Impact of Actin Filament Stabilization on Adult Hippocampal and Olfactory Bulb Neurogenesis
The Journal of Neuroscience, March 3, 2010 • 30(9):3419–3431 • 3419 Development/Plasticity/Repair Impact of Actin Filament Stabilization on Adult Hippocampal and Olfactory Bulb Neurogenesis Golo Kronenberg,1,2,5* Karen Gertz,1,2* Tina Baldinger,1 Imke Kirste,5 Sarah Eckart,3 Ferah Yildirim,1 Shengbo Ji,1 Isabella Heuser,5 Helmut Schro¨ck,6 Heide Ho¨rtnagl,4 Reinhard Sohr,4 Pierre Chryso Djoufack,7 Rene´Ju¨ttner,8 Rainer Glass,8 Ingo Przesdzing,1 Jitender Kumar,8 Dorette Freyer,1 Rainer Hellweg,3 Helmut Kettenmann,8 Klaus Benno Fink,7 and Matthias Endres1,2 1Klinik und Poliklinik fu¨r Neurologie, 2Center for Stroke Research Berlin, 3Klinik fu¨r Psychiatrie und Psychotherapie, and 4Institut fu¨r Pharmakologie und Toxikologie, Charite´-Universita¨tsmedizin Berlin, D-10117 Berlin, Germany, 5Klinik und Hochschulambulanz fu¨r Psychiatrie und Psychotherapie, Charite´- Universita¨tsmedizin Berlin, D-14050 Berlin, Germany, 6Institut fu¨r Neurophysiologie, Medizinische Fakulta¨t Mannheim, Universita¨t Heidelberg, D-68167 Mannheim, Germany, 7Institut fu¨r Pharmakologie und Toxikologie, Universita¨t Bonn, D-53113 Bonn, Germany, and 8Max Delbru¨ck Center for Molecular Medicine, D-13092 Berlin, Germany Rearrangement of the actin cytoskeleton is essential for dynamic cellular processes. Decreased actin turnover and rigidity of cytoskeletal structures have been associated with aging and cell death. Gelsolin is a Ca 2ϩ-activated actin-severing protein that is widely expressed throughout the adult mammalian brain. Here, we used gelsolin-deficient (Gsn Ϫ/Ϫ) mice as a model system for actin filament stabiliza- tion. In Gsn Ϫ/Ϫ mice, emigration of newly generated cells from the subventricular zone into the olfactory bulb was slowed.
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