UBE2L6 Rabbit Pab

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Leader in Biomolecular Solutions for Life Science UBE2L6 Rabbit pAb Catalog No.: A13670 Basic Information Background Catalog No. The modification of proteins with ubiquitin is an important cellular mechanism for A13670 targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin- Observed MW conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a 18kDa member of the E2 ubiquitin-conjugating enzyme family. This enzyme is highly similar in primary structure to the enzyme encoded by the UBE2L3 gene. Two alternatively spliced Calculated MW transcript variants encoding distinct isoforms have been found for this gene. 10kDa/17kDa Category Primary antibody Applications WB,IF Cross-Reactivity Human, Mouse, Rat Recommended Dilutions Immunogen Information WB 1:500 - 1:2000 Gene ID Swiss Prot 9246 O14933 IF 1:50 - 1:200 Immunogen A synthetic peptide corresponding to a sequence within amino acids 50 to the C- terminus of human UBE2L6 (NP_004214.1). Synonyms UBE2L6;RIG-B;UBCH8 Contact Product Information 400-999-6126 Source Isotype Purification Rabbit IgG Affinity purification [email protected] www.abclonal.com.cn Storage Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. Validation Data Western blot analysis of extracts of various cell lines, using UBE2L6 antibody (A13670) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. Immunofluorescence analysis of HeLa cells Immunofluorescence analysis of NIH/3T3 using UBE2L6 antibody (A13670) at dilution cells using UBE2L6 antibody (A13670) at of 1:100. Blue: DAPI for nuclear staining. dilution of 1:100. Blue: DAPI for nuclear staining. Antibody | Protein | ELISA Kits | Enzyme | NGS | Service For research use only. Not for therapeutic or diagnostic purposes. Please visit http://abclonal.com for a complete listing of recommended products..

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Figure S1. DMD Module Network. the Network Is Formed by 260 Genes from Disgenet and 1101 Interactions from STRING. Red Nodes Are the Five Seed Candidate Genes
Figure S1. DMD module network. The network is formed by 260 genes from DisGeNET and 1101 interactions from STRING. Red nodes are the five seed candidate genes. Figure S2. DMD module network is more connected than a random module of the same size. It is shown the distribution of the largest connected component of 10.000 random modules of the same size of the DMD module network. The green line (x=260) represents the DMD largest connected component, obtaining a z-score=8.9. Figure S3. Shared genes between BMD and DMD signature. A) A meta-analysis of three microarray datasets (GSE3307, GSE13608 and GSE109178) was performed for the identification of differentially expressed genes (DEGs) in BMD muscle biopsies as compared to normal muscle biopsies. Briefly, the GSE13608 dataset included 6 samples of skeletal muscle biopsy from healthy people and 5 samples from BMD patients. Biopsies were taken from either biceps brachii, triceps brachii or deltoid. The GSE3307 dataset included 17 samples of skeletal muscle biopsy from healthy people and 10 samples from BMD patients. The GSE109178 dataset included 14 samples of controls and 11 samples from BMD patients. For both GSE3307 and GSE10917 datasets, biopsies were taken at the time of diagnosis and from the vastus lateralis. For the meta-analysis of GSE13608, GSE3307 and GSE109178, a random effects model of effect size measure was used to integrate gene expression patterns from the two datasets. Genes with an adjusted p value (FDR) < 0.05 and an │effect size│>2 were identified as DEGs and selected for further analysis. A significant number of DEGs (p<0.001) were in common with the DMD signature genes (blue nodes), as determined by a hypergeometric test assessing the significance of the overlap between the BMD DEGs and the number of DMD signature genes B) MCODE analysis of the overlapping genes between BMD DEGs and DMD signature genes.
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Uncovering Ubiquitin and Ubiquitin-Like Signaling Networks Alfred C
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Product Information
Product information Monoclonal anti-human UBE2L6 antibody (clone K1H3) Mouse IgG2b, Cat. No. IBAUB0907 Immunogen: Recombinant human UBE2L6 (1-152aa) purified from E. coli NCBI Accession No.: NP_004214 Isotype: Mouse IgG2b heavy chain and light chain Clone: Anti-human UBE2L6 mAb, clone K1H3, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human UBE2L6 protein. Description: Ubiquitin-conjugating enzyme E2L6 (UBE2L6), also known as UbcH8, is a member of the E2 ubiquitin-conjugating enzyme family. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination of a protein substrate requires the concerted action of 3 classes of enzymes: E1 ubiquitin-activating enzymes, E2 ubiquitin- conjugating enzymes, and E3 ubiquitin protein ligases. The E2 ubiquitin-conjugating enzyme is highly similar in primary structure to the enzyme encoded by UBE2L3 gene. Concentration: 1mg/ml Form: Liquid. In Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% Glycerol. Storage: Can be stored at +4°C. For long term storage, aliquot and store at -20°C. Avoid repeated freezing and thawing cycles. Usage: The antibody has been tested by ELISA, Western blot analysis, Flow cytometry and ICC/IF immunohistochemistry to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Application: ELISA, WB, IHC, Flow cytometry, ICC/IF For research use only. This product is not intended or approved for human, diagnostics or veterinary use. Manufactured for: Immuno-Biological Laboratories, Inc.
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Targeting the Ubiquitin System in Glioblastoma', Frontiers in Oncology
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Figure S1. HAEC ROS Production and ML090 NOX5-Inhibition
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bioRxiv preprint doi: https://doi.org/10.1101/416677; this version posted September 13, 2018. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. Warm Temperatures, Cool Sponges: The Effect of Increased Temperatures on the Antarctic Sponge Isodictya sp. M. González-Aravena1*, N.J. Kenny2*^, M. Osorio1, A. Font1, A. Riesgo2, C.A. Cárdenas1^ 1 Departamento Científico, Instituto Antártico Chileno, Plaza Muñoz Gamero 1055, Punta Arenas, 6200965, Chile 2 Life Sciences Department, The Natural History Museum, Cromwell Road, London SW7 5BD, UK * Authors contributed equally to manuscript ^ Corresponding authors MGA: [email protected] NJK: [email protected] MO: [email protected] AF: [email protected] AR: [email protected] CAC: [email protected] Corresponding author details: NJK: +44 20 7942 6475 CAC: +56 61 2298124 1 bioRxiv preprint doi: https://doi.org/10.1101/416677; this version posted September 13, 2018. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. Abstract Although the cellular and molecular responses to exposure to relatively high temperatures (acute thermal stress or heat shock) have been studied previously, only sparse empirical evidence of how it affects cold-water species is available. As climate change becomes more pronounced in areas such as the Western Antarctic Peninsula, it has become crucial to understand the capacity of these species to respond to thermal stress.
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