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German Center for Infection Research GERMAN CENTER FOR INFECTION RESEARCH Annual Report 2018 Cover image: This image shows a scanning electron microscope image of thread-like Ebola viruses (in blue) protruding from an infected cell. ANNUAL REPORT 2018 The DZIF at a glance The German Center for Infection Research (DZIF) coordinates and oversees the strategic planning of translational infection research within Germany. Its mission is to translate results from basic biomedical research into clinical research. 35 DZIF research centres work concertedly against the global threat of infectious diseases. Table of contents Editorial ............................................................................................................................................................................. 3 About the DZIF ............................................................................................................................................................. 4 Science – Translation in focus Emerging Infections ................................................................................................................................................. 6 Tuberculosis ................................................................................................................................................................... 8 Malaria .............................................................................................................................................................................. 10 HIV ........................................................................................................................................................................................ 12 Hepatitis .......................................................................................................................................................................... 14 Gastrointestinal Infections .............................................................................................................................. 16 Infections of the immunocompromised Host .................................................................................. 18 Healthcare-associated and Antibiotic-resistant bacterial Infections ........................ 20 Novel Antibiotics ..................................................................................................................................................... 22 Research infrastructures Product Development Unit ............................................................................................................................ 24 Clinical Trial Unit ..................................................................................................................................................... 24 African Partner Institutions ............................................................................................................................ 25 Novel Antivirals ......................................................................................................................................................... 25 Biobanking .................................................................................................................................................................... 26 Pathogen Repository ........................................................................................................................................... 26 Bioinformatics ............................................................................................................................................................ 27 Epidemiology .............................................................................................................................................................. 27 DZIF-Academy ........................................................................................................................................................... 28 Successful Translation ........................................................................................................................................ 29 DZIF-Highlights 2018 ............................................................................................................................................. 30 Science and public ................................................................................................................................................ 32 External collaborations ..................................................................................................................................... 34 German Centers for Health Research .................................................................................................... 37 Facts and figures Organisation and bodies ............................................................................................................................. 38 Partner sites and member establishments .................................................................................... 40 Finances ................................................................................................................................................................. 44 Personnel and awards .................................................................................................................................. 46 Indicators 2018.................................................................................................................................................... 48 Publications ......................................................................................................................................................... 50 Member establishments ............................................................................................................................. 54 Imprint .................................................................................................................................................................... 55 2 Editorial nfectious diseases pose major challenges for science, research fields. This report will describe two vaccine research I medicine, politics in Germany and throughout the world. projects in detail: a therapeutic vaccination against hepatitis The German Center for Infection Research (DZIF) tackles B for which preclinical development has been concluded and these challenges through translational research. Since 2019, which is now ready for clinical testing, and a vaccine candidate a new Executive Board comprising five members has been against the Epstein Barr virus which is ready for the product supervising the activities of the DZIF. The new Board inherited development according to the Good Manufacturing Practice a successful network from its predecessors, the “founding” (GMP) guidelines. Executive Board, including numerous successful achievements. Once again, our Annual Report illustrates the extensiveness The DZIF’s Scientific Advisory Board recently rated the DZIF as of the thematic units dedicated to infection research at the a “key player at an international global level”, allowing the new DZIF. Firmly established themes within the DZIF include the Executive Board to build on a solid foundation and to continue development of new antibiotics, the fight against multidrug- the strategic development of the translational infection resistant bacteria, research into infections that are prominent research. Special thanks go to the predecessors Martin Krönke, on a global scale such as HIV, malaria, tuberculosis and Ulrike Protzer and Dirk Heinz, who contributed substantially to gastrointestinal diseases as well as newly emerging pathogens this development through their dedication. and how to combat them. There are several prime examples The specific focus now is to further improve on these that should be of interest such as a new antibiotic against successful projects, to develop new themes and projects and tuberculosis that is due to enter clinical phase II trials. DZIF to keep adapting the strategy in line with changing demands. researchers have also tested new antibodies with confirmed In 2018, focus was placed on internationalisation which set the efficacy against HIV, a virus that continues to be a leading course for partnerships with globally active institutions: CEPI cause of death in many countries. The permanent control of (Coalition for Epidemic Preparedness Innovation) and CARB-X HIV and eventually finding a cure for the infection continue to (Combating Antibiotic Resistant Biopharmaceutical Accelerator). feature on the DZIF agenda. The development of new vaccines and new approaches towards We have selected various highlights from all fields of research managing multidrug-resistant bacteria, viruses and parasites will for this report to give you a view of the scope of work carried continue to play an important role in the future. out at the DZIF. You can read about what DZIF scientists Prevention, diagnostics and therapy are central themes at have accomplished and achieved in the field of translational the DZIF which has categorised its activities into nine different research in 2018. We hope you enjoy reading this report. Yours sincerely The DZIF Executive Board Prof. Hans-Georg Kräusslich Prof. Dirk Busch Prof. Ingo Autenrieth Prof. Maura Dandri Prof. Dirk Heinz 3 ABOUT THE DZIF ABOUT DZIF THE United in tackling major challenges Infection researchers at the DZIF are currently confronted with four major challenges: tropical and emerging infections,
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