 January 2010 Introduction The Broadcast Bulletin reports on the outcome of investigations into alleged breaches of those Ofcom codes which broadcasting licensees are required to comply. These include: a) Ofcom‟s Broadcasting Code (“the Code”) which took effect on 16 December 2009 and covers all programmes broadcast on or after 16 December 2009. The Broadcasting Code can be found at http://www.ofcom.org.uk/tv/ifi/codes/bcode/. Note: Programmes broadcast prior to 16 December 2009 are covered by the 2005 Code which came into effect on 25 July 2005 (with the exception of Rule 10.17 which came into effect on 1 July 2005). -
Duke University Commencement ~ 2013
Sunday, the Twelfth of May, Two Thousand and Thirteen ten o’clock in the morning ~ wallace wade stadium Duke University Commencement ~ 2013 One Hundred Sixty-First Commencement Notes on Academic Dress Academic dress had its origin in the Middle Ages. When the European universities were taking form in the thirteenth and fourteenth centuries, scholars were also clerics, and they adopted Mace and Chain of Office robes similar to those of their monastic orders. Caps were a necessity in drafty buildings, and copes or capes with hoods attached were Again at commencement, ceremonial use is needed for warmth. As the control of universities made of two important insignia given to Duke gradually passed from the church, academic University in memory of Benjamin N. Duke. costume began to take on brighter hues and to Both the mace and chain of office are the gifts employ varied patterns in cut and color of gown of anonymous donors and of the Mary Duke and type of headdress. Biddle Foundation. They were designed and executed by Professor Kurt J. Matzdorf of New The use of academic costume in the United Paltz, New York, and were dedicated and first States has been continuous since Colonial times, used at the inaugural ceremonies of President but a clear protocol did not emerge until an Sanford in 1970. intercollegiate commission in 1893 recommended a uniform code. In this country, the design of a The Mace, the symbol of authority of the gown varies with the degree held. The bachelor’s University, is made of sterling silver throughout. It is thirty-seven inches long and weighs about gown is relatively simple with long pointed Significance of Colors sleeves as its distinguishing mark. -
1987-04-05 Liverpool
ARSENAL vLIVERPOOL thearsenalhistory.com SUNDAY 5th APRIL 1987 KICK OFF 3. 5pm OFFICIAL SOUVENIR "'~ £1 ~i\.c'.·'A': ·ttlewcrrJs ~ CHALLENGE• CUP P.O. CARTER, C.B.E. SIR JOHN MOORES, C.B.E. R.H.G. KELLY, F.C.l.S. President, The Football League President, The Littlewoods Organisation Secretary, The Football League 1.30 p.m. SELECTIONS BY THE BRISTOL UNICORNS YOUTH BAND (Under the Direction of Bandmaster D. A. Rogers. BEM) 2.15 p.m. LITTLEWOODS JUNIOR CHALLENGE Exhibition 6-A-Side Match organised by the National Association of Boys' Clubs featuring the Finalists of the Littlewoods Junior Challenge Cup 2.45 p.m. FURTHER SELECTIONS BY THE BRISTOL UNICORNS YOUTH BAND 3.05 p.m. PRESENTATION OF THE TEAMS TO SIR JOHN MOORES, C.B.E. President, The Littlewoods Organisation NATIONAL ANTHEM 3.15 p.m. KICK-OFF 4.00 p.m. HALF TIME Marching Display by the Bristol Unicorns Youth Band 4.55 p.m. END OF MATCH PRESENTATION OF THE LITTLEWOODS CHALLENGE CUP BY SIR JOHN MOORES Commemorative Covers The official commemorative cover for this afternoon's Littlewoods Challenge Cup match Arsenal v Liverpool £1.50 including post and packaging Wembley offers these superbly designed covers for most major matches played at the Stadium and thearsenalhistory.com has a selection of covers from previous League, Cup and International games available on request. For just £1.50 per year, Wembley will keep you up to date on new issues and back numbers, plus occasional bargain packs. MIDDLE TAR As defined by H.M. Government PLEASE SEND FOR DETAILS to : Mail Order Department, Wembley Stadium Ltd, Wembley, Warning: SMOKING CAN CAUSE HEART DISEASE Middlesex HA9 ODW Health Departments' Chief Medical Officers Front Cover Design by: CREATIVE SERVICES, HATFIELD 3 ltlewcms ARSENAL F .C. -
Llista De 35.597 Morts Documentades De Persones Refugiades I Migrants
