CA8 Rabbit Pab

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Leader in Biomolecular Solutions for Life Science CA8 Rabbit pAb Catalog No.: A7544 Basic Information Background Catalog No. The protein encoded by this gene was initially named CA-related protein because of A7544 sequence similarity to other known carbonic anhydrase genes. However, the gene product lacks carbonic anhydrase activity (i.e., the reversible hydration of carbon Observed MW dioxide). The gene product continues to carry a carbonic anhydrase designation based 33kDa on clear sequence identity to other members of the carbonic anhydrase gene family. The absence of CA8 gene transcription in the cerebellum of the lurcher mutant in mice with a Calculated MW neurologic defect suggests an important role for this acatalytic form. Mutations in this 32kDa gene are associated with cerebellar ataxia, mental retardation, and dysequilibrium syndrome 3 (CMARQ3). Polymorphisms in this gene are associated with osteoporosis, Category and overexpression of this gene in osteosarcoma cells suggests an oncogenic role. Alternative splicing results in multiple transcript variants. Primary antibody Applications WB, IHC Cross-Reactivity Human, Mouse Recommended Dilutions Immunogen Information WB 1:500 - 1:2000 Gene ID Swiss Prot 767 P35219 IHC 1:50 - 1:200 Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human CA8 (NP_004047.3). Synonyms CA8;CA-RP;CA-VIII;CALS;CAMRQ3;CARP Contact Product Information www.abclonal.com Source Isotype Purification Rabbit IgG Affinity purification Storage Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. Validation Data Western blot analysis of extracts of various cell lines, using CA8 antibody (A7544) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. Immunohistochemistry of paraffin- embedded mouse cerebellum using CA8 antibody (A7544) at dilution of 1:100 (40x lens). Antibody | Protein | ELISA Kits | Enzyme | NGS | Service For research use only. Not for therapeutic or diagnostic purposes. Please visit http://abclonal.com for a complete listing of recommended products..

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A Survey of the Ce-Tubulin Gene Family in Chicken: Unexpected Sequence Heterogeneity in the Polypeptides Encoded by Five Expressed Genes
The EMBO Journal vol.7 no.4 pp.931 -940, 1988 A survey of the ce-tubulin gene family in chicken: unexpected sequence heterogeneity in the polypeptides encoded by five expressed genes Lisa F.Pratt1 and Don W.Cleveland encoding both a- and ,B-tubulin lay beneath this heterogeneity of microtubule utilization (see Cleveland and Sullivan, 1985; Department of Biological Chemistry, The Johns Hopkins University Cleveland, 1987). For ,3-tubulin, extensive analyses in School of Medicine, 725 N. Wolfe St., Baltimore, MD 21205, USA chicken (Sullivan and Cleveland, 1984; Sullivan et al., 1985, 'Present address: Division of Clinical Immunology, Scripps Clinic and 1986a,b; Murphy et al., 1987; Montiero and Cleveland, Research Foundation, 10666 N. Torrey Pines Road, La Jolla, CA 92037, USA 1988), mouse (Lewis et al., 1985a; Sullivan and Cleveland, 1986; Wang et al., 1986) and human (Hall et al., 1983; Lee Communicated by K.Weber et al., 1983; Lewis et al., 1985b; Sullivan and Cleveland, 1986) have revealed six functional vertebrate f-tubulins. At To characterize the a-tubulin gene family in chicken, we least four [and probably five-see Lopata and Cleveland have isolated five chicken a-tubulin genes and determined (1987)] of these represent distinct ,B-tubulin isotypes whose the majority of the sequences of the encoded polypep- sequences (particularly within a carboxy-terminal variable tides. Three of these (cA3, ca5/6 and ca8) encode novel, domain) have been evolutionarily conserved (Sullivan and expressed a-tubulins that have not previously been Cleveland, 1986; Wang et al., 1986). analyzed, whereas one gene segment is a pseudogene and For a-tubulin, the analyses are less complete.
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CA8 (NM 004056) Human Tagged ORF Clone – RG210228 | Origene
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CA8 Antibody / Carbonic Anhydrase VIII [Clone CPTC-CA8-2] (V7363)
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