Paratyphoid Vaccine Development CONFIDENTIAL
Paratyphoid vaccine development CONFIDENTIAL Andrew J Pollard Typhoid Vaccine use WHO WHO SAGE Gavi funding prequalification recommendations Nov 2017 Jan 2018 Oct 2017 TyVac UOXF, UMB UOXF UMB Banglades Nepal Malawi h 20,000 >58,000 28,000 Buddha Basnyat John Clemens Melita Gordon Shrijana Shrestha Firdausi Qadri Interim analysis 2019 BMGF/WELLCOME SALMONELLA CONVENING: SALMONELLA PARATYPHI London, May 1, 2019 © Bill & Melinda Gates Foundation | Typhoid & paratyphoid incidence rates per 100,000, age-standardized, 2017 14.3 million (12.5 – 16.3) cases in 2017 Paratyphoid, global estimates by year (thousands) Year Incidence Deaths YLDs YLLs DALYs 5,508 28.5 15.0 2,071 2,086 1990 (4,233 – 7,086) (12.7 – 56.7) (9.4 – 22.6) (913 – 4,172) (925 – 4,184) 5,139 27.3 14.0 1,977 1,991 1995 (3,963 – 6,543) (12.4 – 53.8) (8.8 – 21.0) (888 – 3,912) (897 – 3,926) 4,698 25.2 12.9 1,817 1,830 2000 (3,640 – 5,953) (11.5 – 49.9) (8.1 – 19.5) (835 – 3,600) (846 – 3,611) 4,232 23.0 11.6 1,649 1,661 2005 (3,311 – 5,327) (10.5 – 45.3) (7.3 – 17.3) (756 – 3,259) (764 – 3,273) 3,794 20.9 10.4 1,477 1,487 2010 (2,992 – 4,739) (9.5 – 40.6) (6.7 – 15.5) (670 – 2,862) (684 – 2,875) 3,397 19.1 9.4 1,354 1,364 2017 (2,666 – 4,184) (8.7 – 37.3) (5.9 – 13.9) (622 – 2,620) (633 – 2,631) Malaria 45,015 (31,720 – 60,994) Typhoid fever 8,437 (4,732 – 13,512) Invasive Non-typhoidal Salmonella (iNTS) 4,263 (2,385 – 7,382) Acute hepatitis B 3,526 (2,625 – 4,119) Dengue 2,923 (1,629 – 3,967) Acute hepatitis A 1,498 (1,134 – 1,869) Paratyphoid fever 1,364 (633 – 2,631) Acute hepatitis E 739 (517 – 935) Rabies 634 (504 – 836) Yellow fever 314 (67 – 900) 1 10 100 1000 10000 100000 DALYs (thousands) Variation • Time • Vaccination • Geography • Age Variable incidence of S.
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