Llista de 35.597 morts documentades de persones refugiades i migrants, conseqüència de les polítiques restrictives de l'"Europa Fortalesa” Documentació de UNITED a dia 30 de setembre de 2018 Polítiques assassines - És hora de canviar! Informació sobre la campanya: UnitedAgainstRefugeeDeaths.eu, [email protected], Facebook: UNITED Against Refugee Deaths, Twitter: @UNITED__Network #AgainstRefugeeDeaths UNITED for Intercultural Action, xarxa europea contra el nacionalisme, el racisme, el feixisme i per al suport a immigrants i refugiats. - www.unitedagainstracism.org Secretariat a Amsterdam: Postbus 413 NL-1000 AK Amsterdam, Holanda, tel. +31-6-48808808, [email protected], La Llista de morts documentades de UNITED es pot reutilitzar lliurement, traduir i redistribuir, sempre que se n'esmenti la font. Les persones investigadores poden obtenir aquesta llista en xls amb més dades de UNITED. nom, gènere, edat origen causa de mort fonts I.D. Identitat Desconeguda trobat nombre 30/09/18 7 I.D. (4 dones; 3 homes) Síria ofegats, cossos trobats a les costes d'Enez, província d'Edirne a Turquia; 2 desapareguts, 3 rescatats IOM/TurkCoastG 28/09/18 1 I.D. (dona) desconegut ofegada, cos trobat en avançat estat de descomposició a la platja de Penya Parda a La Herradura (ES) GranadaHoy/EFE/IOM 25/09/18 1 Hayat Belkacem (dona, 19) Marroc disparada per la marina del Marroc, van interceptar una embarcació migrant amb destinació a Espanya; 3 ferits Ansamed/Aljazeera/DailyMail/NYTimes 25/09/18 1 I.D. (home) Àfrica suposadament ofegat, cos trobat a la riba de l'illa d'Alborán, entre el Marroc i Espanya LV/IOM 23/09/18 1 I.D. -
49310 Hospital Radio
FRONT COVER DOCUMENT 126: FRONT COVER DOCUMENT 126 21/5/09 01:25 Page 1 IFC Heartbeat 126: IFC Heartbeat 126 21/5/09 01:27 Page 1 01 INTRO 126:01 INTRO 126 21/5/09 01:35 Page 1 Spring 2009 Issue 126 The Official Journal of the Hi Everyone, Hospital Broadcasting Association Heroes – we salute them all in this issue; whether it is the winners of the Hospital Radio Awards (you can find the full in this issue ... results on page 4), the heroes that Brett discusses in his column or indeed, Matt’s hero – let’s raise a glass to them all. In A Spin with our ‘Spin Doctor’ ................................................................2 But we must not forget the back room heroes either as All About Awards .......................................................................................... 3 without their hard work and dedication, Awards and National Hospital Radio Awards – The Winners .................................. 4 Conference just would not happen. So thank you Sean, Iain, All About Awards .......................................................................................... 5 John, Marie and every member of the team – we really do Committee Report ........................................................................................ 8 appreciate all you have done. And also sincere thanks to Andy Charity Law Update ...................................................................................... 9 Langford for the photographs. Awards for All ............................................................................................... -
Leinster Title Since 2011
VENI VIDI VICI Captain Stephen Cluxton imperiously Back in the saddle! raises the Delaney Cup in salute to the Kilkenny Captain Dublin supporters at Croke Park Lester Ryan raises the Bob O’Keeffe Cup as the Cats restored themselves to a first Leinster title since 2011 Back L-R: Kevin Nolan, Dean Rock, Darren Daly, Cian O’Sullivan, James McCarthy, Paddy Andrews, Cormac Costello, Sean Currie, Eoghan O’Gara, Michael Fitzsimons, Michael Darragh Macauley, Bernard Brogan, Denis Bastick, Tomás Brady, Darragh Back L-R: Aidan Fogarty, Tomás Keogh, Michael Walsh, Padraig Walsh, Brian Hogan, Paul Murphy, Joey Holden, Kieran Joyce, Jackie Nelson, Jonny Cooper, Kevin McManamon. Tyrrell, John Power, T.J. Reid, Colin Fennelly, Michael Walsh, Jonjo Farrell, Lester Ryan. Front L-R: Eric Lowndes, Davy Byrne, Paul Mannion, Nicky Devereaux, Philly McMahon, Stephen Cluxton, Diarmuid Connolly, Rory Front L-R: Mark Kelly, Eoin Murphy, Brian Kennedy, Conor Fogarty, Cillian Buckley, Richie Hogan, Eoin Larkin. David Herity, J.J. O’Carroll, Paul Flynn, Jack McCaffrey, Bryan Cullen, Alan Brogan. Delaney, Henry Shefflin, Tommy Walsh. Comhairle Laighean C.L.G. Tionólfar Comhdháil Cinn Bliana 2014 Arklow Bay Hotel, Cill Mhantáin ar dé hAoine, 30ú Eanair, 2015 ar 7.00 pm 2 Leinster GAA Convention Report 2014 Report Leinster GAAConvention Kilkenny - Electric Leinster Minor Hurling Champions 2014 Back L-R: Jason Barcoe, Donnacha O Connor, Jason Cleere, John Walsh, RossButler, Andrew Gaffney, Pat Lyng, Conor Delaney, Eoin Kenny Alan Murphy, Billy Ryan, Robbie Donnelly, Bill McDowell Front L-R: Gary Bryan, Liam Hennessy, Conor Doheny, Cathal McGrath, Darren Brennan,Luke Scanlon, Darragh Joyce (C), Conor Browne, Ronan Corcoran, Sean Morrissey, Liam Blanchfield.