bioRxiv preprint doi: https://doi.org/10.1101/244590; this version posted January 9, 2018. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC 4.0 International license. 1 2 3 4 Expression of the Eight GABAA Receptor α Subunits in the 5 Developing Zebrafish Central Nervous System 6 7 8 Bryan Monesson-Olson1, 2, Jon J. McClain2, Abigail E. Case2, Hanna E. Dorman2, Daniel R. 9 Turkewitz3, Aaron B. Steiner3 and Gerald B. Downes1, 2* 10 11 12 13 1Neuroscience and Behavior Graduate Program 14 2Biology Department, University of Massachusetts, Amherst, MA 01003, USA 15 3Department of Biology and Health Sciences, Pace University, Pleasantville, NY 10570, USA 16 17 18 *Corresponding author: 19 Gerald B. Downes 20 Email:
[email protected] bioRxiv preprint doi: https://doi.org/10.1101/244590; this version posted January 9, 2018. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC 4.0 International license. 21 ABSTRACT 22 GABA is a robust regulator of both developing and mature neural networks. It exerts 23 many of its effects through GABAA receptors, which are heteropentamers assembled from a 24 large array of subunits encoded by distinct genes. In mammals, there are 19 different GABAA 25 subunit types, which are divided into the α, β, γ, δ, ε, π, θ and ρ subfamilies.